专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2594944B1 AUTOMATIC ANALYSIS DEVICE, ANALYSIS METHOD AND INFORMATION PROCESSING DEVICE 有权转让
公开(公告)号：EP2594944B1
公开(公告)日：2020-06-03
申请号：EP11806654.7
申请日：2011-07-04
申请人： Hitachi High-Technologies Corporation
发明人： KAMIHARA Kumiko , MITSUYAMA Satoshi , MIMURA Tomonori , MANRI Chihiro
IPC分类号： G01N35/00

2. 发明公开

EP2711713A1 AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS PROGRAM 有权转让
标题翻译： VORRICHTUNGFÜRAUTOMATISCHE ANALYSEN UNDER PROGRAMMFÜRAUTOMATISCHE ANALYSEN
公开(公告)号：EP2711713A1
公开(公告)日：2014-03-26
申请号：EP12785094.9
申请日：2012-04-17
申请人： Hitachi High-Technologies Corporation
发明人： MANRI Chihiro , MITSUYAMA Satoshi , MIMURA Tomonori , KAMIHARA Kumiko
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , G01N35/00693 , G01N2035/00673 , G01N2035/00702 , G01N2035/0453
摘要： Accuracy control of an automatic analysis device that mixes a sample and a reagent to measure temporal change of a mixed solution is realized. A plurality of measurement point data is acquired from a reaction process of the sample and the reagent. Parameters and test values of approximate equations for approximating the plurality of measurement point data are accumulated in a storage unit. A distribution map of reference data corresponding to the parameters or the test values is created based on predetermined numbers of the parameters or the test values accumulated in the storage unit. Next, a plurality of screens for individually superimposing, on the distribution map, curved lines corresponding to a plurality of regression function candidates obtained by applying a plurality of regression functions are arranged and presented on a display screen, so as to approximate the data to the distribution map of the reference data.
摘要翻译：实现了混合样品和试剂以测量混合溶液的时间变化的自动分析装置的精度控制。从样品和试剂的反应过程获得多个测量点数据。用于近似多个测量点数据的近似等式的参数和测试值被累积在存储单元中。基于在存储单元中累积的参数或测试值的预定数量来创建与参数或测试值对应的参考数据的分布图。接下来，在分配图上单独叠加多个屏幕，将与通过应用多个回归函数获得的多个回归函数候选对应的曲线布置并呈现在显示屏上，以将数据近似为分布图的参考数据。

3. 发明授权

EP2439511B1 FLOW TYPE PARTICLE IMAGE ANALYSIS METHOD AND DEVICE 有权转让
标题翻译：方法和设备流式颗粒图像分析
公开(公告)号：EP2439511B1
公开(公告)日：2015-08-19
申请号：EP10783244.6
申请日：2010-05-17
申请人： Hitachi High-Technologies Corporation
发明人： MANRI Chihiro , OOWADA Norio , MITSUYAMA Satoshi
IPC分类号： G01N15/14
CPC分类号： G01N15/1459 , G01N2015/1452

4. 发明公开

EP2594944A1 AUTOMATIC ANALYSIS DEVICE, ANALYSIS METHOD AND INFORMATION PROCESSING DEVICE 有权转让
标题翻译：汽车零部件分析师，分析师，信息技术专家
公开(公告)号：EP2594944A1
公开(公告)日：2013-05-22
申请号：EP11806654.7
申请日：2011-07-04
申请人： Hitachi High-Technologies Corporation
发明人： KAMIHARA Kumiko , MITSUYAMA Satoshi , MIMURA Tomonori , MANRI Chihiro
IPC分类号： G01N35/00
CPC分类号： G01N21/75 , B01F11/0266 , B01F15/00214 , G01N21/272 , G01N35/00594 , G01N35/00603 , G01N35/00623 , G01N35/00663 , G01N2035/00465 , G01N2035/00702 , G01N2035/0097 , G16C20/10 , Y10T436/11
摘要： An automatic analyzer includes sample vessels 16 each containing a sample to be measured; reaction vessels 21 in which to mix a sample and a reagent; a sample dispenser 5 for dispensing a sample from any of the sample vessels 16 to any of the reaction vessels 21; reagent vessels 18 each containing a reagent to be mixed with a sample; a reagent dispenser 6 for dispensing a reagent from any of the reagent vessels 18 to any of the reaction vessels 21; a stirrer 7 for stirring the sample-reagent mix contained in any reaction vessel 21; and a photometric measurement unit 8 for obtaining multiple measurement data points during the progress of reaction of a mixed solution. The analyzer performs the steps of: selecting at least one approximation formula; generating an approximation curve from the measurement data points; calculating a shape descriptor from the approximation curve; and judging abnormalities based on the shape descriptor. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
摘要翻译：自动分析仪包括：样品容器16，每个样品容器16包含待测样品; 用于混合样品和试剂的反应容器21; 用于将样品从任何样品容器16分配到任何反应容器21的样品分配器5; 每个试剂容器18含有待与样品混合的试剂; 用于将试剂从任何试剂容器18分配到任何反应容器21的试剂分配器6; 用于搅拌包含在任何反应容器21中的样品 - 试剂混合物的搅拌器7; 以及用于在混合溶液的反应进行期间获得多个测量数据点的光度测量单元8。分析仪执行以下步骤：选择至少一个近似公式; 从测量数据点生成近似曲线; 从近似曲线计算形状描述符; 并根据形状描述符判断异常。这不仅允许从每个测量结果准确地检测到异常，而且允许识别异常的原因。

5. 发明公开

EP2287620A1 METHOD FOR ASSISTING JUDGMENT OF ABNORMALITY OF REACTION PROCESS DATA AND AUTOMATIC ANALYZER 有权转让
标题翻译：方法有助于评估反应过程数据和自动分析仪异常
公开(公告)号：EP2287620A1
公开(公告)日：2011-02-23
申请号：EP09754759.0
申请日：2009-05-28
申请人： Hitachi High-Technologies Corporation
发明人： MITSUYAMA Satoshi , FUKUYAMA Yuki , TAKADA Hidekatsu , BAN Hideyuki , MIMURA Tomonori
IPC分类号： G01N35/00 , G01N21/78
CPC分类号： G01N21/77 , G01N21/272 , G01N21/78 , G01N35/00603 , G01N2035/0097
摘要： In the event of a suspected abnormality in the device, sample or reagent, a laboratory technician had to examine the abnormal reaction process data item by item, and infer the cause of the abnormality, which took effort and time in some cases. Abnormality judgment is assisted using: indicator computation means that computes an indicator indicating a feature parameter of a given waveform by applying a pre-defined evaluation formula to time series data of photometric values; relative indicator computation means that computes a value indicating a relationship of the indicator of target data to the indicator computed in the past; and indicator display means that simultaneously displays a value computed by the indicator computation means and the value computed by the relative indicator computation means. According to the present method, which is a method for assisting judgment of abnormality wherein a feature parameter of a given absorbance change is computed, it can be made easier to find certain abnormalities, and it becomes possible to attain more efficient device maintenance and improved device reliability without the addition of any new parts.
摘要翻译：在该装置中，样品或试剂，在疑似异常的情况下，检查技师必须检查由物品的异常反应过程数据项，并推断出异常，历时的时间和精力在某些情况下的原因。异常判断是利用辅助的：指标计算bedeutet，DASS计算到指示器通过应用预定义的评估式来测光值的时序数据指示一个给定的波形的特征参数; 相对指标计算bedeutet，DASS计算一个值，指示目标数据在过去计算出的指示器的指示器的关系; 和指示器显示bedeutet，DASS同时显示由所述指标计算部件和由所述相对指标计算部件计算出的值计算的值。。根据本发明的方法，所有这些都为worin给定的吸光度变化的特征量被计算，它可以制成更容易找到某些异常异常判定支援方法，并且变得可以实现装置维护的效率和改进的装置可靠性不添加任何新部件。

6. 发明授权

EP2461153B1 PARTICLE IMAGE ANALYSIS DEVICE 有权转让
公开(公告)号：EP2461153B1
公开(公告)日：2019-10-02
申请号：EP10804341.5
申请日：2010-07-23
申请人： Hitachi High-Technologies Corporation
发明人： SUZUKI Akiko , OOWADA Norio , TAKI Miki , MITSUYAMA Satoshi , MANRI Chihiro
IPC分类号： G01N21/27 , G01N15/14 , G01N21/47

7. 发明公开

EP2927694A1 AUTOMATED ANALYZER AND AUTOMATED ANALYSIS METHOD 有权转让
标题翻译：自动分析仪自动化分析仪ANALYSEVERFAHREN
公开(公告)号：EP2927694A1
公开(公告)日：2015-10-07
申请号：EP13856862.1
申请日：2013-11-05
申请人： Hitachi High-Technologies Corporation
发明人： TARUMI Shinji , YABUTANI Chie , MAKINO Akihisa , MANRI Chihiro , MITSUYAMA Satoshi
IPC分类号： G01N33/86 , G01N33/49 , G01N35/00
CPC分类号： G01N21/82 , G01N21/17 , G01N21/25 , G01N21/27 , G01N21/272 , G01N30/8693 , G01N33/49 , G01N33/4905 , G01N33/53 , G01N33/86 , G01N35/00 , G01N35/00584 , G01N2021/513 , G01N2021/5961 , G01N2035/00425 , G01N2035/00702 , G01N2035/0097 , G01N2035/0453 , G06F19/00 , G06F19/321
摘要： Provided is technology for blood clotting reactions capable of analyzing a blood clotting reaction with a high degree of precision by precisely detecting and removing noise, regardless of the location where the noise is generated in the light intensity data. This automated analyzer approximates, with an approximation curve, time series data for transmitted light intensity or scattered light intensity of light emitted onto a sample, and, in this process, removes abnormal data points that deviate from the approximation curve (see FIG. 2 ).
摘要翻译：提供了能够通过精确地检测和去除噪声来高精度地分析血液凝固反应的凝血反应技术，而不管光强数据中产生噪声的位置如何。该自动分析仪用近似曲线逼近用于发射到样品上的光的透射光强度或散射光强度的时间序列数据，并且在该过程中，去除偏离近似曲线的异常数据点（参见图2）。

8. 发明公开

EP2562547A1 AUTOMATIC ANALYSIS DEVICE AND AUTOMATIC ANALYSIS METHOD 审中-公开
标题翻译： VORRICHTUNGFÜRAUTOMATISCHE分析仪VERFAHRENFÜRAUTOMATISCHE分析仪
公开(公告)号：EP2562547A1
公开(公告)日：2013-02-27
申请号：EP11771862.7
申请日：2011-04-05
申请人： Hitachi High-Technologies Corporation
发明人： MANRI Chihiro , MITSUYAMA Satoshi , MIMURA Tomonori , KAMIHARA Kumiko
IPC分类号： G01N35/00 , G01N21/75
摘要： There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
摘要翻译：提供了一种用于自动确定或预测在自动分析器中出现的用于混合样品和试剂的反应曲线中出现的样品特异性的线范围并测量样品和试剂的混合物随时间的变化的技术。本发明通过功能近似反应曲线数据，并在反应的早期阶段或第二阶段自动确定曲线部分。本发明确定不包括每个样品的曲线部分的线范围，并使用确定的线范围内的吸光度数据计算实验室测试值。本发明还根据在反应曲线中途的一点获得的吸光度数据，自动确定反应初期的起始时间，根据线的结束时间和计划的预测线范围并且基于预测结果来计算预测值。

9. 发明公开

EP2461153A1 PARTICLE IMAGE ANALYSIS DEVICE 有权转让
标题翻译： VORRICHTUNG ZUR PARTIKELBILDANALYSE
公开(公告)号：EP2461153A1
公开(公告)日：2012-06-06
申请号：EP10804341.5
申请日：2010-07-23
申请人： Hitachi High-Technologies Corporation
发明人： SUZUKI Akiko , OOWADA Norio , TAKI Miki , MITSUYAMA Satoshi , MANRI Chihiro
IPC分类号： G01N21/27 , G01N15/14 , G01N21/47
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/1459 , G01N35/00613 , G01N2015/1409 , G01N2015/1465
摘要： A conventional flow type particle analysis apparatus could not detect both a human error, such as leaving behind a sample, a shortage of the sample, or a shortage of a reagent, and an abnormality of a flow path system by an inexpensive and simple method. A particle analysis apparatus according to the present invention includes means that perform processes upon image processing of images (110) acquired in a measurement of the sample, simultaneously with a normal image processing for classifying target particles. The means included are: image processing means (110a) for calculating information of RGB density distributions of each whole image; abnormal state determination processing means (110c) for determining whether or not the acquired images are in an abnormal state according to tendencies of the RGB density distributions; and an abnormality judgment process means for making final determination of the existence of an abnormality by calculating an appearance frequency of abnormal images after all measurements for the one sample is completed. These means allow diagnosis of abnormalities to be conducted simultaneously with normal analysis without changing the configuration of the conventional apparatus.
摘要翻译：传统的流式粒子分析装置通过廉价且简单的方法不能同时检测诸如留下样品，样品短缺或试剂短缺以及流路系统异常的人为错误。根据本发明的粒子分析装置包括在用于分类目标粒子的正常图像处理的同时，对在样本的测量中获取的图像（110）进行图像处理的处理。包括的装置是：用于计算每个整个图像的RGB浓度分布的信息的图像处理装置（110a）用于根据RGB密度分布的趋势确定所获取的图像是否处于异常状态的异常状态确定处理装置（110c）; 以及异常判断处理装置，用于通过在完成所述一个样本的所有测量之后计算异常图像的出现频率来最终确定异常的存在。这些装置允许诊断异常与正常分析同时进行，而不改变常规装置的结构。

10. 发明公开

EP2439511A1 FLOW TYPE PARTICLE IMAGE ANALYSIS METHOD AND DEVICE 有权转让
标题翻译： VERFAHREN UND VORRICHTUNG ZUR FLIESSPARTIKELBILDANALYSE
公开(公告)号：EP2439511A1
公开(公告)日：2012-04-11
申请号：EP10783244.6
申请日：2010-05-17
申请人： Hitachi High-Technologies Corporation
发明人： MANRI Chihiro , OOWADA Norio , MITSUYAMA Satoshi
IPC分类号： G01N15/14
CPC分类号： G01N15/1459 , G01N2015/1452
摘要： The in-focus point is to be adjusted accurately and efficiently, and also displacement of the in-focus position and the thickness of the flow of a sample liquid are to be checked accurately. At each of mutually different multiple focal positions, focal adjustment parameter values are obtained from images of standard particles made of the same substance. Each focal adjustment parameter value is figured out as any one of the ratio between the density value around the center of the standard particle image and the density value around the outline, the difference therebetween, and the density value around the center. The in-focus position is adjusted on the basis of the relationship between the obtained focal adjustment parameter values and the focal positions. Moreover, on the basis of the relationship between the focal adjustment parameter values and the focal positions, the parameter values are converted into focal positions, and the focal positions and dispersion thereof are used to check the displacement of the in-focus position and the thickness of the sample liquid.
摘要翻译：要精确有效地调整对焦点，并且准确检查样品液体的对焦位置和流动的厚度。在每个相互不同的多个焦点位置，从相同物质制成的标准粒子的图像中获得焦点调整参数值。每个焦点调整参数值被计算为标准粒子图像的中心附近的密度值与轮廓周围的密度值之间的比率，它们之间的差异以及围绕中心的密度值之间的任何一个。基于获得的焦点调整参数值和焦点位置之间的关系来调整对焦位置。此外，基于焦点调整参数值与焦点位置之间的关系，参数值被转换为焦点位置，并且其焦点位置和色散用于检查对焦位置和厚度的位移的样品液体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式