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    • 1. 发明公开
    • VERFAHREN UND VORRICHTUNGEN ZUR VESIKELBILDUNG, INSBESONDERE UNTER VERWENDUNG VON BLOCK-COPOLYMEREN
    • 法及囊泡设备,特别是使用嵌段共聚物
    • EP2555863A2
    • 2013-02-13
    • EP11712554.2
    • 2011-04-06
    • Bühler AG
    • BOHM, ArturoLISNER, JochenBRAUN, JörgENGEL, Helen AliciaWINDHAB, Erich JosefMEIER, Wolfgang
    • B01J13/04A61K8/11A61K9/50C09B67/00
    • B01J13/04A61K9/1273A61K9/1277A61K2800/412C09B67/0097
    • Producing vesicles comprises (a) providing a first fluid (1), which contains at least an amphiphilic substance, (b) passing the first fluid by at least a pore of a first side of a porous material, preferably a membrane (78) to a second side of the porous material, (c) forming at least a drop from the first fluid at the second side of the porous material, and (d) forming at least a vesicle by separation, preferably shearing the drop by passing a second fluid (2) at the second side of the porous material. Producing vesicles comprises (a) providing a first fluid (1), which contains at least an amphiphilic substance, (b) passing the first fluid by at least a pore of a first side of a porous material, preferably a membrane (78) to a second side of the porous material, (c) forming at least a drop from the first fluid at the second side of the porous material, and (d) forming at least a vesicle by separation, preferably shearing the drop by passing a second fluid (2) at the second side of the porous material, where the chemical composition of the second fluid is different from the chemical composition the first fluid. Independent claims are included for: (1) a composition comprising a carrier fluid and the vesicle, where the chemical composition of the vesicle is different from the chemical composition of the carrier fluid, preferably the vesicles contain at least an ingredient in a first concentration and the carrier fluid contains the ingredient in a second concentration, which is different from the first concentration, preferably less than the first concentration, more preferably less than 80% (preferably less than 30%) of the first concentration, where the pH values in the inner areas of the vesicle and in the carrier fluid are substantially equal; and (2) a device for producing the vesicles or the composition comprising the porous material, preferably a membrane and/or a receptacle for the porous material comprising the first and second side and at least a pore, which extends from the first side to the second side, a first fluid chamber to supply the first fluid at the first side of the porous material, and a second fluid chamber for passing the second fluid at the second side of the porous material, where at least a dimension of the second fluid chamber is adjusted by a movement of at least a surface limiting the second fluid chamber relative to the second side, preferably at least a dimension of the second fluid chamber in the area of the second side and substantially perpendicular to the second side, preferably the width of a gap of the second fluid chamber in the area of the second side, and a means for pressurizing the first fluid and/or the second fluid and/or the porous material with mechanical vibrations and/or waves, contain a tube resonator, a piezoelectric film, an unbalanced producer and/or an electromagnet. - ACTIVITY : Cardiovascular-Gen.; Osteopathic; Gastrointestinal-Gen. - MECHANISM OF ACTION : None given.
    • 制备囊泡包括:(a)提供至少包含两亲性物质的第一流体(1),(B)由至少一种多孔材料的第一侧上的孔,优选的膜(78)使所述第一流体 所述多孔材料的至少形成在所述多孔材料的第二侧上的与所述第一流体滴和第二侧,(C)(d)形成至少由分离的囊泡,优选通过使第二流体剪切降 (2)在所述多孔材料的第二侧上。 制备囊泡包括:(a)提供至少包含两亲性物质的第一流体(1),(B)由至少一种多孔材料的第一侧上的孔,优选的膜(78)使所述第一流体 所述多孔材料的至少形成在所述多孔材料的第二侧上的与所述第一流体滴和第二侧,(C)(d)形成至少由分离的囊泡,优选通过使第二流体剪切降 (2)在该多孔材料,其中所述第二流体的化学组成是由化学组成与第一流体不同的第二侧。 独立权利要求中包括了:(1),其包括载液和囊泡,其中所述囊泡的化学组成是从载体流体的化学组成不同的组合物,优选所述囊泡至少在成分包含在第一浓度和 载体流体含有第二浓度的成分,所有这些是从所述第一浓度,优选大于所述第一浓度,更优选地,第一浓度小于80%(优选小于30%),小于不同,其中在所述的pH值 在载体液中的囊泡和内面积基本上相等; 和(2)用于制备囊泡或包含多孔材料的组合物,优选的膜和/或用于所述多孔材料,其包含第一和第二侧上的插座和至少一个孔,其从第一侧延伸到所述的装置 第二侧,第一流体室以在所述多孔材料的第一侧提供第一流体,和用于使所述第二流体在所述多孔材料的第二侧上,其中至少所述第二流体室的尺寸的第二流体腔室 由至少一个表面上的第二流体相对于所述第二侧上的腔室的限制的运动,优选地至少一个在所述第二侧面的所述区域中的第二流体腔室的尺寸,并且基本上垂直于所述第二侧,优选宽度调整 在第二侧部的区域中的第二流体室的间隙,并且用于加压所述第一流体和/或所述第二流体和/或机械振动和/或声波,共多孔材料的装置 ntain的管谐振器,压电薄膜不平衡生产者和/或电磁体的。 活动:心血管基因。 骨科; 胃肠基因。 作用机理:没有给出。