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1. 发明公开

EP2142225A4 PREMIXED BIOLOGICAL HYDRAULIC CEMENT PASTE COMPOSITION AND USING THE SAME 有权转让
标题翻译：生物学水E E UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG
公开(公告)号：EP2142225A4
公开(公告)日：2012-12-12
申请号：EP08748159
申请日：2008-04-21
申请人： INNOVATIVE BIOCERAMIX INC
发明人： YANG QUANZU , LU DONGHUI
IPC分类号： A61L24/02 , A61K6/06 , A61L24/00 , A61L27/00
CPC分类号： A61L24/0089 , A61K6/0067 , A61K6/0612 , A61L24/0015 , A61L24/0042 , A61L27/446 , A61L27/54 , A61L27/58 , A61L2300/406 , A61L2300/44 , A61L2300/602 , A61K6/0038 , C08L7/00 , C08L23/20 , C08L71/02 , C08L91/005 , C08L1/284 , A61K6/0017 , A61K6/083 , A61K6/087 , A61K6/097
摘要： A premixed cement paste for use in medical or dental applications. The premixed cement paste remains fluid when stored in a hermetically sealed condition, but hydrates and hardens to set when placed in a physiological environment. The cement paste includes at least one calcium silicate compound and at least one substantially water-free liquid carrier mixed with the at least one calcium silicate compound; the substantially water-free liquid carrier avoids hydration of the mixture during storage, but undergoes exchange with aqueous physiological solutions so that the cement past hydrates and hardens to set when placed in a physiological environment. The paste may be placed in the physiological environment by injection, for example. The at least one calcium silicate compound may be, for example, calcium silicate, dicalcium silicate, tricalcium silicate, or mixtures thereof. The substantially water-free liquid may be, for example, ethylene glycol, polyethylene glycol, liquid glycerol, glycerin, ethyl alcohol, vegetable oil, animal oil, silicon oil, hydroxypropyl methylcellulose, or mixtures thereof. The substantially water-free liquid carrier preferably includes water in an amount less than about 20% by weight percent of the paste. The paste may include a secondary phase for enhanced properties, such as, for example, a fibrous or particulate material for enhanced mechanical properties, biodegradable or soluble materials that provide room for bone in-growth, bioactive materials such as antibiotics that elute into the physiological environment from the set cement, and radio-opaque materials that enhance X-ray imaging of the cement.
摘要翻译：用于医疗或牙科应用的预混水泥浆。当密封状态下储存时，预混合水泥糊保持流体状态，但在置于生理环境中时会水合并固化。水泥浆料包括至少一种硅酸钙化合物和至少一种与至少一种硅酸钙化合物混合的基本上无水的液体载体; 基本上无水的液体载体避免了在储存期间混合物的水合，但是与水性生理溶液进行交换，使得当放置在生理环境中时，水泥过去水合并硬化。例如，可以通过注射将糊状物置于生理环境中。所述至少一种硅酸钙化合物可以是例如硅酸钙，硅酸二钙，硅酸三钙或其混合物。基本上不含水的液体可以是例如乙二醇，聚乙二醇，液体甘油，甘油，乙醇，植物油，动物油，硅油，羟丙基甲基纤维素或其混合物。基本上无水的液体载体优选包含少于糊料的约20重量％的量的水。糊剂可以包括用于增强性能的第二相，例如用于增强机械性能的纤维或颗粒材料，为骨生长提供空间的生物可降解或可溶性材料，生物活性材料例如洗涤到生理学中的抗生素来自集水泥的环境，以及增强水泥X射线成像的不透射线材料。

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