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1. 发明授权

EP3171910B1 VORRICHTUNG ZUR EXTRAKORPORALEN ENTFERNUNG PROTEINGEBUNDENER TOXINE 有权
公开(公告)号：EP3171910B1
公开(公告)日：2019-08-28
申请号：EP15739520.3
申请日：2015-07-20
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FABIG, Anselm , TSCHULENA, Ulrich , STEPPAN, Sonja
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36

2. 发明授权

EP3116644B1 ADSORBERGRANULAT ZUR ENTFERNUNG URÄMISCHER TOXINE 有权转让
公开(公告)号：EP3116644B1
公开(公告)日：2019-02-27
申请号：EP15709944.1
申请日：2015-03-13
申请人： Fresenius Medical Care Deutschland GmbH , PSS Polymer Standards Service GmbH
发明人： TSCHULENA, Ulrich , REINHOLD, Günter , PASSLICK-DEETJEN, Jutta , LEINENBACH, Hans Peter , HÖRBERG, Annika , OLESCHKO, Kirsten
IPC分类号： B01J20/32 , A61M1/36 , B01J20/28

3. 发明公开

EP2934620A1 HÄMODIAFILTRATIONSVERFAHREN 有权
公开(公告)号：EP2934620A1
公开(公告)日：2015-10-28
申请号：EP13818983.2
申请日：2013-12-19
申请人： Fresenius Medical Care Deutschland GmbH
发明人： TSCHULENA, Ulrich , JANKOWSKI, Joachim , FABIG, Anselm , MÜLLER, Carsten
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/3639 , A61M1/16 , A61M1/3403 , A61M1/3434 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3681 , A61M2202/0445 , A61M2202/0498 , A61M2205/054 , A61M2205/3344 , A61M2230/207
摘要： The invention relates to a device for haemodiafiltration comprising an extracorporeal circulation (10) for receiving blood to be cleaned and comprising a haemodialyser and/or haemofilter (20) which is connected to the blood circulation (10), said blood circulation (10) having at least one respective supply line (12, 14) located upstream and downstream of the haemodialyser and/or haemofilter (20), for supplying a substitution fluid. The invention is characterised in that the device also comprises measuring devices for recording the transmembrane pressure and/or haematocrit (HKT) and/or blood density, the measuring devices being connected to a control unit (100) for controlling one or more of the transmembrane pressure, and/or haematocrit (HKT) and/or blood density and said control unit (100) being constructed in such a way that the control is carried out (13, 15) with the aid of at least one of the infusion speeds (Q
s pre, Q
s post) of the substitution fluid. The invention is also characterised in that the blood to be cleaned is exposed to a high-frequency electromagnetic field and/or an electric DC field (70) before and/or during the contact with the dialyser.
摘要翻译：本发明涉及一种用于血液透析过滤的装置，其包括用于接收待清洁的血液的体外循环（10）并且包括连接到血液循环（10）的血液透析器和/或血液滤过器（20），所述血液循环（10）位于血液透析器和/或血液滤过器（20）上游和下游的至少一个相应的供应管线（12,14），用于供应替代流体。本发明的特征在于，该装置还包括用于记录跨膜压力和/或血细胞比容（HKT）和/或血液密度的测量装置，测量装置连接到控制单元（100）以控制一个或多个跨膜压力和/或血细胞比容（HKT）和/或血液密度，并且所述控制单元（100）以这样的方式构造，使得借助至少一种输液速度（13,15）执行控制 Q spre，Q spost）。本发明的特征还在于，在与透析器接触之前和/或期间，待清洁的血液暴露于高频电磁场和/或直流电场（70）。

5. 发明公开

EP3171910A1 VORRICHTUNG ZUR EXTRAKORPORALEN ENTFERNUNG PROTEINGEBUNDENER TOXINE 有权
公开(公告)号：EP3171910A1
公开(公告)日：2017-05-31
申请号：EP15739520.3
申请日：2015-07-20
申请人： Fresenius Medical Care Deutschland GmbH
发明人： FABIG, Anselm , TSCHULENA, Ulrich , STEPPAN, Sonja
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36
CPC分类号： A61M1/3681 , A61M1/16 , A61M1/3472 , A61M2205/054
摘要： The present invention relates to a device for the extracorporeal removal of protein-bound toxins from the blood, comprising at least one haemocatharsis device, more particularly at least one dialysis machine, haemofilter or adsorber, and at least one means for generating a field in the haemocatharsis device and/or in an element with a fluid connection to the haemocatharsis device, in particular in a line portion connected to the haemocatharsis device, wherein the means comprises at least two strip conductors, which are arranged on at least two, preferably opposite sides of the haemocatharsis device or of the element such that the field is preferably generated predominantly within the haemocatharsis device or preferably predominantly within the element.
摘要翻译：本发明涉及一种用于从血液中体外去除蛋白质结合毒素的装置，包括至少一个血液透析装置，更具体地至少一个透析机，血液过滤器或吸附器，以及至少一个用于在血液处理装置和/或与血液处理装置流体连接的元件中，特别是在连接到血液处理装置的管线部分中的装置，其中所述装置包括至少两个带状导体，所述至少两个带状导体布置在至少两个，优选相对侧的血容器装置或元件，使得该场优选主要在血容器装置内或优选主要在元件内产生。

6. 发明授权

EP2941283B1 VORRICHTUNG UND VERFAHREN ZUR ENTFERNUNG PROTEINGEBUNDENER TOXINE AUS DEM BLUT VON PATIENTEN UNTER EINSATZ EINES HOCHFREQUENTEN, ELEKTROMAGNETISCHEN FELDES UND EINES ELEKTROSTATISCHEN GLEICHFELDES 有权
标题翻译： DEVICE AND METHOD FOR REMOVING蛋白连接毒素患者的血液中利用高频电磁场和静电方法技术领域
公开(公告)号：EP2941283B1
公开(公告)日：2017-04-05
申请号：EP14702194.3
申请日：2014-01-06
申请人： Fresenius Medical Care Deutschland GmbH
发明人： JANKOWSKI, Joachim , FABIG, Anselm , TSCHULENA, Ulrich , MÜLLER, Carsten
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/16 , A61M1/3681 , A61M2202/0445 , A61M2202/07 , A61M2205/054 , A61M2205/057 , A61M2205/50 , B01D61/30 , B01D61/32 , B01D61/422 , B01D2311/2603 , B01D2311/2615 , B01D2313/365 , C02F1/48 , C02F2201/48

7. 发明授权

EP2934620B1 HÄMODIAFILTRATIONSVERFAHREN 有权
公开(公告)号：EP2934620B1
公开(公告)日：2016-12-14
申请号：EP13818983.2
申请日：2013-12-19
申请人： Fresenius Medical Care Deutschland GmbH
发明人： TSCHULENA, Ulrich , JANKOWSKI, Joachim , FABIG, Anselm , MÜLLER, Carsten
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/3639 , A61M1/16 , A61M1/3403 , A61M1/3434 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3681 , A61M2202/0445 , A61M2202/0498 , A61M2205/054 , A61M2205/3344 , A61M2230/207

8. 发明公开

EP2934619A1 VORRICHTUNG ZUR ENTFERNUNG PROTEINGEBUNDENER TOXINE AUS BLUTPLASMA 有权
标题翻译：装置脱除蛋白偶联毒素血浆
公开(公告)号：EP2934619A1
公开(公告)日：2015-10-28
申请号：EP13818668.9
申请日：2013-12-19
申请人： Fresenius Medical Care Deutschland GmbH
发明人： TSCHULENA, Ulrich , JANKOWSKI, Joachim , FABIG, Anselm
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36
CPC分类号： A61M1/3486 , A61M1/16 , A61M1/1601 , A61M1/34 , A61M1/3403 , A61M1/3406 , A61M1/3472 , A61M1/3482 , A61M1/3618 , A61M1/3679 , A61M1/3681 , A61M2202/0415 , A61M2202/0445 , A61M2202/07 , A61M2205/054 , A61M2205/33 , A61M2205/3317 , A61M2205/3324 , A61M2205/75 , B01D15/08 , B01D63/00 , B03C1/02
摘要： The invention relates to a device for the extracorporeal removal of protein-bound toxins from blood plasma comprising: a first (10), second (12), third (24) and fourth (27) line device; a dialyser or haemofilter (18) and/or an adsorber (19) located between the first (10) and the second (12) line device; a means for generating a field (14), said means at least partially surrounding the first line device (10) and/or the dialyser or haemofilter (18) and/or the adsorber (19); a controllable fluid transport device (16) located in the first (10) and/or second (12) line device and at least one controllable body fluid transport device (16) located in the third (24) and/or fourth (27) line device; a filter (20), the permeate side of the filter (20) being connected to the first (10) and the second (12) line device, the inlet (22) on the dialysis side of the filter (20) being connected to the third line device (24) which can be connected to a patient (P), and the outlet (26) on said dialysis side being connected to the fourth line device (26) which can be connected to the patient (P). In said device, a controllable flow rate of fluid through the line devices (10, 12, 24, 27), the dialyser or haemofilter (18) and/or the adsorber (19) can be produced by means of the fluid transport devices (16).

9. 发明公开

EP3471107A1 MEDICAL DEVICE AND COMPUTER-IMPLEMENTED METHOD OF PREDICTING RISK, OCCURRENCE OR PROGRESSION OF ADVERSE HEALTH CONDITIONS IN TEST SUBJECTS IN SUBPOPULATIONS ARBITRARILY SELECTED FROM A TOTAL POPULATION 审中-公开
公开(公告)号：EP3471107A1
公开(公告)日：2019-04-17
申请号：EP17196137.8
申请日：2017-10-12
申请人： Fresenius Medical Care Deutschland GmbH
发明人： TSCHULENA, Ulrich , BELLOCCHIO, Francesco , NERI, Luca , ARMSEN, Wencke , BARBIERI, Carlo
IPC分类号： G16H50/50 , G16H50/80
摘要： A computer-implemented method of generating a generalized model for adaptively predicting occurrence or progression of a first adverse health condition for a first subpopulation arbitrarily selected from a total population, includes extracting information about characterizing features of a plurality of second subpopulations, about occurrences and/or severity of the first adverse health condition found therein and/or about corresponding prognostic results, from a plurality of publications. One or more of the characterizing features are associated with corresponding first factors indicating a relation with an adverse or beneficial contribution of the characterizing feature to the occurrence or progression of the first adverse health condition, and with corresponding second factors indicating the relative frequency of occurrence in the respective second subpopulation considered in the respective publication. The characterizing features and their first and second factors are combined into a generalized model for the total population, including calculating a baseline risk of patient. The generalized model is stored on a computer accessible and readable medium in a retrievable manner.

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