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1. 发明公开

EP2930239A4 1,4-BUTANEDIOL PRODUCTION METHOD, MICROORGANISM, AND GENE 审中-公开
标题翻译： FUR HERSTELLUNGSVERFAHREN 1,4-丁二醇，Mikroorganismus UND JAN
公开(公告)号：EP2930239A4
公开(公告)日：2016-06-29
申请号：EP13859911
申请日：2013-11-28
申请人： SHOWA DENKO KK
发明人： AOKI HIROBUMI , KOKIDO YUZURU , HASHIMOTO YOKO , YONEDA TADASHI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P7/18
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/1029 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y101/01035 , C12Y101/01036 , C12Y101/01157 , C12Y203/01009 , C12Y402/01017 , C12Y402/01055 , C12Y402/01119 , C12Y402/0112 , C12Y503/03003
摘要： A method of manufacturing 1,4-butanediol through acetyl-CoA, acetoacetyl-CoA, 3-hydroxybutyryl-CoA, crotonyl-CoA, and 4-hydroxybutyryl-CoA by using a microbe and/or a culture thereof, wherein the microbe in the manufacturing method for 1,4-butanediol includes any one of genes among (a) a gene that has a base sequence of sequence number 1, (b) a gene that has a base sequence such that one or more bases are deleted, substituted, or added in a base sequence of sequence number 1, wherein the gene has a base sequence with an identity greater than or equal to 90% with respect to the base sequence of sequence number 1, and (c) a gene that hybridizes with a gene that has a base sequence complementary with a gene that has a base sequence described in sequence number 1 on a stringent condition, and includes any one or more genes among (d) genes that have base sequences of sequence numbers 2 to 9, (e) genes that have base sequences such that one or more bases are deleted, substituted, or added in base sequences of sequence numbers 2 to 9, wherein the genes have base sequences with an identity greater than or equal to 90% with respect to original base sequences thereof, and (f) genes that hybridize with genes that have base sequences complementary with genes that have base sequences of sequence numbers 2 to 9 on a stringent condition.
摘要翻译：通过使用微生物和/或其培养物，通过乙酰辅酶A，乙酰乙酰辅酶A，3-羟基丁酰基-CoA，巴豆酰基-CoA，和4-羟基丁酰-CoA的制造1,4-丁二醇的方法，其中，在所述微生物对于1,4-丁二醇的制造方法包括：间基因之一年（a）该基因具有序列号1的碱基序列，（b）将所述基因具有的碱基序列，例如阙一个或多个碱基缺失，取代，或在序列号1的碱基序列，其中所述基因具有大于或等于90％，相对于序列号1的碱基序列的同一性的碱基序列，和（c）的基因阙与基因杂交加入具有与阙对严格条件在序列号1中记载的碱基序列的基因互补的碱基序列，并且包括其中（d）中的基因的任何一种或多种基因阙具有2至9的序列号的碱基序列，（e）中该基因具有的碱基序列，例如阙一个或多个碱基缺失，取代，或添加在序列编号2〜9，其中，所述基因具有的碱基序列具有标识大于或等于90％，相对于它的原始碱基序列，和（f）的基因阙与基因杂交阙具有基因阙互补的碱基序列的碱基序列有序列号在严格条件2〜9的碱基序列。

2. 发明公开

EP2927325A4 METHOD FOR PRODUCING 1,4-BUTANEDIOL, AND MICROORGANISM 审中-公开
标题翻译：用于生产1,4-丁二醇和微生物
公开(公告)号：EP2927325A4
公开(公告)日：2016-05-11
申请号：EP13857866
申请日：2013-09-20
申请人： SHOWA DENKO KK
发明人： AOKI HIROBUMI , KOKIDO YUZURU , HASHIMOTO YOKO , YONEDA TADASHI
IPC分类号： C12P7/18 , C12N1/19 , C12N1/21 , C12N9/02 , C12N9/04 , C12N9/88 , C12N9/90 , C12N15/09 , C12N15/52
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y101/01036 , C12Y101/01157 , C12Y402/0112 , C12Y503/03003

3. 发明公开

EP2770062A4 PRODUCTION METHOD FOR ORGANIC ACID USING CoA-TRANSFERASE 有权
标题翻译： HERSTELLUNGSVERFAHRENFÜR有机食品SATURE MITTELS COA-TRANSFERASE
公开(公告)号：EP2770062A4
公开(公告)日：2015-07-15
申请号：EP12841518
申请日：2012-10-10
申请人： SHOWA DENKO KK , UNIV HOKKAIDO NAT UNIV CORP
发明人： MATSUMOTO KEN ICHIRO , TAGUCHI SEIICHI , AOKI HIROBUMI
IPC分类号： C12P7/40 , C12N15/09 , C12P7/42
CPC分类号： C12P7/42

4. 发明公开

EP2924123A4 1,4-BUTANEDIOL MANUFACTURING METHOD AND MICROORGANISM 审中-公开
标题翻译： 1,4-丁二醇方法和微生物
公开(公告)号：EP2924123A4
公开(公告)日：2016-07-06
申请号：EP13857642
申请日：2013-09-20
申请人： SHOWA DENKO KK
发明人： AOKI HIROBUMI , KOKIDO YUZURU , HASHIMOTO YOKO , YONEDA TADASHI
IPC分类号： C12P7/18 , C12N1/19 , C12N1/21 , C12N15/09
CPC分类号： C12N9/0008 , C12P7/16 , C12P7/18 , C12Y102/0101 , Y02E50/10

5. 发明公开

EP2933339A4 METHOD FOR MANUFACTURING BUTANEDIOLS, METHOD FOR PRODUCTION OF MICROORGANISMS FOR MANUFACTURING BUTANEDIOLS, AND MICROORGANISMS 审中-公开
标题翻译：用于生产丁二醇，工艺用于生产微生物用于生产丁二醇和微生物
公开(公告)号：EP2933339A4
公开(公告)日：2016-06-22
申请号：EP13861721
申请日：2013-12-04
申请人： SHOWA DENKO KK
发明人： AOKI HIROBUMI , KOKIDO YUZURU , HASHIMOTO YOKO , YONEDA TADASHI
IPC分类号： C12P7/18 , C12N1/19 , C12N1/21 , C12N9/04
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N9/90 , C12Y101/01035 , C12Y102/0101 , C12Y203/01009 , C12Y301/02002 , C12Y301/0202 , C12Y402/01017 , C12Y503/03003

6. 发明公开

EP1574565A4 METHOD OF SELECTING ESCHERICHIA COLI STRAIN OVEREXPRESSING FOREIGN GENE, ESCHERICHIA COLI MUTANT THUS SELECTED AND PROCESS FOR PRODUCING ENZYME AND COMPOUND USING THE SAME 有权
标题翻译： VERFAHREN ZUR SELEKTION EINES EINFREMDGENÜBEREXPRIMIERENDENESCHERICHIA-COLI-STAMMS，SO SELEKTIONIERTEESCHERICHIA-COLI-MUTANTE UND VERFAHREN ZUR HERSTELLUNG EINES ENZYMS UND EINERVERBINDUNG UNTER VERWENDUNG DAVON
公开(公告)号：EP1574565A4
公开(公告)日：2006-01-18
申请号：EP03780728
申请日：2003-12-11
申请人： SHOWA DENKO KK
发明人： YAZAKI KAZUFUMI , AOKI HIROBUMI , KAMACHI HARUMI
IPC分类号： C12N1/21 , C12N9/88 , C12N15/60 , C12P13/04
CPC分类号： C12N9/88 , C12P13/04
摘要： A method of selecting an Escherichia coli strain overexpressing a foreign gene with the use of a stress-tolerance ability (for example, ability to decompose hydrogen peroxide) as an indication; an E. coli mutant selected by this selection method; a process for producing an enzyme by using this mutant; and a process for producing a useful compound such as an amino acid (in particular, an L-amino acid) by using the mutant. Thus, an E. coli mutant suffering from no decrease in gene expression level even after subculturing can be obtained and a compound can be efficiently produced with the use of a plant ammonialyase, etc.
摘要翻译：选择使用应激耐受能力（例如，分解过氧化氢的能力）过表达外源基因的大肠杆菌菌株作为适应症的方法; 通过该选择方法选择的大肠杆菌突变体; 使用该突变体来制造酶的方法; 以及使用该突变体制备氨基酸（特别是L-氨基酸）等有用化合物的方法。因此，即使在继代培养后也可以获得基因表达水平不降低的大肠杆菌突变体，并且可以利用植物氨化酶等有效地生产化合物。

7. 发明公开

EP2924122A4 1,4-BUTANEDIOL MANUFACTURING METHOD AND MICROORGANISM 有权
标题翻译： 1,4-BANDANDIOL-HERSTELLUNGSVERFAHREN UND MIKORORGANISMUS
公开(公告)号：EP2924122A4
公开(公告)日：2016-05-11
申请号：EP13856298
申请日：2013-09-13
申请人： SHOWA DENKO KK
发明人： AOKI HIROBUMI , KOKIDO YUZURU , HASHIMOTO YOKO , YONEDA TADASHI
IPC分类号： C12P7/18 , C12N1/19 , C12N1/21 , C12N9/02 , C12N9/04 , C12N9/88 , C12N9/90 , C12N15/09 , C12N15/52
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y101/01035 , C12Y101/01036 , C12Y101/01157 , C12Y102/0101 , C12Y402/01017 , C12Y402/01055 , C12Y402/01119 , C12Y402/0112 , C12Y503/03003

8. 发明公开

EP1591531A4 PROCESS FOR ACYL-TRANSFER ENZYME REACTIONS WITH ACYL- COENZYME A 有权
标题翻译：用乙酰辅酶A进行乙烯传输循环的方法A
公开(公告)号：EP1591531A4
公开(公告)日：2010-01-27
申请号：EP04703935
申请日：2004-01-21
申请人： SHOWA DENKO KK
发明人： KAMACHI MOTOAKI , KAMACHI HARUMI , AOKI HIROBUMI , ERATA TOMOKI , TAJIMA KENJI
IPC分类号： C12N9/10 , C12N15/54 , C12P7/62 , C12P13/00 , C12P13/02
CPC分类号： C12P13/02 , C12N9/1029 , C12P7/625 , C12P13/001

9. 发明公开

EP1142997A4 NOVEL RHODOCOCCUS, RHODOCOCCUS-ORIGIN NITRILASE GENE, NITRILEHYDRATASE GENE AND AMIDASE GENE AND PROCESS FOR PRODUCING CARBOXYLIC ACIDS BY USING THE SAME 有权
标题翻译：红球菌菌株，腈GEN OFF红球菌属，NITRILHYDRATAS基因和酰胺酶GEN及其制备方法羧酸及其用途下
公开(公告)号：EP1142997A4
公开(公告)日：2004-03-24
申请号：EP00970065
申请日：2000-10-25
申请人： SHOWA DENKO KK
发明人： AOKI HIROBUMI , KAMACHI HARUMI
IPC分类号： C12N1/21 , C12N9/78 , C12N15/55 , C12P7/40 , C12N15/09 , C07K14/37 , C12P13/02
CPC分类号： C12R1/01 , C12N9/78 , C12P7/40
摘要： A novel rhodococcus and a process for producing carboxylic acids by hydrolyzing cyano group of nitrile compounds by using this bacterium. A process for producing carboxylic acids (in particular, cyanocarboxylic acids) by using transformants having been transformed by plasmids containing rhodococcus-origin nitrilase gene, nitrilehydratase gene and amidase gene showing an excellent site-selectivity to cyano group of aromatic polynitrile compounds; these transformants, plasmids, genes and a process for producing enzymes by using these transformants; and the enzymes thus obtained. The carboxylic acids (in particular, cyanocarboxylic acids) thus obtained are useful as starting materials in the synthesis of drugs, pesticides, dyes and other chemical products.
摘要翻译：本发明涉及一种新颖的红球菌细菌和用新颖红球菌属细菌，以产生相应的羧酸水解腈化合物的氰基的处理。因此，本发明涉及一种生产羧酸的方法，在使用与含有腈水解酶基因，腈水合酶基因的质粒，并在从能够显示出对特别优异位置选择性的红球菌属细菌的酰胺酶基因转化的转化体的特殊氰基羧酸氰基芳族化合物聚腈的，寻求的转化，求的质粒，以搜寻基因，使用该转化在产酶的方法，以及通过该方法获得的酶。的羧酸，在通过本发明获得的具体氰基羧酸作为起始原料用于药物的合成中有用，农用化学品，dyestuffand其他化学品。

10. 发明公开

EP2899270A4 METHOD FOR PRODUCING BUTANEDIOL 审中-公开
标题翻译：用于生产丁二醇
公开(公告)号：EP2899270A4
公开(公告)日：2016-07-20
申请号：EP13838126
申请日：2013-08-20
申请人： SHOWA DENKO KK
发明人： AOKI HIROBUMI , KOKIDO YUZURU , YONEDA TADASHI
IPC分类号： C12P7/18 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/88 , C12N15/52
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/88 , C12N15/52 , C12Y101/01036 , C12Y203/01194

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