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1. 发明公开

EP3428262A1 IMAGE PROCESSING DEVICE, OBSERVATION DEVICE, AND PROGRAM 有权
公开(公告)号：EP3428262A1
公开(公告)日：2019-01-16
申请号：EP16893530.2
申请日：2016-03-11
申请人： Nikon Corporation
发明人： KII Hiroaki , KIYOTA Yasujiro , UOZUMI Takayuki , YAMAZAKI Yoichi
IPC分类号： C12M1/00
摘要： An image processing device includes an image processing unit that performs image processing on an observed image in which a cell is imaged and an image processing method selector that is configured to determine an observed image processing method for analyzing the imaged cell on the basis of information of a processed image obtained through image processing of the image processing unit.

2. 发明公开

EP2418473A1 ORGANISM SAMPLE OBSERVATION DEVICE 有权转让
标题翻译： VORRICHTUNG ZUR BEOBACHTUNG VON ORGANISMUSPROBEN
公开(公告)号：EP2418473A1
公开(公告)日：2012-02-15
申请号：EP10761751.6
申请日：2010-04-09
申请人： Nikon Corporation
发明人： KURODA Hideo , WATANABE Hirotada , WADA Yoichi , KIYOTA Yasujiro , UOZUMI Takayuki , KOSHIBA Ryuji
IPC分类号： G01N21/17 , G01N21/64 , G02B21/36
CPC分类号： G02B21/367 , G01N21/6486 , G02B21/16 , G02B21/365 , G06K9/00134 , G06K9/0014
摘要： The present invention relates to a biological specimen observation apparatus whereby observation of a biological specimen can be performed accurately. In macro observation, a biological change region is extracted from a macro image (S32), a micro observation point corresponding to an extracted biological change region is registered (S33), and an object for tracking is identified. In micro observation, it is judged from the micro image whether or not biological change has continued in the biological change region at the micro observation point (S41), and the registered micro observation point is updated on the basis of this judgment result (S42). By this means, it is possible to carry out both macro observation for detecting a biological change region and micro observation for observing the progress of growth of a partial minute region where biological change has been exhibited, and therefore it is possible to carry out accurate observation of a biological specimen. The present invention can be applied to a biological specimen observation apparatus which carries out observation of a biological specimen, for example.
摘要翻译：本发明涉及一种能够准确地进行生物样本的观察的生物样本观察装置。在宏观观察中，从宏观图像提取生物变化区域（S32），登记与提取的生物变化区域对应的微观观察点（S33），并且识别跟踪对象。在微观观察中，从微观图像判断微观察点处的生物变化区域的生物变化是否持续（S41），并根据该判断结果更新登记的微观察点（S42）。通过这种方式，可以进行用于检测生物变化区域的宏观观察和用于观察已经展示生物变化的部分微小区域的生长进展的微观察，因此可以进行准确的观察的生物标本。本发明可以应用于例如进行生物样本的观察的生物样本观察装置。

3. 发明公开

EP3865565A1 IMAGE PROCESSING DEVICE, IMAGE PROCESSING METHOD, PROGRAM AND EVALUATION METHOD 审中-实审
公开(公告)号：EP3865565A1
公开(公告)日：2021-08-18
申请号：EP19871996.5
申请日：2019-10-04
申请人： NIKON CORPORATION
发明人： DAN Tomoro , KII Hiroaki , UOZUMI Takayuki , KIYOTA Yasujiro
IPC分类号： C12M1/34 , C12Q1/04 , G06T7/00
摘要： An image processing device includes: a colony region extraction unit that is configured to extract a colony region of pluripotent stem cells from a microscopic image obtained using transmitted illumination; a high luminance region extraction unit that is configured to extract, from the microscopic image, a high luminance region that is a region on the basis of a group of pixels with larger luminance values than a standard value from among pixels constituting the microscopic image; an extraction target region extraction unit that is configured to extract an extraction target region from the microscopic image on the basis of the colony region extracted by the colony region extraction unit and the high luminance region extracted by the high luminance region extraction unit; and an output unit that is configured to output, as an extraction result, the extraction target region extracted by the extraction target region extraction unit.

4. 发明公开

EP3467103A1 METHOD FOR PRODUCING NEURAL STEM CELLS, MEDIUM, SUPPLEMENT, SUPPLEMENT SET, MEDIUM KIT, AND CELL CULTURE DEVICE 审中-实审
公开(公告)号：EP3467103A1
公开(公告)日：2019-04-10
申请号：EP17802926.0
申请日：2017-05-26
申请人： Nikon Corporation
发明人： KII Hiroaki , KIYOTA Yasujiro , UOZUMI Takayuki , FURUE Miho , SUGA Mika
IPC分类号： C12N5/0797 , C12M3/00
摘要： The present invention provides a method for producing neural stem cells, the method including a culture step of culturing cells using a medium that contains a TGF-β receptor inhibitor and a protein kinase C inhibitor. The method for producing neural stem cells is a method that includes a first culture step of culturing cells using a first medium that does not contain a TGF-β receptor inhibitor and a protein kinase C inhibitor, and a second culture step of culturing the cells using a second medium that contains a TGF-β receptor inhibitor and a protein kinase C inhibitor, after the first culture step. The method for producing neural stem cells is a method that includes a first culture step of culturing cells using a first medium that contains ascorbic acid or an ascorbic acid derivative, and a second culture step of culturing the cells using a second medium that contains a TGF-β receptor inhibitor and a protein kinase C inhibitor, after the first culture step.

5. 发明公开

EP3428261A1 IMAGE PROCESSING DEVICE, OBSERVATION DEVICE, AND PROGRAM 审中-公开
公开(公告)号：EP3428261A1
公开(公告)日：2019-01-16
申请号：EP16893527.8
申请日：2016-03-11
申请人： Nikon Corporation
发明人： KII Hiroaki , KIYOTA Yasujiro , UOZUMI Takayuki , KAWASHIMA Kazuhiro , YAMAZAKI Yoichi
IPC分类号： C12M1/00
摘要： An image processing device includes: an associating unit configured to associate information on an identification element used to identify a cell in imaged cell information with information on a non-identification element serving as an element of the cell which is not the identification element on the basis of the information on the identification element and information of the non-identification element; and a status determination unit configured to determine a cell status on the basis of the information on the identification element and the information on the non-identification element associated together by the linking unit.

6. 发明公开

EP3964562A1 CELL TRACKING METHOD, IMAGE PROCESSING DEVICE, AND PROGRAM 审中-实审
公开(公告)号：EP3964562A1
公开(公告)日：2022-03-09
申请号：EP20796277.0
申请日：2020-04-23
申请人： NIKON CORPORATION
发明人： ICHIHASHI Toru , KII Hiroaki , TAKASAKI Tetsuomi , UOZUMI Takayuki , YAMAZAKI Yoichi , KINEHARA Masaki
IPC分类号： C12M1/34 , G06T7/00 , G06T7/246 , C12Q1/02 , G01N33/483
摘要： A cell tracking method is a cell tracking method for performing cell tracking on the basis of a plurality of cell images captured in time series, and includes an extraction process of extracting a tracking region corresponding to the cell for each of the plurality of cell images, a position calculation process of calculating a change in a position of the tracking region extracted in the extraction process on the basis of the plurality of cell images and tracking the cell on the basis of the calculated change in the position of the tracking region, a determination process of determining whether or not the cell as a tracking target is in a cell division state on the basis of the cell image, and a stop process of stopping the tracking of the cell when the cell is determined to be in the cell division state in the determination process.

7. 发明公开

EP3865566A1 SUBCULTURE STAGE CALCULATION DEVICE, SUBCULTURE STAGE CALCULATION METHOD, AND PROGRAM 审中-公开
公开(公告)号：EP3865566A1
公开(公告)日：2021-08-18
申请号：EP19872004.7
申请日：2019-10-02
申请人： NIKON CORPORATION , Kyoto University
发明人： DAN Tomoro , KII Hiroaki , UOZUMI Takayuki , SATO Yoshiko , YOSHIDA Shinsuke
IPC分类号： C12M1/34
摘要： A passage timing calculation device includes a time change calculating section configured to calculate a time change in an area occupied by an extraction target region that is a region in which a striated pattern appears from a plurality of microscope images of pluripotent stem cells captured at different times, a change point detecting section configured to detect a change point of the time change in an area occupied by the extraction target region, and a passage timing calculating section configured to determine a passage timing of the pluripotent stem cells on the basis of the change point.

8. 发明公开

EP3428263A1 EVALUATION DEVICE, OBSERVATION DEVICE, AND PROGRAM 有权
公开(公告)号：EP3428263A1
公开(公告)日：2019-01-16
申请号：EP16893536.9
申请日：2016-03-11
申请人： Nikon Corporation , National Institutes of Biomedical Innovation, Health and Nutrition
发明人： KII Hiroaki , KIYOTA Yasujiro , UOZUMI Takayuki , FURUE Miho , SUGA Mika
IPC分类号： C12M1/00 , C12Q1/68
摘要： An evaluation device includes a state determination unit which is configured to determine a state of cells which are an observation target under non-standard conditions on the basis of information acquired from an image of cells under standard conditions.

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