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1. 发明公开

EP4097145A1 REDUCTION OF ADSORPTION 审中-公开
公开(公告)号：EP4097145A1
公开(公告)日：2022-12-07
申请号：EP21703182.2
申请日：2021-01-29
申请人： LEUKOCARE AG
发明人： GEISSLER, Andreas , KEMTER, Kristina , HAUCK, Sabine , BÖCKEL, Maximilian Maarten
IPC分类号： C07K17/14 , C07K17/02

2. 发明公开

EP4186523A1 A NOVEL METHOD FOR STABILIZATION OF A BIOPHARMACEUTICAL DRUG PRODUCT DURING PROCESSING 审中-实审
公开(公告)号：EP4186523A1
公开(公告)日：2023-05-31
申请号：EP22199752.1
申请日：2017-09-15
申请人： Leukocare AG
发明人： SCHOLZ, Martin , KEMTER, Kristina , ALTRICHTER, Jens , KRIEHUBER, Thomas
IPC分类号： A61K39/395 , A61K48/00 , C12N7/00 , C12N15/86
摘要： The present invention relates to a method of producing a biopharmaceutical drug product comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1 ) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a biopharmaceutical drug product, said second phase comprising at least one processing step selected from (b1 ) re-buffering, (b2) freezing, (b3) thawing, and (b4) filling; wherein said at least one processing step in this second phase is carried out in the presence of a composition comprising (i) at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function; and (ii) one or more sugar(s); in an amino acid:sugar ratio between 10:1 to 1 :100 (w/w). The present invention further relates to a biopharmaceutical drug product obtained or obtainable by the method of the invention.

3. 发明公开

EP3744833A1 STABILISATION METHOD FOR VIRUSES 审中-公开
公开(公告)号：EP3744833A1
公开(公告)日：2020-12-02
申请号：EP20168140.0
申请日：2012-06-28
申请人： LEUKOCARE AG
发明人： SCHOLZ, Martin , ALTRICHTER, Jens , KEMTER, Kristina
IPC分类号： C12N7/02 , C12N7/00 , A61K9/19
摘要： The present invention relates to a method for stabilising viruses, the method comprising embedding the viruses in an aqueous solution, wherein the solution comprises at least three different amino acids and wherein the solution is free or substantially free of sugar(s), silanes and protein(s).

4. 发明公开

EP3511336A1 METHOD FOR PREVENTING THE UNFOLDING OF A (POLY)PEPTIDE AND/OR INDUCING THE (RE-)FOLDING OF A (POLY)PEPTIDE 有权
公开(公告)号：EP3511336A1
公开(公告)日：2019-07-17
申请号：EP19153060.9
申请日：2012-06-28
申请人： LEUKOCARE AG
发明人： SCHOLZ, Martin , ALTRICHTER, Jens , KEMTER, Kristina
IPC分类号： C07K1/113 , A61K9/19 , A61K47/18 , A61K47/28 , A61L2/00 , A61K39/395 , A61K9/08 , C07K16/24 , C07K16/32 , C07K14/005 , C12N7/00 , C12N9/04 , C12N9/96
摘要： The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide after drying, comprising the step of embedding the (poly)peptide in an aqueous solution, wherein the solution comprises (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide; and wherein the solution is free or substantially free of (a) sugar; and (b-i) protein; and/or (b-ii) denaturing compounds; and (c) silanes.

5. 发明公开

EP3060247A1 A NOVEL METHOD FOR THE PRODUCTION OF STABILE VACCINES 审中-公开
标题翻译：新方法制备稳定的疫苗
公开(公告)号：EP3060247A1
公开(公告)日：2016-08-31
申请号：EP14789274.9
申请日：2014-10-24
申请人： LEUKOCARE AG
发明人： SCHOLZ, Martin , ALTRICHTER, Jens , KEMTER, Kristina , SCHERLIESS, Regina , STECKEL, Hartwig
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , C12N2760/16151 , C12N2760/16251 , C12N2760/16351
摘要： The present invention relates to a method for producing stabilised vaccines, the method comprising: (a) mixing antigens with a solution comprising: (i) chitosan; (ii) at least three different amino acids and/or at least one dipeptide or tripeptide; and (iii) a sugar; and (b) drying the mixture obtained in (a).

6. 发明公开

EP4013436A1 METHOD FOR OBTAINING EFFICIENT COMPOSITIONS COMPRISING VIRAL VECTORS FOR VACCINATION OR GENE THERAPY 无效
公开(公告)号：EP4013436A1
公开(公告)日：2022-06-22
申请号：EP20753949.5
申请日：2020-08-14
申请人： LEUKOCARE AG
发明人： REINAUER, Eva , KEMTER, Kristina , ALTRICHTER, Jens
IPC分类号： A61K35/76 , A61K35/761 , A61K39/12 , A61K39/235 , A61K48/00

7. 发明公开

EP3512939A1 A NOVEL METHOD FOR OBTAINING EFFICIENT VIRAL VECTOR-BASED COMPOSITIONS FOR VACCINATION OR GENE THERAPY 审中-公开
公开(公告)号：EP3512939A1
公开(公告)日：2019-07-24
申请号：EP17772654.4
申请日：2017-09-15
申请人： Leukocare AG
发明人： KEMTER, Kristina , SCHOLZ, Martin
IPC分类号： C12N7/00 , A61K9/00

8. 发明公开

EP3512496A1 A NOVEL METHOD FOR PRODUCING LOW VISCOUS AND HIGHLY CONCENTRATED BIOPHARMACEUTICAL DRUG PRODUCTS IN LIQUID FORMULATION 审中-公开
公开(公告)号：EP3512496A1
公开(公告)日：2019-07-24
申请号：EP17769042.7
申请日：2017-09-15
申请人： LEUKOCARE AG
发明人： SCHOLZ, Martin , KEMTER, Kristina , ALTRICHTER, Jens , KRIEHUBER, Thomas
IPC分类号： A61K9/00 , A61K47/18 , A61K9/08

9. 发明公开

EP3512545A1 A NOVEL METHOD FOR STABILIZATION OF A BIOPHARMACEUTICAL DRUG PRODUCT DURING PROCESSING 有权
公开(公告)号：EP3512545A1
公开(公告)日：2019-07-24
申请号：EP17764856.5
申请日：2017-09-15
申请人： Leukocare AG
发明人： SCHOLZ, Martin , KEMTER, Kristina , ALTRICHTER, Jens , KRIEHUBER, Thomas
IPC分类号： A61K39/395 , A61K48/00 , C12N7/00 , C12N15/86

10. 发明授权

EP2726495B1 METHOD FOR PREVENTING THE UNFOLDING OF A (POLY)PEPTIDE AND/OR INDUCING THE (RE-)FOLDING OF A (POLY)PEPTIDE 有权
公开(公告)号：EP2726495B1
公开(公告)日：2019-03-06
申请号：EP12733061.1
申请日：2012-06-28
申请人： LEUKOCARE AG
发明人： SCHOLZ, Martin , ALTRICHTER, Jens , KEMTER, Kristina
IPC分类号： C07K1/113 , A61K39/395 , A61K9/19 , A61K47/18 , A61K47/28 , A61L2/00 , A61K9/08 , C07K16/24 , C07K16/32 , C12N9/04 , C12N9/96

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