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1. 发明授权

EP1904170B1 REMOTELY ENABLED PACEMAKER AND IMPLANTABLE SUBCUTANEOUS CARDIOVERTER/DEFIBRILLATOR SYSTEM 有权
标题翻译：远程致动的节奏和皮下植入式心脏/除颤器系统
公开(公告)号：EP1904170B1
公开(公告)日：2012-12-19
申请号：EP06750093.4
申请日：2006-04-12
申请人： Medtronic, Inc.
发明人： MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61N1/025 , A61N1/37211 , A61N1/37229 , A61N1/37288

2. 发明授权

EP1345653B1 LEADLESS FULLY AUTOMATIC PACEMAKER FOLLOW-UP 有权
标题翻译：心脏起搏器无线全自动跟踪控制
公开(公告)号：EP1345653B1
公开(公告)日：2006-07-05
申请号：EP01995439.5
申请日：2001-11-08
申请人： MEDTRONIC, INC.
发明人： COMBS, William, J. , BERG, Gary
IPC分类号： A61N1/37 , A61N1/372
CPC分类号： A61N1/37252 , A61N1/3702 , A61N1/37288
摘要： A leadless fully automatic folow-up (LFAPF) device that is triggered into operation either locally or remotely is implemented extra-corporeally to access cardiac data such as ECGs stored in one or more implantable medical device (IMDs) implaned in one or more patients. A telemetry unit is used in the LFAPF to transmit and test stored data in the IMDs. The telemetry unit implements a series of adjustable commands depending on the desired level of detail of the follow-up. An alternate embodiment representing intra-corporeal use of an additional device includes cardiac data monitoring and cardioversion pulse synchroniyation in cooperation with another IMD such as a pacer.

3. 发明公开

EP1345653A2 LEADLESS FULLY AUTOMATIC PACEMAKER FOLLOW-UP 有权
标题翻译：心脏起搏器无线全自动跟踪控制
公开(公告)号：EP1345653A2
公开(公告)日：2003-09-24
申请号：EP01995439.5
申请日：2001-11-08
申请人： Medtronic, Inc.
发明人： COMBS, William, J. , BERG, Gary
IPC分类号： A61N1/37 , A61N1/372
CPC分类号： A61N1/37252 , A61N1/3702 , A61N1/37288
摘要： A leadless fully automatic folow-up (LFAPF) device that is triggered into operation either locally or remotely is implemented extra-corporeally to access cardiac data such as ECGs stored in one or more implantable medical device (IMDs) implaned in one or more patients. A telemetry unit is used in the LFAPF to transmit and test stored data in the IMDs. The telemetry unit implements a series of adjustable commands depending on the desired level of detail of the follow-up. An alternate embodiment representing intra-corporeal use of an additional device includes cardiac data monitoring and cardioversion pulse synchroniyation in cooperation with another IMD such as a pacer.

4. 发明公开

EP0794812A2 METHOD AND APPARATUS FOR RATE-RESPONSIVE CARDIAC PACING 失效
标题翻译：方法和装置时钟敏感HERSTIMULATOREN
公开(公告)号：EP0794812A2
公开(公告)日：1997-09-17
申请号：EP95942858.0
申请日：1995-11-13
申请人： MEDTRONIC, INC.
发明人： YERICH, Charles, G. , COMBS, William, J. , KLECKNER, Karen, J. , PANKEN, Eric, J. , SCHALLHORN, Richard, S. , WAHLSTRAND, John, D.
IPC分类号： A61N1
CPC分类号： A61N1/36585
摘要： A body-implantable rate-responsive cardiac pacemaker is provided with circuitry for sensing a plurality of physiologic parameters known to be indicative of a patient's metabolic demand for increased cardiac output. In one embodiment, a rate-responsive pacemaker is provided with an activity sensor for detecting the patient's level of physical activity, and is further provided with an impedance sensing circuit for detecting the patient's level of minute ventilation by monitoring cardiac impedance. A rate-response transfer function, implemented by the pacemaker's control circuitry, periodically computes a rate-responsive pacing rate as a function of the outputs from both physiologic sensing circuits. The pacemaker's pacing rate is variable within a rate range defined by predetermined (programmable) upper and lower limits. In the preferred embodiment, the influence of activity sensing and minute ventilation parameters varies in accordance with the current pacing rate. In particular, the influence of activity sensing in rate determination in accordance with the rate-response function is greater than that of minute ventilation, for slower pacing rates, while the influence of minute ventilation sensing dominates over that of activity sensing for higher pacing rates. Rate response operation of the disclosed system is recorded in the form of histogram data stored over a predetermined history time. The relative influence of the activity sensing and minute ventilation sensing on rate determination is periodically scaled or balanced based upon comparison of the histogram data with predetermined desired response data.

5. 发明授权

EP1011803B1 IMPLANTABLE IMPEDANCE MEASUREMENT SYSTEM 失效
标题翻译：植入阻抗测量装置
公开(公告)号：EP1011803B1
公开(公告)日：2004-09-01
申请号：EP98906031.4
申请日：1998-01-29
申请人： Medtronic, Inc.
发明人： COMBS, William, J. , CONDIE, Catherine, R. , MARTIN, Roy , WARKENTIN, Dwight, H. , WAHLSTRAND, John, D.
IPC分类号： A61N1/37 , A61B5/05 , A61B5/08
CPC分类号： A61B5/4878 , A61B5/0535 , A61B5/0809 , A61N1/3627 , A61N1/3702

6. 发明公开

EP1011803A1 IMPLANTABLE IMPEDANCE MEASUREMENT SYSTEM 失效
标题翻译：植入阻抗测量装置
公开(公告)号：EP1011803A1
公开(公告)日：2000-06-28
申请号：EP98906031.4
申请日：1998-01-29
申请人： MEDTRONIC, INC.
发明人： COMBS, William, J. , CONDIE, Catherine, R. , MARTIN, Roy , WARKENTIN, Dwight, H. , WAHLSTRAND, John, D.
IPC分类号： A61N1/37 , A61B5/05 , A61B5/08
CPC分类号： A61B5/4878 , A61B5/0535 , A61B5/0809 , A61N1/3627 , A61N1/3702
摘要： An edema monitor and trigger initiates diagnostic reporting or corrective action when activated. It includes means for recording of Long Term Average and Short Term Average values and means for removing unwanted recurring noise. Preferred embodiment uses impedance measurement made on periodic basis with processing of signal values indicative of current or voltage.

7. 发明公开

EP0794814A1 METHOD AND APPARATUS FOR AUTOMATIC PACING THRESHOLD DETERMINATION 失效
标题翻译：方法和设备REIZUNGSSCHWELLWERTS的自动确定
公开(公告)号：EP0794814A1
公开(公告)日：1997-09-17
申请号：EP95939922.0
申请日：1995-11-13
申请人： MEDTRONIC, INC.
发明人： CONDIE, Catherine, R. , COMBS, William, J. , STROEBEL, John, C. , MARKOWITZ, H., Toby , WAHLSTRAND, John, D. , BAXTER, Daniel, J. , GREENINGER, Daniel, R. , KLECKNER, Karen, J.
IPC分类号： A61N1
CPC分类号： A61N1/36521 , A61N1/3712 , A61N1/3714
摘要： A method and apparatus for automatic determination of a pacemaker patient's pacing stimulation threshold. Circuitry is provided in a pacemaker for obtaining a signal reflecting cardiac impedance, which is known to reliably reflect certain aspects of cardiac function. Circuitry is also provided for monitoring the cardiac impedance waveform during a predetermined capture detect window following delivery of stimulating pulses. One or more values are derived which characterize the morphology of the impedance waveform during the capture detect window associated with each stimulation pulse delivered. These values are compared to predetermined control values in order to assess whether a stimulation pulse has achieved cardiac capture. The assessment of whether cardiac capture has been achieved is also based partly upon the conventional sensing of atrial and/or ventricular cardiac signals occurring during the capture detect window. In one embodiment of the invention, the control values against which impedance waveform characterization values are compared are obtained by delivering a series of stimulation pulses having sufficient energy to ensure that capture is achieved, and by monitoring the impedance waveform during delivery of these pulses.

8. 发明公开

EP1904170A2 REMOTELY ENABLED PACEMAKER AND IMPLANTABLE SUBCUTANEOUS CARDIOVERTER/DEFIBRILLATOR SYSTEM 有权
标题翻译：远程致动的节奏和皮下植入式心脏/除颤器系统
公开(公告)号：EP1904170A2
公开(公告)日：2008-04-02
申请号：EP06750093.4
申请日：2006-04-12
申请人： MEDTRONIC, INC.
发明人： MARKOWITZ, H., Toby , HETTRICK, Douglas, A. , COMBS, William, J. , SHELDON, Todd, J. , THOMPSON, David, L. , GHANEM, Raja, N. , WANASEK, Kevin, A.
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61N1/025 , A61N1/37211 , A61N1/37229 , A61N1/37288
摘要： Subcutaneous Implantable cardioverter-defibrillators (SubQ ICDs) are disclosed that are entirely implantable subcutaneously with minimal surgical intrusion into the body of the patient and provide distributed cardioversion-defibrillation sense and stimulation electrodes for delivery of cardioversion-defibrillation shock and pacing therapies across the heart when necessary. The SubQ ICD is implemented with other implantable and external medical devices and communicates to provide drugs and therapy in a coordinated and synergistic manner.

9. 发明公开

EP1341581A2 ATRIAL AWARE VVI: A METHOD FOR ATRIAL SYNCHRONOUS VENTRICULAR (VDD/R) PACING USING THE SUBCUTANEOUS ELECTRODE ARRAY AND A STANDARD PACING LEAD 审中-公开
标题翻译： ATRIAL AWARE VVI：使用皮下电极阵列和标准起搏导联进行心房同步心室（VDD / R）起搏的方法
公开(公告)号：EP1341581A2
公开(公告)日：2003-09-10
申请号：EP01995355.3
申请日：2001-11-08
申请人： Medtronic, Inc.
发明人： PANKEN, Eric, J. , COMBS, William, J. , SHELTON, Michael, B.
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： An algorithm is implemented in a circuit for sensing P-waves in a pacemaker to ensure ventricular pacing synchronization with sensed atrial depolarization waves. VDD and VDDR pacing (atrial synchronized, ventricular inhibited pacing) are implemented via a single standard ventricular pacing lead (unipolar or bipolar) and preferably a subcutaneous electrode array (SEA). Specifically, an implanted ventricular lead provides ventricular pacing and ventricular sensing while the SEA enable atrial sensing, thus eliminating the need for an implanted atrial lead or a specialized single pass VDD lead. The algorithm manages the sensed cardiac waves to effect a desired pacing regimen based on the input from the single lead and SEA.
摘要翻译：在用于感测起搏器中的P波的电路中实施算法以确保心室起搏与感测的心房去极化波同步。 VDD和VDDR起搏（心房同步，心室抑制起搏）通过单一标准心室起搏导联（单极或双极）和优选皮下电极阵列（SEA）实施。具体而言，植入的心室导线可以提供心室起搏和心室感应，而SEA则可以实现心房感知，从而不再需要植入心房导联或专门的单通VDD导联。该算法基于来自单个导联和SEA的输入来管理感测的心脏波以实现期望的起搏方案。

10. 发明授权

EP0593745B1 WORK-MODULATED PACING RATE DECELERATION 失效
标题翻译：降低PACER速度因数量保护正常工作
公开(公告)号：EP0593745B1
公开(公告)日：1997-02-05
申请号：EP93911562.2
申请日：1993-03-25
申请人： MEDTRONIC, INC.
发明人： SHELTON, Michael, Brent , COMBS, William, J. , BENNETT, Tommy, D. , TOLLINGER, Michael, R. , RIFF, Kenneth, M.
IPC分类号： A61N1/365 , A61N1/372
CPC分类号： A61N1/36514
摘要： A rate-responsive cardiac pacemaker in which deceleration of the pacing rate is modulated according to recent patient activity or 'work'. Based on signals provided from an activity sensor in the pacemaker, the pacemaker maintains and periodically recomputes a Work value corresponding to the amount of patient activity detected over time. In response to a decrease in or cessation of detected patient activity, the pacemaker reduces the pacing rate, first at a more rapid deceleration rate, then at a lower deceleration rate, and then once again at a more rapid deceleration rate. The length of time during which the pacing rate is reduced at the lower deceleration rate is modulated according to the Work value maintained by the pacemaker. The work-modulated pacing rate deceleration occurs only if certain achievement criteria are met, the achievement criteria being specified in terms of the amount of time the pacemaker's target pacing rate exceeds a predetermined rest value, and the difference between the target rate and the rest rate.

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