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1. 发明公开

EP4391796A1 CROWN ROT RESISTANCE 审中-公开
公开(公告)号：EP4391796A1
公开(公告)日：2024-07-03
申请号：EP22859608.6
申请日：2022-08-22
申请人： Commonwealth Scientific and Industrial Research Organisation
发明人： JIANG, Yunfeng , ZHENG, Zhi , AYLIFFE, Michael , GARDINER, Donald , LIU, Chunji , GLASSOP, Donna
IPC分类号： A01H1/00 , A01H1/04 , A01H6/46 , C12N15/82 , C12N9/04 , C12Q1/6895
CPC分类号： C12Q1/6895 , C12N9/0008 , C12Y102/01044 , C12N15/8282 , A01H6/4624 , A01H5/10 , A01H1/1255 , C12Q2600/1320130101

2. 发明授权

EP3456820B1 NEUARTIGE 7BETA-HYDROXYSTEROID DEHYDROGENASE-MUTANTEN UND VERFAHREN ZUR HERSTELLUNG VON URSODESOXYCHOLSÄURE 有权
公开(公告)号：EP3456820B1
公开(公告)日：2024-06-19
申请号：EP18203708.5
申请日：2011-12-16
IPC分类号： C12N9/04 , C12P33/06 , C12P33/02
CPC分类号： C12N9/0008 , C12P33/00 , C12N9/0006 , C12Y101/01201

3. 发明公开

EP4321615A3 ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 审中-实审
公开(公告)号：EP4321615A3
公开(公告)日：2024-02-21
申请号：EP23201197.3
申请日：2010-04-30
申请人： Genomatica, Inc.
发明人： Burgard, Anthony P. , Burk, Mark J. , Osterhout, Robin E. , Pharkya, Priti
IPC分类号： C12N1/21 , C12P7/18 , C12N9/04 , C07C29/80
摘要： A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient account to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacelyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

4. 发明公开

EP4306638A1 VARIANT OF RUMINOCOCCUS GNAVUS STRAIN-DERIVED 7-BETA-HSDH, IMPROVING CONVERSION RATE FROM 7-KETO-LCA TO URSODEOXYCHOLIC ACID, AND METHOD FOR PRODUCING URSODEOXYCHOLIC ACID BY USING SAME 审中-实审
公开(公告)号：EP4306638A1
公开(公告)日：2024-01-17
申请号：EP22887491.3
申请日：2022-10-20
申请人： Ace Biopharm Co., Ltd.
发明人： MIN, Byeong Gyu , JANG, Hyung Wook , PARK, Jae Bum , KIM, So Young , SOHN, Min Jeong
IPC分类号： C12N9/04 , C12N15/70 , C12P33/00
摘要： Provided is a variant of RUMINOCOCCUS GNAVUS strain-derived 7 beta-hydroxysteroid (7-beta-HSDH) to improve the conversion rate from 7-keto lithocholic acid (7-Keto-LCA) to ursodeoxycholic acid (UDCA), and a method of producing UDCA using the same. The conversion efficiency of 7-Keto-LCA to UDCA is improved through the preparation of variants via enzyme modification and the development of recombinant protein production, which is expected to be widely utilized to improve UDCA biosynthesis and biosynthetic efficiency.

5. 发明公开

EP4269598A1 MICROORGANISM OF GENUS CORYNEBACTERIUM, PRODUCING L-AMINO ACIDS, AND METHOD FOR PRODUCING L-AMINO ACIDS USING SAME 审中-实审
公开(公告)号：EP4269598A1
公开(公告)日：2023-11-01
申请号：EP22767363.9
申请日：2022-02-21
申请人： CJ Cheiljedang Corporation
发明人： LEE, Han Hyoung , BYUN, Hyo Jeong , KIM, Byeong Soo , KIM, Hee Ju , JUNG, Moo Young , KIM, Hyung Joon , PARK, Seul-Gi
IPC分类号： C12N15/77 , C12N9/04 , C12N9/12 , C12P13/08 , C12P13/22
摘要： The present disclosure relates to a microorganism of the genus Corynebacterium producing L-amino acid, a method for producing L-amino acid using the same, use of L-amino acid production, and a composition for producing L-amino acid.

7. 发明授权

EP4056691B1 NOVEL MALATE DEHYDROGENASE VARIANT, AND METHOD FOR PRODUCING L-LYSINE USING SAME 有权转让
公开(公告)号：EP4056691B1
公开(公告)日：2023-10-25
申请号：EP21870486.4
申请日：2021-04-01
发明人： PARK, Goun , BAE, Jee Yeon , LEE, Han Hyoung , BAE, Hyun Won , KIM, Hyo Jin , SHIN, Yong Uk
IPC分类号： C12N9/04 , C12N15/77 , C12P13/08

8. 发明公开

EP4251731A1 GLYCOSIDE PRODUCT BIOSYNTHESIS AND RECOVERY 审中-实审转让
公开(公告)号：EP4251731A1
公开(公告)日：2023-10-04
申请号：EP21899075.2
申请日：2021-11-24
申请人： Manus Bio Inc.
发明人： KUMARAN, Ajikumar, Parayil , SANTOS, Christine, Nicole, S. , DONALD, Jason , LOVE, Aaron , ZHENG, Yiying , GHADERI, Adel , SHASTRY, Vineet , CHEN, Lu , TOOMEY, Christopher , LYNCH, Hannah , NIEMINEN, Eric
IPC分类号： C12N1/15 , C12N1/19 , C12N15/63 , C12N9/04 , C12N9/10

10. 发明公开

EP4208541A1 METHODS AND CELLS FOR PRODUCTION OF VOLATILE COMPOUNDS 审中-实审
公开(公告)号：EP4208541A1
公开(公告)日：2023-07-12
申请号：EP21769462.9
申请日：2021-09-01
申请人： Danmarks Tekniske Universitet
发明人： POGREBNYAKOV, Ivan , NIELSEN, Alex Toftgaard
IPC分类号： C12N9/10 , C12N9/16 , C12N9/88 , C12N9/04 , C12N15/52 , C12P7/28

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