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1. 发明公开

EP1563089A2 SOLID PHASE BASED NUCLEIC ACID ASSAYS COMBINING HIGH AFFINITY AND HIGH SPECIFICITY 审中-公开
标题翻译：固相基于核酸分析具有高亲和力和特异性
公开(公告)号：EP1563089A2
公开(公告)日：2005-08-17
申请号：EP03749248.5
申请日：2003-08-29
申请人： Bayer Healthcare LLC , Bayer Technology Services GmbH
发明人： WARNER, Brian , QUINN, Jack , BURMEISTER, Jens , DORN, Ingmar , DIESSEL, Edgar
IPC分类号： C12Q1/68 , C12P19/34 , C12M1/34 , C07H21/02 , C07H21/04 , C07H19/00
CPC分类号： C12Q1/6837 , C12Q1/6827 , C12Q1/6834 , C12Q2565/543 , C12Q2561/125 , C12Q2537/143 , C12Q2535/125 , C12Q2565/537 , C12Q2565/519 , C12Q2535/131 , C12Q2525/186
摘要： The invention relates to methods for detection of nucleic acids on a solid phase, combining high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization with highly specific enzymatic discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays.

2. 发明公开

EP2411530A2 SOLID PHASE BASED NUCLEIC ACID ASSAYS COMBINING HIGH AFFINITY CAPTURING AND DETECTION BY SPECIFIC HYBRIDIZATION 审中-公开
标题翻译：核酸测试程序上捕捉高亲和力的结合和证明特异性杂交固相BASE
公开(公告)号：EP2411530A2
公开(公告)日：2012-02-01
申请号：EP07759429.9
申请日：2007-03-27
申请人： Bayer Technology Services GmbH
发明人： BURMEISTER, Jens , DORN, Ingmar , WARNER, Brian
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6827 , C12Q2539/101 , C12Q2537/161 , C12Q2535/131
摘要： This invention relates to methods for detection of nucleic acids on a solid phase with high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization-based capturing with highly specific hybridization-based discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays. The detection of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) is of importance in human or veterinary diagnostics, food control, environmental analysis, crop protection, biochemical/pharmacological research, or forensic medicine.

3. 发明公开

EP1671250A2 VERFAHREN ZUR BESTIMMUNG EINER WIRKSTOFFDOSIERUNG 审中-公开
标题翻译：方法确定活性剂量
公开(公告)号：EP1671250A2
公开(公告)日：2006-06-21
申请号：EP04765437.1
申请日：2004-09-21
申请人： Bayer Technology Services GmbH
发明人： SCHMITT, Walter , WILLMANN, Stefan , DIEßEL, Edgar , DORN, Ingmar , BURMEISTER, Jens
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , G06Q50/24
摘要： The invention relates to a method for determining the dosage of at least one active ingredient based on a genetic analysis. The method comprises the following steps: a) analysis (101) of specific genetic sequences, using a genetic sequence-specific analysis device, in particular a sequence-specific sensor, or determination of the expression of proteins, either by RNA transcription using quantitative RNA-specific identification methods or by the direct measurement of the protein expression by a protein analysis device; b) assignment of the genetic sequences to physiological functions of the human or animal body, in particular to those physiological functions that influence the decomposition, absorption, release or distribution behaviour of the active ingredient in the body; c) transmission of the genetic and assignment data to a physiology-based pharmacokinetic model (PBPK model) (108); d) input of active ingredient-specific data into the PBPK model (108); e) input of characteristic patient data, optionally from direct measurements on the body; f) calculation of physiological influence parameters that are required for the PBPK model from the patient data, using information contained in the knowledge database and transmission of said parameters to the PBPK model (108); g) calculation of the individual dose from the data in steps c), d) and f), using the PBPK model (108).

4. 发明公开

EP1966594A1 VORRICHTUNG UND VERFAHREN ZUM NACHWEIS VON MYKOTOXINEN 有权
标题翻译：设备和检测方法的霉菌毒素
公开(公告)号：EP1966594A1
公开(公告)日：2008-09-10
申请号：EP06829574.0
申请日：2006-12-13
申请人： Bayer Technology Services GmbH , Bayer CropScience Aktiengesellschaft
发明人： BURMEISTER, Jens , DORN, Ingmar , RABE, Uwe , HÄUSER-HAHN, Isolde
IPC分类号： G01N21/77 , G01N33/543 , G01N33/569
CPC分类号： G01N21/7703 , G01N21/6428 , G01N21/648 , G01N33/54373 , G01N2021/7786 , G01N2333/37
摘要： The invention relates to a device and a method for identifying mycotoxins and to kits which are suitable for carrying out said method.

5. 发明授权

EP1831246B1 SONDE ZUM NACHWEIS VON NUKLEINSÄUREN 有权
标题翻译： SONDE ZUM NACHWEIS VONNUKLEINSÄUREN
公开(公告)号：EP1831246B1
公开(公告)日：2008-05-07
申请号：EP05818326.0
申请日：2005-12-13
申请人： Bayer Technology Services GmbH
发明人： BURMEISTER, Jens , SEITZ, Oliver , KÖHLER, Olaf , RÖGLIN, Lars
IPC分类号： C07K14/00 , G01N33/68
CPC分类号： A61K49/0056 , A61K49/0021 , A61K49/0054 , C07K1/13 , C07K14/003 , C12Q1/682 , C12Q2525/117 , C12Q2525/107 , C12Q2565/107 , C12Q2525/307
摘要： The invention relates to a probe for detecting nucleic acids, to a method for producing the probe, methods for carrying out analytical reactions and test kits containing the reagents that are required for carrying out the probe-based analytical reaction.
摘要翻译：本发明涉及用于检测核酸的探针，用于生产该探针的方法，用于进行分析反应的方法以及包含进行基于探针的分析反应所需的试剂的检测试剂盒。

6. 发明公开

EP1831246A2 SONDE ZUM NACHWEIS VON NUKLEINSÄUREN 有权
标题翻译： PROBE FOR检测的NUCLEIC
公开(公告)号：EP1831246A2
公开(公告)日：2007-09-12
申请号：EP05818326.0
申请日：2005-12-13
申请人： Bayer Technology Services GmbH
发明人： BURMEISTER, Jens , SEITZ, Oliver , KÖHLER, Olaf , RÖGLIN, Lars
IPC分类号： C07K14/00 , G01N33/68
CPC分类号： A61K49/0056 , A61K49/0021 , A61K49/0054 , C07K1/13 , C07K14/003 , C12Q1/682 , C12Q2525/117 , C12Q2525/107 , C12Q2565/107 , C12Q2525/307
摘要： The invention relates to a probe for detecting nucleic acids, to a method for producing the probe, methods for carrying out analytical reactions and test kits containing the reagents that are required for carrying out the probe-based analytical reaction.

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