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1. 发明公开

EP1896844A1 METHOD FOR PROCYANIDIN ANALYSIS 有权
标题翻译：原花青素分析程序
公开(公告)号：EP1896844A1
公开(公告)日：2008-03-12
申请号：EP06780775.0
申请日：2006-06-28
申请人： SUNTORY LIMITED
发明人： FUKUI, Yuko
IPC分类号： G01N33/14
CPC分类号： G01N33/14 , G01N2030/8813 , Y10T436/142222
摘要： The present invention relates to a novel method for quantifying procyanidin and flavan-3-ols contained in natural products, foods and drinks, pharmaceuticals and/or cosmetics. The present invention provides a method for quantifying procyanidin (a generic name for a mixture of catechin n-mer; n ≥ 1) contained in test samples such as natural products, foods and drinks, pharmaceuticals and/or cosmetics, which comprises a) pretreating a test sample using a column to remove contaminants which affect the analysis of procyanidin and flavan-3-ol; and b) effecting high performance liquid chromatography (HPLC) to separate and quantify procyanidin and flavan-3-ols in the solution treated to remove contaminants during the above pretreatment step a).

2. 发明公开

EP1783136A1 LIPASE INHIBITOR 审中-公开
标题翻译： LIPASEINHIBITOR
公开(公告)号：EP1783136A1
公开(公告)日：2007-05-09
申请号：EP05780412.2
申请日：2005-08-22
申请人： SUNTORY LIMITED
发明人： FUKUI, Yuko , NAKAI, Masaaki , ASAMI, Sumio
IPC分类号： C07H13/08 , A61K31/7024 , A61P3/04
CPC分类号： A61K31/7024 , A23F3/16 , A23F3/18 , A23F3/34 , A23L33/105 , A23V2002/00 , A23V2250/214 , A23V2250/21 , A23V2200/02 , A23V2200/30
摘要： The present invention provides lipase inhibitory agents comprising a gallotannin or ellagitannin component(s) isolated from teas or Tellima grandiflora as well as foods and beverages and medicines containing said inhibitory agents.
The present invention provides lipase inhibitory agents comprising at least one of compounds represented by formula I below:

wherein R 1 , R 2 and R 3 independently represent H or a gallic acid residue, and R 4 and R 5 represent H or a gallic acid residue, or R 4 and R 5 together form an HHDP group represented by the formula below:

provided that at least two of R 1 to R 5 represent a gallic acid residue or when all of R 1 , R 2 and R 3 are H, R 4 and R 5 together form the HHDP group; as well as foods and beverages and medicines containing said lipase inhibitory agents.
摘要翻译：本发明提供脂肪酶抑制剂，其包含从茶或大蒜中分离出的gal单宁或鞣花素组分以及含有所述抑制剂的食品和饮料和药物。本发明提供脂肪酶抑制剂，其包含至少一种由下式I表示的化合物：其中R 1，R 2和R 3独立地表示H或没食子酸残基，R 4和R 5表示H或没食子酸残基，或R 4和R 5一起形成由下式表示的HHDP基团：条件是R 1至R 5中的至少两个表示没食子酸残基，或者当R 1，R 2和R 3全部为H时，R 4和R 5一起形成HHDP组; 以及含有所述脂肪酶抑制剂的食品和饮料和药物。

3. 发明公开

EP1767205A1 LIPASE INHIBITORS 审中-公开
标题翻译：脂肪酶缝边
公开(公告)号：EP1767205A1
公开(公告)日：2007-03-28
申请号：EP05758202.5
申请日：2005-07-05
申请人： SUNTORY LIMITED
发明人： NAKAI, Masaaki , FUKUI, Yuko , ASAMI, Sumio , HASHIMOTO, Fumio
IPC分类号： A61K31/353
CPC分类号： A61K36/82 , A23F3/163 , A23L2/52 , A23L33/105 , A61K31/353 , C07D311/62
摘要： The present invention provides lipase inhibitors containing dimers having an epigallocatechin gallate (EGCG) unit derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of proanthocyanidins represented by the formula:

wherein R 1 and R 2 independently represent H or OH, and R 3 and R 4 independently represent H or a galloyl group; as well as foods and beverages and pharmaceutical compositions containing said lipase inhibitors.
摘要翻译：本发明提供含有来自茶叶的表没食子儿茶素没食子酸酯（EGCG）单元的二聚体以及含有所述抑制剂的食品和饮料以及药物的脂肪酶抑制剂。更具体地说，本发明提供了含有至少一种由下式表示的原花色素的脂肪酶抑制剂：其中R 1和R 2独立地表示H或OH，R 3和R 4独立地表示H或加成酯基; 以及含有所述脂肪酶抑制剂的食品和饮料和药物组合物。

4. 发明授权

EP1001028B1 GENE ENCODING PROTEIN HAVING AURONE SYNTHESIZING ACTIVITY 有权
标题翻译： GEN，对于具有欧龙 - 合成活动代码的蛋白质。
公开(公告)号：EP1001028B1
公开(公告)日：2006-05-31
申请号：EP99913692.2
申请日：1999-04-16
申请人： SUNTORY LIMITED
发明人： SAKAKIBARA, Keiko , FUKUI, Yuko , TANAKA, Yoshikazu , KUSUMI, Takaaki , MIZUTANI, Masako , NAKAYAMA, Toru
IPC分类号： C12N15/53 , C12N15/29 , C12N9/02 , C12P17/04 , C07K1/22 , C12N5/14 , A01H5/00 , C12N15/52
CPC分类号： C12N9/0059 , C12N15/52 , C12N15/825 , C12P17/04
摘要： A protein having an aurone synthase activity relating to the flower colors of Antirrhinum majus, etc., a gene, in particular, cDNA encoding the same and utilization thereof. By transferring this gene into a plant lacking chalcone isomerase, etc. and expressing it therein, the flower of the plant can be made yellow.

5. 发明公开

EP1072684A1 GENES ENCODING PROTEINS HAVING ACTIVITY OF TRANSFERRING SUGAR ONTO AURONE 审中-公开
标题翻译： GENE，DIEFÜRPROTEINE KODIEREN，DIE EINE ZUCKER-ÜBERTRAGUNGSAKTIVITÄTAUF AURON BESITZEN
公开(公告)号：EP1072684A1
公开(公告)日：2001-01-31
申请号：EP00903988.4
申请日：2000-02-16
申请人： SUNTORY LIMITED
发明人： SAKAKIBARA, Keiko , FUKUI, Yuko , TANAKA, Yoshikazu , KUSUMI, Takaaki , YOSHIKAWA, Takafumi
IPC分类号： C12N15/54 , C12N1/21 , C12N9/10 , A01H5/00 , C12P19/18
CPC分类号： C12N15/825 , C12N9/1048 , C12N9/1051 , C12N15/8243 , C12P19/60
摘要： There is provided a gene encoding a protein derived from, for example, snapdragons and petunias, said protein having an amino acid sequence as set forth in SEQ ID NO: 2, 8, and 10, and having an activity of transferring a glycosyl group to aurones, and a method of producing said protein using said gene. By introducing this gene into plants that do not have said gene, a yellow pigment aurone can be stabilized and plants having yellow flowers can be obtained.
摘要翻译：提供了编码来自例如快速聚糖和矮牵牛的蛋白质的基因，所述蛋白质具有如SEQ ID NO：2,8和10所示的氨基酸序列，并且具有将糖基转移到噢ones，以及使用该基因产生所述蛋白质的方法。通过将该基因导入到不具有该基因的植物中，可以稳定黄色颜料噢one one can，可以得到具有黄花的植物。

6. 发明公开

EP0810287A1 GENES CODING FOR PROTEINS HAVING ACYL TRANSFER ACTIVITY 失效
标题翻译： GENE，DIEFÜR蛋白质麻省理工学院ACYLTRANSFERASEAKTIVITÄTKODIEREN
公开(公告)号：EP0810287A1
公开(公告)日：1997-12-03
申请号：EP96902462.9
申请日：1996-02-16
申请人： SUNTORY LIMITED
发明人： ASHIKARI, Toshihiko , TANAKA, Yoshikazu , FUJIWARA, Hiroyuki , NAKAO. Masahiro , FUKUI, Yuko , SAKAKIBARA, Keiko , MIZUTANI, Masako , KUSUMI, Takaaki
IPC分类号： C12N15/54 , C12N9/10 , C12N1/21 , C12N5/00 , A01H5/00
CPC分类号： C07H15/203 , C12N9/1029 , C12N15/825 , C12P19/445
摘要： Proteins having an aromatic-acyltransferase activity; a gene system coding for the same; a process for producing the proteins using the gene system; and uses of the genes and the proteins. The genes and the proteins acylate plant pigments such as anthocyanin to thereby cause color tone changes, thus providing plants, particularly flowers, having colors that have not been inherent therein.
摘要翻译：具有芳香 - 酰基转移酶活性的蛋白质; 编码该基因的基因系统; 使用该基因系统产生蛋白质的方法; 以及基因和蛋白质的使用。基因和蛋白质使植物颜料如花青素酰化，从而引起色调变化，从而提供植物，特别是具有尚未固有的颜色的植物。

7. 发明公开

EP2030509A1 PROANTHOCYANIDIN-CONTAINING TEA BEVERAGE 审中-公开
标题翻译：含原花青素的茶饮料
公开(公告)号：EP2030509A1
公开(公告)日：2009-03-04
申请号：EP07743711.9
申请日：2007-05-18
申请人： Suntory Limited
发明人： MORIGUCHI, Shigeo , FUKUI, Yuko , ZEIDA, Mitsuhiro
IPC分类号： A23F3/18 , A23F3/16
CPC分类号： A23F3/163 , A61K36/15
摘要： The object is to provide beverages that allow for sustained intake and which have an effect of improving the vascular endothelial function as by promoting the secretion of NO from vascular endothelial cells so as to potentiate the NO action.
The object is attained by providing proanthocyanidins containing tea beverages that contain procyanidin B1 (PB1) and procyanidin B3 (PB3) in a total amount not smaller than a certain concentration and which are free from any peculiar flavor to become easier to drink; they allow for sustained intake and have an effect of improving the vascular endothelial function.
摘要翻译：本发明的目的在于提供一种能够持续摄取并且具有改善血管内皮功能的效果的饮料，如通过促进血管内皮细胞分泌NO以增强NO的作用。该目的是通过提供含有原花青素B1（PB1）和原花青素B3（PB3）的原花青素含量总量不小于一定浓度并且没有任何特殊风味以便于饮用的含茶饮料而实现的; 它们允许持续摄入并具有改善血管内皮功能的作用。

8. 发明公开

EP1772148A1 LIPASE INHIBITORS 有权转让
标题翻译：脂肪酶抑制剂
公开(公告)号：EP1772148A1
公开(公告)日：2007-04-11
申请号：EP05758209.0
申请日：2005-07-05
申请人： SUNTORY LIMITED
发明人： NAKAI, Masaaki , FUKUI, Yuko , ASAMI, Sumio , HASHIMOTO, Fumio
IPC分类号： A61K31/352
CPC分类号： A61K36/82 , A23F3/163 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K31/353 , C07D311/62 , C07D493/14 , A23V2250/21 , A23V2250/214 , A23V2200/332 , A23V2200/326
摘要： The present invention provides lipase inhibitors containing flavan-3-ol monomers or acylates thereof derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of flavan-3-ol monomers represented by the formula:

wherein R 1 and R 3 independently represent H or OH, R 2 represents H, R 4 represents H, G, 3MeG or p-cou, R 5 represents H or G, R 4 ' and R 5 ' independently represent H or G, R 4 " represents H or G, and G, 3MeG and p-cou respectively represent the groups of the formulae:

or acylates thereof; as well as foods and beverages and medicines containing said lipase inhibitors.

9. 发明公开

EP1767204A1 LIPASE INHIBITORS 有权转让
标题翻译：脂肪酶抑制剂
公开(公告)号：EP1767204A1
公开(公告)日：2007-03-28
申请号：EP05765571.4
申请日：2005-07-05
申请人： SUNTORY LIMITED
发明人： NAKAI, Masaaki , FUKUI, Yuko , ASAMI, Sumio , HASHIMOTO, Fumio
IPC分类号： A61K31/352
CPC分类号： A61K36/82 , A23F3/163 , A23L33/105 , A23V2002/00 , A61K31/352 , A23V2200/332 , A23V2250/21 , A23V2250/214
摘要： The present invention provides lipase inhibitors containing dimers of flavan-3-ols derived from teas as well as foods and beverages and medicines containing said inhibitors. More specifically, the present invention provides lipase inhibitors containing at least one of assamicains represented by the formula:

wherein G represents a galloyl group;
theasinensins represented by the formula:

wherein R 1 represents G or H, and R 2 represents G; and theaflavins represented by the formula:

wherein R 1 and R 2 independently represent G or H; as well as foods and beverages and medicines containing said lipase inhibitors.
摘要翻译：本发明提供含有由茶衍生的黄烷-3-醇二聚体的脂肪酶抑制剂以及含有所述抑制剂的食品和饮料以及药物。更具体地说，本发明提供了含有至少一种由下式表示的阿尔巴卡因的脂肪酶抑制剂：其中G代表没食子酰基; 由下式表示的亚山菌素：其中R1代表G或H，R2代表G; 和由下式表示的茶黄素：其中R1和R2独立地代表G或H; 以及含有所述脂肪酶抑制剂的食物和饮料以及药物。

10. 发明公开

EP1754702A1 EPIGALLOCATECHIN DIMERS OR TRIMERS HAVING LIPASE INHIBITORY ACTIVITY AND/OR ANTIOXIDATIVE ACTIVITY 有权转让
标题翻译： EPIGALLOCATECHIN-DIMEE ODER TRIMERE MIT LIPASEHEMMENDER UND / ODER抗氧化剂WIRKUNG
公开(公告)号：EP1754702A1
公开(公告)日：2007-02-21
申请号：EP05743859.0
申请日：2005-05-26
申请人： SUNTORY LIMITED
发明人： NAKAI, Masaaki , FUKUI, Yuko , ASAMI, Sumio
IPC分类号： C07D311/62 , A23L1/30 , A61K31/353 , A61P3/04 , A61P39/06 , A61P43/00 , C09K15/08
CPC分类号： C07D311/62 , A23L33/105
摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.
摘要翻译：本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食来源的脂肪的吸收和/或有助于抑制和预防肥胖，以及具有掺入其中的这种脂肪酶活性抑制剂。本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且在掺入时不会损害食品或饮料的风味。本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。本发明的另一个目的是提供抗氧化剂。为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄烷）或三聚体掺入食品或饮料中。结果，可以抑制膳食来源的脂肪的吸收，并且另外获得抗氧化作用。本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

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