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1. 发明公开

EP2416159A1 METHOD FOR DETECTING ANTIBODY AGAINST SITH-1 IN BIOLOGICAL SAMPLE 审中-公开
标题翻译：生物样品中检测抗SITH-1抗体的方法
公开(公告)号：EP2416159A1
公开(公告)日：2012-02-08
申请号：EP10758800.6
申请日：2010-03-31
申请人： Japan Tobacco, Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： TAKAKURA, Yoshimitsu , OKA, Naomi , KONDO, Kazuhiro , KOBAYASHI, Nobuyuki
IPC分类号： G01N33/569 , G01N33/53 , C07K14/03
CPC分类号： C07K14/005 , C07K2319/70 , C12N2710/16522 , G01N33/56994 , G01N33/6854 , G01N2333/03 , G01N2469/20
摘要： The present invention provides a method for detecting an antibody against a small protein encoded by the intermediate stage transcript of HHV-6 (SITH-1) in a biological sample.
The method of the present invention comprises:
1) providing the SITH-1 protein;
2) binding the SITH-1 protein provided in step 1) to a carrier; and
3) contacting the biological sample with the SITH-1 protein-bound carrier prepared in step 2) to detect the SITH-1 protein antibody.
摘要翻译：本发明提供了检测生物样品中由HHV-6（SITH-1）的中间阶段转录物编码的小蛋白质的抗体的方法。本发明的方法包括：1）提供SITH-1蛋白质; 2）将步骤1）中提供的SITH-1蛋白与载体结合; 和3）将生物样品与步骤2）中制备的结合SITH-1蛋白的载体接触以检测SITH-1蛋白抗体。

2. 发明授权

EP2987859B1 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
公开(公告)号：EP2987859B1
公开(公告)日：2018-08-08
申请号：EP15187953.3
申请日：2008-09-25
申请人： Japan Tobacco Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , KOBAYASHI, Nobuyuki
IPC分类号： C12N15/09 , A01K67/027 , C07K14/03 , C07K16/08 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , C12Q1/68 , C07K14/005 , C12N7/00 , G01N33/68
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

3. 发明公开

EP2199391A1 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
标题翻译：麻醉师麻醉病人艾滋病病毒感染者维多利亚·多芬
公开(公告)号：EP2199391A1
公开(公告)日：2010-06-23
申请号：EP08833887.6
申请日：2008-09-25
申请人： Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , Kobayashi, Nobuyuki
IPC分类号： C12N15/09 , A01K67/027 , C07K14/03 , C07K16/08 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , C12Q1/68
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.
摘要翻译：公开了蛋白质和基因，每种蛋白质和基因都是涉及疱疹病毒潜伏感染的因素。在大约50％的精神障碍患者中检测到抗因子抗体，而在健康人中几乎检测不出抗体。此外，其中引入了SITH-1的小鼠产生精神障碍，例如躁狂抑郁症或抑郁症状障碍。基于这些发现，可以提供客观地确定精神障碍和精神障碍的动物模型的方法。

4. 发明公开

EP3163301A1 METHOD FOR DIAGNOSING, TREATING, OR PREVENTING MOOD DISORDER 有权转让
标题翻译： VERFAHREN ZUR DIAGNOSE，BEHANDLUNG，ODERPRÄVENTIONVONSTIMMUNGSSTÖRUNGEN
公开(公告)号：EP3163301A1
公开(公告)日：2017-05-03
申请号：EP15811939
申请日：2015-06-25
申请人： JAPAN TOBACCO INC , VIRUS IKAGAKU KENKYUSHO INC
发明人： KONDO KAZUHIRO , KOBAYASHI NOBUYUKI , OKA NAOMI
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N33/53
摘要： An object of the present invention is to provide a novel method of diagnosing and/or treating a mood disorder, the method being superior to the conventional technologies. The present invention attains the object by providing a method of diagnosing and/or treating a mood disorder by use of an anti-SITH-1 antibody level and an anti-HHV-6 antibody level each serving as an index.
摘要翻译：本发明的一个目的是提供一种诊断和/或治疗心境障碍的新方法，该方法优于常规技术。本发明的目的在于提供一种利用抗SITH-1抗体水平和抗HHV-6抗体水平作为指标来诊断和/或治疗情感障碍的方法。

5. 发明公开

EP1681346A1 RECOMBINANT VIRUS VECTOR ORIGINATING IN HHV-6 OR HHV-7, METHOD OF PRODUCING THE SAME, METHOD OF TRANSFORMING HOST CELL USING THE SAME, HOST CELL TRANSFORMED THEREBY AND GENE THERAPY METHOD USING THE SAME 审中-公开
标题翻译： HHV-6或HHV-7衍生重组病毒载体，方法其制造，一种使用宿主细胞的转化体，BY转化的宿主细胞和基因治疗方法使用THEREOF
公开(公告)号：EP1681346A1
公开(公告)日：2006-07-19
申请号：EP04772443.0
申请日：2004-08-30
申请人： Soiken Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro
IPC分类号： C12N15/09 , C12N15/869 , C12N5/10 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/16543 , C12N2800/204 , C12N2840/20 , C12N2840/203
摘要： It is intended to provide a virus vector by which an exogenous nucleotide sequence can be inserted and easily transferred into a mammalian host cell and a gene encoded by the exogenous nucleotide sequence can be expressed in the host cell, and which has a low risk of pathogenicity and is appropriately usable in gene therapy of mammals. Namely, a recombinant vector originating in HHV-6 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U5, U6, U7, U8, U24, and U25 regions of HHV-6; or a recombinant vector originating in HHV-7 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U7, U8, U24, U24a, and U25 regions of HHV-7.
摘要翻译：它的目的是提供，通过该外源核苷酸序列可以被插入和容易地转移到哺乳动物宿主细胞中，并通过所述外源核苷酸序列编码能在宿主细胞中过表达的基因的病毒载体，并且其具有致病性的低风险并且是在哺乳动物中的基因治疗适当地使用。即，重组载体源自在HHV-6其中有外源性核苷酸序列中的部分对应于选自下组U2，U3，U4，U5，U6，U7，U8，U24中的至少一个区域，和U25区域的HHV-6; 或重组载体在HHV-7其中具有至外源核苷酸序列中的部分对应于选自下组U2，U3，U4，U7，U8，U24，U24A和HHV的U25区域的选择的至少一个区域始发 7日

6. 发明公开

EP3163301A4 METHOD FOR DIAGNOSING, TREATING, OR PREVENTING MOOD DISORDER 有权转让
公开(公告)号：EP3163301A4
公开(公告)日：2017-12-27
申请号：EP15811939
申请日：2015-06-25
申请人： JAPAN TOBACCO INC , VIRUS IKAGAKU KENKYUSHO INC
发明人： KONDO KAZUHIRO , KOBAYASHI NOBUYUKI , OKA NAOMI
IPC分类号： G01N33/53
CPC分类号： G01N33/6854 , G01N33/53
摘要： An object of the present invention is to provide a novel method of diagnosing and/or treating a mood disorder, the method being superior to the conventional technologies. The present invention attains the object by providing a method of diagnosing and/or treating a mood disorder by use of an anti-SITH-1 antibody level and an anti-HHV-6 antibody level each serving as an index.

7. 发明公开

EP2987859A1 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
标题翻译： ER TEN ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON ON
公开(公告)号：EP2987859A1
公开(公告)日：2016-02-24
申请号：EP15187953.3
申请日：2008-09-25
申请人： Japan Tobacco Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , KOBAYASHI, Nobuyuki
IPC分类号： C12N15/09 , A01K67/027 , C07K14/03 , C07K16/08 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569 , C12Q1/68 , C07K14/005 , C12N7/00 , G01N33/68
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.
摘要翻译：公开了蛋白质和基因，每种蛋白质和基因都是涉及疱疹病毒潜伏感染的因素。在大约50％的精神障碍患者中检测到抗因子抗体，而在健康人中几乎检测不出抗体。此外，其中引入了SITH-1的小鼠产生精神障碍，例如躁狂抑郁症或抑郁症状障碍。基于这些发现，可以提供客观地确定精神障碍和精神障碍的动物模型的方法。

8. 发明授权

EP2199391B1 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
标题翻译：与疱疹病毒有兴趣因子及其用途递延感染
公开(公告)号：EP2199391B1
公开(公告)日：2015-11-11
申请号：EP08833887.6
申请日：2008-09-25
申请人： Japan Tobacco, Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , Kobayashi, Nobuyuki
IPC分类号： C07K14/005 , C12N7/00 , G01N33/68
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

9. 发明公开

EP2199391A4 FACTOR INVOLVED IN LATENT INFECTION WITH HERPESVIRUS, AND USE THEREOF 有权转让
标题翻译：与疱疹病毒有兴趣因子及其用途递延感染
公开(公告)号：EP2199391A4
公开(公告)日：2011-01-19
申请号：EP08833887
申请日：2008-09-25
申请人： JAPAN TOBACCO INC , VIRUS IKAGAKU KENKYUSHO INC
发明人： KONDO KAZUHIRO , KOBAYASHI NOBUYUKI
IPC分类号： C12N15/09 , A01K67/027 , C07K14/03 , C07K16/08 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/569
CPC分类号： C07K14/005 , A01K2267/0356 , C12N7/00 , C12N2710/10343 , C12N2710/16522 , C12N2710/16571 , C12N2740/10043 , G01N33/6854 , G01N33/6893 , G01N33/6896 , G01N2333/035 , G01N2800/304
摘要： Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

10. 发明授权

EP3163301B1 METHOD FOR TREATING, OR PREVENTING MOOD DISORDER 有权转让
公开(公告)号：EP3163301B1
公开(公告)日：2019-08-07
申请号：EP15811939.6
申请日：2015-06-25
申请人： Japan Tobacco, Inc. , Virus Ikagaku Kenkyusho Inc.
发明人： KONDO, Kazuhiro , KOBAYASHI, Nobuyuki , OKA, Naomi
IPC分类号： G01N33/53 , A61P25/24 , A61P31/22 , A01K67/027 , C12N5/10

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