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1. 发明授权

EP2851083B8 RADIATION-STERILIZATION-RESISTANT PROTEIN COMPOSITION 有权转让
公开(公告)号：EP2851083B8
公开(公告)日：2018-08-08
申请号：EP13790434.8
申请日：2013-05-13
申请人： Teijin Limited , Teijin Pharma Limited , The Chemo-Sero-Therapeutic Research Institute
发明人： KAGEYAMA, Yukako , FUJINAGA, Kentaro , YAMAGUCHI, Ayuko , AKIYAMA, Yusuke , KATOU, Souichirou , KIMURA, Yukiko , HONDA, Susumu , SATAKE, Makoto , KANEKO, Hiroaki , ISHIWARI, Ayumi , HIRASHIMA, Masaki
IPC分类号： A61L27/26 , A61L27/50 , A61L28/00 , A61L29/04 , A61L31/04 , A61K47/38 , A61L15/22 , A61L17/10 , A61K38/00 , A61K9/70 , A61K38/48 , A61L31/14 , A61K38/17
CPC分类号： A61K47/38 , A61K9/7007 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4833 , A61L15/225 , A61L17/10 , A61L27/26 , A61L27/505 , A61L28/0026 , A61L29/049 , A61L31/041 , A61L31/143 , C12Y302/01021 , C08L1/00 , C08L89/00
摘要： A protein composition which comprises a mixture of glycine, phenylalanine and histidine and/or a cellulose ether derivative as an additive and has resistance to radiation sterilization.

2. 发明授权

EP2851083B1 RADIATION-STERILIZATION-RESISTANT PROTEIN COMPOSITION 有权转让
公开(公告)号：EP2851083B1
公开(公告)日：2018-06-20
申请号：EP13790434.8
申请日：2013-05-13
申请人： Teijin Limited , Teijin Pharma Limited , The Chemo-Sero-Therapeutic Research Institute
发明人： KAGEYAMA, Yukako , FUJINAGA, Kentaro , YAMAGUCHI, Ayuko , AKIYAMA, Yusuke , KATOU, Souichirou , KIMURA, Yukiko , HONDA, Susumu , SATAKE, Makoto , KANEKO, Hiroaki , ISHIWARI, Ayumi , HIRASHIMA, Masaki
IPC分类号： A61L27/26 , A61L27/50 , A61L28/00 , A61L29/04 , A61L31/04 , A61K47/38 , A61L15/22 , A61L17/10 , A61K38/00 , A61K9/70 , A61K38/48 , A61L31/14 , A61K38/17
CPC分类号： A61K47/38 , A61K9/7007 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4833 , A61L15/225 , A61L17/10 , A61L27/26 , A61L27/505 , A61L28/0026 , A61L29/049 , A61L31/041 , A61L31/143 , C12Y302/01021 , C08L1/00 , C08L89/00
摘要： A protein composition which comprises a mixture of glycine, phenylalanine and histidine and/or a cellulose ether derivative as an additive and has resistance to radiation sterilization.

3. 发明公开

EP3366301A1 RADIATION STERILIZATION-RESISTANT PROTEIN COMPOSITION 审中-公开
公开(公告)号：EP3366301A1
公开(公告)日：2018-08-29
申请号：EP18167342.7
申请日：2013-05-13
申请人： Teijin Limited , Teijin Pharma Limited , The Chemo-Sero-Therapeutic Research Institute
发明人： KAGEYAMA, Yukako , FUJINAGA, Kentaro , YAMAGUCHI, Ayuko , AKIYAMA, Yusuke , KATOU, Souichirou , KIMURA, Yukiko , HONDA, Susumu , SATAKE, Makoto , KANEKO, Hiroaki , ISHIWARI, Ayumi , HIRASHIMA, Masaki
IPC分类号： A61K38/00 , A61K9/70 , A61K38/48 , A61K47/38 , A61L15/44 , A61P7/04
CPC分类号： A61K47/38 , A61K9/7007 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4833 , A61L15/225 , A61L17/10 , A61L27/26 , A61L27/505 , A61L28/0026 , A61L29/049 , A61L31/041 , A61L31/143 , C12Y302/01021 , C08L1/00 , C08L89/00
摘要： A protein composition which comprises a cellulose ether derivative selected from the group consisting of hydroxypropyl cellulose, methyl cellulose, hydroxypropylmethyl cellulose, and mixtures thereof as an additive and which is sterilized with radiation, wherein the protein is fibrinogen and/or an enzyme.

4. 发明公开

EP2851095A1 SHEET MOLDING AND HEMOSTATIC MATERIAL 有权转让
标题翻译：片模和止血材料
公开(公告)号：EP2851095A1
公开(公告)日：2015-03-25
申请号：EP13791531.0
申请日：2013-05-13
申请人： Teijin Limited , Teijin Pharma Limited , The Chemo-Sero-Therapeutic Research Institute
发明人： KAGEYAMA, Yukako , FUJINAGA, Kentaro , YAMAGUCHI, Ayuko , AKIYAMA, Yusuke , OONO, Akitoshi , HONDA, Susumu , SATAKE, Makoto , KANEKO, Hiroaki , IMAMURA, Takayuki , KAWAMURA, Ryoichi , HIRASHIMA, Masaki
IPC分类号： A61L24/00 , A61K38/00 , A61K38/48 , A61K47/34 , A61L15/44 , A61P7/04
CPC分类号： A61L26/0066 , A61K38/363 , A61K38/4833 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L26/0052 , A61L26/0085 , A61L26/009 , A61L2300/25 , A61L2300/252 , A61L2300/418 , A61L2400/04 , C08L89/00
摘要： A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.
摘要翻译：一种聚合物组合物的成型片材产品，该聚合物组合物包含至少一种选自纤维蛋白原和凝血酶的蛋白质和至少一种选自脂族聚酯和水溶性聚合物的聚合物，以及层压成型片材产品，提供由纤维蛋白原和水溶性聚合物组成的第一聚合物组合物层和由凝血酶和脂肪族聚酯组成的第二聚合物组合物层。这些成型产品被施用到伤口部位并用作止血材料。

5. 发明公开

EP2851083A1 RADIATION-STERILIZATION-RESISTANT PROTEIN COMPOSITION 有权转让
标题翻译：辐照灭菌耐药蛋白组成
公开(公告)号：EP2851083A1
公开(公告)日：2015-03-25
申请号：EP13790434.8
申请日：2013-05-13
申请人： Teijin Limited , Teijin Pharma Limited , The Chemo-Sero-Therapeutic Research Institute
发明人： KAGEYAMA, Yukako , FUJINAGA, Kentaro , YAMAGUCHI, Ayuko , AKIYAMA, Yusuke , KATOU, Souichirou , KIMURA, Yukiko , HONDA, Susumu , SATAKE, Makoto , KANEKO, Hiroaki , ISHIWARI, Ayumi , HIRASHIMA, Masaki
IPC分类号： A61K38/00 , A61K9/70 , A61K38/48 , A61K47/38 , A61L15/44 , A61P7/04
CPC分类号： A61K47/38 , A61K9/7007 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4833 , A61L15/225 , A61L17/10 , A61L27/26 , A61L27/505 , A61L28/0026 , A61L29/049 , A61L31/041 , A61L31/143 , C12Y302/01021 , C08L1/00 , C08L89/00
摘要： A protein composition which comprises a mixture of glycine, phenylalanine and histidine and/or a cellulose ether derivative as an additive and has resistance to radiation sterilization.

6. 发明授权

EP2363469B1 PROCESS FOR PREPARING INCLUSION BODY-FORMING PROTEIN 有权转让
公开(公告)号：EP2363469B1
公开(公告)日：2018-08-15
申请号：EP09822044.5
申请日：2009-10-21
申请人： The Chemo-Sero-Therapeutic Research Institute , Teijin Pharma Limited
发明人： NAKATAKE, Hiroshi , META, Akihiro , SUENAGA, Kiyotaka , HIRASHIMA, Masaki , MAEDA, Hiroaki
IPC分类号： C12N15/09 , C12N1/21 , C12P21/02 , C12N9/64
CPC分类号： C12N9/6491 , C07K2319/02 , C12P21/02
摘要： A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment consisting of a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline and/or alanine at the 21st position is substituted with the other amino acid, downstream of which nucleotide sequence is bound a nucleotide sequence of a gene of a protein of interest, and a process for preparing an inclusion body-forming protein consisting of the following steps: (1) preparing an expression vector in which a nucleic acid fragment is incorporated consisting of a nucleotide sequence coding for a modified signal peptide downstream of which is bound a nucleotide sequence of a gene of a protein of interest, (2) preparing a host cell transformed with the expression vector that produces an inclusion body-forming protein, and (3) purifying the inclusion body-forming protein from culture obtained by culturing the host cell that produces the inclusion body-forming protein. The above other amino acid is selected from the group consisting of aspartic acid, glutamic acid, lysine, histidine, phenylalanine and tyrosine.

7. 发明公开

EP2363469A1 PROCESS FOR PRODUCING PROTEIN CAPABLE OF FORMING INCLUSION BODY 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG EINESEINSCHLUSSKÖRPER-BILDENDEN蛋白
公开(公告)号：EP2363469A1
公开(公告)日：2011-09-07
申请号：EP09822044.5
申请日：2009-10-21
申请人： The Chemo-Sero-Therapeutic Research Institute , Teijin Pharma Limited
发明人： NAKATAKE, Hiroshi , META, Akihiro , SUENAGA, Kiyotaka , HIRASHIMA, Masaki , MAEDA, Hiroaki
IPC分类号： C12N15/09 , C12N1/21 , C12P21/02 , C12N9/64
CPC分类号： C12N9/6491 , C07K2319/02 , C12P21/02
摘要： A process for preparing an inclusion body-forming protein is provided. A nucleic acid fragment consisting of a nucleotide sequence coding for a modified alkaline phosphatase signal peptide (modified APSP) where leucine at the 13th position in the amino acid sequence shown in SEQ ID NO: 1 is substituted with proline and/or alanine at the 21st position is substituted with the other amino acid, downstream of which nucleotide sequence is bound a nucleotide sequence of a gene of a protein of interest, and a process for preparing an inclusion body-forming protein consisting of the following steps: (1) preparing an expression vector in which a nucleic acid fragment is incorporated consisting of a nucleotide sequence coding for a modified signal peptide downstream of which is bound a nucleotide sequence of a gene of a protein of interest, (2) preparing a host cell transformed with the expression vector that produces an inclusion body-forming protein, and (3) purifying the inclusion body-forming protein from culture obtained by culturing the host cell that produces the inclusion body-forming protein. The above other amino acid is selected from the group consisting of aspartic acid, glutamic acid, lysine, histidine, phenylalanine and tyrosine.
摘要翻译：提供了制备包涵体形成蛋白的方法。由编码改变的碱性磷酸酶信号肽（修饰的APSP）的核苷酸序列组成的核酸片段，其中第21位的氨基酸序列中的第13位的亮氨酸被脯氨酸和/或丙氨酸取代位置被其他氨基酸取代，其中核苷酸序列的下游与感兴趣蛋白质的基因的核苷酸序列结合，以及由以下步骤组成的包含体形成蛋白的方法：（1）制备表达载体，其中掺入核酸片段，由编码下游的修饰信号肽的核苷酸序列组成，所述核苷酸序列结合目的蛋白质的基因的核苷酸序列，（2）制备用表达载体转化的宿主细胞产生包涵体形成蛋白质，（3）通过培养产生的宿主细胞获得的培养物纯化包涵体形成蛋白质是包涵体形成蛋白。上述其它氨基酸选自天冬氨酸，谷氨酸，赖氨酸，组氨酸，苯丙氨酸和酪氨酸。

8. 发明公开

EP1132402A1 PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY 有权
标题翻译： PEPTIDFRAGMENTE MIT DEN ZELLTOD VERHINDERNDERAKTIVITÄT
公开(公告)号：EP1132402A1
公开(公告)日：2001-09-12
申请号：EP99972642.5
申请日：1999-11-12
申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute
发明人： HIRASHIMA, Masaki , MAEDA, Hiroaki , NOZAKI, Chikateru
IPC分类号： C07K14/47 , A61K38/17 , C12N5/06 , C07K16/18
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at the C-terminal of selenoprotein P, or having said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or having a partial sequence of either of the above amino acid sequences, a medicament for treatment comprising said peptide fragment or a series of peptide fragments, an antibody to said peptide fragment or a series of peptide fragments, and a method for screening a cell death-inhibitory activity using said peptide fragment or a series of peptide fragments. The preferable peptide fragment or a series of peptide fragments of the present invention has the amino acid sequences shown in SEQ ID NO: 1 and/or SEQ ID NO: 2 or has a partial sequence thereof.
摘要翻译：本发明提供具有细胞死亡抑制活性的肽片段或一系列肽片段，其具有由硒蛋白P的C末端上的103个氨基酸残基组成的氨基酸序列，或具有所述氨基酸序列与一个或多个其中缺少，取代或添加的几个氨基酸残基或具有上述氨基酸序列之一的部分序列，包含所述肽片段或一系列肽片段的治疗药物，所述肽片段的抗体或一系列的肽片段，以及使用所述肽片段或一系列肽片段筛选细胞死亡抑制活性的方法。本发明优选的肽片段或一系列肽片段具有SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列或其部分序列。

9. 发明公开

EP3147358A1 METHOD FOR MONOMERIZING MATRIX METALLOPROTEINASE-7 (MMP-7) AGGREGATE 审中-实审转让
标题翻译： VERFAHREN ZUR单体EINES基质金属蛋白酶-7-AGGREGATS（MMP-7）
公开(公告)号：EP3147358A1
公开(公告)日：2017-03-29
申请号：EP15795955.2
申请日：2015-05-20
申请人： The Chemo-Sero-Therapeutic Research Institute
发明人： NAKATAKE, Hiroshi , HIRASHIMA, Masaki , TAKEO, Hideki , MATSUYAMA, Reiko , MORIKAWA, Wataru
IPC分类号： C12N9/64 , A61K38/46 , A61K47/02 , A61K47/10 , A61K47/16 , A61K47/26 , A61P19/00 , A61P25/00 , C12N9/96
CPC分类号： C12N9/96 , A61K38/46 , A61K38/4886 , A61K47/02 , A61K47/10 , A61K47/16 , A61K47/26 , C12N9/64 , C12N9/6491 , C12N15/52 , C12Y304/24023
摘要： A method for monomerization of MMP-7 aggregates is provided. A method for monomerization of MMP-7 aggregates which comprises treating MMP-7 aggregates with a buffer solution comprising a monovalent cation chloride (sodium chloride, potassium chloride, etc.) at a low concentration or with a buffer solution not comprising a monovalent cation chloride, a process for preparing MMP-7 which involves said method for monomerization, and a (pharmaceutical) composition comprising MMP-7 in the aforementioned buffer solution. In case that a (pharmaceutical) composition comprising MMP-7 at a low concentration is prepared, the aforementioned buffer solution comprising sugar alcohols or sugars is used.
摘要翻译：提供了MMP-7聚集体的单体化方法。用于单体化MMP-7聚集体的方法，其包括用包含低浓度的一价阳离子氯化物（氯化钠，氯化钾等）或不含一价阳离子氯化物的缓冲溶液处理MMP-7聚集体制备涉及所述单体化方法的MMP-7的方法，以及在上述缓冲溶液中含有MMP-7的（药物）组合物。在制备含有低浓度的MMP-7的（药物）组合物的情况下，使用上述包含糖醇或糖的缓冲溶液。

10. 发明授权

EP1921140B1 MUTANT TRANSPOSON VECTOR AND USE THEREOF 有权
标题翻译：突变体转座子及其用途
公开(公告)号：EP1921140B1
公开(公告)日：2011-12-14
申请号：EP06780756.0
申请日：2006-07-04
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： KAMINAKA, Kazuyoshi , MAEDA, Hiroaki , HIRASHIMA, Masaki , KAWAMURA, Ryoichi , MATSUDA, Junichi , KUWANA, Takashi
IPC分类号： C12N15/09 , A01K67/027 , C12N5/10
CPC分类号： C12N15/79 , A01K2217/05 , A01K2227/30 , C12N15/102 , C12N15/85 , C12N15/90 , C12N2800/30 , C12N2800/90 , C12N2820/00
摘要： Disclosed are a mutant transposon vector and a method for introducing a foreign gene into a cell. A mutant transposon vector having a nucleic acid fragment inserted therein, the nucleic acid fragment having the properties (i) and (ii) or the properties (i) to (iii) below; a foreign gene-expressing cell which is prepared by introducing the mutant transposon vector into the chromosomal DNA of an established cell or a cell capable of being individuated and then additionally introducing a foreign gene-expressing cassette into a recombinant system (e.g., Cre-Lox system); a recombinant animal created by using the cell (in the case where the cell capable of being individuated is used); and a method for producing a foreign protein from the cell or the recombinant animal: (i) comprising a 5'-TIR sequence and a 3'-TIR sequence of transposon gene; (ii) having a sequence at which a recombination reaction occurs inserted between at least one set of DR regions of two sets of DR regions present in a 5'-TIR sequence or a 3'-TIR sequence of transposon gene; and (iii) having a restriction recognition site or a foreign gene-expressing cassette inserted between a 5'-TIR sequence and a 3'-TIR sequence of transposon gene.

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