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1. 发明授权

EP2340785B1 ARTIFICIAL DURA MATER AND MANUFACTURING METHOD THEREOF 有权转让
标题翻译：人工硬脑膜及其制造方法
公开(公告)号：EP2340785B1
公开(公告)日：2016-05-18
申请号：EP10750329.4
申请日：2010-02-08
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： XU, Tao , YUAN, Yuyu
IPC分类号： A61F2/02 , A61L27/20 , A61L27/24 , A61L27/54 , A61L31/06 , D01D5/00 , B32B5/22 , A61L27/14
CPC分类号： A61F2/02 , A61L27/14 , A61L27/18 , A61L27/26 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/58 , B32B5/26 , B32B2250/20 , B32B2307/7163 , B32B2307/728 , B32B2307/73 , B32B2535/00 , D01D5/003 , D04H1/435 , D04H1/72 , D04H1/728 , D04H3/005 , D04H3/009 , D04H3/011 , D04H3/02 , D04H3/073

2. 发明公开

EP3375461A1 TISSUE REPAIR FIBER MEMBRANE, PREPARATION METHOD AND APPLICATION THEREOF, AND TISSUE REPAIR PRODUCT 有权
公开(公告)号：EP3375461A1
公开(公告)日：2018-09-19
申请号：EP16868041.1
申请日：2016-11-25
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： DENG, Kunxue , YUAN, Yuyu
IPC分类号： A61L27/24
CPC分类号： A61K9/0024 , A61F2/0045 , A61K45/06 , A61L27/24 , A61L31/041 , A61L31/044 , A61L31/046 , A61L31/047 , A61L31/16 , A61L2300/236 , A61L2300/252 , A61L2430/00
摘要： A tissue repair fibrous membrane, preparation method and application thereof, and tissue repair product. The tissue repair fibrous membrane is formed by interweaving fiber filaments having a diameter of 10 nm to 100 µm, and has pore structures formed by interweaving between the fiber filaments. The fiber filaments have concave structures, and have annular convex structures thereon in the radial direction of the filaments.

3. 发明公开

EP3015120A1 TISSUE REPAIR SCAFFOLD AND PREPARATION METHOD AND PURPOSE THEREOF 有权
标题翻译：组织修复支架及其制备方法和用途
公开(公告)号：EP3015120A1
公开(公告)日：2016-05-04
申请号：EP14818651.3
申请日：2014-06-26
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： DENG, Kunxue , YANG, Yaya , YUAN, Yuyu
IPC分类号： A61L27/40 , A61L27/14 , A61L27/20 , A61L27/22 , A61L27/24
CPC分类号： A61L27/48 , A61L27/18 , A61L27/20 , A61L27/222 , A61L27/24 , A61L27/26 , A61L27/44 , A61L27/54 , A61L27/56 , A61L27/60 , A61L31/125 , A61L31/146 , A61L31/16 , A61L2430/32 , A61L2430/34 , A61L2430/38
摘要： The present invention provides a tissue repair scaffold and a preparation method and purpose thereof. The tissue repair scaffold comprises at least one composite fiber layer, and the composite fiber layer comprises a composite fiber formed by an adhesion factor and a hydrophobic synthetic material. The composite fiber layer may further form a porous three-dimensional mesh structure with a hydrophilic material. The tissue repair scaffold is applied to brain meninge repair, spinal meninge repair, a tissue engineering scaffold material, artificial skin, a wound assistant, a biological membrane, a wound cladding material, a hemostatic material, a postoperative adhesion prevention material, or a cosmetic material.
摘要翻译：本发明提供了一种组织修复支架及其制备方法和用途。组织修复支架包括至少一个复合纤维层，并且复合纤维层包含由粘附因子和疏水性合成材料形成的复合纤维。复合纤维层还可以形成具有亲水性材料的多孔三维网状结构。该组织修复支架应用于脑脑膜修复，脊髓脑膜修复，组织工程支架材料，人造皮肤，伤口助剂，生物膜，伤口包层材料，止血材料，术后粘连预防材料或化妆品材料。

4. 发明公开

EP3449956A1 MEDICAL HYDROGEL COMPOSITION, AND MEDICAL HYDROGEL, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 有权转让
公开(公告)号：EP3449956A1
公开(公告)日：2019-03-06
申请号：EP17788820.3
申请日：2017-04-28
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： LIN, Limin , YANG, Yaya , MA, Cheng , DENG, Kunxue , YUAN, Yuyu
IPC分类号： A61L27/52 , A61L27/26 , A61L31/14 , A61L31/04 , A61L31/06 , A61L26/00
摘要： A medical hydrogel composition, a medical hydrogel, a preparation method therefore and an application thereof, and a medical hydrogel kit. The medical hydrogel composition comprises a first component and a second component; the first component comprises polylysine and polyethylene imine; the second component comprises one or more of 4-arm-polyethylene glycol-succinimidyl glutarate, 4-arm-polyethylene glycol-succinimidyl succinate, and 4-arm-polyethylene glycol-succinimidyl carbonate; the degree of polymerization of the polylysine is 20 or more. The medical hydrogel is formed by reacting the first component with the second component of the medical hydrogel composition. The medical hydrogel kit comprises the medical hydrogel composition and a buffer solution used for dissolving the components of the medical hydrogel composition. The medical hydrogel has a degree of swelling of -10% - 50%, and can be applied in narrow parts where cranial, spinal, and peripheral nerves are densely distributed.

5. 发明公开

EP3312327A1 REINFORCED ELECTROSPUN FIBROUS MEMBRANE AND PREPARATION METHOD THEREOF 有权
标题翻译：增强型电纺丝纤维膜及其制备方法
公开(公告)号：EP3312327A1
公开(公告)日：2018-04-25
申请号：EP16811022.9
申请日：2016-06-16
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： LI, Guangyao , DENG, Kunxue , YANG, Yaya , YUAN, Yuyu
IPC分类号： D04H1/728 , D04H1/42 , D01D5/00
CPC分类号： D01D5/0007 , A61F2/08 , A61L27/58 , D01D5/00 , D04H1/42 , D04H1/728
摘要： The present application discloses a reinforced electrospun fibrous membrane and a preparation method thereof. The reinforced electrospun fibrous membrane comprises: an electrospun fibrous membrane body and a plurality of parallel reinforcing thread sets fixed to the electrospun fibrous membrane body via through holes thereon, wherein each of the reinforcing thread sets comprises a starting end and a terminal end, both being connected to an edge of the electrospun fibrous membrane body; each of the reinforcing thread sets comprises at least one reinforcing fibrous thread comprising a main thread and an auxiliary thread respectively arranged at a front side and a bottom side of the electrospun fibrous membrane body and configured to interlace each other at the through hole. By providing reinforcing thread sets on the electrospun fibrous membrane body to impart the electrospun fibrous membrane with a greater mechanical property, the mechanical strength required for the movement of the tissue is ensured, and the electrospun fibrous membrane is easy to be folded or rolled into other shapes. The electrospun fibrous membrane body may be made of degradable materials, which are gradually degraded and absorbed in the process of inducing new tissue formation, thereby providing space for the formation of new tissues.
摘要翻译：本申请公开了一种增强电纺纤维膜及其制备方法。增强电纺纤维膜包括：电纺纤维膜体和通过其上的通孔固定到电纺纤维膜体上的多根平行的增强线组，每根增强线组包括起始端和终止端，二者均为连接到电纺纤维膜体的边缘; 每根增强丝线组包括至少一根增强纤维丝线，所述增强纤维丝线包括主丝线和辅助丝线，所述主丝线和辅助丝线分别设置在所述电纺纤维薄膜体的前侧和底侧，并被配置为在所述通孔处彼此交织。通过在电纺纤维膜体上设置增强线组以赋予电纺纤维膜更大的机械性能，确保了组织移动所需的机械强度，并且电纺纤维膜易于折叠或卷成其他形状。静电纺纤维膜体可以由可降解材料制成，在诱导新组织形成的过程中逐渐被降解和吸收，从而为新组织形成提供空间。

6. 发明授权

EP3015120B1 TISSUE REPAIR SCAFFOLD AND PREPARATION METHOD AND PURPOSE THEREOF 有权
公开(公告)号：EP3015120B1
公开(公告)日：2019-08-07
申请号：EP14818651.3
申请日：2014-06-26
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： DENG, Kunxue , YANG, Yaya , YUAN, Yuyu
IPC分类号： A61L27/40 , A61L27/14 , A61L27/20 , A61L27/22 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/60 , A61L31/12 , A61L31/14 , A61L31/16 , A61L27/44

7. 发明授权

EP3312327B1 REINFORCED ELECTROSPUN FIBROUS MEMBRANE AND PREPARATION METHOD THEREOF 有权
公开(公告)号：EP3312327B1
公开(公告)日：2019-07-31
申请号：EP16811022.9
申请日：2016-06-16
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： LI, Guangyao , DENG, Kunxue , YANG, Yaya , YUAN, Yuyu
IPC分类号： D04H1/728 , D04H1/42 , D01D5/00

8. 发明公开

EP2921136A1 FIBER MEMBRANES FOR REPAIRING TISSUE AND PRODUCTS AND PREPARATION METHOD THEREOF 有权
标题翻译：纤维膜对组织产品和生产用于制造修理
公开(公告)号：EP2921136A1
公开(公告)日：2015-09-23
申请号：EP13854718.7
申请日：2013-11-14
申请人： Medprin Regenerative Medical Technologies Co., Ltd.
发明人： GUO, Zeyue , LAI, Kuilin , WANG, Guoshuai , ZHAN, Zefeng , XU, Tao , YUAN, Yuyu
IPC分类号： A61F2/02 , A61F2/06 , A61L27/44 , A61L27/56 , D01D5/00
CPC分类号： A61F2/0045 , A61F2/0063 , A61F2/0077 , A61F2002/0068 , A61F2002/009 , A61L31/04 , A61L31/047 , A61L31/125 , A61L31/146 , A61L31/16 , B29C47/0021 , B29K2023/12 , B29K2027/16 , B29K2075/00 , B29L2031/755 , D01D5/003 , D01D5/0069 , C08L89/00
摘要： The present invention relates to a fibrous membrane used for tissue repair and products and preparation methods thereof, wherein the fibrous membrane used for tissue repair is formed by interweaving fibrous filaments with diameters of 10nm-100µm, and has a porous structure, with the fluffiness of 200-2,000cm 3 /g. In addition, the present invention also relates to a composite fibrous membrane, an implantable membrane and an anti-adhesion tissue repair membrane comprising the fibrous membrane used for tissue repair as well as preparation methods and applications thereof.
摘要翻译：本发明涉及用于组织修复和产品及其制备方法的纤维膜，worin用于组织修复纤维膜是通过交织纤维状长丝具有10nm-100微米的合适的直径形成，并且具有多孔结构，具有的蓬松 200-2,000cm 3 / g以下。此外，本发明因此涉及一种复合纤维膜，可植入膜和防粘连组织修复膜，其包含用于组织修复以及制备方法和应用它的纤维膜。

9. 发明公开

EP2340785A1 ARTIFICIAL DURA MATER AND MANUFACTURING METHOD THEREOF 有权转让
标题翻译：赫尔辛基·杜拉（DUA）MATER UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP2340785A1
公开(公告)日：2011-07-06
申请号：EP10750329.4
申请日：2010-02-08
申请人： Medprin Regenerative Medical Technologies Co., Ltd
发明人： XU, Tao , YUAN, Yuyu
IPC分类号： A61F2/02 , A61L27/20 , A61L27/24 , A61L27/54 , A61L31/06 , D01D5/00
CPC分类号： A61F2/02 , A61L27/14 , A61L27/18 , A61L27/26 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/58 , B32B5/26 , B32B2250/20 , B32B2307/7163 , B32B2307/728 , B32B2307/73 , B32B2535/00 , D01D5/003 , D04H1/435 , D04H1/72 , D04H1/728 , D04H3/005 , D04H3/009 , D04H3/011 , D04H3/02 , D04H3/073
摘要： Disclosed are an artificial dura and its manufacturing method. The artificial dura mater consists of an electrospun layer by electrospinning. The electrospun layer has at least a hydrophobic electrospun layer. And there is at least a hydrophilic electrospun layer on the hydrophobic electrospun layer. A transition layer is formed between the hydrophobic electrospun layer and the hydrophilic electrospun layer. Cytokine and/or medicine can be added with every layer of the artificial dura mater, furthermore, can be adhered to the hydrophobic electrospun layer and/or the hydrophilic electrospun layer by bio-printing technique. The dura mater has a characteristic of good biocompatibility, accelerating the regeneration process of its tissue, excellent repairing effect, anti-adhesion, complete absorption, good mechanical properties, low infection rate, and capability of adding other therapeutic substances.
摘要翻译：公开了人造硬膜及其制造方法。人造硬脑膜由静电纺丝层组成。电纺层至少具有疏水性电纺丝层。并且在疏水性电纺丝层上至少有一个亲水的电纺丝层。在疏水性电纺丝层和亲水性电纺丝层之间形成过渡层。细胞因子和/或药物可以与人造硬膜的每一层相加，此外，可以通过生物印刷技术粘附到疏水性电纺丝层和/或亲水性电纺丝层。硬脑膜具有生物相容性好，加速组织再生过程，修复效果好，抗粘连，吸收全，机械性能好，感染率低，加入其他治疗物质的能力。

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