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    • 10. 发明公开
    • Catheter systems
    • Kathetersysteme
    • EP2425871A2
    • 2012-03-07
    • EP11175829.8
    • 2011-07-28
    • St. Jude Medical, Atrial Fibrillation Division, Inc.
    • Paul, SauravTegg, Troy T.Byrd, Israel A.Thao, RikiPuryear, Harry A.Nemec, LindaBerns, John M.
    • A61N1/32
    • A61N1/327A61B18/14A61B2018/0016
    • Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
    • 导管系统包括用于电穿孔介导治疗,电穿孔诱发的原发性坏死治疗和电场诱导的凋亡治疗的方向敏感的多极尖端电极组件,包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。 用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及用于光学监测治疗进展以及确认治疗后成功的光纤装置。 光纤温度感测电极导管包括具有空腔的尖端电极,其内表面被浸渍或涂覆有随着温度变化而变色的热变色/热致变色材料。 光纤/检测器装置监测热致变色或热致变色材料,获取光信号并产生指示光信号光谱的输出信号。 分析仪基于检测器输出和预定的光谱对温度校准数据来确定电极温度。