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1. 发明授权

EP0410661B1 Bicyclic derivatives 失效
标题翻译： Bizyklische Derivate。
公开(公告)号：EP0410661B1
公开(公告)日：1994-06-15
申请号：EP90308023.2
申请日：1990-07-23
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI PHARMA
发明人： Bird, Thomas Geoffrey Colerick , Kingston, John Francis, 24 Cornfield Close , Waterson, David
IPC分类号： C07D407/04 , C07D317/46 , A61K31/36
CPC分类号： C07D407/04 , C07D317/46

2. 发明授权

EP0351194B1 Thiazole derivatives having a 5-lipoxygenase-inhibiting activity 失效
标题翻译：噻唑衍生物具有5-脂氧合酶抑制活性。
公开(公告)号：EP0351194B1
公开(公告)日：1994-06-15
申请号：EP89307041.7
申请日：1989-07-11
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI PHARMA
发明人： Bird, Thomas Geoffrey Colerick , Edwards, Philip Neil , Crawley, Graham Charles , Girodeau, Jean-Marc Marie Maurice , Edwards, Martin Paul , Kingston, John Francis
IPC分类号： C07D277/20 , A61K31/425 , C07D417/06 , C07D277/24 , A61K31/435
CPC分类号： C07D417/06 , C07D277/24

3. 发明授权

EP0375404B1 Heterocyclic derivatives 失效
标题翻译： Heterozyklische Derivate。
公开(公告)号：EP0375404B1
公开(公告)日：1994-02-09
申请号：EP89313384.3
申请日：1989-12-20
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI-PHARMA
发明人： Edwards, Philip Neil , Girodeau, Jean-Marc Marie Maurice
IPC分类号： C07D309/10 , C07D335/02 , C07D313/04 , C07D307/20 , A61K31/34 , A61K31/35 , A61K31/38 , C07D405/04
CPC分类号： C07D309/10 , C07D307/20 , C07D313/04 , C07D335/02

4. 发明授权

EP0225182B1 Cephalosporin compounds 失效
标题翻译： CEPHALOSPORIN化合物
公开(公告)号：EP0225182B1
公开(公告)日：1993-02-10
申请号：EP86309279.7
申请日：1986-11-27
申请人： ICI PHARMA
发明人： Arnould, Jean-Claude , Lohmann, Jean Jacques , Pasquet, Georges
IPC分类号： C07D501/46 , A61K31/545 , C07D498/04 , C07D471/04
CPC分类号： C07D501/46 , C07D519/00

5. 发明授权

EP0127992B1 Cephalosporin derivatives 失效
标题翻译： CEPHALOSPORIN衍生物
公开(公告)号：EP0127992B1
公开(公告)日：1993-01-13
申请号：EP84303585.8
申请日：1984-05-25
申请人： ICI PHARMA
发明人： Jung, Frederic Henri
IPC分类号： C07D501/46 , C07D498/04 , C07D471/04 , A61K31/545
CPC分类号： C07D505/00

6. 发明公开

EP0462813A2 Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase 失效
标题翻译： Bicyclische Pyranderivate和ihre Verwendung als 5-脂氧合酶。
公开(公告)号：EP0462813A2
公开(公告)日：1991-12-27
申请号：EP91305532.3
申请日：1991-06-19
申请人： ZENECA LIMITED , ICI PHARMA
发明人： Bruneau, Pierre André Raymond , Crawley, Graham Charles, Chapel House
IPC分类号： C07D413/12 , C07D417/12 , C07D498/04 , A61K31/535 , A61K31/54
CPC分类号： C07D413/10 , C07D413/12 , C07D417/12
摘要： The invention concerns a bicyclic heterocyclic compound of the formula I, or a pharmaceutically-acceptable salt thereof. The invention concerns also processes for the manufacture of a bibyclic heterocyclic compound of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said compound. Also included in the invention is a method of treating various inflammatory or allergic diseases using a bibyclic heterocyclic compound of the formula I, or a pharmaceutically-acceptable salt thereof, and the use of such a compound in the production of a new medicament for such use.
摘要翻译：本发明涉及式I的双环杂环化合物或其药学上可接受的盐。本发明还涉及制备式I的双环杂环化合物或其药学上可接受的盐以及含有所述化合物的药物组合物的方法。本发明还包括使用式I的双环杂环化合物或其药学上可接受的盐来治疗各种炎性或过敏性疾病的方法，以及这种化合物在制备用于这种用途的新药物中的用途。

7. 发明公开

EP0409413A3 Diaryl ether heterocycles 失效
标题翻译：二元醚等离子体
公开(公告)号：EP0409413A3
公开(公告)日：1991-07-17
申请号：EP90306765.0
申请日：1990-06-20
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI PHARMA
发明人： Edwards, Philip Neil , Bird, Thomas Geoffrey Colerick
IPC分类号： C07D309/10 , C07D409/12 , A61K31/35
CPC分类号： C07D409/12 , C07D307/20 , C07D309/10
摘要： The invention concerns a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof,
wherein Ar¹ is optionally substituted phenyl or naphthyl;
X¹ is oxy, thio, sulphinyl or sulphonyl;
Ar² is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms;
R¹ is (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and
R² and R³ together form a group of the formula -A²-X²-A³- wherein each of A² and A³ is (1-4C)alkylene and X² is oxy, thio, sulphinyl, sulphonyl or imino. The invention also concerns processes for the manufacture of a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said heterocycle. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

8. 发明公开

EP0420511A2 Heterocyclic derivatives 失效
标题翻译：杂环衍生物
公开(公告)号：EP0420511A2
公开(公告)日：1991-04-03
申请号：EP90310332.3
申请日：1990-09-21
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI PHARMA
发明人： Crawley, Graham Charles , Edwards, Philip Neil
IPC分类号： C07D405/12 , C07D409/12 , C07D401/12 , A61K31/47 , A61K31/50
CPC分类号： C07D409/12 , C07D401/12 , C07D405/12
摘要： The invention concerns a heterocyclic derivative of the formula I
wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms;
X¹ is oxy, thio, sulphinyl, sulphonyl or imino;
Ar is phenylene which may optionally bear one or two substituents or
Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms;
R¹ is (1-6C)alkyl, (3-6C)alkenyl or (3-6C)alkynyl; and
R² and R³ together form a group of the formula -A²-X²-A³- which, together with the carbon atom to which A² and A³ are attached, defines a ring having 4 to 7 ring atoms, wherein A² and A³, which may be the same or different, each is (1-4C)alkylene and X² is oxy, thio, sulphinyl, sulphonyl or imino;
or a pharmaceutically-acceptable salt thereof.
The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
摘要翻译：本发明涉及式I的杂环衍生物，其中Q是含有一个或两个氮原子的任选取代的6元单环或10元双环杂环部分; X 1是氧，硫，亚磺酰基，磺酰基或亚氨基; Ar为可任选带有一个或两个取代基的亚苯基或Ar为含最多三个氮原子的任选取代的6-元杂环部分; （1-6C）烷基，（3-6C）链烯基或（3-6C）炔基; 并且R 2和R 3一起形成式-A 2 -X 2 -A 3 - 的基团，其与连接A 2和A 3的碳原子一起定义一个具有4-7个环原子的环，其中A 2和A 3可以各自是（1-4C）亚烷基，X 2是氧，硫，亚磺酰基，磺酰基或亚氨基; 或其药学上可接受的盐。本发明的化合物是5-脂氧合酶的抑制剂。

9. 发明公开

EP0375404A3 Heterocyclic derivatives 失效
标题翻译：杂环衍生物
公开(公告)号：EP0375404A3
公开(公告)日：1991-01-16
申请号：EP89313384.3
申请日：1989-12-20
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI-PHARMA
发明人： Edwards, Philip Neil , Girodeau, Jean-Marc Marie Maurice
IPC分类号： C07D309/10 , C07D335/02 , C07D313/04 , C07D307/20 , A61K31/34 , A61K31/35 , A61K31/38 , C07D405/04
CPC分类号： C07D309/10 , C07D307/20 , C07D313/04 , C07D335/02
摘要： The invention concerns a heterocyclic derivative of the formula I,
wherein Ar¹ is optionally substituted phenyl or naphthyl;
A¹ is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo-(3-6C)alkylene;
Ar² is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms;
R¹ is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and
R² and R³ together form a group of the formula -A²-X-A³- wherein each of A² and A³ is (1-4C)alkylene and X is oxy, thio, sulphinyl, sulphonyl or imino;
or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
摘要翻译：本发明涉及式I的杂环衍生物，其中Ar 1是任选取代的苯基或萘基; A 1是（1-6C）亚烷基，（3-6C）亚烯基，（3-6C）亚炔基或环 - （3-6C）亚烷基; Ar 2是任选取代的亚苯基或含有至多三个氮原子的6元杂环部分; （1-6C）烷基，（3-6C）烯基，（3-6C）炔基，氰基 - （1-4C）烷基或（2-4C）烷酰基或任选取代的苯甲酰基; R 2和R 3一起形成式-A 2 -X-A 3 - 的基团，其中A 2和A 3各自是（1-4C）亚烷基，X是氧，硫，亚磺酰基，磺酰基或亚氨基; 或其药学上可接受的盐。本发明的化合物是5-脂氧合酶的抑制剂。

10. 发明公开

EP0381375A1 Heterocyclic derivatives 失效
标题翻译：杂环衍生物
公开(公告)号：EP0381375A1
公开(公告)日：1990-08-08
申请号：EP90300780.5
申请日：1990-01-25
申请人： IMPERIAL CHEMICAL INDUSTRIES PLC , ICI PHARMA
发明人： Crawley, Graham Charles , Edwards, Martin Paul
IPC分类号： C07D417/12 , A61K31/435 , A61K31/495
CPC分类号： C07D417/12
摘要： The invention concerns a thiazole of the formula I,
wherein Q¹ is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms;
X is oxy, thio, sulphinyl, sulphonyl or imino;
Ar is phenylene which may optionally bear one or two substituents, or Ar is an optionally substituted 6-membered heterocyclene moiety contining up to three nitrogen atoms;
R¹ is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl;
R² is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl or substituted (1-4C)alkyl or R² is optionally substituted benzoyl; and
Q² is optionally substituted thiazolyl;
or a pharmaceutically-acceptable salt thereof.
The invention also concerns processes for the manufacture of a thiazole of the formula I and pharmaceutical compositions containing said thiazole.
摘要翻译：本发明涉及式I的噻唑，其中Q 1是含有一个或两个氮原子的任选取代的6元单环或10元双环杂环部分; X是氧基，硫基，亚磺酰基，磺酰基或亚氨基; Ar是可以任选地带有一个或两个取代基的亚苯基，或Ar是连续至多三个氮原子的任选取代的6元杂环烯基团; R 1是氢，（1-6C）烷基，（2-6C）烯基，（2-6C）炔基或取代的（1-4C）烷基; （1-6C）烷基，（3-6C）烯基，（3-6C）炔基或取代的（1-4C）烷基或R 2是任选取代的苯甲酰基; 和Q 2是任选取代的噻唑基; 或其药学上可接受的盐。本发明还涉及制备式I的噻唑和含有所述噻唑的药物组合物的方法。

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