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1. 发明公开

EP0284174A1 Therapeutic preparations 有权
标题翻译：治疗方法
公开(公告)号：EP0284174A1
公开(公告)日：1988-09-28
申请号：EP88300281.8
申请日：1988-01-14
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI PHARMA
发明人： Bruneau, Pierre Andre Raymond , Carey, Frank , Delvare, Christian Robert Ernest , Gibson, Keith Hopkinson , McMillan, Rodger Martin
IPC分类号： C07D231/56 , C07D401/06 , C07D405/06 , C07D409/06 , C07D401/10 , C07D403/06 , C07D417/06 , C07D403/12 , C07D405/12 , C07D401/12 , C07D413/06
CPC分类号： C07D231/56 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The invention concerns pharmaceutical compositions containing a 1,2-dihydro-3 H -indazol-3-one derivative of the formula I
wherein Ra is hydrogen, halogeno, nitro, hydroxy, (2-6C)alkanoyloxy, (1-6C)alkyl, (1-6C)alkoxy, fluoro-(1-4C)alkyl, (2-6C)alkanoyl, amino, (1-6C)alkylamino, di-[(1-4C)alkyl]amino, (2-6C)alkanoylamino or hydroxy-(1-6C)alkyl; Rb is hydrogen, halogeno, (1-6C)alkyl or (1-6C)alkoxy; and Y is a group of the formula -A¹-X-A²-Q in which A¹ is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene, or A¹ is phenylene; X is oxy, thio, sulphinyl, sulphonyl, imino, (1-6C)alkylimino, (1-6C)alkanoylimino, iminocarbonyl or phenylene, or X is a direct link to A²; A² is (1-6C)alkylene, (3-6C)alkenylene or (3-6C)alkynylene or A² is cyclo(3-6C)alkylene or is a direct link to Q, or the group A¹-X-A² is a direct link to Q; or Y is (2-10)alkyl, (3-10C)alkenyl or (3-6C)alkynyl; and Q is aryl or heteroaryl.
The invention also provides novel 1,2-dihydro-3 H -indazol-3-ones, processes for their production and the use of 1,2-dihydro-3 H -indazol-3-one for the manufacture of medicaments for the treatment of various allergic and inflammatory diseases.
摘要翻译：本发明涉及含有式I 的1,2-二氢-3H-吲唑-3-酮衍生物的药物组合物，其中R a是氢，卤素，硝基，羟基，（2-6C）烷酰氧基，（1-6C ）（1-6C）烷氧基，氟 - （1-4C）烷基，（2-6C）烷酰基，氨基，（1-6C）烷基氨基，二 - [（1-4C） 6C）烷酰基氨基或羟基 - （1-6C）烷基; Rb是氢，卤代，（1-6C）烷基或（1-6C）烷氧基; 并且Y是式-A 1 -XA 2 -Q的基团，其中A 1是（1-6C）亚烷基，（3-6C）亚烯基，（3-6C）亚炔基或环（ 3-6C）亚烷基，或A 1是亚苯基; X是氧基，硫基，亚磺酰基，磺酰基，亚氨基，（1-6C）烷基亚氨基，（1-6C）烷酰基亚氨基，亚氨基羰基或亚苯基，或X是与A 2的直接连接。 A 2是（1-6C）亚烷基，（3-6C）亚烯基或（3-6C）亚炔基或A 2是环（3-6C）亚烷基或与Q直接相连，或基团A <1> -XA <2>是与Q的直接链接; 或Y为（2-10）烷基，（3-10C）烯基或（3-6C）炔基; Q是芳基或杂芳基。本发明还提供新的1,2-二氢-3H-吲唑-3-酮，其制备方法和1,2-二氢-3H-吲唑-3-酮用于制备用于治疗各种药物的药物过敏性和炎性疾病。

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