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1. 发明公开

EP1811030A4 METHOD OF STABILIZING, AND BLUING, OF ANTHOCYANIN PIGMENT USING GENE CODING FOR TRANSFERASE OF AROMATIC ACYL TO 3 -POSITION OF ANTHOCYANIN 有权
标题翻译：方法稳定化和花青素的蓝色利用转移酶芳香酰基到3位花色素苷编码基因
公开(公告)号：EP1811030A4
公开(公告)日：2009-11-25
申请号：EP05800037
申请日：2005-10-28
申请人： INT FLOWER DEV PTY LTD
发明人： TANAKA YOSHIKAZU , KATSUMOTO YUKIHISA , MIZUTANI MASAKO , FUKUI YUKO , TOGAMI JUNICHI
IPC分类号： C12N15/09 , A01H5/00 , C12N9/10 , C12P19/60
CPC分类号： C12P19/445 , C12N9/10 , C12N9/1029 , C12N15/825

2. 发明授权

EP0810287B1 GENES CODING FOR PROTEINS HAVING ACYL TRANSFER ACTIVITY 失效
标题翻译：基因代码为酰基转移酶蛋白
公开(公告)号：EP0810287B1
公开(公告)日：2009-11-18
申请号：EP96902462.9
申请日：1996-02-16
申请人： International Flower Developments Proprietary Limited
发明人： ASHIKARI, Toshihiko , TANAKA, Yoshikazu , FUJIWARA, Hiroyuki , NAKAO. Masahiro , FUKUI, Yuko , SAKAKIBARA, Keiko , MIZUTANI, Masako , KUSUMI, Takaaki
IPC分类号： C12N15/54 , C12N9/10 , C12N5/00 , C12N1/21 , A01H5/00
CPC分类号： C07H15/203 , C12N9/1029 , C12N15/825 , C12P19/445

3. 发明公开

EP0652219A1 New extractive process for the recovery of naturally occurring macrolides 失效转让
标题翻译： Extraktives Verfahren zur Gewinnung vonnatürlichenMakroliden。
公开(公告)号：EP0652219A1
公开(公告)日：1995-05-10
申请号：EP94308107.5
申请日：1994-11-03
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： Gletsos, Constantine
IPC分类号： C07D498/18 , C12P17/18
CPC分类号： C07D498/18 , C12P17/188 , C12P19/445
摘要： This invention concerns a process for separating a macrolide from acidic, basic and non-polar neutral impurities present in a macrolide containing solution which comprises one or more of the following processes in any order:

a. a solution of said macrolide in a water-immiscible solvent is extracted with aqueous base to substantially remove all acidic impurities;
b. a solution of said macrolide in a water-immiscible solvent is extracted with aqueous acid to substantially remove all basic impurities;
c. a solution of said macrolide is subjected to one or more of the following in order to remove non-polar neutral impurities:

(i) extraction with a non-aromatic hydrocarbon solvent in which the macrolide is insoluble,
(ii) treatment with a sufficient quantity of a miscible macrolide non-solvent to cause the macrolide to become insoluble in the resulting solvent mixture and thus separate from the solution whereby the macrolide can be separated from the solvent mixture,
(iii) triturate with a macrolide crystallizing solvent.
摘要翻译：本发明涉及一种将大环内酯与含有大环内酯的溶液中存在的含有大环内酯的溶液中的酸性，碱性和非极性中性杂质分离的方法，该方法包括以下任一顺序的一种或多种以下方法：a。所述大环内酯在与水不混溶的溶剂中的溶液用碱水溶液萃取以基本上除去所有酸性杂质; 湾所述大环内酯在与水不混溶的溶剂中的溶液用酸水溶液萃取以基本上除去所有碱性杂质; C。对所述大环内酯类的溶液进行以下一种或多种以除去非极性中性杂质：（i）用大环内酯不溶性的非芳族烃溶剂萃取，（ii）以足够量处理的混溶性大环内酯非溶剂，以使大环内酯在所得溶剂混合物中变得不溶，从而与溶液分离，由此大环内酯可以与溶剂混合物分离，（iii）用大环内酯结晶溶剂研磨。

4. 发明授权

EP0388153B1 Immunosuppressant agent 失效
标题翻译：免疫抑制剂。
公开(公告)号：EP0388153B1
公开(公告)日：1994-12-28
申请号：EP90302670.6
申请日：1990-03-13
申请人： Merck & Co., Inc.
发明人： Kaplan, Louis , Borris, Robert P. , Byrne, Kevin M. , Wicker, Linda S. , Zink, Deborah L.
IPC分类号： C07H19/01 , A61K31/70 , C12P19/26 , C12N1/20
CPC分类号： C07H19/01 , C12P19/445 , Y10S435/898

5. 发明公开

EP0608110A1 Isolation and structure of halistatin 2, and its use as an anti-tumor agent 失效
标题翻译： Isolierung und Struktur von Halistatin 2，und dessen Verwendung als Antitumor-Mittel。
公开(公告)号：EP0608110A1
公开(公告)日：1994-07-27
申请号：EP94300361.6
申请日：1994-01-19
申请人： ARIZONA BOARD OF REGENTS
发明人： Pettit, George R. , Gao, Feng
IPC分类号： C07D493/22 , C07H19/01 , C12P17/18 , C12P19/00 , A61K31/365 , A61K31/71
CPC分类号： C07D493/22 , C07H9/02 , C12P17/181 , C12P19/445
摘要： An intensive long-term investigation of marine organisms as sources of new anticancer drugs has led to the isolation and structural elucidation (primarily by high field NMR and mass spectrometry) of halistatin 2, a new polyether macrolide of the halipyran-type, from the Western Indian Ocean sponge Axinella cf. carteri (Dendy). Halistatin 2 (1.4 x 10- 6 % yield) caused the accumulation of cells arrested in mitosis, inhibited tubulin polymerization, and inhibited the binding of radiolabeled vinblastine and GTP to tubulin. Further, Halistatin 2 displayed significant activity against selected human tumor cell lines.
Halistatin 2 has the following structural formula :
摘要翻译：对海洋生物进行深入的长期调查，作为新的抗癌药物的来源，导致了halistatin 2（Halipyran型的新型聚醚大环内酯类）的隔离和结构解释（主要是通过高场NMR和质谱），西方印度洋海绵Axinella参考卡特里（Dendy）。 Halistatin 2（1.4×10 -6％产率）引起细胞中有丝分裂停滞的积累，抑制微管蛋白聚合，并抑制放射性标记的长春花碱和GTP与微管蛋白的结合。此外，Halistatin 2对选定的人肿瘤细胞系显示出显着的活性。 Halistatin 2具有以下结构式：

6. 发明授权

EP0314330B1 Microbiological process for making UK-61.689 and microorganisms useful therefor 有权转让
标题翻译：制作UK-61.689的微生物过程及其有用的微生物
公开(公告)号：EP0314330B1
公开(公告)日：1993-10-06
申请号：EP88309429.4
申请日：1988-10-10
申请人： PFIZER INC.
发明人： Tynan III, Edward Joseph
IPC分类号： C12P17/06 , C07D493/10
CPC分类号： C07H19/01 , C12P17/16 , C12P17/162 , C12P19/445 , C12R1/03

7. 发明公开

EP0551428A1 ACIDIC POLYCYCLIC ETHER ANTIBIOTIC 失效
标题翻译：酸性多环醚抗菌素。
公开(公告)号：EP0551428A1
公开(公告)日：1993-07-21
申请号：EP91919557.0
申请日：1991-08-30
申请人： PFIZER INC.
发明人： CULLEN, Walter Patrick , DIRLAM, John Philip , MAEDA, Hiroshi , TONE, Junsuke
IPC分类号： A23K1 , A61K31 , A61P31 , A61P33 , C07D493 , C07H17 , C07H19 , C12P17 , C12P19 , C12R1
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P17/181 , C12P19/445 , C12R1/01
摘要： PCT No. PCT/US91/06084 Sec. 371 Date Mar. 12, 1993 Sec. 102(e) Date Mar. 12, 1993 PCT Filed Aug. 30, 1991.An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.

8. 发明授权

EP0184291B1 Polyether antibiotic A80190 有权
标题翻译：聚醚抗生素A80190
公开(公告)号：EP0184291B1
公开(公告)日：1992-05-27
申请号：EP85307186.8
申请日：1985-10-08
申请人： ELI LILLY AND COMPANY
发明人： Hamill, Robert L. , Yao, Raymond Che-Fong , Boeck, Laverne Dwaine
IPC分类号： C07D493/10 , C12P17/18 , C12P19/60 , A61K31/35 , A61K31/70 , A23K1/16
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P19/445 , C12P19/60 , C12R1/03

9. 发明公开

EP0341019A2 Polyether antibiotic 失效
标题翻译： Polyäther-Antibiotika。
公开(公告)号：EP0341019A2
公开(公告)日：1989-11-08
申请号：EP89304398.4
申请日：1989-05-02
申请人： ELI LILLY AND COMPANY
发明人： Hamill, Robert L. , Yao, Raymond Che-Fong
IPC分类号： C07D493/10 , C07H17/04 , A61K31/35 , A61K31/70 , C12P19/58 , C12P17/06 , A23K1/17
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P19/445 , C12P19/60 , C12R1/03
摘要： New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4′-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
摘要翻译：新的聚醚抗菌素A82810，其酰基和烷基酯，酰基酯和氨基甲酸酯衍生物及其盐是有用的抗菌和抗球虫剂，并增加动物的饲料利用效率。通过培养Actinomodura fibrosa sp。制备A82810的方法十一月还提供了NRRL 18348和A82810化合物与氨基脲，4,4'-二硝基苯甲酰胺，某些萘胺和苯胺化合物和二氯吲哚醇的协同组合物。

10. 发明授权

EP0133971B1 Antibiotikum, dessen Herstellung sowie dessen Verwendung 有权转让
标题翻译：抗生素，其制备及其用途
公开(公告)号：EP0133971B1
公开(公告)日：1988-04-06
申请号：EP84108945.1
申请日：1984-07-27
申请人： F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft
发明人： Liu, Chao-Min , Westley, John
IPC分类号： C07D493/10 , C07H7/06 , A61K31/70 , A61K31/335 , C12P17/18 , C12P19/44
CPC分类号： C07H19/01 , C12P19/445 , C12P19/60 , C12R1/55

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