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1. 发明授权

EP1833563B1 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 有权
标题翻译： LV阈值测量和获得管理
公开(公告)号：EP1833563B1
公开(公告)日：2015-06-24
申请号：EP05854717.5
申请日：2005-12-20
申请人： Medtronic, Inc.
发明人： SHELDON, Todd, J. , STROEBEL, John, C. , PARIKH, Purvee, Praduman , KLECKNER, Karen, J.
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371

2. 发明公开

EP2303403A1 ELECTROGRAM STORAGE FOR SUSPECTED NON-PHYSIOLOGICAL EPISODES 有权
标题翻译：电动GRAM储存，当你认为非生理EPISODES
公开(公告)号：EP2303403A1
公开(公告)日：2011-04-06
申请号：EP08794872.5
申请日：2008-07-30
申请人： Medtronic, Inc.
发明人： OUSDIGIAN, Kevin, T. , CONDIE, Catherine, R. , KLECKNER, Karen, J. , GUNDERSON, Bruce, D.
IPC分类号： A61N1/37 , A61B5/0245 , A61N1/08
CPC分类号： A61N1/3702 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/053 , A61B5/0538 , A61B5/7264 , A61B2560/0276 , A61N1/3704 , A61N2001/083
摘要： Techniques for storing electrograms (EGMs) that are associated with sensed episodes or events that may be non-physiological and, instead, associated with a sensing integrity condition are described. In some examples, a device or system identifies suspected non-physiological NSTs, and stores an EGM for the suspected non-physiological NSTs within an episode log. In some examples, a device or system determines whether to store an EGM for a suspected non- physiological episode or event based on whether an impedance integrity criterion has been satisfied. For example, a device or system may store an EGM for a detected short interval if the impedance integrity criterion has been met. In some examples, a device or system determines whether to buffer EGM data based on whether an impedance integrity criterion or other sensing integrity criterion has been met.

3. 发明公开

EP1684852A2 CARDIAC PACING MODALITY HAVING IMPROVED BLANKING, TIMING, AND THERAPY DELIVERY METHODS FOR EXTRA-SYSTOLIC STIMULATION PACING THERAPY 有权
标题翻译：具有改进的消隐，时间和治疗传递方法的extrasystolic起搏治疗起搏器HERZSCHRITTMACHERMODALITÄT
公开(公告)号：EP1684852A2
公开(公告)日：2006-08-02
申请号：EP04794308.9
申请日：2004-10-06
申请人： MEDTRONIC, INC.
发明人： DENO, Curtis, D. , SPLETT, Vincent, E. , GILLBERG, Jeffery, M. , ZILLMER, Glenn, C. , KLEPFER, Ruth, N. , KLECKNER, Karen, J.
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/3627
摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an 'extra-systolic interval' or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.

4. 发明授权

EP1117462B1 MULTI-SITE CARDIAC PACING SYSTEM HAVING CONDITIONAL REFRACTORY PERIOD 有权
标题翻译：更随心区刺激性SYSTEM有条件不应期
公开(公告)号：EP1117462B1
公开(公告)日：2005-01-19
申请号：EP00943360.8
申请日：2000-06-30
申请人： Medtronic, Inc.
发明人： KLECKNER, Karen, J. , JURAN, Carleen, J. , BETZOLD, Robert, A. , WENDELL, Thomas, C.
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684
摘要： Multi-site cardiac pacing systems for providing pacing to multiple sites in a patient's heart, e.g., in a single heart chamber or in right and left heart chambers, while avoiding inappropriate responses to double sensing of an evoked depolarization conducted between the sites. A conditional refractory period and further post-event time periods, e.g. a conventional refractory period, are started upon a sense event or pacing pulse sensed at or delivered to a first pace/sense site. A sense event detected at another sense site that occurs during the conditional refractory period is characterized as a conditional refractory event, and it restarts shortened post-event time periods and terminates the conditional refractory period. The restarted post-event time periods are reduced in length by the elapsed time between the starting and termination of the conditional refractory period. The undue prolongation of the post-event period due to a sense event resulting from sensing of delayed propagation of a depolarization between the spaced apart pace/sense sites is avoided. However, the full length post-event time periods are restarted if a sense event is then detected during the previously restarted post-event time periods. Multi-site single heart chamber pacemaker and right and left heart chamber pacemaker embodiments of the invention are disclosed. In an atrial synchronous bi-ventricular pacemaker embodiment, the undue prolongation of the post-event period due to a ventricular event sense event resulting from sensing of delayed propagation of a single ventricular depolarization between the left and right ventricles is avoided, and legitimate atrial sense event signals occurring thereafter are not characterized as refractory and are able to restart the AV delay.

5. 发明授权

EP1140287B1 REGULARIZATION OF VENTRICULAR RATE DURING ATRIAL TACHYARRHYTHMIA 有权
标题翻译：房性心动过速期间心室心率调节
公开(公告)号：EP1140287B1
公开(公告)日：2004-08-11
申请号：EP99967630.7
申请日：1999-12-22
申请人： MEDTRONIC, INC.
发明人： IGEL, David, A. , MARKOWITZ, H., Toby , BETZOLD, Robert, A. , KLECKNER, Karen, J. , SCHROETTER, Jeramy, A.
IPC分类号： A61N1/368
摘要： A pacing system provided with a mode switching feature and ventricular rate regularization (VRR) function adapted to stabilize or regularize ventricular heart rate during chronic or paroxysmal atrial tachyarrhythmia. In a preferred embodiment, the pacing system nominally operates in an atrial synchronized pacing mode such as DDD or DDDR pacing mode. In response to detection of atrial rhythm characteristics consistent with an atrial tachyarrhythmia, e.g., atrial fibrillation, a mode switch into a non-atrial synchronized, ventricular rate regularization pacing mode, e.g. DDIR or VDIR pacing mode, is made. If the VRR function is programmed on, the ventricular pacing rate based upon a rate responsive sensor derived ventricular pacing rate modulated on a beat by beat basis by preceding intrinsic or paced ventricular events, the stability of the intrinsic ventricular heart rate, and any atrial pace events to regularize the ventricular pacing rate. The pacing system may also be permanently programmed to the DDIR pacing mode with the VRR feature functioning continuously. The pacing system may also be permanently programmed to the VVIR pacing mode with VRR function activated, but without consideration of atrial pace events.

6. 发明授权

EP1885446B1 SYSTEM FOR REMOTE PACING THRESHOLD ASSESSMENT 有权
标题翻译：系统起搏阈值的远程评估
公开(公告)号：EP1885446B1
公开(公告)日：2012-12-05
申请号：EP06739405.6
申请日：2006-03-23
申请人： Medtronic, Inc.
发明人： YERICH, Charles, G. , KLECKNER, Karen, J.
IPC分类号： A61N1/37
CPC分类号： G06F19/3418 , A61N1/371 , A61N1/37282 , G06F19/00
摘要： A cardiac rhythm management system includes an implantable medical device capable of delivering cardiac therapy and sensing an EGM. The implantable medical device undergoes threshold testing and transmits testing data to a computer via a remote monitor.

7. 发明授权

EP1684852B1 CARDIAC PACING MODALITY HAVING IMPROVED BLANKING, TIMING, AND THERAPY DELIVERY METHODS FOR EXTRA-SYSTOLIC STIMULATION PACING THERAPY 有权
标题翻译：具有改进的消隐，时间和治疗传递方法的extrasystolic起搏治疗起搏器HERZSCHRITTMACHERMODALITÄT
公开(公告)号：EP1684852B1
公开(公告)日：2012-01-25
申请号：EP04794308.9
申请日：2004-10-06
申请人： MEDTRONIC, INC.
发明人： DENO, Curtis, D. , SPLETT, Vincent, E. , GILLBERG, Jeffery, M. , ZILLMER, Glenn, C. , KLEPFER, Ruth, N. , KLECKNER, Karen, J.
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61N1/3627
摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an 'extra-systolic interval' or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.

8. 发明公开

EP1885446A1 SYSTEM AND METHOD FOR REMOTE PACING THRESHOLD ASSESSMENT 有权
标题翻译：系统起搏阈值的远程评估
公开(公告)号：EP1885446A1
公开(公告)日：2008-02-13
申请号：EP06739405.6
申请日：2006-03-23
申请人： MEDTRONIC, INC.
发明人： YERICH, Charles, G. , KLECKNER, Karen, J.
IPC分类号： A61N1/37
CPC分类号： G06F19/3418 , A61N1/371 , A61N1/37282 , G06F19/00
摘要： A cardiac rhythm management system includes an implantable medical device capable of delivering cardiac therapy and sensing an EGM. The implantable medical device undergoes threshold testing and transmits testing data to a computer via a remote monitor.

9. 发明公开

EP0794812A2 METHOD AND APPARATUS FOR RATE-RESPONSIVE CARDIAC PACING 失效
标题翻译：方法和装置时钟敏感HERSTIMULATOREN
公开(公告)号：EP0794812A2
公开(公告)日：1997-09-17
申请号：EP95942858.0
申请日：1995-11-13
申请人： MEDTRONIC, INC.
发明人： YERICH, Charles, G. , COMBS, William, J. , KLECKNER, Karen, J. , PANKEN, Eric, J. , SCHALLHORN, Richard, S. , WAHLSTRAND, John, D.
IPC分类号： A61N1
CPC分类号： A61N1/36585
摘要： A body-implantable rate-responsive cardiac pacemaker is provided with circuitry for sensing a plurality of physiologic parameters known to be indicative of a patient's metabolic demand for increased cardiac output. In one embodiment, a rate-responsive pacemaker is provided with an activity sensor for detecting the patient's level of physical activity, and is further provided with an impedance sensing circuit for detecting the patient's level of minute ventilation by monitoring cardiac impedance. A rate-response transfer function, implemented by the pacemaker's control circuitry, periodically computes a rate-responsive pacing rate as a function of the outputs from both physiologic sensing circuits. The pacemaker's pacing rate is variable within a rate range defined by predetermined (programmable) upper and lower limits. In the preferred embodiment, the influence of activity sensing and minute ventilation parameters varies in accordance with the current pacing rate. In particular, the influence of activity sensing in rate determination in accordance with the rate-response function is greater than that of minute ventilation, for slower pacing rates, while the influence of minute ventilation sensing dominates over that of activity sensing for higher pacing rates. Rate response operation of the disclosed system is recorded in the form of histogram data stored over a predetermined history time. The relative influence of the activity sensing and minute ventilation sensing on rate determination is periodically scaled or balanced based upon comparison of the histogram data with predetermined desired response data.

10. 发明公开

EP1833563A1 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 有权
标题翻译： LV阈值测量和获得管理
公开(公告)号：EP1833563A1
公开(公告)日：2007-09-19
申请号：EP05854717.5
申请日：2005-12-20
申请人： MEDTRONIC, INC.
发明人： SHELDON, Todd, J. , STROEBEL, John, C. , PARIKH, Purvee, Praduman , KLECKNER, Karen, J.
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate o ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or 'CRT').

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