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1. 发明公开

EP4026588A1 METHOD FOR ACQUIRING DATA FOR DISTINGUISHING PRESENCE OF CANCER CELLS AND/OR DISTINGUISHING ANTICANCER DRUG RESISTANCE, METHOD FOR ACQUIRING PREDICTION DATA, USE OF DISTINCTION MARKER IN SAME, AND DISTINGUISHING KIT 审中-实审
公开(公告)号：EP4026588A1
公开(公告)日：2022-07-13
申请号：EP20861322.4
申请日：2020-09-04
申请人： Keio University
发明人： HISHIKI, Takako , SUEMATSU, Makoto
IPC分类号： A61P35/00 , G01N21/65 , C12N5/09 , C12Q1/02 , A61K33/243 , G01N33/50 , A61K31/7068
摘要： The present invention aims to provide a method of acquiring data for determination of, and a method of acquiring prediction data on the presence of cancer cells and/or the resistance to anticancer drugs, use of a marker for determining thereof, and a kit for determining thereof, in particular, to determine the resistance to anticancer drugs before administration of the anticancer drugs to patients. The resistance of cancer tissues of cancer patients to anticancer drugs can be determined by detecting polysulfide, which is a marker for the resistance to anticancer drugs, in the cancer tissues of the cancer patients before administration of the anticancer drugs.

2. 发明授权

EP2381259B1 METHOD FOR MEASURING LIVER DISEASE MARKERS AND TEST METHOD FOR PHARMACEUTICAL PREPARATION 有权
标题翻译：测量肝脏疾病标记方法和试验程序医药制造
公开(公告)号：EP2381259B1
公开(公告)日：2016-09-21
申请号：EP09834674.5
申请日：2009-11-26
申请人： Keio University
发明人： SOGA, Tomoyoshi , SUGIMOTO, Masahiro , SUEMATSU, Makoto , HONMA, Masashi , YAMAMOTO, Takehito , SUZUKI, Hiroshi
IPC分类号： G01N33/68 , C07K5/02 , G01N27/62 , G01N33/576 , G01N33/497 , G01N33/487
CPC分类号： G01N33/487 , C07K5/0215 , G01N33/497 , G01N33/576 , G01N33/6812 , G01N33/6893 , G01N2800/08 , G01N2800/60

3. 发明公开

EP1975621A1 METHOD FOR DETERMINATION OF OXIDATIVE STRESS 有权
标题翻译： VERFAHREN ZUR FESTSTELLUNG VON氧化应激
公开(公告)号：EP1975621A1
公开(公告)日：2008-10-01
申请号：EP07706844.3
申请日：2007-01-16
申请人： Keio University
发明人： SOGA, Tomoyoshi , SUEMATSU, Makoto
IPC分类号： G01N33/68 , G01N27/62
CPC分类号： G01N33/6893 , G01N2430/00 , G01N2500/00 , G01N2800/00
摘要： Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by measuring blood concentration of ophthalmic acid, which is a substance that varies in blood depending on the variation of reduced glutathione (GSH) concentration in a biological sample with the use of an analyzer such as a capillary electrophoresis-mass spectrometer. Further, an anti-oxidative stress agent is screened by administering an anti-oxidative stress candidate agent to anon-human animal under oxidative stress conditions, measuring blood concentration of ophthalmic acid, and evaluating the degree of decrease in the ophthalmic acid concentration.
摘要翻译：提供了能够容易且快速地检测活体上的氧化应激的生物标志物，并且能够通过药物给药预防组织损伤或细胞坏死，并且其是研究各种药剂的毒性和药代动力学的有力标记。通过使用诸如毛细管电泳 - 质谱仪的分析仪，通过测量根据生物样品中还原型谷胱甘肽（GSH）浓度的变化的血液变化的眼睛液的血液浓度来测定氧化应激。此外，通过在氧化应激条件下对anon-human动物施用抗氧化应激候选试剂，测定眼酸的血药浓度，评价眼酸浓度的降低程度来筛选抗氧化应激剂。

4. 发明授权

EP2975393B1 MALDI SAMPLE PREPARATION METHOD AND SAMPLE PREPARATION DEVICE 有权转让
标题翻译：马德里自治区自治区人大常委会
公开(公告)号：EP2975393B1
公开(公告)日：2017-06-07
申请号：EP14778323.7
申请日：2014-04-04
申请人： Shimadzu Corporation , Keio University
发明人： OGATA, Koretsugu , TAKAHASHI, Kazuteru , KUBO, Akiko , SUEMATSU, Makoto , YAMAMOTO, Takushi
IPC分类号： G01N27/64 , H01J49/00 , H01J49/04 , B05D3/10 , B05D7/00 , B05D1/00
CPC分类号： H01J49/0418 , B05D1/60 , B05D3/107 , B05D7/5483 , H01J49/0004
摘要： After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.
摘要翻译：将诸如生物医学组织切片的样品附接到导电载玻片（S1）之后，通过气相沉积适当地形成基质物质的膜层以覆盖样品（S2）。膜层中的基质物质的晶体非常细且均匀。随后，将形成有基质膜层的载玻片置于汽化溶剂气氛中，溶剂渗入基质膜层（S3）。当充分渗透的溶剂蒸发时，样品中待测量的物质进入基质并重结晶。此外，通过气相沉积在表面上再次形成基质膜层（S4）。添加的基质膜层在MALDI期间吸收激光束的过量能量，抑制待测物质的变性等，从而可以在保持高空间分辨率的同时实现高检测灵敏度。

5. 发明公开

EP2975393A1 MALDI SAMPLE PREPARATION METHOD AND SAMPLE PREPARATION DEVICE 有权转让
标题翻译：样品制备方法和样品制备装置
公开(公告)号：EP2975393A1
公开(公告)日：2016-01-20
申请号：EP14778323.7
申请日：2014-04-04
申请人： Shimadzu Corporation , Keio University
发明人： OGATA, Koretsugu , TAKAHASHI, Kazuteru , KUBO, Akiko , SUEMATSU, Makoto , YAMAMOTO, Takushi
IPC分类号： G01N27/64
CPC分类号： H01J49/0418 , B05D1/60 , B05D3/107 , B05D7/5483 , H01J49/0004
摘要： After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.
摘要翻译：将生物体组织切片等试样贴附于导电性载玻片（S1）后，通过蒸镀适当地形成基质物质的膜层以覆盖试样（S2）。基体物质在膜层中的晶体非常细且均匀。随后，将其上形成基质膜层的载玻片置于蒸发的溶剂气氛中，并且溶剂渗入基质膜层（S3）。当充分渗透的溶剂蒸发时，样品中待测量的物质进入基体并重结晶。此外，通过气相沉积再次在表面上形成基质膜层（S4）。所添加的基质膜层在MALDI期间吸收激光束的过多能量，这抑制了待测物质的变性等，从而可以在保持高空间分辨率的同时实现高检测灵敏度。

6. 发明授权

EP1975621B1 METHOD FOR DETERMINATION OF OXIDATIVE STRESS 有权
标题翻译：检测方法的氧化应激
公开(公告)号：EP1975621B1
公开(公告)日：2010-09-01
申请号：EP07706844.3
申请日：2007-01-16
申请人： Keio University
发明人： SOGA, Tomoyoshi , SUEMATSU, Makoto
IPC分类号： G01N33/68 , G01N27/62
CPC分类号： G01N33/6893 , G01N2430/00 , G01N2500/00 , G01N2800/00

7. 发明公开

EP1997504A1 NOVEL ANTITHROMBOTIC AGENT 审中-公开
标题翻译：使用抗微生物剂MITTEL
公开(公告)号：EP1997504A1
公开(公告)日：2008-12-03
申请号：EP07715291.6
申请日：2007-03-01
申请人： Keio University
发明人： SUEMATSU, Makoto , MANDAI, Shintaro
IPC分类号： A61K38/00 , A61P9/10
CPC分类号： A61K38/38 , A61K38/385 , A61K47/60 , A61K47/643
摘要： The present invention provides: a pharmaceutical composition comprising an albumin conjugated with polyethylene glycol; and a method of treating a human thrombosis or a human ischemic disease, comprising intravenously administering an albumin conjugated with polyethylene glycol to a patient.
摘要翻译：本发明提供：包含与聚乙二醇缀合的白蛋白的药物组合物; 以及治疗人类血栓形成或人类缺血性疾病的方法，包括向患者静脉内施用与聚乙二醇缀合的白蛋白。

8. 发明公开

EP2381259A1 LIVER DISEASE MARKER, METHOD AND APPARATUS FOR MEASURING SAME, AND TEST METHOD FOR PHARMACEUTICAL PREPARATION 有权
标题翻译：测量肝脏疾病标记方法和试验程序医药制造
公开(公告)号：EP2381259A1
公开(公告)日：2011-10-26
申请号：EP09834674.5
申请日：2009-11-26
申请人： Keio University , The University of Tokyo
发明人： SOGA, Tomoyoshi , SUGIMOTO, Masahiro , SUEMATSU, Makoto , HONMA, Masashi , YAMAMOTO, Takehito , SUZUKI, Hiroshi
IPC分类号： G01N33/68 , C07K5/072 , G01N27/62 , G01N33/576
CPC分类号： G01N33/487 , C07K5/0215 , G01N33/497 , G01N33/576 , G01N33/6812 , G01N33/6893 , G01N2800/08 , G01N2800/60
摘要： A normal person (i.e. a control) and liver diseases such as drug induced liver injury, an asymptomatic hepatitis B carrier, an asymptomatic hepatitis C carrier, chronic hepatitis B, chronic hepatitis C, liver cancer, a nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and simple steatosis (SS) are identified by measuring the concentrations of γ-Glu-X (X represents an amino acid or an amine) peptides or the levels of AST or ALT in blood and carrying out, for example, a multiple logistic regression based on the measured value.
摘要翻译：一个正常的人（即，对照）和肝脏疾病：如药物诱导的肝损伤，在无症状乙肝携带者，在无症状的丙型肝炎载体，慢性乙型肝炎，慢性丙型肝炎，肝癌症，非酒精性脂肪肝疾病（NAFLD），非酒精性脂肪性肝炎（NASH）和单纯性脂肪肝（SS）通过测量³-GLU-X的浓度（X darstellt于氨基酸或的胺）的肽或AST或ALT的血液中的水平，并执行，例如标明，基于所测量的值的多元逻辑回归。

9. 发明公开

EP2075754A1 PLATELET THROMBUS FORMATION SIMULATOR 审中-公开
标题翻译： SIMULATORFÜRDIE BILDUNG VONPLÄTTCHCHHROMBOSE
公开(公告)号：EP2075754A1
公开(公告)日：2009-07-01
申请号：EP07828314.0
申请日：2007-09-14
申请人： Keio University
发明人： SUEMATSU, Makoto , KAWAHARA, Hitoshi
IPC分类号： G06Q50/00
CPC分类号： A61B17/12022 , A61B5/02035 , G06F19/00 , G16H50/50
摘要： A platelet thrombus formation simulator, said simulator equipped with the following means:
(a) a means that selects, from previously stored equations, an equation for the computation of adhesion force according to parallel activation grade;
(b) a means that calculates the platelet adhesion force based on the equation depending on the activation grade of each platelet; and
(c) a means that outputs the coagulation condition of platelets based on the calculated adhesion force of each platelet.
摘要翻译：一种血小板血栓形成模拟器，所述模拟器装备有以下装置：（a）从先前存储的方程中选择根据平行激活等级计算粘附力的方程式的装置; （b）根据每个血小板的活化等级计算血小板粘附力的方法; 和（c）基于每个血小板计算的粘附力输出血小板的凝血状态的装置。

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