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1. 发明公开

EP2292579A1 PROCESS FOR PRODUCTION OF HALOGENATED -FLUOROETHERS 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG HALOGENIERTER ALPHA-FLUORETHER
公开(公告)号：EP2292579A1
公开(公告)日：2011-03-09
申请号：EP09754571.9
申请日：2009-05-14
申请人： Central Glass Company, Limited
发明人： ISHII, Akihiro , YASUMOTO, Manabu
IPC分类号： C07C41/22 , C07C43/12 , C07C43/17 , C07C67/307 , C07C69/708
CPC分类号： C07C41/22 , C07C67/307 , C07C43/12 , C07C43/17 , C07C69/708
摘要： Halogenated α-fluoroethers (or bis-derivatives thereof) can be produced by reacting a halogenated hemiacetal (or bis-derivative thereof) with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base. The reaction is conducted preferably in the presence of "a salt or complex of an organic base with hydrogen fluoride", whereby the objective dehydroxyfluorination can proceed extremely favorably. It is still preferable to use as the starting substrate a halogenated hemiacetal prepared from fluoral or 3,3,3-trifluoropyruvic acid ester. Thus, industrially important halogenated α-fluoroethers can be industrially produced with high selectivity and in high yield.
摘要翻译：卤化的± - 氟醚（或其双衍生物）可以通过在有机碱的存在下使卤代半缩醛（或其双衍生物）与硫酰氟（SO 2 F 2）反应来制备。反应优选在“有机碱与氟化氢的盐或络合物”的存在下进行，从而目标脱羟基氟化可以非常有利地进行。使用由氟或3,3,3-三氟丙酮酸酯制备的卤化半缩醛作为起始底物更为优选。因此，工业上重要的卤代± - 氟醚可以以高选择性和高产率工业生产。

2. 发明公开

EP1721887A1 OPTICALLY ACTIVE 1-ARYL-2-FLUORO-SUBSTITUTED ETHYLAMINE AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译： OPTISCH AKTIVES 1-ARYL-2-FLUORSUBSTITUIERTES ETHYLAMIN UND VERFAHREN ZU DESSEN HERSTELLUNG
公开(公告)号：EP1721887A1
公开(公告)日：2006-11-15
申请号：EP05719359.1
申请日：2005-02-21
申请人： CENTRAL GLASS COMPANY, LIMITED
发明人： ISHII, Akihiro , KANAI, Masatomi , KURIYAMA, Yokusu , YASUMOTO, Manabu , INOMIYA, Kenjin , OOTSUKA, Takashi , SUTO, Katsuhide , UEDA, Koji
IPC分类号： C07C209/62 , C07C209/52 , C07C211/29 , C07C249/02 , C07C251/24 , C07B61/00
CPC分类号： C07C251/24 , C07C209/52 , C07C209/62 , C07C211/29 , C07C249/02
摘要： The present invention relates to a method of producing an optically active 1-aryl-2-fluoro-substituted ethylamine compound of the formula [2] or a salt thereof by hydrogenolysis of an optically active secondary amine compound of the formula [1] or a salt thereof in the presence of a transition metal catalyst of Group VIII

[where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon]

[where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon].
摘要翻译：本发明涉及式[2]的光学活性1-芳基-2-氟取代乙胺化合物或其盐的制备方法，其通过将式[1]的光学活性仲胺化合物或的盐，其中第VIII族的过渡金属催化剂[其中Ar表示芳基; n表示1或2的整数; 和*表示不对称碳] [其中Ar表示芳基; n表示1或2的整数; 和*表示不对称碳]。

3. 发明授权

EP2292579B1 PROCESS FOR PRODUCTION OF HALOGENATED ALPHA-FLUOROETHERS 有权
标题翻译：用于生产卤化ALPHA-氟醚
公开(公告)号：EP2292579B1
公开(公告)日：2017-01-25
申请号：EP09754571.9
申请日：2009-05-14
申请人： Central Glass Company, Limited
发明人： ISHII, Akihiro , YASUMOTO, Manabu
IPC分类号： C07C41/22 , C07C43/12 , C07C43/17 , C07C67/307 , C07C69/708
CPC分类号： C07C41/22 , C07C67/307 , C07C43/12 , C07C43/17 , C07C69/708

4. 发明公开

EP2727905A1 PROCESS FOR PRODUCING FLUOROSULFURIC ACID AROMATIC-RING ESTERS 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG AROMATISCHER RINGESTER AUSFLUORSCHWEFELSÄURE
公开(公告)号：EP2727905A1
公开(公告)日：2014-05-07
申请号：EP12804675.2
申请日：2012-06-15
申请人： CENTRAL GLASS COMPANY, LIMITED
发明人： ISHII, Akihiro , ISHIMARU, Takehisa , YAMAZAKI, Takako , YASUMOTO, Manabu
IPC分类号： C07C303/24 , C07C305/26
CPC分类号： C07C303/24 , C07C305/26
摘要： A production process of a fluorosulfuric acid aromatic-ring ester according to the present invention includes reaction of an aromatic-ring hydroxyl compound with sulfuryl fluoride (SO 2 F 2 ) in the presence of a tertiary amine except pyridine and methylpyridine. The sulfuryl fluoride, used as the reactant in the production process according to the present invention, is widely adapted as a fumigant and is easily available on a large scale. Further, the target compound can be obtained rapidly with a high yield under moderate reaction conditions in the production process according to the present invention. In this way, all of the prior art problems can be solved in the production process according to the present invention. The production process according to the present invention is thus particularly useful for industrial production of the fluorosulfuric acid aromatic-ring ester.
摘要翻译：根据本发明的氟代硫酸芳环酯的制备方法包括在除了吡啶和甲基吡啶之外的叔胺存在下，芳环羟基化合物与硫酰氟（SO 2 F 2）的反应。在根据本发明的生产方法中用作反应物的硫酰氟被广泛地用作熏蒸剂，并且容易获得大量。此外，在本发明的制备方法中，在中等反应条件下，可以快速获得目标化合物。以这种方式，可以在根据本发明的制造方法中解决所有现有技术问题。因此，根据本发明的制备方法对于工业生产氟代硫酸芳环酯特别有用。

5. 发明授权

EP2383252B1 METHOD FOR MANUFACTURING HYDROXYL GROUP SUBSTITUTION PRODUCT 有权
标题翻译：制备羟基取代产物的方法
公开(公告)号：EP2383252B1
公开(公告)日：2014-06-25
申请号：EP09833432.9
申请日：2009-12-15
申请人： Central Glass Company, Limited
发明人： ISHII, Akihiro , YASUMOTO, Manabu , UEDA, Koji
IPC分类号： C07C67/307 , C07C69/63 , C07D207/16 , C07C67/31
CPC分类号： C07D207/16 , C07C67/307 , C07C67/31 , C07C69/63 , C07C69/68

6. 发明授权

EP1642884B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE 1-ALKYL-SUBSTITUTED 2,2,2-TRIFLUOROETHYLAMINE 有权
标题翻译：工艺制备光学活性1-烷基取代的2,2,2- TRIFLUORETHYLAMINS
公开(公告)号：EP1642884B1
公开(公告)日：2010-12-15
申请号：EP04745665.2
申请日：2004-06-08
申请人： CENTRAL GLASS COMPANY, LIMITED
发明人： ISHII, Akihiro , KURIYAMA, Yokusu , YASUMOTO, Manabu , KANAI, Masatomi , INOMIYA, Kenjin , OOTSUKA, Takashi , UEDA, Koji
IPC分类号： C07C209/52 , C07C209/62 , C07C211/15 , C07B53/00 , C07B61/00
CPC分类号： C07C209/62 , C07B2200/07 , C07C209/52 , C07C211/15 , C07C249/02 , C07C251/08
摘要： A process for producing an optically active, 1-alkyl-substituted 2,2,2-trifluoroethylamine represented by the formula [3] (wherein R represents C1-6 alkyl and * indicates asymmetric carbon) or a salt of the compound. These compounds are important intermediates for medicines and agricultural chemicals. The process comprises asymmetrically reducing an optically active imine represented by the formula [1] with the aid of a catalyst comprising a Group VIII metal in a hydrogen atmosphere to convert it to an optically active secondary amine represented by the formula [2] and subjecting the secondary amine or a salt thereof to hydrogenolysis to produce the target compound.

7. 发明公开

EP1935866A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE FLUOROBENZYL ALCOHOL 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEM FLUORBENZYLALKOHOL
公开(公告)号：EP1935866A1
公开(公告)日：2008-06-25
申请号：EP06811202.8
申请日：2006-10-04
申请人： CENTRAL GLASS COMPANY, LIMITED
发明人： ISHII, Akihiro , UEDA, Koji , YASUMOTO, Manabu
IPC分类号： C07C29/09 , C07C33/46 , C07C67/08 , C07C69/80 , C07B57/00
CPC分类号： C07C29/095 , C07B57/00 , C07B2200/07 , C07C67/08 , C07C67/60 , C07C33/40 , C07C33/22 , C07C69/80
摘要： A fluorine-containing benzaldehyde is reacted with an alkyl Grignard reagent to convert it to a magnesium alkoxide of racemic, fluorine-containing, benzyl alcohol, and subsequently the magnesium alkoxide is reacted with phthalic anhydride to obtain a phthalate half ester of racemic, fluorine-containing, benzyl alcohol, and the half ester is optically resolved by optically active 1-phenylethylamine, and then the ester group is hydrolyzed, thereby producing an optically active, fluorine-containing, benzyl alcohol.
摘要翻译：将含氟苯甲醛与烷基格氏试剂反应，将其转化成外消旋，含氟苄基醇的烷氧基镁，随后将醇盐与邻苯二甲酸酐反应，得到外消旋，通过光学活性1-苯基乙胺光学拆分半酯，然后将酯基水解，从而制备光学活性的含氟苄基醇。

8. 发明授权

EP1935866B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE FLUOROBENZYL ALCOHOL 有权
标题翻译：工艺生产光学活性氟苄醇
公开(公告)号：EP1935866B1
公开(公告)日：2011-12-14
申请号：EP06811202.8
申请日：2006-10-04
申请人： CENTRAL GLASS COMPANY, LIMITED
发明人： ISHII, Akihiro , UEDA, Koji , YASUMOTO, Manabu
IPC分类号： C07C29/09 , C07C33/46 , C07C67/08 , C07C69/80 , C07B57/00
CPC分类号： C07C29/095 , C07B57/00 , C07B2200/07 , C07C67/08 , C07C67/60 , C07C33/40 , C07C33/22 , C07C69/80
摘要： A fluorobenzaldehyde is reacted with an alkyl Grignard reagent to convert them into a magnesium alkoxide of a racemic fluorobenzyl alcohol. Subsequently, the magnesium alkoxide is reacted with phthalic anhydride to obtain a half ester of phthalic acid with the racemic fluorobenzyl alcohol. The half ester is optically resolved with optically active 1-phenylethylamine. Thereafter, the ester group is hydrolyzed. Thus, an optically active fluorobenzyl alcohol is produced.

9. 发明公开

EP2383252A1 METHOD FOR MANUFACTURING HYDROXYL GROUP SUBSTITUTION PRODUCT 有权
标题翻译：制备羟基取代产物的方法
公开(公告)号：EP2383252A1
公开(公告)日：2011-11-02
申请号：EP09833432.9
申请日：2009-12-15
申请人： Central Glass Company, Limited
发明人： ISHII, Akihiro , YASUMOTO, Manabu , UEDA, Koji
IPC分类号： C07C67/307 , C07C69/63 , C07D207/16
CPC分类号： C07D207/16 , C07C67/307 , C07C67/31 , C07C69/63 , C07C69/68
摘要： In the present invention, a hydroxyl group substitution product is manufactured by reaction of an alcohol with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base and a nucleophile (X - ). The present invention is thus effective as an industrial manufacturing method that uses a relatively cheap reagent suitable for large-scale applications and can be accomplished in a simple process with easy purification operation and less waste generation and is suitably applicable for manufacturing of optically active hydroxyl group substitution products, notably optically active α-hydroxyl group substitution ester and optically active 4-hydroxyl group substitution proline. The manufacturing method of the present invention solves all of the prior art problems and can be applied for industrial uses.
摘要翻译：在本发明中，通过醇与硫酰氟（SO 2 F 2）在有机碱和亲核试剂（X-）存在下反应来制备羟基取代产物。因此，本发明作为使用适于大规模应用的相对便宜的试剂的工业制造方法是有效的，并且可以通过简单的方法实现，易于纯化操作和较少的废物产生，并且适用于制备光学活性羟基取代产物，特别是光学活性的α-羟基取代酯和光学活性的4-羟基取代脯氨酸。本发明的制造方法解决了所有现有技术问题，并且可以应用于工业用途。

10. 发明公开

EP2216337A1 METHOD FOR PRODUCING 4-DEOXY-4-FLUORO-D-GLUCOSE DERIVATIVE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES 4-DESOXY-4-FLOR-D-GLUCOSE-DERIVATS
公开(公告)号：EP2216337A1
公开(公告)日：2010-08-11
申请号：EP08858948.6
申请日：2008-11-26
申请人： Central Glass Company, Limited
发明人： ISHII, Akihiro , YASUMOTO, Manabu , OOTSUKA, Takashi , NIGORIKAWA, Yasuko
IPC分类号： C07H15/04 , C07H1/00 , C07H5/02
CPC分类号： C07H1/00 , C07H5/02 , C07H15/04
摘要： There is disclosed a method for producing a 4-deoxy-4-fluoro-D-glucose derivative by reacting a D-galactose derivative with either sulfuryl fluoride (SO 2 F 2 ), trifluoromethanesulfonyl fluoride (CF 3 SO 2 F) or perfluorobutanesulfonyl fluoride (C 4 F 9 SO 2 F) in the presence of an organic base or in the presence of an organic base and a salt or complex of an organic base and hydrogen fluoride.
摘要翻译：公开了通过使D-半乳糖衍生物与硫酰氟（SO 2 F 2），三氟甲磺酰氟（CF 3 SO 2 F）或全氟丁磺酰氟反应生成4-脱氧-4-氟-D-葡萄糖衍生物的方法（C 4 F 9 SO 2 F）在有机碱的存在下或在有机碱和有机碱和氟化氢的盐或络合物的存在下反应。

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