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1. 发明公开

EP3247336A4 MULTIPHASIC PARTICLES FABRICATED BY WETTABILITY ENGENDERED TEMPLATED SELF-ASSEMBLY (WETS) METHODS 审中-公开
公开(公告)号：EP3247336A4
公开(公告)日：2018-07-11
申请号：EP16740562
申请日：2016-01-19
申请人： UNIV MICHIGAN REGENTS
发明人： TUTEJA ANISH , KOBAKU SAI PRADEEP REDDY
IPC分类号： A61K9/50 , A61K9/16 , A61K9/26 , A61K39/00 , A61K47/30 , B82Y5/00
CPC分类号： B82Y30/00 , A61K9/501 , A61K9/5089 , A61K9/5115 , A61K9/5192 , B82Y5/00
摘要： Methods for forming multiphasic microparticles by using wettability engendered template self-assembly (WETS) techniques are provided. A template is used that defines wettable regions to polar and non-polar liquids and non-wettable regions to polar and non-polar liquids. A first liquid is applied to the template and forms a solid or semi-solid release layer. A second liquid is applied over the release layer to form a solid or semi-solid first layer and a third liquid is applied over the first layer to form a solid or semi-solid second layer. The first layer and the second layer can be released from the template by removing the release layer from the template with a treatment agent to form multiphasic microparticles. Methods for making the templates and multiphasic microparticles are also provided.

2. 发明授权

EP2315584B1 MICROENCAPSULATE AND PROCESS FOR THE MANUFACTURE THEREOF 有权
标题翻译：微晶纤维素及其制造方法
公开(公告)号：EP2315584B1
公开(公告)日：2018-03-07
申请号：EP09788261.7
申请日：2009-07-31
申请人： Feyecon B.V. , Friesland Brands B.V.
发明人： Poortinga, Albert Thijs , Trambitas, Daniela Oana , Hofland, Gerard Willem
IPC分类号： B01J13/04 , A61K9/50 , B01J13/02
CPC分类号： A61K9/5089 , A61K9/501 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5052 , B01J13/043
摘要： The present invention relates to a microencapsulate comprising microcapsules having a diameter of 0.1 mum to 25 mum, said microcapsules comprising: -a core particle having a diameter of 90 nm to 23 mum and containing at least 3% of the active component by weight of said core particle; and-a coating that fully envelops the core particle and containing at least 20 wt. % of a hydrophobic polymer selected from cellulosic ethers, cellulosic esters, zein, shellac, gluten, polylactide, hydrophobic starch derivatives, polyvinyl acetate polymers, polymers or copolymers derived from an acrylic acid ester and/or a methacrylic acid ester and combinations thereof; wherein the core particle contains a release trigger component and/or the coating contains a release trigger component, said release trigger component being selected from: -a water-swellable polymer having a water-uptake capacity at 37° C. and pH 7.0 of less than 20 wt. % and a water-uptake capacity at 37° C. and pH 2.0 of at least 50 wt. %; and-an edible salt having a water solubility at 37° C. and a pH of 7.0 of less than 1 mg/ml and a water solubility at 37° C. and a pH of 2.0 of at least 5 mg/ml; The microencapsulate of the present invention does not release the encapsulated active component when incorporated in water-containing foodstuffs, beverages, nutritional compositions or pharmaceutical compositions. Following ingestion, however, the active component is released rapidly.

3. 发明公开

EP3256211A1 DEVICES AND METHODS FOR THERAPEUTIC HEAT TREATMENT 有权
标题翻译：用于治疗性热处理的装置和方法
公开(公告)号：EP3256211A1
公开(公告)日：2017-12-20
申请号：EP16735961.1
申请日：2016-06-15
申请人： Boston Scientific Scimed, Inc.
发明人： SUTERMEISTER, Derek C. , WILLARD, Martin R. , HAVERKOST, Patrick A. , OSTROOT, Timothy A.
IPC分类号： A61N1/40 , A61B18/04 , A61B18/00
CPC分类号： A61K41/0052 , A61B18/04 , A61B2018/00125 , A61B2018/00136 , A61B2018/00148 , A61B2018/00154 , A61K9/0009 , A61K9/501 , A61K9/5094 , A61N1/406 , A61N2/004
摘要： An example implantable microparticle for delivering therapeutic heat treatment comprises a generally spherical body. The body may be formed from a first material comprising a biodegradable material and a second material comprising a Curie temperature material. The biodegradable material may be a non-Curie temperature material or have a Curie temperature lower than a Curie temperature of the Curie temperature material. The first material and the second material are mixed to form a composite having a Curie temperature in the range of 35 °C and 100 °C.

4. 发明公开

EP3220968A1 BIOACTIVE WOUND DRESSING AND TEETH COATING BASED ON MORPHOGENETICALLY ACTIVE AMORPHOUS CALCIUM POLYPHOSPHATE 审中-公开
标题翻译：基于形态活性非晶态多金属钙的生物活性创伤敷料和牙齿涂料
公开(公告)号：EP3220968A1
公开(公告)日：2017-09-27
申请号：EP15794552.8
申请日：2015-11-12
申请人： NanotecMARIN GmbH
发明人： MÜLLER, Werner Ernst Ludwig Georg
IPC分类号： A61L27/12 , A61K8/24 , A61K8/67 , A61L26/00 , A61K9/14
CPC分类号： A61L27/12 , A61K6/0017 , A61K8/0283 , A61K8/24 , A61K8/671 , A61K9/0024 , A61K9/14 , A61K9/501 , A61K9/70 , A61K2800/412 , A61L26/00 , A61L26/0004 , A61L2300/624 , A61L2400/12 , A61L2430/12 , A61Q11/00
摘要： This invention relates to a method for sealing dentinal tubules exposed at the tooth surface as a consequence of enamel defects, based on amorphous calcium polyphosphate (Ca-polyP) nano- or microparticles that strongly bind both to tooth enamel, cementum and dentin surfaces. The inventive method can also be used for the production of morphogenetically active tooth implants. A further aspect of this invention concerns the incorporation of such nano- or microparticles, after encapsulation of retinol (“retinol/aCa-polyP nano- or microspheres”), into wound dressings and related materials that are made, e.g., by electrospinning. The resulting, inventive retinol/aCa-polyP nano- or microspheres fiber mats show antimicrobial and wound healing properties and was found to increase the expression of the genes encoding for leptin and the leptin receptor, as well as the fatty acid binding protein 4 (FABP4) in a synergistic manner. This inventive material is the first material that can be used to promote wound healing through affecting the leptin/leptin receptor expression.
摘要翻译：本发明涉及基于与牙釉质，牙骨质和牙本质表面强烈结合的无定形聚磷酸钙（Ca-polyP）纳米颗粒或微颗粒，由于牙釉质缺陷而密封暴露在牙齿表面的牙本质小管的方法。本发明的方法也可以用于生成形态上有生命的牙齿植入物。本发明的另一方面涉及在将视黄醇（“视黄醇/ aCa-polyP纳米或微球体”）包封入例如通过电纺制备的伤口敷料和相关材料中后纳入这种纳米颗粒或微颗粒。所得本发明的视黄醇/ aCa-polyP纳米或微球体纤维垫显示出抗微生物和伤口愈合性质，并且发现其增加编码瘦蛋白和瘦蛋白受体的基因以及脂肪酸结合蛋白4（FABP4 ）以协同的方式。本发明材料是可用于通过影响瘦素/瘦素受体表达来促进伤口愈合的第一种材料。

5. 发明公开

EP3079705A4 MULTILAYERED NANOPARTICLE AND METHODS OF MANUFACTURING AND USING THE SAME 审中-公开
标题翻译： MEHRSCHICHTIGER NANOPARTIKEL SOWIE VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON
公开(公告)号：EP3079705A4
公开(公告)日：2017-07-19
申请号：EP14870520
申请日：2014-12-09
申请人： UNIV NANYANG TECH , SINGAPORE HEALTH SERV PTE LTD
发明人： VENKATRAMAN SUBRAMANIAN , WONG TZEE LING TINA , NEU BJORN
IPC分类号： A61K31/7088 , A61K9/14 , A61K47/30 , A61P17/02 , A61P27/02
CPC分类号： C12N15/113 , A61K9/501 , A61K9/5036 , A61K9/5052 , A61K9/5078 , A61K9/5089 , A61K9/5107 , A61K31/713 , A61K48/0041 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： The invention relates to a multilayered nanoparticle for delivery of RNA to a cell and methods of manufacturing and using the same. The multilayered nanoparticle has a core nanoparticle coated by alternating positively and negatively charged polymer layers, wherein the at least one of the negatively charged polymer layers is RNA.
摘要翻译：本发明涉及用于将RNA递送至细胞的多层纳米颗粒及其制造和使用方法。多层纳米颗粒具有由交替的正电荷和负电荷聚合物层交替涂覆的核心纳米颗粒，其中所述至少一个带负电荷的聚合物层是RNA。

6. 发明公开

EP3083765A4 METHOD OF SYNTHESIS OF SILICA VESICLES AND USE THEREOF 审中-公开
标题翻译： VERFAHREN ZUR SYNTHESE VON SILICA-VESIKELN UND VERWENDUNG DAVON
公开(公告)号：EP3083765A4
公开(公告)日：2017-07-05
申请号：EP14871778
申请日：2014-12-19
申请人： UNIV QUEENSLAND
发明人： YU CHENGZHONG , MITTER NEENA , ZHANG JUN
IPC分类号： C08G77/22 , A61K9/00 , A61K9/14 , A61K9/32 , A61K9/50 , A61K9/51 , A61K9/52 , A61K47/00 , A61K47/02 , A61K47/30 , A61K47/32 , A61K47/34 , B82Y30/00 , B82Y40/00 , C01B13/14 , C01B13/16 , C01B13/36 , C01B33/00 , C08K3/34 , C08K3/36
CPC分类号： A61K9/5031 , A61K9/501 , A61K9/5115 , A61K9/5146 , A61K39/12 , A61K39/39 , A61K2039/55505 , B82Y30/00 , B82Y40/00 , C01B33/18 , C01P2004/64 , C01P2006/16 , C12N2770/24034
摘要： The invention relates, in part, to a method of producing silica vesicles including under controlled conditions to thereby heavily influence the morphology and characteristics of the vesicles. The vesicles are shown to be effective as delivery agents for chemical and biological agents. They are also shown to be useful in methods of treatment and as components of an immunogenic composition.
摘要翻译：本发明部分涉及包括在受控条件下生产二氧化硅囊泡的方法，从而严重影响囊泡的形态和特征。显示囊泡作为化学和生物制剂的递送剂是有效的。它们也被证明可用于治疗方法和作为免疫原性组合物的组分。

7. 发明公开

EP3046870A4 SILICA MICRO- AND NANO-CAPSULES AND METHODS FOR MAKING THEM 有权
标题翻译： KIESELSÄURE-MIKRO- UND --ANOKAPSELN SOWIE VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP3046870A4
公开(公告)日：2017-04-26
申请号：EP14843901
申请日：2014-09-16
申请人： UNIV QUEENSLAND
发明人： MIDDELBERG ANTON PETER JACOB , ZHAO CHUN-XIA , WIBOWO DAVID , PETERS BRENTON CHARLES
IPC分类号： B82Y5/00 , A61K9/107 , A61K9/50 , A61K9/51 , A61K38/16 , B01F3/08 , B01F17/30 , C07K14/00
CPC分类号： B01J13/06 , A01N25/28 , A01N25/30 , A01N43/56 , A61K9/1075 , A61K9/501 , A61K9/5031 , A61K9/5052 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5169 , A61K38/16 , B01F17/005 , B82Y5/00 , C07K7/06 , C07K14/00 , C07K14/001

8. 发明公开

EP3125858A1 COMPOSITIONS AND METHODS FOR ENHANCING THE TOPICAL APPLICATION OF AN ACIDIC BENEFIT AGENT 有权转让
标题翻译：组合物和方法，以改善局部使用酸性的有益物质
公开(公告)号：EP3125858A1
公开(公告)日：2017-02-08
申请号：EP15712736.6
申请日：2015-03-10
申请人： JOHNSON & JOHNSON CONSUMER INC.
发明人： SUN, Ying , WU, Jeffrey M. , FASSIH, Ali
IPC分类号： A61K8/25 , A61K8/34 , A61K8/36 , A61Q7/00 , A61K8/02 , A61K31/00 , A61K8/11
CPC分类号： A61K9/501 , A61K8/022 , A61K8/11 , A61K8/25 , A61K8/345 , A61K8/36 , A61K8/4953 , A61K9/0014 , A61K31/192 , A61K31/196 , A61K31/40 , A61K31/405 , A61K31/60 , A61K31/616 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22 , A61K2800/41 , A61K2800/652 , A61Q7/00
摘要： A powder is disclosed including core/shell particles having an average particle size of less than 1000 microns, each particle contains a liquid core that is substantially free of water and includes A) a polar liquid having a percent surface polarity of at least 24%, an active ingredient, and C) from about 0.1% to about 20% by weight of at least one solubility enhancing agent that is not an active ingredient; and a shell comprising hydrophobic particles. The powder can be used to topically administer the active ingredient to a human or animal.
摘要翻译：甲粉末盘游离缺失包括具有上小于1000微米的平均粒径的核/壳颗粒，每个颗粒包含一个液体芯所做的是基本上不含水，并且包括A）具有至少24％的百分表面极性的极性液体成分活性，和C）约0.1％至约20％（重量）的至少一种增溶剂没有不上的活性成分; 和壳包含疏水性颗粒。该粉末可用于局部给药的活性成分到人类或动物。

9. 发明公开

EP3071233A1 COMPOSITIONS FOR OBTAINING AN IMPROVED LUNG FUNCTION COMPRISING ACTIVATED CARBON COMPRISING ADSORBED IODINE AND/OR AN ADSORBED IODIDE SALT AND A SODIUM/IODIDE SYMPORTER INHIBITOR. 失效
标题翻译： COMPOSITIONS FOR GENERATING改进肺功能与碘吸附和/或吸附的碘化物和钠/ JODID同向转运体抑制剂活性炭
公开(公告)号：EP3071233A1
公开(公告)日：2016-09-28
申请号：EP14802021.7
申请日：2014-11-20
申请人： Pharmalundensis AB
发明人： SKOGVALL, Staffan
IPC分类号： A61K45/06 , A61K33/00 , A61K33/18 , A61K33/44 , A61P11/00
CPC分类号： A61K33/20 , A61K9/0053 , A61K9/501 , A61K33/00 , A61K33/18 , A61K33/44 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition for obtaining an improved lung function in a human or an animal lung affected by airway obstruction such as COPD or asthma, is provided. The composition comprises a pharmacologically effective amount of activated carbon comprising adsorbed iodine and/or an adsorbed iodide salt and a sodium/iodide symporter inhibitor, such as perchlorate. Additionally, a method for obtaining an improved lung function in a human or animal lung affected by airway obstruction, such as COPD or asthma, is provided. The method comprises the steps of administering a pharmacologically effective amount of activated carbon comprising adsorbed iodine and/or an adsorbed iodide salt, and administering a sodium/iodide symporter inhibitor, such as perchlorate, in connection to the administration of the pharmacologically effective amount of activated carbon comprising adsorbed iodine and/or an adsorbed iodide salt.

10. 发明公开

EP3038611A1 NOVEL 2,4-DINITROPHENOL FORMULATIONS AND METHODS USING SAME 有权转让
标题翻译：新的2,4-二硝基酚制剂和方法
公开(公告)号：EP3038611A1
公开(公告)日：2016-07-06
申请号：EP14839060.2
申请日：2014-08-29
申请人： Yale University
发明人： SHULMAN, Gerald I. , PERRY, Rachel Jamison
IPC分类号： A61K31/06 , A61P1/16 , A61K9/22
CPC分类号： A61K31/06 , A61K9/0053 , A61K9/501 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K45/06
摘要： The present invention includes a low dose and sustained release formulation of 2,4-dinitrophenol (DNP). The compositions of the invention are useful for preventing or treating a disease or disorder, such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, insulin resistance and/or diabetes, in a subject in need thereof.

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