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1. 发明授权

EP2085761B1 OBTAINING SENSING RESULTS INDICATING TIME VARIATION 有权
公开(公告)号：EP2085761B1
公开(公告)日：2018-11-28
申请号：EP09151642.7
申请日：2009-01-29
申请人： Palo Alto Research Center Incorporated
发明人： Kiesel, Peter , Martini, Joerg , Bassler, Michael , Beck, Markus , Johnson, Noble M. , Hegyi, Alex , Buergel, Tobias
IPC分类号： G01N21/05 , G01N21/03 , G01N15/10 , G01N15/14
CPC分类号： G01N21/05 , G01N15/1459 , G01N2015/1075 , G01N2021/0346
摘要： In response to objects having relative motion within an encoding/sensing region relative to an encoder/sensor that, e.g., photosenses emanating light or performs impedance-based sensing, sensing results can indicate sensed time-varying waveforms with information about the objects, about their relative motion, about excitation characteristics, about environmental characteristics, and so forth. An encoder/sensor can include, for example, a non-periodic arrangement of sensing elements; a longitudinal sequence of sensing elements with a combined sensing pattern that approximates a superposition or scaled superposition of simpler sensing patterns; and/or IC-implemented sensing elements that include photosensing arrays on ICs and readout/combine circuitry that reads out photosensed quantities from cells in groups in accordance with cell-group sensing patterns and combines the readout photosensed quantities to obtain the sensing results. Objects can move fluidically as in flow cytometry, through scanning movement as in document scanning, or in other ways.

2. 发明授权

EP2605184B1 Traffic monitoring based on non-imaging detection 有权转让
公开(公告)号：EP2605184B1
公开(公告)日：2018-08-22
申请号：EP12197291.3
申请日：2012-12-14
申请人： Palo Alto Research Center Incorporated
发明人： Kiesel, Peter , Bern, Marshall W , Martini, Joerg , Huck, Malte
IPC分类号： G06K9/00 , G08G1/01 , G01S1/00 , G08G1/015 , G01S17/02 , G01S17/89 , G01S3/783 , G08G1/04
CPC分类号： G01J1/04 , G01S11/12 , G01S17/88 , G08G1/015 , G08G1/04
摘要： Traffic monitors based on non-imaging radiation detectors are described. A traffic monitor includes a non-imaging radiation detector that senses spatially patterned radiation emanating from objects moving in a traffic pattern. The detector generates a time varying output signal based on the sensed radiation. Signal processing circuitry is used to analyze the time varying output signal using time domain analysis to provide the traffic information.

3. 发明公开

EP2210633A3 Drug delivery device with sensor system 有权
标题翻译：与传感器系统的药物输送装置
公开(公告)号：EP2210633A3
公开(公告)日：2011-06-08
申请号：EP10151234.1
申请日：2010-01-20
申请人： Palo Alto Research Center Incorporated
发明人： Uhland, Scott , Peeters, Eric , Preas, Bryan T. , Martini, Joerg
IPC分类号： A61M5/172 , A61M5/168
CPC分类号： A61M5/1723 , A61M5/16836 , A61M5/1684 , A61M2205/3303 , A61M2205/3306 , A61M2205/3317 , A61M2205/3368
摘要： A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition.

4. 发明公开

EP2156786A1 Improved specificity of analyte detection in etalons 有权
标题翻译： Etalonen的VerbesserteSpezifizitätund Analyterkennung
公开(公告)号：EP2156786A1
公开(公告)日：2010-02-24
申请号：EP09167956.3
申请日：2009-08-17
申请人： Palo Alto Research Center Incorporated
发明人： Martini, Joerg , Bruce, Richard H. , Torres, Francisco E. , Kiesel, Peter , Recht, Michael I. , Roe, Jeffrey
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. A first container includes (i) an optical cavity detection region, (ii) a reservoir for one or more modifiers of one or more optical properties of the optical cavity detection region, and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container. The optical cavity detection region and the reservoir define separate areas of the first container. The movement of the one or more modifiers between the reservoir and the optical cavity detection region is responsive to changes in concentration of the analyte. A second container includes an optical cavity detection region, and a set of one or more bounding regions through which objects in the fluid can transfer into the container. Also provided are optical components for guiding light into the optical cavity detection regions of the first and second containers.
摘要翻译：提供了用于检测流体中分析物浓度的系统和方法。第一容器包括（i）光腔检测区域，（ii）用于一个或多个光学腔检测区域的一个或多个光学特性的修改器的储存器，以及（iii）一组或多个边界区域，流体中的物体可以转移到容器中。光腔检测区域和储存器限定第一容器的分开的区域。储存器和光学腔检测区域之间的一个或多个改性剂的运动响应分析物浓度的变化。第二容器包括光腔检测区域和一组一个或多个界限区域，流体中的物体可通过该区域传送到容器中。还提供了用于将光引导到第一和第二容器的光学腔检测区域中的光学部件。

5. 发明公开

EP2778230A3 Compositions and methods for performing assays 有权
标题翻译： Zusammensetzungen und Verfahren zurDurchführungvon测试
公开(公告)号：EP2778230A3
公开(公告)日：2015-08-12
申请号：EP14160138.5
申请日：2014-03-14
申请人： Palo Alto Research Center Incorporated
发明人： Recht, Michael I. , Kiesel, Peter , Torres, Francisco E. Torres , Martini, Joerg
IPC分类号： C12Q1/00 , G01N33/58 , G01N21/64
CPC分类号： G01N21/6486 , C12Q1/00 , G01N33/582 , G01N2333/90209
摘要： The disclosure relates to compositions for use in assays, the compositions comprising at least one latent fluorophore including at least one enzyme-reactive quenching group and a conjugative group; and a support connectable to the latent fluorophore by the conjugative group. The disclosure further relates to methods of measuring the presence and/or concentration of an analyte, as well as methods of measuring the relative activity of at least two enzymes.
摘要翻译：本公开涉及用于测定的组合物，所述组合物包含至少一种包含至少一种酶反应性猝灭基团和共轭基团的潜在荧光团; 以及通过共轭基团连接到潜在荧光团的支持体。本公开还涉及测量分析物的存在和/或浓度的方法以及测量至少两种酶的相对活性的方法。

6. 发明授权

EP2085758B1 Causing Relative Motion 有权
标题翻译：造成相对运动
公开(公告)号：EP2085758B1
公开(公告)日：2014-06-04
申请号：EP09151766.4
申请日：2009-01-30
申请人： Palo Alto Research Center Incorporated
发明人： Kiesel, Peter , Beck, Markus , Bassler, Michael , Johnson, Noble M. , Hegyi, Alex , Buergel, Tobias , Martini, Joerg
IPC分类号： G01N15/10 , G01N21/05 , G01N15/12 , G01N15/14 , G01N21/17 , G01N21/00 , B01L3/00
CPC分类号： G01N21/1717 , G01N15/1459 , G01N2015/1075 , G01N2021/1723

7. 发明公开

EP2156787A1 Method of detecting analyte 有权
标题翻译： Verfahren zur Erkennung eines分析
公开(公告)号：EP2156787A1
公开(公告)日：2010-02-24
申请号：EP09167957.1
申请日：2009-08-17
申请人： Palo Alto Research Center Incorporated
发明人： Martini, Joerg , Bruce, Richard H. , Torres, Francisco E. , Kiesel, Peter , Recht, Michael I. , Roe, Jeffrey
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound.
摘要翻译：提供了用于检测流体中分析物浓度的系统和方法。该方法包括检测系统中两个或更多个区域的第一区域的光学特性，位于容器中的第一区域具有用于一个或多个第一区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应分析物浓度的变化。下一步骤检测系统中两个或更多个区域的第二区域的光学特性，位于容器中的第二区域具有用于一个或多个第二区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应化合物浓度的变化，其中化合物不是分析物。第一区域的检测光学特性和第二区域的检测光学特性用于实施例中，以分离物对第一区域的检测光学特性的影响与化合物的影响分开，其中化合物是干扰复合。

8. 发明公开

EP2085761A2 Obtaining Sensing Results Indicating Time Variation 有权
标题翻译：获得指示的时间变化的测量结果
公开(公告)号：EP2085761A2
公开(公告)日：2009-08-05
申请号：EP09151642.7
申请日：2009-01-29
申请人： Palo Alto Research Center Incorporated
发明人： Kiesel, Peter , Martini, Joerg , Bassler, Michael , Beck, Markus , Johnson, Noble M. , Hegyi, Alex , Buergel, Tobias
IPC分类号： G01N21/05 , B01L3/00
CPC分类号： G01N21/05 , G01N15/1459 , G01N2015/1075 , G01N2021/0346
摘要： In response to objects having relative motion within an encoding/sensing region relative to an encoder/sensor that, e.g., photosenses emanating light or performs impedance-based sensing, sensing results can indicate sensed time-varying waveforms with information about the objects, about their relative motion, about excitation characteristics, about environmental characteristics, and so forth. An encoder/sensor can include, for example, a non-periodic arrangement of sensing elements; a longitudinal sequence of sensing elements with a combined sensing pattern that approximates a superposition or scaled superposition of simpler sensing patterns; and/or IC-implemented sensing elements that include photosensing arrays on ICs and readout/combine circuitry that reads out photosensed quantities from cells in groups in accordance with cell-group sensing patterns and combines the readout photosensed quantities to obtain the sensing results. Objects can move fluidically as in flow cytometry, through scanning movement as in document scanning, or in other ways.

9. 发明公开

EP2072006A1 Controlling transfer of objects affecting optical characteristics 有权
标题翻译： Steuerung des Transfers von Objekten mit optischen Merkmalen
公开(公告)号：EP2072006A1
公开(公告)日：2009-06-24
申请号：EP08171499.0
申请日：2008-12-12
申请人： Palo Alto Research Center Incorporated
发明人： Martini, Joerg , Roe, Jeffrey , Kiesel, Peter , Bassler, Michael , Bell, Alan G. , Bruce, Richard H. , Johnson, Noble M.
IPC分类号： A61B5/00 , G01N21/85 , G01N21/03 , G01N21/39
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/03 , G01N21/39 , G01N21/8507
摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.
摘要翻译：诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部分中的分析物和非分析物容器。该产品还可以包括流体组件，例如控制影响或移动光谱特征或特性的物体的转移的过滤组件，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中间强度宽度，作为全宽半最大值（FWHM）。分析物，例如葡萄糖分子可以主要包括在一组物体中，其比其它物体更快速地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。因此，来自容器的输出光包括关于分析物的信息。

10. 发明授权

EP2156786B1 Improved specificity of analyte detection in etalons 有权
标题翻译：改进的特异性和分析物识别的标准具
公开(公告)号：EP2156786B1
公开(公告)日：2015-11-11
申请号：EP09167956.3
申请日：2009-08-17
申请人： Palo Alto Research Center Incorporated
发明人： Martini, Joerg , Bruce, Richard H. , Torres, Francisco E. , Kiesel, Peter , Recht, Michael I. , Roe, Jeffrey
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359

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