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2. 发明授权

EP2598437B1 INTRINSICALLY MAGNETIC HYDROXYAPATITE 有权转让
标题翻译：固有磁性的羟基磷灰石
公开(公告)号：EP2598437B1
公开(公告)日：2017-04-05
申请号：EP11752344.9
申请日：2011-07-28
申请人： Consiglio Nazionale Delle Ricerche , Fin-Ceramica Faenza S.p.A.
发明人： TAMPIERI, Anna , LANDI, Elena , SANDRI, Monica , PRESSATO, Daniele , RIVAS REY, José , BANOBRE LOPEZ, Manuel , MARCACCI, Maurilio
IPC分类号： C01B25/32 , C01B25/45 , A61L27/12 , A61L27/54 , A61K47/02 , A61K49/00 , A61K49/08
CPC分类号： A61K47/02 , A61K49/0002 , A61K49/08 , A61L27/12 , A61L27/54 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/02 , A61L2430/06 , C01B25/32 , C01B25/322 , C01B25/45 , C01P2004/62 , C01P2006/62 , C01P2006/64

3. 发明公开

EP1948561A1 A PLURISUBSTITUTED HYDROXYAPATITE AND THE COMPOSITE THEREOF WITH A NATURAL AND/OR SYNTHETIC POLYMER, THEIR PREPARATION AND USES THEREOF 有权转让
标题翻译：多羟基磷灰石和IT的复合材料具有天然的和/或合成聚合物及其制备方法和用途发明
公开(公告)号：EP1948561A1
公开(公告)日：2008-07-30
申请号：EP06809000.0
申请日：2006-10-12
申请人： FIN - CERAMICA FAENZA S.P.A. , C.N.R. Consiglio Nazionale delle Ricerche
发明人： LANDI, Elena , TAMPIERI, Anna , CELOTTI, Giancarlo , SPRIO, Simone , PRESSATO, Daniele , DE LUCA, Claudio
IPC分类号： C01B25/32 , C01B25/16 , A61L27/00 , A61L31/12 , A61F2/28
CPC分类号： C01B25/322 , A61F2/28 , A61F2310/00293 , A61L27/12 , A61L27/46 , C01B25/16
摘要： The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treating bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses.

5. 发明公开

EP3157590A1 INJECTABLE APATITIC CEMENT IONICALLY MULTI-SUBSTITUTED FOR REGENERATIVE VERTEBROPLASTY AND KYPHOPLASTY 有权
标题翻译：注射用复方替代治疗复发性脊柱侧凸和KYOPOPLASTY的注射用可溶性水泥
公开(公告)号：EP3157590A1
公开(公告)日：2017-04-26
申请号：EP15741332.9
申请日：2015-06-18
申请人： Consiglio Nazionale Delle Ricerche (C.N.R.) , Universita' Cattolica Del Sacro Cuore
发明人： SPRIO, Simone , TAMPIERI, Anna , SANDRI, Monica , PANSERI, Silvia , LOGROSCINO, Giandomenico
IPC分类号： A61L27/12 , A61L27/42 , A61L24/00 , A61L24/02
摘要： An injectable apatite cement, in which the calcium in the a phase is partially substituted with strontium, and in which tricalcium phosphate in the β phase is also present is described. Also described is a method for its preparation and its use in bone regeneration, in particular in vertebroplasty, in kyphoplasty, and in pathologies characterized by a loss of bone substance.
摘要翻译：描述了一种可注射的磷灰石水泥，其中a相中的钙被锶部分取代，并且其中还存在β相中的磷酸三钙。还描述了其制备方法及其在骨再生中的用途，特别是在椎体成形术中，椎体后凸成形术中以及以骨物质损失为特征的病理学中的用途。

6. 发明公开

EP2637709A1 IMPLANTS FOR LOAD BEARING BONE SUBSTITUTIONS HAVING HIERARCHICAL ORGANIZED ARCHITECTURE DERIVING FROM TRANSFORMATION OF VEGETAL STRUCTURES 有权转让
标题翻译：植入物LAST佩戴KNOCHENERSÄTZE具有层次有组织架构从植物结构的转型
公开(公告)号：EP2637709A1
公开(公告)日：2013-09-18
申请号：EP11794855.4
申请日：2011-11-08
申请人： Consiglio Nazionale Delle Ricerche , Universidad de Sevilla , Laboratoire d'Evaluation des Matériels Implantables
发明人： TAMPIERI, Anna , SPRIO, Simone , RUFFINI, Andrea , WILL, Julia , GREIL, Peter , MÜLLER, Frank , MARTÍNEZ FERNÁNDEZ, Julian , TORRES RAYA, Carmen , VARELA FERIA, Francisco Manuel , RAMÍREZ RICO, Joaquín , HARMAND, Marie-Françoise
IPC分类号： A61L27/12 , A61L27/24 , A61L27/56
CPC分类号： A61K9/501 , A61F2/28 , A61K38/39 , A61L27/10 , A61L27/12 , A61L27/46 , A61L27/56 , A61L2430/02
摘要： The present invention relates to a bone substitute comprising a core based on hydroxyapatite (HA), obtained from at least one porous wood, or based on collagen fibres and hydroxyapatite, and a shell, based on hydroxyapatite (HA) or silicon carbide (SiC), obtained from at least one wood having a lower porosity than the at least one wood of the core. The porous wood has a total porosity of between 60% and 95%, preferably between 65% and 85%, and it is selected from amongst the choices of rattan, pine, abachi and balsa wood. The wood of the shell has a porosity of between 20% and 60%, preferably between 30% and 50%. The bone substitute is utilized for the substitution and regeneration of bone, preferably for bones subjected to mechanical loads, such as long bones of the leg and arm, preferably the tibia, metatarsus, femur, humerus or radius.

7. 发明公开

EP3589680A1 FILTER FOR THE EXCHANGE OF HEAT AND MOISTURE FOR APPLICATION IN THE MEDICAL FIELD AND PROCEDURE FOR THE PRODUCTION THEREOF 有权
公开(公告)号：EP3589680A1
公开(公告)日：2020-01-08
申请号：EP18717989.0
申请日：2018-02-27
申请人： Consiglio Nazionale Delle Ricerche
发明人： SANDRI, Monica , TAMPIERI, Anna , SPRIO, Simone
IPC分类号： C08J3/075 , A61M16/10

8. 发明公开

EP3426224A1 PHYSICAL SOLAR FILTER CONSISTING OF SUBSTITUTED HYDROXYAPATITE IN AN ORGANIC MATRIX 有权
公开(公告)号：EP3426224A1
公开(公告)日：2019-01-16
申请号：EP17718738.2
申请日：2017-03-06
申请人： Consiglio Nazionale delle Ricerche
发明人： TAMPIERI, Anna , SANDRI, Monica , SPRIO, Simone
IPC分类号： A61K8/24 , A61K8/29 , A61K8/19 , C01B25/32 , A61Q17/04

9. 发明公开

EP3236947A1 PRODUCTS FOR THE DELIVERY OF THERAPEUTIC/DIAGNOSTIC COMPOUNDS TO THE HEART 有权
标题翻译：用于向心脏递送治疗/诊断化合物的产品
公开(公告)号：EP3236947A1
公开(公告)日：2017-11-01
申请号：EP15825795.6
申请日：2015-12-22
申请人： Consiglio Nazionale Delle Ricerche , Istituto Nazionale Assicurazione Contro gli Infortuni sul Lavoro
发明人： CATALUCCI, Daniele , MIRAGOLI, Michele , IAFISCO, Michele , TAMPIERI, Anna
IPC分类号： A61K9/14 , A61K9/51
CPC分类号： A61K9/5115 , A61K9/007 , A61K9/143 , A61K9/5192 , A61K31/7105 , A61K38/03 , A61K47/52 , A61K47/6929 , C12N15/113 , C12N2310/141 , C12N2320/32
摘要： The invention relates to a process for the preparation of a product comprising one or more nanoparticles of calcium phosphate (CaP-NP) with negative surface charge having a ζ-potential in the range from −41.0 mV to −27.0 mV comprising the steps of: a) maintaining a mixture having a pH in the range from 7 to 10 and comprising an aqueous solution of calcium, an aqueous solution of phosphate and a solution of citrate ions at a temperature in the range from 20° C. to 40° C. for a time in the range from 30 seconds to 10 minutes; b) removing non-reacted ions from the solution of step a), thus obtaining a suspension of one or more nanoparticles of calcium phosphate (CaP-NP); c) recovering the product of one or more nanoparticles of calcium phosphate (CaP-NP) from the suspension of step b). In an advantageous embodiment, the process of the invention provides, in the mixture of step a), also an aqueous solution of one or more therapeutic/diagnostic compounds. The product of the invention may be used as a vehicle for one or more diagnostic/therapeutic compounds for the treatment of cardiovascular diseases through inhalation administration.
摘要翻译：本发明涉及用于制备包含一种或多种具有-41.0mV至-27.0mV范围内的ζ-电位的负表面电荷的磷酸钙纳米颗粒（CaP-NP）的产品的方法，包括以下步骤： a）维持pH值在7至10范围内的混合物，并且包含钙的水溶液，磷酸盐的水溶液和柠檬酸盐离子的溶液，温度范围为20℃至40℃，用于时间在30秒到10分钟之间; b）从步骤a）的溶液中除去未反应的离子，从而获得一种或多种磷酸钙纳米颗粒（CaP-NP）的悬浮液; c）从步骤b）的悬浮液中回收一种或多种磷酸钙纳米颗粒（CaP-NP）的产物。在一个有利的实施方案中，本发明的方法在步骤a）的混合物中还提供一种或多种治疗/诊断化合物的水溶液。本发明的产品可以用作通过吸入给药来治疗心血管疾病的一种或多种诊断/治疗化合物的载体。

10. 发明公开

EP3177273A1 PROCESS FOR OBTAINING FLUORIDE-DOPED CITRATE-COATED AMORPHOUS CALCIUM PHOSPHATE NANOPARTICLES 有权
标题翻译：获得氟化物掺杂的柠檬酸盐包覆的非晶态磷酸钙纳米颗粒的方法
公开(公告)号：EP3177273A1
公开(公告)日：2017-06-14
申请号：EP15748187.0
申请日：2015-07-21
申请人： Consejo Superior de Investigaciones Cientificas (CSIC) , Consiglio Nazionale Delle Ricerche
发明人： DELGADO LÓPEZ, José Manuel , GÓMEZ MORALES, Jaime , FERNÁNDEZ PENAS, Raquel , IAFISCO, Michele , TAMPIERI, Anna , PANSERI, Silvia
IPC分类号： A61K9/19 , A61K6/00 , A61K9/51 , A61L24/00
CPC分类号： A61K33/42 , A61K6/0008 , A61K6/0017 , A61K6/0038 , A61K6/0643 , A61K8/21 , A61K8/24 , A61K8/362 , A61K9/167 , A61K9/1682 , A61K9/19 , A61K9/5115 , A61K9/5123 , A61K9/5192 , A61K31/194 , A61K33/16 , A61K2800/413 , A61K2800/621 , A61K2800/70 , A61K2800/84 , A61L24/0015 , A61L24/02 , A61L2430/02 , A61L2430/12 , A61Q11/00 , C01B25/32
摘要： Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity; it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue; it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.
摘要翻译：获得氟化物掺杂的柠檬酸盐涂覆的无定形磷酸钙纳米粒子的方法。由于其可生物降解性和生物活性，该材料在生物医学领域具有应用前景; 它也促进细胞粘附和成骨。在牙科领域，它可用于牙膏，漱口水，口香糖，凝胶和氟化物清漆作为牙本质和牙釉质的再矿化剂。它基于一方面由氯化钙和柠檬酸钠形成的两种溶液，另一方面由磷酸二氢钠和碳酸钠与氟化物化合物形成，其在室温下混合。这个过程是生态高效和环保的，因为它不会留下任何酸渣; 它由单一阶段组成，并且首次获得用柠檬酸盐涂覆并掺杂氟化物的无定形磷酸钙，其增强其再矿化作用。

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