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1. 发明公开

EP2569615A2 WIDE DYNAMIC RANGE IMAGING 审中-公开
标题翻译：广泛的动态范围成像
公开(公告)号：EP2569615A2
公开(公告)日：2013-03-20
申请号：EP11781317.0
申请日：2011-05-12
申请人： LI-COR, INC.
发明人： LESIAK, Christopher J. , BOUZID, Ahmed , FRANZEN, David
IPC分类号： G01N21/64 , G01B11/24
CPC分类号： H04N5/361 , H04N5/2355 , H04N5/35581
摘要： Systems and methods for extending the dynamic range of imaging systems, and more particularly fluorescence or luminescence imaging systems, having low optical background, and a linear detector response. Images of a sample at each of a set of exposure times are acquired, a system-level dark estimate for each exposure time is subtracted from each image to form dark-corrected images, and the different exposures (dark-corrected images) are merged into a wider dynamic-range image. Typically merging is performed on a pixel-by pixel basis.
摘要翻译：用于扩展成像系统的动态范围的系统和方法，更具体地说是具有低光学背景和线性检测器响应的荧光或发光成像系统。采集一组曝光时间中的每一个曝光时间的样本图像，从每个图像中减去每个曝光时间的系统级暗估计以形成经过深度校正的图像，并且将不同曝光（经深色校正的图像）合并到更广泛的动态范围图像。通常，合并是以像素为单位进行的。

2. 发明公开

EP2297510A2 FLUORESCENCE FILTERING SYSTEM AND METHOD FOR MOLECULAR IMAGING 审中-公开
标题翻译：荧光滤光片和方法分子图片
公开(公告)号：EP2297510A2
公开(公告)日：2011-03-23
申请号：EP09751205.7
申请日：2009-05-13
申请人： LI-COR, INC.
发明人： BOUZID, Ahmed , LAMB, Donald, T. , RAGATZ, Andrew, G. , MIDDENDORF, Lyle, R.
IPC分类号： F21V5/00
CPC分类号： G01J3/10 , A61B5/0071 , G01J3/0208 , G01J3/12 , G01J3/4406 , G01J2003/104 , G01J2003/1213 , G01J2003/1226 , G01N21/6456
摘要： An optical system is disclosed that can be used for fluorescence filtering for molecular imaging. In one preferred embodiment, a source subsystem is disclosed comprising a light source and a first set of filters designed to pass wavelengths of light in an absorption band of a fluorescent material. A detector subsystem is also disclosed comprising a light detector, imaging optics, a second set of filters designed to pass wavelengths of light in an emission band of the fluorescent material, and an aperture located at a front focal plane of the imaging optics. A telecentric space is created between the light detector and the imaging optics, such that axial rays from a plurality of field points emerge from the imaging optics parallel to each other and perpendicular to the second set of filters.

3. 发明公开

EP1853883A1 ON-CHIP SPECTRAL FILTERING USING CCD ARRAY FOR IMAGING AND SPECTROSCOPY 审中-公开
标题翻译：片上的光谱滤波使用CCD矩阵成像和光谱
公开(公告)号：EP1853883A1
公开(公告)日：2007-11-14
申请号：EP06736751.6
申请日：2006-03-02
申请人： LI-COR, INC.
发明人： BOUZID, Ahmed , FRANZEN, David L. , LESIAK, Christopher
IPC分类号： G01J3/40
CPC分类号： G01J3/2803 , G01J3/4406
摘要： A spectral filtering apparatus and method is presented, which enables the functions of hyperspectral imaging to be performed with increased speed, simplicity, and performance that are required for commercial products. The apparatus includes a photosensitive array having a plurality of photosensitive elements such that different subsections of photosensitive elements of the array receive light of a different wavelength range of a characteristic spectrum of a target, and output electronics combines signals of at least two photosensitive elements in a subsection of the array and outputs the combined signal as a measure of the optical energy within a bandwidth of interest of the characteristic spectrum.

4. 发明公开

EP3635350A1 MODE MATCHING METHOD FOR ABSORPTION SPECTROSCOPY SYSTEMS 审中-公开
公开(公告)号：EP3635350A1
公开(公告)日：2020-04-15
申请号：EP18802344.4
申请日：2018-03-30
申请人： LI-COR, INC.
发明人： BOUZID, Ahmed
IPC分类号： G01J3/02 , G01J3/10 , G01N21/39 , G02B17/00 , H01S3/00

5. 发明公开

EP2569614A2 HIGH DYNAMIC RANGE SCANNING WITH REDUCED CHANNEL CROSS-TALK 审中-公开
标题翻译：具有高动态范围和受限制的信道扫描关于SPEAKING
公开(公告)号：EP2569614A2
公开(公告)日：2013-03-20
申请号：EP11781316.2
申请日：2011-05-12
申请人： LI-COR, INC.
发明人： BOUZID, Ahmed , LESIAK, Christopher J.
IPC分类号： G01N21/64 , G01B11/00
CPC分类号： G01J1/58 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G02B21/002 , G02B21/16 , G02B27/145
摘要： A multi-channel scanning system adapted to implement a low channel cross-talk, extra-wide dynamic range scanning method by scanning the same location more than once, wherein at least one time, the power of the excitation light and detector gain are set to High for at least one of the channels and Low for at least one of the other channels and different settings are used in subsequent scans. The scans of the same channel taken with different High and Low settings are merged together to produce one wider dynamic range image.

6. 发明授权

EP2792137B1 LUMINESCENCE IMAGING SCANNER 失效
标题翻译：发光成像扫描仪
公开(公告)号：EP2792137B1
公开(公告)日：2015-09-30
申请号：EP12716819.3
申请日：2012-03-28
申请人： LI-COR, INC.
发明人： BOUZID, Ahmed , LESIAK, Chris , KONZ, Daniel W. , FRANZEN, David L. , BIGGS, William , ANDERSON, Jon P.
IPC分类号： G01N21/76 , H04N1/193 , H04N1/10
CPC分类号： C12Q1/6825 , G01J1/0403 , G01N21/62 , G01N21/6486 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/54373 , H04N1/1017 , H04N1/191 , H04N1/1933
摘要： Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.

7. 发明公开

EP1989531A1 FLUORESCENCE FILTERING SYSTEM AND METHOD FOR MOLECULAR IMAGING 有权转让
标题翻译：荧光滤光片和方法分子图片
公开(公告)号：EP1989531A1
公开(公告)日：2008-11-12
申请号：EP06720779.5
申请日：2006-02-15
申请人： LI-COR, INC.
发明人： BOUZID, Ahmed
IPC分类号： G01N21/25
CPC分类号： G01N21/6428 , G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G01N2021/6471
摘要： An optical system is disclosed that can be used for fluorescence filtering for molecular imaging. In one preferred embodiment, a source subsystem is disclosed comprising a light source and a first set of filters designed to pass wavelengths of light in an absorption band of a fluorescent material. A detector subsystem is also disclosed comprising a light detector, imaging optics, a second set of filters designed to pass wavelengths of light in an emission band of the fluorescent material, and an aperture located at a front focal plane of the imaging optics. A telecentric space is created between the light detector and the imaging optics, such that axial rays from a plurality of field points emerge from the imaging optics parallel to each other and perpendicular to the second set of filters.

8. 发明公开

EP3908877A1 LASER LINE ILLUMINATION USING COMBINED SINGLE-MODE AND MULTI-MODE LASER SOURCES 审中-公开
公开(公告)号：EP3908877A1
公开(公告)日：2021-11-17
申请号：EP20738447.0
申请日：2020-01-07
申请人： LI-COR, INC.
发明人： NICHOLLS, Irma , BOUZID, Ahmed , LESIAK, Christopher
IPC分类号： G02B27/10 , G02B3/00 , G02B26/10 , H01S5/40

9. 发明公开

EP2960644A1 TELECENTRIC, WIDE-FIELD FLUORESCENCE SCANNING SYSTEMS AND METHODS 有权转让
标题翻译： VERFAHREN电视台电视台
公开(公告)号：EP2960644A1
公开(公告)日：2015-12-30
申请号：EP15173327.6
申请日：2015-06-23
申请人： LI-COR, INC.
发明人： BOUZID, Ahmed
IPC分类号： G01N21/64
CPC分类号： G02B21/16 , G01N21/6456 , G01N2021/6463 , G01N2021/6478 , G02B13/22 , G02B17/008 , G02B17/0605 , G02B17/0615 , G02B21/002 , G02B21/04 , G02B21/361 , G06F15/17306 , G06F17/30595 , G06F17/30867
摘要： A wide-field fluorescence imaging system (210) comprises a sample platform (200), a light source (201) for illuminating a sample on the sample platform with excitation light (202), a light detector (205) having an array of sensing locations, a first filter (207) that passes wavelengths of light other than the excitation light, a second filter (206) that passes fluorescent light emitted from the sample, and a bi-telecentric optical imaging system comprising imaging optics (203a, 203b) arranged and positioned such that a first telecentric space is created or exists between the sample platform and an entry aperture stop of the bi-telecentric optical imaging system, wherein the chief rays from a plurality of field points on the sample platform are parallel to each other when passing through the first filter, and such that a second telecentric space is created or exists between the light detector and an exit aperture stop of the bi-telecentric optical imaging system, wherein the chief rays from the plurality of field points are parallel to each other when passing through the second filter. In this manner, light collected from different points in the field of view pass through the first filter at the same angles and also through the second filter at the same angles to thereby reduce or eliminate angular spectral shifting effects.
摘要翻译：宽场荧光成像系统（210）包括样品平台（200），用于用激发光（202）照射样品平台上的样品的光源（201），具有感测阵列的光检测器（205）位置，通过除了激发光之外的光的波长的第一滤光器（207），使从样品发射的荧光传递的第二滤光器（206）和包括成像光学器件（203a，203b）的双远心光学成像系统，布置和定位成使得在样本平台和双远心光学成像系统的进入孔径光阑之间产生或存在第一远心空间，其中来自样品平台上的多个场点的主射线彼此平行当通过第一过滤器并且使得在光检测器和双远心光学成像系统的出口孔径光阑之间产生或存在第二远心空间时，其中主射线当多个场点在通过第二过滤器时彼此平行。以这种方式，从视场中的不同点收集的光以相同的角度穿过第一滤光器，并且以相同的角度穿过第二滤光器，从而减少或消除角光谱偏移效应。

10. 发明公开

EP2792137A1 LUMINESCENCE IMAGING SCANNER 失效
标题翻译：发光成像扫描仪
公开(公告)号：EP2792137A1
公开(公告)日：2014-10-22
申请号：EP12716819.3
申请日：2012-03-28
申请人： LI-COR, INC.
发明人： BOUZID, Ahmed , LESIAK, Chris , KONZ, Daniel W. , FRANZEN, David L. , BIGGS, William , ANDERSON, Jon P.
IPC分类号： H04N1/191 , G01N21/76
CPC分类号： C12Q1/6825 , G01J1/0403 , G01N21/62 , G01N21/6486 , G01N21/76 , G01N33/53 , G01N33/5302 , G01N33/54373 , H04N1/1017 , H04N1/191 , H04N1/1933
摘要： Systems, devices, and methods for accurately imaging chemiluminescence and other luminescence are disclosed. A compact, flat-bed scanner having a light-tight enclosure, one or more detector bars of linear charge-coupled device (CCD) or complementary metal oxide semiconductor (CMOS) imaging chips, and high working numerical aperture (NA) optics scans closely over a sample in one direction and then the opposite direction. Averages or other combinations of intensity readings for each pixel location (x, y) between the two or more passes are averaged together in order to compensate for luminescence that varies over time. On-chip pixel binning and multiple clock frequencies can be used to maximize the signal to noise ratio in a CCD-based scanner.
摘要翻译：公开了用于精确成像化学发光和其他发光的系统，装置和方法。具有不透光外壳，线性电荷耦合器件（CCD）或互补金属氧化物半导体（CMOS）成像芯片的一个或多个检测器条以及高工作数值孔径（NA）光学器件的紧凑平板扫描器紧密扫描在一个方向上，然后是相反的方向。为了补偿随时间变化的发光，对两次或多次通过之间的每个像素位置（x，y）的强度读数的平均值或其他组合进行平均。片上像素合并和多个时钟频率可用于最大化基于CCD的扫描仪的信噪比。

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