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1. 发明公开

EP2210633A3 Drug delivery device with sensor system 有权
标题翻译：与传感器系统的药物输送装置
公开(公告)号：EP2210633A3
公开(公告)日：2011-06-08
申请号：EP10151234.1
申请日：2010-01-20
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric , Preas, Bryan T. , Martini, Joerg
IPC分类号： A61M5/172 , A61M5/168
CPC分类号： A61M5/1723 , A61M5/16836 , A61M5/1684 , A61M2205/3303 , A61M2205/3306 , A61M2205/3317 , A61M2205/3368
摘要： A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition.

2. 发明授权

EP2514477B1 Delivery devices with collimated gas stream and particle source 有权
公开(公告)号：EP2514477B1
公开(公告)日：2020-07-29
申请号：EP12164304.3
申请日：2012-04-16
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric
IPC分类号： A61M37/00 , A61M5/30 , A61D7/00 , A61K9/00 , A61K9/70

3. 发明公开

EP2506269A1 Low temperature thermistor manufacturing process 审中-公开
标题翻译：低温热敏电阻制造工艺
公开(公告)号：EP2506269A1
公开(公告)日：2012-10-03
申请号：EP12160505.9
申请日：2012-03-21
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Daniel, Jurgen H. , Whiting, Gregory
IPC分类号： H01C7/02 , H01C7/04 , H01C17/065
CPC分类号： H01C17/06506 , H01C7/02 , H01C7/023 , H01C7/026 , H01C7/04 , H01C7/043 , H01C7/044 , H01C7/047 , Y10T29/49083
摘要： A thermistor (10) has a mixture of a temperature sensitive material (16) and a conductive material, and an electrode (14,15) in electrical contact with the mixture. A method of manufacturing a thermistor includes depositing (40) conductive contacts onto a substrate, printing (44) a thermistor mixture of temperature sensitive material and a conductive material over the contact, and annealing (46) the thermistor mixture to produce a flexible thermistor on the conductive contacts.
摘要翻译：热敏电阻（10）具有温度敏感材料（16）和导电材料的混合物，以及与混合物电接触的电极（14,15）。一种制造热敏电阻的方法包括：将导电触点沉积（40）到衬底上;在触点上印刷（44）温度敏感材料和导电材料的热敏电阻混合物;以及对热敏电阻混合物进行退火（46）以产生柔性热敏电阻导电接点。

4. 发明授权

EP2514411B1 Needleless Transdermal Drug Delivery Devices 有权
标题翻译：针经皮剂型
公开(公告)号：EP2514411B1
公开(公告)日：2015-09-09
申请号：EP12164276.3
申请日：2012-04-16
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric
IPC分类号： A61K9/14 , A61M5/30
CPC分类号： A61K9/0021 , A61M5/30 , A61M5/3015

5. 发明授权

EP2210586B1 Drug deactivation system and method of deactivating a drug using the same 有权
标题翻译：药物失活系统和使用它的失活药物的方法
公开(公告)号：EP2210586B1
公开(公告)日：2015-04-29
申请号：EP10151233.3
申请日：2010-01-20
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric , Torres, Francisco E. , Schmaelzle, Philipp H.
IPC分类号： A61K9/00 , A61F7/00 , A61F13/00 , A61K9/70 , A61M5/00 , A61M31/00 , A61N1/00 , A61N5/00
CPC分类号： A61N7/00 , A61F7/00 , Y10S588/90

6. 发明授权

EP2308546B8 Transmucosal drug delivery device and method including microneedles 有权
标题翻译：一种用于粘膜的药物递送和方法与微针装置
公开(公告)号：EP2308546B8
公开(公告)日：2014-10-15
申请号：EP10187042.6
申请日：2010-10-08
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023

7. 发明公开

EP2514411A1 Needleless Transdermal Drug Delivery Devices 有权
标题翻译： Nadellose Transdermale Darreichungsformen
公开(公告)号：EP2514411A1
公开(公告)日：2012-10-24
申请号：EP12164276.3
申请日：2012-04-16
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric
IPC分类号： A61K9/14 , A61M5/30
CPC分类号： A61K9/0021 , A61M5/30 , A61M5/3015
摘要： Drug delivery device and methods are provided for transdermal drug delivery through a skin. The device includes a gas source (18) comprising a gas or capable of selectively producing a gas. The device also includes a first collimator (40) fluidly connected with the gas source (18) adapted to form a first plurality of collimated gas streams comprising the gas. The first collimator (40) has an inlet end (44) and an outlet end (46). The device further includes a first drug source comprising a drug. The first drug source is configured to release the drug into the first plurality of collimated gas streams between the inlet end and outlet end of the first collimator.
摘要翻译：提供药物递送装置和方法用于通过皮肤的透皮药物递送。该装置包括气体源（18），其包括气体或能够选择性地产生气体。该装置还包括与气体源（18）流体连接的第一准直器（40），其适于形成包括气体的第一多个准直气流。第一准直器（40）具有入口端（44）和出口端（46）。该装置还包括包含药物的第一药物源。第一药源构造成将药物释放到第一准直仪的入口端和出口端之间的第一组多个准直气体流中。

8. 发明公开

EP2210594A1 Drug deactivation system and method of deactivating a drug using the same 有权
标题翻译：药物失活系统和使用它的失活药物的方法
公开(公告)号：EP2210594A1
公开(公告)日：2010-07-28
申请号：EP10151232.5
申请日：2010-01-20
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric , Torres, Francisco E. , Schmaelzle, Philipp H.
IPC分类号： A61K9/20 , A61K9/50 , A61K9/00
CPC分类号： A61K9/0002
摘要： A drug deactivation system according to some embodiments includes at least one degradable capsule exposed to at least one drug-retaining region of a drug delivery device and an agent. The agent is configured to render a drug ineffective upon degradation of the at least one capsule. The at least one drug-retaining region is configured to retain one of the drug and the agent and the at least one capsule is configured to retain the other of the drug and the agent.
摘要翻译：根据一些实施方案的药物去活化系统包括暴露于药物递送装置的至少一个药物保留区域和药剂的至少一个可降解胶囊。药剂被配置为在至少一个胶囊降解时使药物无效。所述至少一个药物保持区域构造成保持所述药物和所述药剂中的一个，并且所述至少一个胶囊构造成保留所述药物和所述药剂中的另一个。

9. 发明授权

EP2210594B1 Drug deactivation system and method of deactivating a drug using the same 有权
标题翻译：活性剂去活系统和方法的活性成分的失活，从而
公开(公告)号：EP2210594B1
公开(公告)日：2015-04-29
申请号：EP10151232.5
申请日：2010-01-20
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric , Torres, Francisco E. , Schmaelzle, Philipp H.
IPC分类号： A61K9/20 , A61K9/50 , A61K9/00
CPC分类号： A61K9/0002

10. 发明公开

EP2514408A1 Drug Delivery Devices and Methods with Collimated Gas Stream and Release-Activatable Tape 有权
标题翻译： Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band Band
公开(公告)号：EP2514408A1
公开(公告)日：2012-10-24
申请号：EP12164295.3
申请日：2012-04-16
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric
IPC分类号： A61K9/00 , A61M5/30
CPC分类号： A61K9/0021 , A61K9/0009 , A61M5/3015
摘要： Drug delivery devices and methods are provided for delivering a substance into a human or animal tissue. The device includes a gas source (18) comprising a gas or capable of selectively producing a gas. The device also includes a drug source positioned and configured to release a drug into the gas. The drug source includes a release-activatable tape (74) having the drug disposed thereon. The device also includes a first collimator (40) fluidly connected with the gas source. The first collimator, which has an inlet end and an outlet end, is adapted to form a collimated gas stream comprising the drug in the gas.
摘要翻译：提供药物递送装置和方法用于将物质递送到人或动物组织中。该装置包括气体源（18），其包括气体或能够选择性地产生气体。该装置还包括定位并构造成将药物释放到气体中的药物源。药物源包括其上设置有药物的可释放活化的带（74）。该装置还包括与气体源流体连接的第一准直器（40）。具有入口端和出口端的第一准直器适于在气体中形成包含药物的准直气流。

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