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1. 发明公开

EP2416159A1 METHOD FOR DETECTING ANTIBODY AGAINST SITH-1 IN BIOLOGICAL SAMPLE 审中-公开
标题翻译：生物样品中检测抗SITH-1抗体的方法
公开(公告)号：EP2416159A1
公开(公告)日：2012-02-08
申请号：EP10758800.6
申请日：2010-03-31
申请人： Japan Tobacco, Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： TAKAKURA, Yoshimitsu , OKA, Naomi , KONDO, Kazuhiro , KOBAYASHI, Nobuyuki
IPC分类号： G01N33/569 , G01N33/53 , C07K14/03
CPC分类号： C07K14/005 , C07K2319/70 , C12N2710/16522 , G01N33/56994 , G01N33/6854 , G01N2333/03 , G01N2469/20
摘要： The present invention provides a method for detecting an antibody against a small protein encoded by the intermediate stage transcript of HHV-6 (SITH-1) in a biological sample.
The method of the present invention comprises:
1) providing the SITH-1 protein;
2) binding the SITH-1 protein provided in step 1) to a carrier; and
3) contacting the biological sample with the SITH-1 protein-bound carrier prepared in step 2) to detect the SITH-1 protein antibody.
摘要翻译：本发明提供了检测生物样品中由HHV-6（SITH-1）的中间阶段转录物编码的小蛋白质的抗体的方法。本发明的方法包括：1）提供SITH-1蛋白质; 2）将步骤1）中提供的SITH-1蛋白与载体结合; 和3）将生物样品与步骤2）中制备的结合SITH-1蛋白的载体接触以检测SITH-1蛋白抗体。

2. 发明公开

EP2987859A1 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
标题翻译： ER TEN ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON
公开(公告)号：EP2987859A1
公开(公告)日：2016-02-24
申请号：EP15187953.3
申请日：2008-09-25
申请人： Japan Tobacco Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , KOBAYASHI, Nobuyuki
IPC分类号： C12N15/09 , A01K67/027 , C07K14/03 , C07K16/08 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , C12Q1/68 , C07K14/005 , C12N7/00 , G01N33/68
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.
摘要翻译：公开了蛋白质和基因，每种蛋白质和基因都是涉及疱疹病毒潜伏感染的因素。在大约50％的精神障碍患者中检测到抗因子抗体，而在健康人中几乎检测不出抗体。此外，其中引入了SITH-1的小鼠产生精神障碍，例如躁狂抑郁症或抑郁症状障碍。基于这些发现，可以提供客观地确定精神障碍和精神障碍的动物模型的方法。

3. 发明授权

EP2199391B1 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
标题翻译：与疱疹病毒有兴趣因子及其用途递延感染
公开(公告)号：EP2199391B1
公开(公告)日：2015-11-11
申请号：EP08833887.6
申请日：2008-09-25
申请人： Japan Tobacco, Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , Kobayashi, Nobuyuki
IPC分类号： C07K14/005 , C12N7/00 , G01N33/68
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

4. 发明授权

EP2987859B1 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
公开(公告)号：EP2987859B1
公开(公告)日：2018-08-08
申请号：EP15187953.3
申请日：2008-09-25
申请人： Japan Tobacco Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , KOBAYASHI, Nobuyuki
IPC分类号： C12N15/09 , A01K67/027 , C07K14/03 , C07K16/08 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , C12Q1/68 , C07K14/005 , C12N7/00 , G01N33/68
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

5. 发明授权

EP3163301B1 METHOD FOR TREATING, OR PREVENTING MOOD DISORDER 有权转让
公开(公告)号：EP3163301B1
公开(公告)日：2019-08-07
申请号：EP15811939.6
申请日：2015-06-25
申请人： Japan Tobacco, Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , KOBAYASHI, Nobuyuki , OKA, Naomi
IPC分类号： G01N33/53 , A61P25/24 , A61P31/22 , A01K67/027 , C12N5/10

6. 发明公开

EP2416158A1 METHOD FOR DETECTING SUBSTANCE IN BIOLOGICAL SAMPLE 审中-公开
标题翻译：爱尔兰生物科学研究所的VERFAHRENFÜRDEN NACHWEIS EINES STOFFES
公开(公告)号：EP2416158A1
公开(公告)日：2012-02-08
申请号：EP10758802.2
申请日：2010-03-31
申请人： Japan Tobacco, Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： TAKAKURA, Yoshimitsu , OKA, Naomi , KONDO, Kazuhiro
IPC分类号： G01N33/543 , C07K17/00
CPC分类号： G01N33/54393 , G01N33/54306 , G01N33/54353 , G01N33/56994 , G01N33/6854 , G01N2333/035 , G01N2333/36
摘要： The present invention provides a method for detecting a substance in a biological sample, a carrier for using in the method, and a kit. The method of the present invention includes 1) providing a carrier on which a biotin-binding protein is bound and providing a biotinylated protein by biotinylating a protein that specifically binds to a substance to be detected; 2) binding the biotinylated protein to the carrier provided in step 1) to produce a biotinylated protein-bound carrier; 3) mixing (a) a biological sample, and (b-i) a cell homogenate extract prepared from cells of the same species as that of the host cells used for expressing, for example, the biotin-binding protein in step 1), and a biotin-binding protein, or (b-ii) a cell homogenate extract prepared from cells of the same species as that of the host cells used for expressing, for example, the biotin-binding protein in step 1) and genetically engineered to express a biotin-binding protein, and adding the mixture to the biotinylated protein-bound carrier produced in step 2); and 4) detecting the substance specifically bound to the biotinylated protein.
摘要翻译：本发明提供了用于检测生物样品中物质的方法，该方法中使用的载体和试剂盒。本发明的方法包括：提供结合有生物素结合蛋白的载体，并通过生物素化与特异性结合待检测物质的蛋白质提供生物素化蛋白; 2）将生物素化蛋白质与步骤1）中提供的载体结合以产生生物素化的蛋白质结合的载体; 3）混合（a）生物样品和（bi）由与用于在步骤1）中表达例如生物素结合蛋白的宿主细胞相同种类的细胞制备的细胞匀浆提取物，和生物素结合蛋白，或（b-ii）从与用于表达例如生物素结合蛋白的步骤1中所用的宿主细胞相同种类的细胞制备的细胞匀浆提取物），并进行遗传工程化以表达生物素结合蛋白，并将混合物加入步骤2）中产生的生物素化蛋白质结合的载体上; 和4）检测与生物素化蛋白质特异结合的物质。

7. 发明公开

EP2405268A1 METHOD FOR DETECTING SUBSTANCE IN BIOLOGICAL SAMPLE 审中-公开
标题翻译：爱尔兰生物科学研究所的VERFAHRENFÜRDEN NACHWEIS EINES STOFFES
公开(公告)号：EP2405268A1
公开(公告)日：2012-01-11
申请号：EP10748752.2
申请日：2010-03-02
申请人： Japan Tobacco, Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： TAKAKURA, Yoshimitsu , OKA, Naomi , KONDO, Kazuhiro
IPC分类号： G01N33/543 , G01N33/53 , C12N15/09
CPC分类号： G01N33/54393
摘要： The present invention provides a method for detecting a substance in a biological sample, a carrier for using in the method, and a kit. The method of the present invention according to an embodiment includes:
1) providing a carrier on which biotin is bound and providing a fusion protein between a protein that specifically binds to a substance to be detected and a biotin-binding protein;
2) binding the fusion protein to the carrier provided in step 1) through binding between biotin and the biotin-binding protein to produce a fusion protein-bound carrier;
3) mixing
(a) a biological sample, and
(b-i) a cell homogenate extract prepared from cells of the same species as the host cells used for expressing the fusion protein in step 1), and a biotin-binding protein, or
(b-ii) a cell homogenate extract prepared from cells of the same species as the host cells used for expressing the fusion protein in step 1), and genetically engineered to express a biotin-binding protein,

and adding the mixture to the fusion protein-bound carrier produced in step 2); and
4) detecting a substance that has bound to the protein that specifically binds to a substance to be detected in the fusion protein.
摘要翻译：本发明提供了用于检测生物样品中物质的方法，该方法中使用的载体和试剂盒。根据一个实施方案的本发明的方法包括：1）提供其上结合有生物素的载体，并在特异性结合待检测物质的蛋白质与生物素结合蛋白质之间提供融合蛋白; 2）通过生物素与生物素结合蛋白之间的结合将融合蛋白与步骤1）中提供的载体结合以产生融合蛋白结合的载体; 3）混合（a）生物样品和（bi）从与步骤1）中用于表达融合蛋白的宿主细胞相同种类的细胞制备的细胞匀浆提取物和生物素结合蛋白，或（b -ii）从与步骤1）中用于表达融合蛋白的宿主细胞相同物种的细胞制备的细胞匀浆提取物，并进行遗传工程改造以表达生物素结合蛋白，并将该混合物加入融合蛋白结合载体在步骤2）中生产; 以及4）检测与融合蛋白中特异性结合待检测物质的蛋白质结合的物质。

8. 发明公开

EP1681346A1 RECOMBINANT VIRUS VECTOR ORIGINATING IN HHV-6 OR HHV-7, METHOD OF PRODUCING THE SAME, METHOD OF TRANSFORMING HOST CELL USING THE SAME, HOST CELL TRANSFORMED THEREBY AND GENE THERAPY METHOD USING THE SAME 审中-公开
标题翻译： HHV-6或HHV-7衍生重组病毒载体，方法其制造，一种使用宿主细胞的转化体，BY转化的宿主细胞和基因治疗方法使用THEREOF
公开(公告)号：EP1681346A1
公开(公告)日：2006-07-19
申请号：EP04772443.0
申请日：2004-08-30
申请人： Soiken Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro
IPC分类号： C12N15/09 , C12N15/869 , C12N5/10 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/16543 , C12N2800/204 , C12N2840/20 , C12N2840/203
摘要： It is intended to provide a virus vector by which an exogenous nucleotide sequence can be inserted and easily transferred into a mammalian host cell and a gene encoded by the exogenous nucleotide sequence can be expressed in the host cell, and which has a low risk of pathogenicity and is appropriately usable in gene therapy of mammals. Namely, a recombinant vector originating in HHV-6 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U5, U6, U7, U8, U24, and U25 regions of HHV-6; or a recombinant vector originating in HHV-7 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U7, U8, U24, U24a, and U25 regions of HHV-7.
摘要翻译：它的目的是提供，通过该外源核苷酸序列可以被插入和容易地转移到哺乳动物宿主细胞中，并通过所述外源核苷酸序列编码能在宿主细胞中过表达的基因的病毒载体，并且其具有致病性的低风险并且是在哺乳动物中的基因治疗适当地使用。即，重组载体源自在HHV-6其中有外源性核苷酸序列中的部分对应于选自下组U2，U3，U4，U5，U6，U7，U8，U24中的至少一个区域，和U25区域的HHV-6; 或重组载体在HHV-7其中具有至外源核苷酸序列中的部分对应于选自下组U2，U3，U4，U7，U8，U24，U24A和HHV的U25区域的选择的至少一个区域始发 7日

9. 发明公开

EP2199391A1 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
标题翻译：麻醉师麻醉病人艾滋病病毒感染者维多利亚·多芬
公开(公告)号：EP2199391A1
公开(公告)日：2010-06-23
申请号：EP08833887.6
申请日：2008-09-25
申请人： Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , Kobayashi, Nobuyuki
IPC分类号： C12N15/09 , A01K67/027 , C07K14/03 , C07K16/08 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , C12Q1/68
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.
摘要翻译：公开了蛋白质和基因，每种蛋白质和基因都是涉及疱疹病毒潜伏感染的因素。在大约50％的精神障碍患者中检测到抗因子抗体，而在健康人中几乎检测不出抗体。此外，其中引入了SITH-1的小鼠产生精神障碍，例如躁狂抑郁症或抑郁症状障碍。基于这些发现，可以提供客观地确定精神障碍和精神障碍的动物模型的方法。

10. 发明公开

EP2267151A1 VIRUS TITRATION METHOD 审中-公开
标题翻译：病毒滴定法
公开(公告)号：EP2267151A1
公开(公告)日：2010-12-29
申请号：EP09727611.7
申请日：2009-03-31
申请人： Japan Tobacco, Inc.
发明人： TAKAKURA, Yoshimitsu , ICHIKAWA, Masako , KONDO, Kazuhiro , SHIMIZU, Akihiro
IPC分类号： C12Q1/06 , C12Q1/68 , G01N33/569
CPC分类号： G01N33/56983 , G01N2333/03 , G01N2333/36
摘要： The present invention relates to a method of quantitatively determining the number of human herpesvirus (HHV) collected from a body fluid and a kit for performing the method. Conventionally, a trained technician has been required to accurately quantitatively determine a number of HHV collected from a body fluid. The method of the present invention is a novel method of quantitative determination that enables measurement of a number of HHV in a body fluid to be simply, accurately, and efficiently determined. The method of the present invention can enable continuous evaluation of the number of HHV in body fluids and, therefore, can be applied to quantitative evaluation of the accumulation of fatigue.
摘要翻译：本发明涉及定量测定从体液中收集的人疱疹病毒（HHV）的数量的方法和用于执行该方法的试剂盒。通常，要求训练有素的技术人员准确定量测定从体液中收集的一些HHV。本发明的方法是定量确定的新方法，其能够简单，准确且有效地确定体液中的HHV的数量的测量。本发明的方法可以对体液中HHV的数量进行连续评估，因此可以应用于定量评估疲劳累积。

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