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1. 发明公开

EP3113839A1 MEDICAL IMPLANT, MEDICAL DEVICE AND METHOD FOR MAKING A MEDICAL IMPLANT 有权转让
标题翻译：医疗植入物，用于医疗植入物生产医疗设备和方法
公开(公告)号：EP3113839A1
公开(公告)日：2017-01-11
申请号：EP15709630.6
申请日：2015-02-27
申请人： Medizinische Hochschule Hannover
发明人： HAVERICH, Axel
IPC分类号： A61N1/375 , A61F2/00 , B65B31/02 , B65B31/04 , B65D81/20 , B65B11/52 , B65D75/30 , A61L31/04 , A61L31/16 , A61L31/14 , A61B90/00
摘要： The present invention relates to a medical implant which is vacuum-packed within an air tight cover material. Further, the present invention relates to a medical device for making a medical implant covered by an air tight cover material, wherein the medical device comprises at least an underpressure generating device and a sealing device, wherein the sealing device is arranged for air tight sealing of the cover material while the medical implant is located within the cover material, wherein the underpressure generating device is coupled or can be coupled with a space which is surrounded by the cover material, and wherein the underpressure generating device and the sealing device are controllable such that after generating a certain underpressure within the space surrounded by the cover material through the underpressure generating device the sealing device is activatable to seal the cover material in an air tight manner to form an air tight protection cover around the medical implant located therein. Further, the present invention relates to a method for making a medical implant covered by an air tight cover material, comprising the steps a) providing the medical implant, b) providing sterile cover material in the form of at least one or at least two pieces, c) placing the medical implant within a space surrounded by the at least one or at least two pieces of the cover material, d) creating an underpressure within the space surrounded by the at least one or at least two pieces of the cover material by evacuating air from this space, e) air tight sealing of the cover material.
摘要翻译：本发明涉及一种医用植入物的所有其是真空包装在气密盖材料内。此外，本发明涉及一种医疗装置，用于制备医用植入物通过在气密覆盖材料覆盖，worin医疗装置的压力产生装置和一个密封装置，worin密封装置下包括至少上被布置为的气密密封盖材料，而医用植入物位于盖材料内，worin的压力下产生装置耦合，或者可以与一个空间耦合的所有这是由覆盖材料包围，并且worin的压力下生成装置和密封装置是可控制的搜索做通过在压力下产生装置由所述覆盖材料包围的空间内的压力下产生特定后的密封装置是激活的，以密封所述盖材料以气密方式形成在围绕位于其中的医疗植入物气密保护盖。此外，本发明涉及一种用于在至少一个或至少两个片的形式制备医学植入物通过在气密覆盖材料提供覆盖，包括提供所述医用植入物的步骤a），b）中的无菌覆盖材料的方法 c）将通过覆盖材料，D）产生的至少一个或至少两片在负压通过由覆盖材料的至少一个或至少两片围成的空间内围成的空间内的医疗植入物从盖材料的该空间中，E）气密密封排出空气。

2. 发明授权

EP2755666B1 VERFAHREN ZUR HERSTELLUNG EINES BIOLOGISCHEN GEWEBEKONSTRUKTS UND VERWENDUNG SPEZIFISCH GEWONNENER AUTOLOGER ZELLEN UND DESSEN MEDIZINISCHE VERWENDUNG 有权
标题翻译：生产生物组织结构并使用特殊获得的自动细胞及其医疗用途的方法
公开(公告)号：EP2755666B1
公开(公告)日：2017-11-29
申请号：EP12772202.3
申请日：2012-09-13
申请人： Medizinische Hochschule Hannover (MHH)
发明人： HAVERICH, Axel , APER, Thomas , WILHELMI, Mathias
IPC分类号： A61K35/44 , A61K35/34 , A61L27/22 , A61K35/33 , A61P43/00
CPC分类号： A61K35/44 , A61K35/12 , A61K35/33 , A61K35/34 , A61K2300/00

4. 发明公开

EP2755666A1 VERFAHREN ZUR HERSTELLUNG EINES BLOLOGISCHEN GEWEBEKONSTRUKTS UND VERWENDUNG SPEZIFISCH GEWONNENER AUTOLOGER ZELLEN 有权
标题翻译：一种用于生产生物组织构造和使用具体获得自体细胞及其医疗用途
公开(公告)号：EP2755666A1
公开(公告)日：2014-07-23
申请号：EP12772202.3
申请日：2012-09-13
申请人： Medizinische Hochschule Hannover (MHH)
发明人： HAVERICH, Axel , APER, Thomas , WILHELMI, Mathias
IPC分类号： A61K35/44 , A61K35/34 , A61L27/22
CPC分类号： A61K35/44 , A61K35/12 , A61K35/33 , A61K35/34 , A61K2300/00
摘要： The method for producing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) that have not been multiply passaged and have a content of EOEC (Early Outgrowth Endothelial Progenitor Cells) and LOEC (Late Outgrowth Endothelial Progenitor Cells). These cells and fibroblasts and/or muscle cells, namely myoblasts, myofibroblasts, smooth muscle cells or their precursors, are seeded as living cells on a matrix or are incorporated into the matrix in order to yield a tissue construct after additional treatment steps. The matrix is preferably a protein preparation, in particular a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample of a patient. Besides its use for the production of bypass materials, prosthetic vessel replacement, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable to be used for cell transplantation.
摘要翻译：用于制备组织构建体用于医疗目的的方法使用还没有被传代多次，并且具有EOEC（早期生长内皮祖细胞）和LOEC（晚期生长内皮祖细胞）的含量的内皮祖细胞（EPC）。这些细胞和成纤维细胞和/或肌细胞，即成肌细胞，肌成纤维细胞，平滑肌细胞或它们的祖细胞，是，在活细胞的形式，接种到基质或以产生组织构建以下进一步的处理步骤引入到基质中。基质优选的蛋白质制剂，更特别是纤维蛋白原制剂。两者细胞和纤维蛋白原制剂可以从来自患者的单一血液样品中获得。除了旁路材料，假体血管移植物，组织贴剂，导管的制备和等时，EOEC含EPC培养或悬浮液，适合作为用于细胞移植。

5. 发明公开

EP4237024A1 IMPLANT FOR NERVE REGENERATION 审中-实审
公开(公告)号：EP4237024A1
公开(公告)日：2023-09-06
申请号：EP21805467.4
申请日：2021-11-02
申请人： Medizinische Hochschule Hannover
发明人： VOGT, Peter , LIEBSCH, Christina , BUCAN, Vesna , HAVERICH, Axel , STRAUSS, Sarah , APER, Thomas , WILHELMI, Mathias
IPC分类号： A61L27/22

6. 发明公开

EP3821919A1 VERFAHREN ZUR HERSTELLUNG EINES BIOARTIFIZIELLEN, PRIMÄR AZELLULÄREN KONSTRUKTS AUF FIBRINBASIS UND DIESES KONSTRUKT SELBST 有权
公开(公告)号：EP3821919A1
公开(公告)日：2021-05-19
申请号：EP21150379.2
申请日：2016-07-07
申请人： Medizinische Hochschule Hannover
发明人： APER, Thomas , WILHELMI, Mathias , HAVERICH, Axel
IPC分类号： A61L27/22 , A61L31/04
摘要： Die vorliegende Erfindung richtet sich auf ein Verfahren zur Herstellung eines bioartifiziellen und primär azellulären Konstrukts auf Fibrinbasis, wobei eine Mischung aus Fibrinogen-haltigen und Thrombin-haltigen zellfreien Zusammensetzungen auf einer Oberfläche aufgebracht und anschließend flächig druckbeaufschlagt werden. In einem weiteren Aspekt richtet sich die vorliegende Erfindung auf solche erfindungsgemäß erhaltenden bioartifiziellen, azellulären Konstrukte auf Fibrinbasis mit verbesserten biomechanischen Eigenschaften, sowie deren Verwendung im Bereich der Implantologie, Knorpelersatz oder Gewebeersatz.

7. 发明公开

EP3319652A1 VERFAHREN ZUR HERSTELLUNG EINES BIOARTIFIZIELLEN, PRIMÄR AZELLULÄREN KONSTRUKTS AUF FIBRINBASIS UND DIESES KONSTRUKT SELBST 有权
标题翻译：在纤维蛋白碱基上制备生物分解性一次性蜂窝状构建体的方法及其构建体本身
公开(公告)号：EP3319652A1
公开(公告)日：2018-05-16
申请号：EP16736169.0
申请日：2016-07-07
申请人： Medizinische Hochschule Hannover
发明人： APER, Thomas , WILHELMI, Mathias , HAVERICH, Axel
IPC分类号： A61L27/22 , A61L31/04
CPC分类号： A61L27/26 , A61L27/225 , A61L27/507 , A61L27/54 , A61L31/046 , A61L33/0011 , A61L33/08 , A61L2300/236 , A61L2300/252 , A61L2300/254 , A61L2300/418 , A61L2300/42 , A61L2420/02 , A61L2430/06 , A61L2430/20
摘要： The invention relates to a method for producing a bioartificial and primarily acellular fibrin-based construct, wherein a mixture of cell-free compositions containing fibrinogen and thrombin is applied to a surface and subsequently pressurised. An additional aspect of the invention is directed to such fibrin-based bioartificial acellular constructs obtained according to the invention, with improved biomechanical properties, as well as to the use of same in the field of implantology, cartilage replacement or tissue replacement.

8. 发明公开

EP3991762A1 IMPLANT FOR NERVE REGENERATION 审中-公开
公开(公告)号：EP3991762A1
公开(公告)日：2022-05-04
申请号：EP20205219.7
申请日：2020-11-02
申请人： Medizinische Hochschule Hannover
发明人： VOGT, Peter , LIEBSCH, Christina , BUCAN, Vesna , HAVERICH, Axel , STRAUSS, Sarah , APER, Thomas , WILHELMI, Mathias
IPC分类号： A61L27/22
摘要： The present invention relates to an implant suitable for nerve regeneration, also referred to as a neural implant, that is especially suitable for bridging defect sites of nerves, especially defect sites within the central nervous system, e.g. for spanning or bridging defects of axons within the spinal cord, which implant comprises or consists of a sheath, which preferably about its axis is circumferentially closed between its ends, the sheath consisting of fibrin and silk fibers arranged in axial direction inside the sheath, optionally fibrin that fills the inner volume of the sheath, e.g. fibrin filling the inner volume of the sheath and between the silk fibers.

9. 发明授权

EP3113839B1 MEDICAL IMPLANT, MEDICAL DEVICE AND METHOD FOR MAKING A MEDICAL IMPLANT 有权转让
公开(公告)号：EP3113839B1
公开(公告)日：2020-03-18
申请号：EP15709630.6
申请日：2015-02-27
申请人： Medizinische Hochschule Hannover
发明人： HAVERICH, Axel
IPC分类号： A61N1/375 , A61F2/00 , B65B31/02 , B65B31/04 , B65D81/20 , B65B11/52 , B65D75/30 , A61L31/04 , A61L31/16 , A61L31/14 , A61B90/00

10. 发明公开

EP2794842A1 VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG EINES BIOARTIFIZIELLEN GEWEBEKONSTRUKTS 有权
标题翻译：方法和设备用于生产生物人工肝组织构建
公开(公告)号：EP2794842A1
公开(公告)日：2014-10-29
申请号：EP12812859.2
申请日：2012-12-20
申请人： Medizinische Hochschule Hannover
发明人： APER, Thomas , WILHELMI, Mathias , HAVERICH, Axel
IPC分类号： C12M3/00 , A61L27/06 , A61L27/22 , A61L27/36 , A61L27/38 , A61L27/50 , A61L27/60
CPC分类号： A61L27/225 , A61F2/062 , A61F2/07 , A61F2/90 , A61L27/06 , A61L27/3804 , A61L27/3808 , A61L27/3826 , A61L27/3834 , A61L27/507 , B29C41/04 , B29C41/36 , B29C41/38 , B29K2101/00 , B29K2901/00 , B29K2905/00 , B29L2031/753 , C12M21/08 , C12M23/48
摘要： The tissue construct with viable cells in an extracellular matrix made of fibrin is produced with a special method, in which a matrix material and cells are shaped into a hollow body, in particular a tubular hollow body, by means of a rotational casting method in a hollow mould (1), the method comprising the following steps: (a) introduction of cells of at least one cell type and/or a fibrinogen preparation into the rotating hollow mould (1) with the aid of an applicator (4), said applicator (4) being displaced along the rotational axis during the introduction and step (a) being performed one or more times; (b) continuation of the rotation process until the fibrinogen solidifies into a dimensionally stable matrix, obtaining a primarily solidified tissue construct; (c) removal of the tissue construct from the mould. The construct can also be obtained in a relatively short time from autologous materials.

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