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    • 1. 发明公开
    • Cis-Bicyclo[4.3.0]non-2-ene derivatives
    • 顺式 - 双环[4.3.0]壬-2-烯衍生物
    • EP0431571A3
    • 1992-01-02
    • EP90123253.8
    • 1990-12-04
    • SAGAMI CHEMICAL RESEARCH CENTERTOA EIYO LTD.
    • Shibasaki, MasakatsuTakahasi, AtsuoAoki, TuyosiSato, HiroyasuYamada, Shin-ichiKudo, MichikoYamaguchi, TakajiKogi, KentaroNarita, Sen-ichi
    • C07C405/00C07C69/738C07C69/712A61K31/557
    • C07C69/738C07C59/46C07C59/62C07C69/712C07C69/732C07C405/0083Y02P20/55
    • A cis-bicyclo[4.3.0]non-2-ene derivative of the formula:

      wherein R is a hydrogen atom, or a protecting group for a hydroxyl group, R¹ is a hydrogen atom, a
              C₁-C₁₂
      straight or branched chain alkyl group, a substituted or unsubstituted phenyl group, a
              C₆-C₁₂
      aralkyl group containing a condensed aromatic ring or an aromatic hetero ring, or 1 equivalent of a cation, A is
              -CH=CH-
              CH₂-,
      or
              -CH₂-CH₂-O- ,
      R² is a
              C₃-C₁₀
      straight or branched chain alkyl group, a
              C₁-C₃
      alkyl group substituted by an aryloxy group which may be substituted, a
              C₃-C₁₂
      straight or branched chain alkenyl group, a
              C₃-C₈
      straight or branched chain alkynyl group, or a
              C₁-C₃
      alkyl group substituted by a phenyl or phenoxy group which may be substituted, by a
              C₁-C₆
      alkoxy group or by a
              C₅-C₈
      cycloalkyl group, R³ is a hydrogen atom, a methyl group, or a vinyl group, and X is a halogen atom.
    • 下式的顺式 - 二环[4.3.0]壬-2-烯衍生物:其中R是氢原子或羟基保护基,R 1是氢原子,C 1 -C 12直链或支链烷基 取代或未取代的苯基,含有稠合芳环或芳香杂环的C 6 -C 12芳烷基,或1当量的阳离子,A是-CH = CH-CH 2 - 或-CH 2 -CH 2 -O - ,R 2为C 3 -C 10直链或支链烷基,被可被取代的芳氧基取代的C 1 -C 3烷基,C 3 -C 12直链或支链链烯基,C 3 -C 8直链或支链 炔基或被苯基或苯氧基取代的C 1 -C 3烷基,它们可以是取代的 通过C 1 -C 6烷氧基或C 5 -C 8环烷基取代,R 3是氢原子,甲基或乙烯基,X是卤素原子。
    • 2. 发明公开
    • Cis-Bicyclo[4.3.0]non-2-ene derivatives
    • Cis-Bicyclo¬4.3.O非2-en-Derivate
    • EP0431571A2
    • 1991-06-12
    • EP90123253.8
    • 1990-12-04
    • SAGAMI CHEMICAL RESEARCH CENTERTOA EIYO LTD.
    • Shibasaki, MasakatsuTakahasi, AtsuoAoki, TuyosiSato, HiroyasuYamada, Shin-ichiKudo, MichikoYamaguchi, TakajiKogi, KentaroNarita, Sen-ichi
    • C07C405/00C07C69/738C07C69/712A61K31/557
    • C07C69/738C07C59/46C07C59/62C07C69/712C07C69/732C07C405/0083Y02P20/55
    • A cis-bicyclo[4.3.0]non-2-ene derivative of the formula:

      wherein R is a hydrogen atom, or a protecting group for a hydroxyl group, R¹ is a hydrogen atom, a

              C₁-C₁₂

      straight or branched chain alkyl group, a substituted or unsubstituted phenyl group, a

              C₆-C₁₂

      aralkyl group containing a condensed aromatic ring or an aromatic hetero ring, or 1 equivalent of a cation, A is

              -CH=CH-



              CH₂-,

      or

              -CH₂-CH₂-O- ,

      R² is a

              C₃-C₁₀

      straight or branched chain alkyl group, a

              C₁-C₃

      alkyl group substituted by an aryloxy group which may be substituted, a

              C₃-C₁₂

      straight or branched chain alkenyl group, a

              C₃-C₈

      straight or branched chain alkynyl group, or a

              C₁-C₃

      alkyl group substituted by a phenyl or phenoxy group which may be substituted, by a

              C₁-C₆

      alkoxy group or by a

              C₅-C₈

      cycloalkyl group, R³ is a hydrogen atom, a methyl group, or a vinyl group, and X is a halogen atom.
    • 下式的顺式 - 双环[4.3.0]壬-2-烯衍生物:其中R是氢原子或羟基保护基,其中R 1是氢原子,C1- C12直链或支链烷基,取代或未取代的苯基,含有稠合芳环或芳族杂环的C 6 -C 12芳烷基或1当量阳离子,A为-CH = CH-CH 2 - 或 -CH 2 -CH 2 -O - ,R 2是C 3 -C 10直链或支链烷基,被可被取代的芳氧基取代的C1-C3烷基,C3-C12直链或支链烯基 C 3 -C 8直链或支链炔基或被可被取代的苯基或苯氧基取代的C 1 -C 3烷基,被C 1 -C 6烷氧基或C 5 -C 8环烷基取代,R 3 >是氢原子,甲基或乙烯基,X是卤素原子。