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1. 发明公开

EP2851095A1 SHEET MOLDING AND HEMOSTATIC MATERIAL 有权转让
标题翻译：片模和止血材料
公开(公告)号：EP2851095A1
公开(公告)日：2015-03-25
申请号：EP13791531.0
申请日：2013-05-13
申请人： Teijin Limited , Teijin Pharma Limited , The Chemo-Sero-Therapeutic Research Institute
发明人： KAGEYAMA, Yukako , FUJINAGA, Kentaro , YAMAGUCHI, Ayuko , AKIYAMA, Yusuke , OONO, Akitoshi , HONDA, Susumu , SATAKE, Makoto , KANEKO, Hiroaki , IMAMURA, Takayuki , KAWAMURA, Ryoichi , HIRASHIMA, Masaki
IPC分类号： A61L24/00 , A61K38/00 , A61K38/48 , A61K47/34 , A61L15/44 , A61P7/04
CPC分类号： A61L26/0066 , A61K38/363 , A61K38/4833 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L26/0052 , A61L26/0085 , A61L26/009 , A61L2300/25 , A61L2300/252 , A61L2300/418 , A61L2400/04 , C08L89/00
摘要： A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.
摘要翻译：一种聚合物组合物的成型片材产品，该聚合物组合物包含至少一种选自纤维蛋白原和凝血酶的蛋白质和至少一种选自脂族聚酯和水溶性聚合物的聚合物，以及层压成型片材产品，提供由纤维蛋白原和水溶性聚合物组成的第一聚合物组合物层和由凝血酶和脂肪族聚酯组成的第二聚合物组合物层。这些成型产品被施用到伤口部位并用作止血材料。

2. 发明授权

EP2202306B1 RECOMBINANT FACTOR X WITH NO GLYCOSYLATION AND METHOD FOR PREPARING THE SAME 有权
标题翻译：重组凝血因子X无其制备糖基化和方法
公开(公告)号：EP2202306B1
公开(公告)日：2012-12-19
申请号：EP08837781.7
申请日：2008-10-08
申请人： The Chemo-Sero-Therapeutic Research Institute
发明人： SOEJIMA, Kenji , IMAMURA, Takayuki , KAWAMURA, Ryoichi , NAKATAKE, Hiroshi , MAEYASHIKI, Arisa , TOGO, Hitomi
IPC分类号： C12N9/64
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006

3. 发明授权

EP1405912B8 GENETICALLY MODIFIED ECARIN AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：经遗传修饰的EC AND及其生产方法
公开(公告)号：EP1405912B8
公开(公告)日：2012-10-24
申请号：EP02745822.3
申请日：2002-07-04
申请人： The Chemo-Sero-Therapeutic Research Institute
发明人： YONEMURA, Hiroshi , IMAMURA, Takayuki , NAKATAKE, Hiroshi , SOEJIMA, Kenji , NOZAKI, Chikateru
IPC分类号： C12P21/02
CPC分类号： C12N9/6418

4. 发明公开

EP1939283A1 PROCESS FOR PRODUCING RECOMBINANT HUMAN THROMBIN BY CULTURED CELL 审中-公开
标题翻译： PROCESS重组人凝血酶通过培养细胞生产
公开(公告)号：EP1939283A1
公开(公告)日：2008-07-02
申请号：EP06810820.8
申请日：2006-09-29
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： ONCHI, Tatsufumi, c/o JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTI C RESEARCH INSTITUTE, KIKUCHI RESEARCH CENTER, , NAKAHARA, Yo, c/o JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTI C RESEARCH INSTITUTE, KIKUCHI RESEARCH CENTER, , IMAMURA, Takayuki , NOUCHI, Toshinobu , NAKATAKE, Hiroshi
IPC分类号： C12N9/74 , C12N5/10 , C12N15/09
CPC分类号： C12N9/6429 , C12Y304/21005
摘要： The present invention provides for a process for preparing a recombinant human thrombin. A process for preparing a recombinant human thrombin which comprises: (1) obtaining a transfectant cell producing a human prothrombin by introducing an expression vector, wherein a gene fragment coding for a human prothrombin gene is incorporated, into an animal cell; (2) purifying a human prothrombin from the culture of the transfectant cell above by an anion exchanger; (3) converting the purified human prothrombin into a human thrombin by subjecting said human prothrombin to the action of ecarin; and (4) purifying the human thrombin from the solution after treatment with ecarin by an affinity method using benzamidine and a cation exchanger, and human thrombin obtained by said process, and a CHO cell that produces human prothrombin.
摘要翻译：本发明提供了用于制备重组人凝血酶的方法。一种制备重组人凝血酶的方法，包括：（1）获得转染细胞通过引入到表达载体中，用于worin人凝血酶原基因的基因片段编码产生人凝血酶原结合，导入动物细胞; （2）纯化从细胞转染子的培养人凝血酶原以上通过在阴离子交换剂; （3）将所述纯化的人凝血酶原成人凝血酶通过使所述人凝血酶原至蝰蛇毒的作用; 和（4）通过在亲和纯化的方法从与蝰蛇毒处理后的溶液中的人凝血酶使用苄脒和阳离子交换剂，以及由所述方法得到的人凝血酶，和CHO细胞没有产生人凝血酶原。

5. 发明公开

EP1405912A1 GENETICALLY MODIFIED ECARIN AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：遗传改良剂VERFAHREN ZU DESSEN HERSTELLUNG
公开(公告)号：EP1405912A1
公开(公告)日：2004-04-07
申请号：EP02745822.3
申请日：2002-07-04
申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute
发明人： YONEMURA, Hiroshi , IMAMURA, Takayuki , NAKATAKE, Hiroshi , SOEJIMA, Kenji , NOZAKI, Chikateru
IPC分类号： C12N15/12 , C07K14/435 , C12P21/02
CPC分类号： C12N9/6418
摘要： A recombinant ecarin protein that specifically activates prothrombin, said protein being efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transformant microorganism or animal cell transformed with an expression vector in which a gene encoding ecarin is incorporated to the downstream of a promoter so as to produce and accumulate ecarin in culture supernatant or within said transformant and recovering the produced ecarin; and (2) purifying a solution containing the recovered ecarin to obtain purified ecarin. The present invention allows for production of recombinant ecarin on an industrial scale.
摘要翻译：用于介导Arg-Ile位点上的凝血酶原-2切割以得到α-凝血酶或用于介导凝血酶原转化的中枢蛋白酶的遗传修饰的ecarin是新的。还包括用于生产重组ecarin的独立权利要求，其包括：（a）培养通过转化微生物或动物细胞而构建的转化体，所述转化体携带携带启动子下游整合的ecarin的基因的表达载体，并收集所产生和累积的ecarin 在培养基或转化体中; 和（b）回收ecarin进行纯化。活动：止血。机制：内肽酶。

6. 发明公开

EP2269594A1 METHOD OF PRODUCING THROMBIN-IMMOBILIZED BIOABSORBABLE SHEET PREPARATION 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES THROMBIN-IMMOBILISITENTEN BIOLOGISCH ABSORBIERBARENFOLIENPRÄPARATS
公开(公告)号：EP2269594A1
公开(公告)日：2011-01-05
申请号：EP09733482.5
申请日：2009-04-15
申请人： The Chemo-Sero-Therapeutic Research Institute
发明人： KAWAMURA, Ryoichi , IMAMURA, Takayuki , OWAKI, Hitomi
IPC分类号： A61K9/70 , A61K38/43 , A61K38/48 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61P7/04 , A61P17/02
CPC分类号： A61L15/44 , A61K38/00 , A61L15/64 , A61L31/148 , A61L31/16 , A61L2300/214 , A61L2300/418 , A61L2300/802 , A61L2400/04
摘要： A process for preparing a bioabsorbable sheet preparation holding thrombin is provided. A process for preparing a bioabsorbable sheet preparation holding thrombin which comprises immersing a bioabsorbable sheet consisting of polyglycolic acid in a thrombin solution containing thrombin as an active ingredient, glycerol as a softening agent, Tween 80 as a permeating agent, and optionally histidine and trehalose as a stabilizing agent followed by drying to hold thrombin on said bioabsorbable sheet, and a bioabsorbable sheet preparation holding thrombin prepared by said process.
摘要翻译：提供了一种制备保持凝血酶的生物可吸收性片剂的方法。一种制备保持凝血酶的生物可吸收性片剂的方法，该方法包括将由聚乙醇酸组成的生物可吸收片材浸入含有凝血酶作为活性成分的凝血酶溶液，甘油作为软化剂，吐温80作为渗透剂，以及任选的组氨酸和海藻糖稳定剂，然后干燥以在所述生物可吸收性片材上保持凝血酶，以及通过所述方法制备保持凝血酶的生物可吸收性片剂制剂。

7. 发明公开

EP2202306A1 GENETICALLY ENGINEERED BLOOD COAGULATION FACTOR X HAVING NO SUGAR CHAIN, AND METHOD FOR PRODUCTION THEREOF 有权
标题翻译： REKOMBINANTER BLUTGERINNUNGSFAKTOR X OHNE GLYCOSYLIERUNG UND METHODEFÜRDESSEN ZUBEREITUNG
公开(公告)号：EP2202306A1
公开(公告)日：2010-06-30
申请号：EP08837781.7
申请日：2008-10-08
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： SOEJIMA, Kenji , IMAMURA, Takayuki , KAWAMURA, Ryoichi , NAKATAKE, Hiroshi , MAEYASHIKI, Arisa , TOGO, Hitomi
IPC分类号： C12N15/09 , A61K38/43 , A61P7/04 , C07K14/745 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： A Factor X (hereinafter referred to as "FX") with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises intervening glycosylation at such an amino acid sequence that is essential for glycosylation in FX to thereby allow for expression of a recombinant FX with no glycosylation, and the recombinant FX with no glycosylation obtained by said method.
摘要翻译：提供了具有高活性的因子X（以下称为“FX”）。本发明涉及一种有效制备重组双链FX的方法，该方法包括在FX中糖基化所必需的氨基酸序列上插入糖基化，从而允许没有糖基化的重组FX的表达，通过所述方法获得的没有糖基化的FX。

8. 发明授权

EP2269594B1 METHOD OF PRODUCING THROMBIN-IMMOBILIZED BIOABSORBABLE SHEET PREPARATION 有权
标题翻译：用于生产凝血酶固定化生物可吸收薄膜的制备
公开(公告)号：EP2269594B1
公开(公告)日：2016-03-02
申请号：EP09733482.5
申请日：2009-04-15
申请人： The Chemo-Sero-Therapeutic Research Institute
发明人： KAWAMURA, Ryoichi , IMAMURA, Takayuki , OWAKI, Hitomi
IPC分类号： A61L15/44 , A61L15/64
CPC分类号： A61L15/44 , A61K38/00 , A61L15/64 , A61L31/148 , A61L31/16 , A61L2300/214 , A61L2300/418 , A61L2300/802 , A61L2400/04

9. 发明授权

EP1405912B1 GENETICALLY MODIFIED ECARIN AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：基因改造蝰蛇毒和方法及其
公开(公告)号：EP1405912B1
公开(公告)日：2012-09-05
申请号：EP02745822.3
申请日：2002-07-04
申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
发明人： YONEMURA, Hiroshi , IMAMURA, Takayuki , NAKATAKE, Hiroshi , SOEJIMA, Kenji , NOZAKI, Chikateru
IPC分类号： C12P21/02
CPC分类号： C12N9/6418

10. 发明公开

EP1405910A1 PROCESS FOR PRODUCING HUMAN THROMBIN BY GENE MODIFICATION TECHNIQUE 有权
标题翻译： VERFAHREN ZUR HERSTELLLUNG VON MENSCHLICHEM THROMBIN MITTELS GENMODIFIKATIONSTECHNIK
公开(公告)号：EP1405910A1
公开(公告)日：2004-04-07
申请号：EP02743820.9
申请日：2002-07-04
申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute
发明人： YONEMURA, Hiroshi , IMAMURA, Takayuki , NAKATAKE, Hiroshi , SOEJIMA, Kenji , NOZAKI, Chikateru
IPC分类号： C12N15/09 , C12P21/02
CPC分类号： C12N9/6424 , C12Y304/21005
摘要： A genetic recombinant human thrombin is provided. Human thrombin is efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transfectant animal cell transfected with an expression vector in which a gene encoding human prethrombin is incorporated to the downstream of a promoter so as to produce and accumulate prethrombin in culture supernatant and recovering the produced human prethrombin; (2) treating a solution containing human prethrombin recovered in step (1) with ecarin so as to convert human prethrombin into human thrombin; and (3) purifying the solution obtained after the above activation process to obtain purified human thrombin. The present invention allows for provision of human thrombin in a large scale in a safe and economical manner due to exclusion of blood-derived components.
摘要翻译：使用包含培养转化体的基因修饰技术生产人凝血酶，通过用艾卡林处理活化后将回收的人凝血酶原转化为人凝血酶，并从反应混合物中纯化人凝血酶是新的。使用基因修饰技术生产人凝血酶包括：（a）培养通过将携带编码凝血酶原基因的基因的表达载体转化到动物细胞构建的转化体，所述基因整合到启动子的下游，并将如此产生的凝血酶原聚集在细胞中收集培养基（b）通过用艾卡林处理活化后将回收的人凝血酶原转化为人凝血酶; 和（c）从反应混合物中纯化此类人凝血酶。活动：止血。没有给出生物数据。行动机制：无给予。

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