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1. 发明公开

EP2794865A1 A LACTONASE DERIVED FROM CANDIDA BOMBICOLA AND USES THEREOF 有权
标题翻译：从内酯酶假丝酵母菌及其用途
公开(公告)号：EP2794865A1
公开(公告)日：2014-10-29
申请号：EP12806020.9
申请日：2012-12-14
申请人： Universiteit Gent
发明人： VAN BOGAERT, Inge , CIESIELSKA, Katarzyna , DEVREESE, Bart , SOETAERT, Wim , ROELANTS, Sophie
IPC分类号： C12N9/18
CPC分类号： C12P19/44 , C12N9/18 , C12P19/445 , C12Y301/01025 , Y02P20/52
摘要： The present disclosure relates to an enzyme derived from Candida bombicola that is capable of lactonizing or polymerizing carbohydrate-containing compounds, lipids, fatty acids, hydroxylated fatty acids, alcohols, dicarboxylic acids or mixtures thereof. Hence, host cells comprising the latter enzyme can be used, via the formation of intra- or inter-molecular ester-bounds, to produce, for example, lactonized sophorolipids or polymers of acidic sophorolipids. On the other hand, host cells having lost their capability to produce a functional enzyme disclosed herein can be used to produce 100% acidic sophorolipids.

2. 发明授权

EP0608111B1 Isolation and structure of spongistatin 1 and its use as an anti-tumor agent 失效
标题翻译：分离和海绵抑制素1的结构以及其作为抗肿瘤剂的用途
公开(公告)号：EP0608111B1
公开(公告)日：1998-05-27
申请号：EP94300362.4
申请日：1994-01-19
申请人： ARIZONA BOARD OF REGENTS
发明人： Pettit, George R. , Herald, Cherry L. , Cichacz, Zbigniew A.
IPC分类号： C07D493/22 , C12P17/18 , A61K31/365
CPC分类号： C07D493/22 , C12P17/181 , C12P19/445

3. 发明公开

EP0810287A1 GENES CODING FOR PROTEINS HAVING ACYL TRANSFER ACTIVITY 失效
标题翻译： GENE，DIEFÜR蛋白质麻省理工学院ACYLTRANSFERASEAKTIVITÄTKODIEREN
公开(公告)号：EP0810287A1
公开(公告)日：1997-12-03
申请号：EP96902462.9
申请日：1996-02-16
申请人： SUNTORY LIMITED
发明人： ASHIKARI, Toshihiko , TANAKA, Yoshikazu , FUJIWARA, Hiroyuki , NAKAO. Masahiro , FUKUI, Yuko , SAKAKIBARA, Keiko , MIZUTANI, Masako , KUSUMI, Takaaki
IPC分类号： C12N15/54 , C12N9/10 , C12N1/21 , C12N5/00 , A01H5/00
CPC分类号： C07H15/203 , C12N9/1029 , C12N15/825 , C12P19/445
摘要： Proteins having an aromatic-acyltransferase activity; a gene system coding for the same; a process for producing the proteins using the gene system; and uses of the genes and the proteins. The genes and the proteins acylate plant pigments such as anthocyanin to thereby cause color tone changes, thus providing plants, particularly flowers, having colors that have not been inherent therein.
摘要翻译：具有芳香 - 酰基转移酶活性的蛋白质; 编码该基因的基因系统; 使用该基因系统产生蛋白质的方法; 以及基因和蛋白质的使用。基因和蛋白质使植物颜料如花青素酰化，从而引起色调变化，从而提供植物，特别是具有尚未固有的颜色的植物。

4. 发明授权

EP0293787B1 Antibiotic 6270B, processes for its production, and its use as an anticoccidiosis agent and a feed additive 失效
标题翻译：抗生素6270B，处理用于其制备及其作为抗球虫剂和饲料添加剂的用途。
公开(公告)号：EP0293787B1
公开(公告)日：1993-11-18
申请号：EP88108532.8
申请日：1988-05-27
申请人： KAKEN PHARMACEUTICAL CO., LTD.
发明人： Kusakabe, Yoko , Suzuki, Hiroshi , Kudo, Hidehiko
IPC分类号： C12P17/02 , C12P1/06 , C07D493/10 , A23K1/17
CPC分类号： C07D519/00 , C12P17/181 , C12P19/445 , C12P19/60 , C12R1/01

5. 发明公开

EP0497515A1 New process for producing FK-506 失效
标题翻译： Verfahren zur Herstellung von FK-506。
公开(公告)号：EP0497515A1
公开(公告)日：1992-08-05
申请号：EP92300624.1
申请日：1992-01-24
申请人： MERCK & CO. INC.
发明人： Salituro, Gino M. , Huang, Leeyuan , Dumont, Francis , Jones, E. Tracy T. , Garrity, George M. , Omstead, Mary Nallin , Fernandez, Isabel Martin , Matas, Teresa Diez
IPC分类号： C12P17/18 , C12P19/44 , C12N1/20
CPC分类号： C12R1/465 , C12P17/188 , C12P19/445 , Y10S435/886
摘要： Described is a new process for producing the macrolide immunosuppressant, FK-506 under fermentation conditions utilizing the microorganism, Streptomyces sp. , (Merck Culture Collection No. MA 6858) ATCC No. 55098. The immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译：描述了在使用微生物Streptomyces sp。（Merck Culture Collection No.MA 6858）ATCC No.55098的发酵条件下生产大环内酯免疫抑制剂FK-506的新方法。免疫抑制剂可用于防止外源性人宿主排斥器官移植，例如骨髓和心脏移植。

6. 发明公开

EP0388153A2 Immunosuppressant agent 失效
标题翻译：免疫抑制剂Mittel。
公开(公告)号：EP0388153A2
公开(公告)日：1990-09-19
申请号：EP90302670.6
申请日：1990-03-13
申请人： MERCK & CO. INC.
发明人： Kaplan, Louis , Borris, Robert P. , Byrne, Kevin M. , Wicker, Linda S. , Zink, Deborah L.
IPC分类号： C07H19/01 , A61K31/70 , C12P19/26 , C12N1/20
CPC分类号： C07H19/01 , C12P19/445 , Y10S435/898
摘要： Described is a new immunosuppressant, L-687,819, a C-31 demethylated derivative of L-683,795 (FK-523), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译：描述了一种新的免疫抑制剂L-687,819，L-683,795（FK-523）的C-31脱甲基衍生物，其在使用新的突变微生物，吸水链霉菌Subsp。子囊菌纲（Merck Culture Collection MA 6646）ATCC No.53855，其是吸水链霉菌亚种（Streptomyces hygroscopicus subsp。）的封闭突变体。子囊菌纲（MA 6475）ATCC No.14891。大环内酯类免疫抑制剂可用于预防异种器官移植的人宿主排斥，例如，骨髓和心脏移植。 r

7. 发明公开

EP0341019A3 Polyether antibiotic 失效
标题翻译：聚乙二醇抗生素
公开(公告)号：EP0341019A3
公开(公告)日：1990-04-04
申请号：EP89304398.4
申请日：1989-05-02
申请人： ELI LILLY AND COMPANY
发明人： Hamill, Robert L. , Yao, Raymond Che-Fong
IPC分类号： C07D493/10 , C07H17/04 , A61K31/35 , A61K31/70 , C12P19/58 , C12P17/06 , A23K1/17
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P19/445 , C12P19/60 , C12R1/03
摘要： New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4′-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.

8. 发明公开

EP0293787A1 Antibiotic 6270B, processes for its production, and its use as an anticoccidiosis agent and a feed additive 失效
标题翻译：抗生素6270B，处理用于其制备及其作为抗球虫剂和饲料添加剂的用途。
公开(公告)号：EP0293787A1
公开(公告)日：1988-12-07
申请号：EP88108532.8
申请日：1988-05-27
申请人： KAKEN PHARMACEUTICAL CO., LTD.
发明人： Kusakabe, Yoko , Suzuki, Hiroshi , Kudo, Hidehiko
IPC分类号： C12P17/02 , C12P1/06 , C07D493/10 , A23K1/17
CPC分类号： C07D519/00 , C12P17/181 , C12P19/445 , C12P19/60 , C12R1/01
摘要： An antibiotic 6270B having the formula:
and a salt thereof.
摘要翻译：具有下式的抗生素6270B：和它们的盐。 ñ

9. 发明公开

EP0242052A2 Macrolide compounds 失效
标题翻译：大环内酯化合物
公开(公告)号：EP0242052A2
公开(公告)日：1987-10-21
申请号：EP87302097.8
申请日：1987-03-11
申请人： AMERICAN CYANAMID COMPANY
发明人： Rudd, Brian A. M. , Fletton, Richard A. , Ward, John B. , Noble, David , Porter, Neil , Lawrence, Gordon C. , Noble, Hazel M.
IPC分类号： C07D493/22 , C07D493/20 , A61K31/365 , C12P17/08 , A01N43/90
CPC分类号： C07H19/01 , A01N43/90 , C12P17/08 , C12P19/445 , C12R1/465
摘要： Compounds of the formula
[wherein

R 1 represents a methyl group;
R 2 represents a methyl group
R 3 represents a methyl, ethyl or isopropyl group; and
-A- represents a ring which is either

(where R 4 is a hydroxy or methoxy group and R 5 is a hydrogen atom or R 4 and R 5 together with the carbon atom to which they are attached represent a group C=0); or when -A-represents ring (ii) wherein R 4 and R 5 together with the carbon atom to which they are attached represent a group C=0 then R 2 may also represent an aldehydo group;
or R 2 represents a hydroxymethyl group and -A- represents
(where R 6 represents a hydrogen atom or a hydroxy group);

(where R 7 is a hydroxy or methoxy group and Z represents either a group CHOH or a group C=0);
or R 1 represents a hydrogen atom and

(where R 8 is a hydroxy or methoxy group); with the provisos that when R 2 represents a methyl group and R 4 represents a methoxy group then R 3 cannot represents a methyl or isopropyl group and when R 2 represents a hydroxymethyl group and R 6 represents a hydroxy group then R 3 cannot represent a methyl group.

Compounds of the invention have antiparasitic activity.
摘要翻译：式[其中R1代表甲基; R2代表甲基，R3代表甲基，乙基或异丙基; （其中R 4为羟基或甲氧基且R 5为氢原子或者R 4和R 5与它们所连接的碳原子一起表示C = O的基团）。或者当-A-代表环（ii），其中R 4和R 5与它们所连接的碳原子一起代表基团C = O时，则R 2也可代表醛基; 或者R 2表示羟甲基，-A-表示（其中R 6表示氢原子或羟基）。（其中R7是羟基或甲氧基，Z表示基团CHOH或C = O）; 或者R1代表氢原子和（其中R8是羟基或甲氧基）。条件是当R 2代表甲基且R 4代表甲氧基时，则R 3不能代表甲基或异丙基，并且当R 2代表羟甲基并且R 6代表羟基时，则R 3不能代表甲基。本发明的化合物具有抗寄生虫活性。

10. 发明公开

EP0214739A2 Anthelmintic avermectin derivative obtainable by fermentation 失效
标题翻译：阿维菌素Avermectin-Derivat，爱尔兰酿酒酵母Verfahren hergestellt werden kann。
公开(公告)号：EP0214739A2
公开(公告)日：1987-03-18
申请号：EP86305766.7
申请日：1986-07-25
申请人： Merck & Co., Inc.
发明人： Goegelman, Robert T. , Inamine, Edward S. , White, Raymond F.
IPC分类号： C07D493/22 , A61K31/365 , C12P17/08
CPC分类号： C07H19/01 , C12P17/181 , C12P19/445 , C12R1/50
摘要： A novel macrolide of formula:
is isolated from the fermentation product obtained by the microorganism Streptomyces bikiniensis NRRL 2737 with 22, 23-dihydro avermectin Bla aglycone as a substrate. The formula of the novel compound isolated from the microorganism is based upon analytical studies. The compound is a highly potent antiparasitic, insecticidal, and anthelmintic agent and can be made into compositions for such uses.
摘要翻译：从具有22,23-二氢阿维菌素Bla糖苷配基作为底物的微生物比基尼克斯链霉菌NRRL 2737获得的发酵产物中分离出一种新型的大环内酯：... ...。从微生物分离的新化合物的配方是基于分析研究。该化合物是一种非常有效的抗寄生虫，杀虫剂和驱肠剂，可以制成这些用途的组合物。

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