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1. 发明公开

EP1861343A2 VERFAHREN ZUR HERSTELLUNG VON ALKYLSUBSTITUIERTEN AROMATEN UND HETEROAROMATEN DURCH KREUZKUPPLUNG VON ALKYLBORONSÄUREN MIT ARYL- ODER HETEROARYLHALOGENIDEN ODER -SULFONATEN UNTER PD-KATALYSE IN GEGENWART EINES LIGANDEN 有权
标题翻译：生产由与芳基烷基硼酸或杂芳基或磺酸盐交叉耦合烷基取代的芳族化合物和杂芳族化合物UNDER PD CATALYSIS在配体的存在下
公开(公告)号：EP1861343A2
公开(公告)日：2007-12-05
申请号：EP06723260.3
申请日：2006-03-07
申请人： Archimica GmbH
发明人： SCHERER, Stefan , MEUDT, Andreas , NERDINGER, Sven , LEHNEMANN, Bernd , JAGUSCH, Thomas , SNIECKUS, Victor
IPC分类号： C07B37/04 , C07C17/26 , C07C67/30 , C07C25/13 , C07C69/76 , C07F5/02
CPC分类号： C07C1/321 , C07B37/04 , C07C17/263 , C07C67/343 , C07C2531/24 , C07D213/30 , C07C15/02 , C07C22/08 , C07C69/76
摘要： The invention relates to a method for producing alkyl-substituted aromatic and heteroaromatic compounds (III) by cross-coupling alkyl boronic acids (II) with aryl- or heteroaryl-halogenides or with aryl- or heteroaryl-sulfonates (I) in the presence of a catalyst and of a Brønsted base in a solvent or solvent mixture, in which: Hal represents chlorine, bromine, iodine, trifluoromethanesulfonate, nonafluorotrimethyl methane sulfonate, methane sulfonate, 4-toluolsulfonate, benzene sulfonate, 2- naphthalene sulfonate, 3-nitrobenzene sulfonate, 4-nitrobenzene sulfonate, 4-chlorobenzene sulfonate or 2,4,6-triisopropylbenzene sulfonate; X1-5, independent of one another, represent carbon, XiRi represents nitrogen, or each two adjacent XiRi's bound via a formal double bond represent, together, O (furane), S (thiophene), NH or NRi (pyrrole); radicals R1-5 represent substituents from the group consisting of {hydrogen, methyl, primary, secondary or tertiary, cyclic or acyclic alkyl radicals having 2 to 20 C atoms, in which optionally one or more hydrogen atoms are substituted by fluoride or chlorine or bromine, e.g. CF3, substituted cyclic or acyclic alkyl groups, hydroxy, alkoxy, amino, alkylamino, dialkylamino, arylamino, diarylamino, alkylarylamino, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, thio, alkylthio, arylthio, diarylphosphino, dialkylphosphino, alkylarylphosphino, optionally substituted aminocarbonyl, CO2-, alkyl- or aryloxycarbonyl, hydroxyalkyl, alkoxyalkyl, fluorine or chlorine, nitro, cyano, aryl- or alkylsulfone, aryl- or alkylsulfonyl} or each two adjacent radicals R1-5 represent, together, an aromatic, heteroaromatic or aliphatic fused ring; alkyl represents any linear, branched or cyclic alkyl radical having 1 to 40 C atoms, in which optionally one or more hydrogen atoms are substituted by foreign atoms or functions of the group {fluorine, optionally chlorine or bromine, hydroxy, alkoxy, amino, alkylamino, dialkylamino, arylamino, diarylamino, alkylarylamino, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, thio, alkylthio, arylthio, diarylphosphino, dialkylphosphino, alkylarylphosphino, optionally substituted aminocarbonyl, CO2-, alkyl- or aryloxycarbonyl, hydroxyalkyl, alkoxyalkyl, flourine or chlorine, nitro, cyano, aryl- or alkylsulfone}, R' and R'', independent of one another, represent the same or different radicals from the group consisting of {hydrogen, methyl, linear, branched or cyclic alkyl, optionally substituted, and phenyl, optionally substituted} or, together, form a ring and represent a bridging structure element from the group consisting of {optionally substituted alkylene, branched alkylene, cyclic alkylene or optionally substituted azaalkylene}.

2. 发明授权

EP1713763B1 VERFAHREN ZUR HERSTELLUNG VON NITRILEN UND ISONITRILEN DURCH DEHYDRATISIERUNGSREAKTIONEN MIT PROPANPHOSPHONSAEUREANHYDRIDEN 有权转让
标题翻译：用于生产和腈异腈涉及脱水与PROPANPHOSPHONSAEUREANHYDRIDEN
公开(公告)号：EP1713763B1
公开(公告)日：2011-05-18
申请号：EP05700951.6
申请日：2005-01-15
申请人： Archimica GmbH
发明人： MEUDT, Andreas , SCHERER, Stefan , NERDINGER, Sven
IPC分类号： C07C253/20 , C07C253/22 , C07C291/10 , C07C255/50
CPC分类号： C07C253/20 , C07C253/22 , C07C291/10 , C07C255/50
摘要： The invention concerns a method for producing: a) nitriles of formula (II) and; b) isonitriles of formula (III) by reacting: a) carboxylic acid amides (RCO-NH2), ammonium salts of carboxylic acids (RCOO-NH4+) or carboxylic acids in the presence of ammonia or ammonium salts (RCOOH +NH3, RCOOH + NH4+) or; b) formamides (H-CO-NHR) or mixtures of amines with formic acid, with cyclic phosphonic acid anhydrides while eliminating water at a temperature ranging from -30 to +120 °C, in which R represents an arbitrarily substituted linear or branched C1-C8 alkyl radical, a C3-C10 cycloalkyl radical, alkenyl radical, alkynyl radical or an aryl radical or heteroaryl radical. As a cyclic phosphonic acid anhydride, a 2,4,6,-substituted 1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide of formula (I) is used, in which: x = 3, 4 or 5; R', independent of one another, represents open-chain or branched, saturated or unsaturated, straight-chain C1 to C16 alkyl radicals or cyclic C3 to C16 alkyl radicals or aryl or heteroaryl.

3. 发明授权

EP1763506B1 VERFAHREN ZUR HERSTELLUNG VON NITRILEN DURCH ELIMINIERUNG VON WASSER AUS ALDEHYDOXIMEN MIT ALKYLPHOSPHONSÄUREANHYDRIDEN 有权转让
标题翻译：用于生产NITRILES通过排除水从ALDEHYDOXIMEN与膦
公开(公告)号：EP1763506B1
公开(公告)日：2008-10-15
申请号：EP05755967.6
申请日：2005-06-04
申请人： Archimica GmbH
发明人： MEUDT, Andreas , SCHERER, Stefan , BÖHM, Claudius
IPC分类号： C07C253/00 , C07C255/03 , C07C255/32
CPC分类号： C07C253/00 , C07D307/68 , C07C255/03 , C07C255/50
摘要： The invention relates to a method for producing the nitriles of formula (II) R1-CN by reacting aldehyde oximes (R1CH = N - OH) with cyclic alkylphosphonic anhydrides at a temperature ranging from -100 to +120 °C, wherein R1 represents H, a linear or branched C1-C12 alkyl group, a C3-C10 cycloalkyl, alkenyl or an aryl or heteroaryl group. The cyclic phosphonic anhydride preferably used is a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide of formula (I), wherein R' independently represents allyl, aryl or open-chain or branched C1 to C12 alkyl groups. Optionally, the reaction can be carried out in the presence of a tertiary amine base NR2 3.

4. 发明公开

EP1763506A1 VERFAHREN ZUR HERSTELLUNG VON NITRILEN DURCH ELIMINIERUNG VON WASSER AUS ALDEHYDOXIMEN MIT ALKYLPHOSPHONSÄUREANHYDRIDEN 有权转让
标题翻译：用于生产NITRILES通过排除水从ALDEHYDOXIMEN与膦
公开(公告)号：EP1763506A1
公开(公告)日：2007-03-21
申请号：EP05755967.6
申请日：2005-06-04
申请人： Archimica GmbH
发明人： MEUDT, Andreas , SCHERER, Stefan , BÖHM, Claudius
IPC分类号： C07C253/00 , C07C255/03 , C07C255/32
CPC分类号： C07C253/00 , C07D307/68 , C07C255/03 , C07C255/50
摘要： The invention relates to a method for producing the nitriles of formula (II) R1-CN by reacting aldehyde oximes (R1CH = N - OH) with cyclic alkylphosphonic anhydrides at a temperature ranging from -100 to +120 °C, wherein R1 represents H, a linear or branched C1-C12 alkyl group, a C3-C10 cycloalkyl, alkenyl or an aryl or heteroaryl group. The cyclic phosphonic anhydride preferably used is a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide of formula (I), wherein R' independently represents allyl, aryl or open-chain or branched C1 to C12 alkyl groups. Optionally, the reaction can be carried out in the presence of a tertiary amine base NR2 3.

5. 发明授权

EP1763497B1 VERFAHREN ZUR HERSTELLUNG VON ALKENEN DURCH ELIMINIERUNG VON WASSER AUS ALKOHOLEN MIT ALKYLPHOSPHONSÄUREANHYDRIDEN 有权转让
标题翻译：用于生产烯烃BY除水由醇膦
公开(公告)号：EP1763497B1
公开(公告)日：2009-04-15
申请号：EP05747587.3
申请日：2005-06-04
申请人： Archimica GmbH
发明人： MEUDT, Andreas , SCHERER, Stefan , BÖHM, Claudius
IPC分类号： C07C1/24 , C07C15/46 , C07C11/02 , C07C13/11
CPC分类号： C07D207/22 , C07C1/24 , C07C2601/08 , C07C15/46 , C07C13/11
摘要： The invention relates to a method for producing a) alkenes of formula (II) by the reaction of a) primary alcohols (R1R2CHCH2 - OH) or b) secondary alcohols (R1R2CHCHR3 - OH) or c) tertiary alcohols (R1R2CH - CR3R4OH) with cyclic alkylphosphonic acid anhydrides at a temperature ranging between -100 and +120 °C, whereby R and/or R1 and/or R2 and/or R3 and/or R4 represent H, a linear or branched C1-C12 alkyl group, or a C3-C10 cycloalkyl group, alkenyl group or an aryl group or heteroaryl group. Preferably, a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide of formula (I) is used as the cyclic phosphonic acid anhydride, where R' represents, (independently of one another), allyl, aryl or open-chained or branched C1 to C12 alkyl groups. Optionally the reaction can be carried out in the presence of a tertiary amine base NR53.

6. 发明授权

EP1861343B1 VERFAHREN ZUR HERSTELLUNG VON ALKYLSUBSTITUIERTEN AROMATEN UND HETEROAROMATEN DURCH KREUZKUPPLUNG VON ALKYLBORONSÄUREN MIT ARYL- ODER HETEROARYLHALOGENIDEN ODER -SULFONATEN UNTER PD-KATALYSE IN GEGENWART EINES LIGANDEN 有权
标题翻译：生产由与芳基烷基硼酸或杂芳基或磺酸盐交叉耦合烷基取代的芳族化合物和杂芳族化合物UNDER PD CATALYSIS在配体的存在下
公开(公告)号：EP1861343B1
公开(公告)日：2009-03-04
申请号：EP06723260.3
申请日：2006-03-07
申请人： Archimica GmbH
发明人： SCHERER, Stefan , MEUDT, Andreas , NERDINGER, Sven , LEHNEMANN, Bernd , JAGUSCH, Thomas , SNIECKUS, Victor
IPC分类号： C07B37/04 , C07C17/26 , C07C67/30 , C07C25/13 , C07C69/76 , C07F5/02
CPC分类号： C07C1/321 , C07B37/04 , C07C17/263 , C07C67/343 , C07C2531/24 , C07D213/30 , C07C15/02 , C07C22/08 , C07C69/76
摘要： The invention relates to a method for producing alkyl-substituted aromatic and heteroaromatic compounds (III) by cross-coupling alkyl boronic acids (II) with aryl- or heteroaryl-halogenides or with aryl- or heteroaryl-sulfonates (I) in the presence of a catalyst and of a Brønsted base in a solvent or solvent mixture, in which: Hal represents chlorine, bromine, iodine, trifluoromethanesulfonate, nonafluorotrimethyl methane sulfonate, methane sulfonate, 4-toluolsulfonate, benzene sulfonate, 2- naphthalene sulfonate, 3-nitrobenzene sulfonate, 4-nitrobenzene sulfonate, 4-chlorobenzene sulfonate or 2,4,6-triisopropylbenzene sulfonate; X1-5, independent of one another, represent carbon, XiRi represents nitrogen, or each two adjacent XiRi's bound via a formal double bond represent, together, O (furane), S (thiophene), NH or NRi (pyrrole); radicals R1-5 represent substituents from the group consisting of {hydrogen, methyl, primary, secondary or tertiary, cyclic or acyclic alkyl radicals having 2 to 20 C atoms, in which optionally one or more hydrogen atoms are substituted by fluoride or chlorine or bromine, e.g. CF3, substituted cyclic or acyclic alkyl groups, hydroxy, alkoxy, amino, alkylamino, dialkylamino, arylamino, diarylamino, alkylarylamino, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, thio, alkylthio, arylthio, diarylphosphino, dialkylphosphino, alkylarylphosphino, optionally substituted aminocarbonyl, CO2-, alkyl- or aryloxycarbonyl, hydroxyalkyl, alkoxyalkyl, fluorine or chlorine, nitro, cyano, aryl- or alkylsulfone, aryl- or alkylsulfonyl} or each two adjacent radicals R1-5 represent, together, an aromatic, heteroaromatic or aliphatic fused ring; alkyl represents any linear, branched or cyclic alkyl radical having 1 to 40 C atoms, in which optionally one or more hydrogen atoms are substituted by foreign atoms or functions of the group {fluorine, optionally chlorine or bromine, hydroxy, alkoxy, amino, alkylamino, dialkylamino, arylamino, diarylamino, alkylarylamino, phenyl, substituted phenyl, heteroaryl, substituted heteroaryl, thio, alkylthio, arylthio, diarylphosphino, dialkylphosphino, alkylarylphosphino, optionally substituted aminocarbonyl, CO2-, alkyl- or aryloxycarbonyl, hydroxyalkyl, alkoxyalkyl, flourine or chlorine, nitro, cyano, aryl- or alkylsulfone}, R' and R'', independent of one another, represent the same or different radicals from the group consisting of {hydrogen, methyl, linear, branched or cyclic alkyl, optionally substituted, and phenyl, optionally substituted} or, together, form a ring and represent a bridging structure element from the group consisting of {optionally substituted alkylene, branched alkylene, cyclic alkylene or optionally substituted azaalkylene}.

7. 发明公开

EP1763497A1 VERFAHREN ZUR HERSTELLUNG VON ALKENEN DURCH ELIMINIERUNG VON WASSER AUS ALKOHOLEN MIT ALKYLPHOSPHONSÄUREANHYDRIDEN 有权转让
标题翻译：用于生产烯烃BY除水由醇膦
公开(公告)号：EP1763497A1
公开(公告)日：2007-03-21
申请号：EP05747587.3
申请日：2005-06-04
申请人： Archimica GmbH
发明人： MEUDT, Andreas , SCHERER, Stefan , BÖHM, Claudius
IPC分类号： C07C1/24 , C07C15/46 , C07C11/02 , C07C13/11
CPC分类号： C07D207/22 , C07C1/24 , C07C2601/08 , C07C15/46 , C07C13/11
摘要： The invention relates to a method for producing a) alkenes of formula (II) by the reaction of a) primary alcohols (R1R2CHCH2 - OH) or b) secondary alcohols (R1R2CHCHR3 - OH) or c) tertiary alcohols (R1R2CH - CR3R4OH) with cyclic alkylphosphonic acid anhydrides at a temperature ranging between -100 and +120 °C, whereby R and/or R1 and/or R2 and/or R3 and/or R4 represent H, a linear or branched C1-C12 alkyl group, or a C3-C10 cycloalkyl group, alkenyl group or an aryl group or heteroaryl group. Preferably, a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide of formula (I) is used as the cyclic phosphonic acid anhydride, where R' represents, (independently of one another), allyl, aryl or open-chained or branched C1 to C12 alkyl groups. Optionally the reaction can be carried out in the presence of a tertiary amine base NR53.
摘要翻译：本发明涉及一种用于制备式R ^{1 - [R ^{2 C-CR ^{3 - [R ^{4 通过的烯烃 a）一级alcolhols的反应（R ^{1 - [R ^{2 CHCH _{2 OH）或b）的仲醇（R ^{1 < / SUP> - [R ^{2 CHCHR ^{3 -OH）或c）叔醇（R ^{1 - [R ^{2 CH- CR ^{3 - [R ^{4 与在范围内的温度的环状烷基膦酸酐OH）-100 C.，之间和+ 120°，由此R 1和/或R ^{1 < / SUP>和/或R ^{2 和/或R ^{3 和/或R ^{4 表示H，直链或支链的C _{1 -C _{12 烷基，或C _{3 -C _{10 的环烷基，链烯基或芳基或杂芳基组。优选地，2,4,6- substituiertem式（I）的-1,3,5,2,4,6- trioxatriphosphinane -2,4,6-三氧化物被用作环状膦酸酐，其中R“darstellt，（彼此独立地），烯丙基，芳基或开链的或支链的C _{1 -C _{12 烷基。任选地，该反应可以在叔胺碱NR ^{5 _{3 的存在下进行。}}}}}}}}}}}}}}}}}}}}}}}}}}

8. 发明公开

EP1744999A1 VERFAHREN ZUR HERSTELLUNG VON ALDEHYDEN UND KETONEN DURCH OXIDATIONEN VON PRIMÄREN UND SEKUNDÄREN ALKOHOLEN MIT ALKYLPHOSPHONSÄUREANHYDRIDEN 审中-公开
标题翻译：用于生产醛类和酮类BY伯和仲醇的氧化膦
公开(公告)号：EP1744999A1
公开(公告)日：2007-01-24
申请号：EP05737845.7
申请日：2005-04-18
申请人： Archimica GmbH
发明人： MEUDT, Andreas , SCHERER, Stefan , BÖHM, Claudius
IPC分类号： C07C45/29 , C07C47/21 , C07C47/54 , C07C49/10 , C07C269/06 , C07C271/22 , C07B41/06
CPC分类号： C07C45/29 , C07B41/06 , C07C269/06 , C07C47/21 , C07C47/54 , C07C49/10 , C07C271/22
摘要： The invention relates to a method for the production of a.) aldehydes of formula (II): R1_ CHO and b.) aldehydes of formula (III): R1_ C(O) _ R2 by reacting a.) primary alcohols (R1CH2-OH) or b.) secondary alcohols (R1-CH(OH)-R2) with cyclic phosphonic acid anhydrides in the presence of dialkyl-, diaryl- and/or alkyl-aryl sulphonic oxides at a temperature in the region of between -100 to + 120 °C, whereby R1 and/or R2 represent H, a substituted linear or branched C1-C12-alkyl radical, a substituted C3-C10 cycloalkyl-, alkenyl-, aryl- or heteroaryl radical. A cyclic phosphonic acid anhydride is used, preferably, as a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane of formula (I), wherein R' independently represents allyl, aryl or open-chained or branched C1 - C12-alkyl-radicals. Optionally, the reaction can be carried out in the presence of a tertiary amine base NR53.

9. 发明公开

EP1713763A1 VERFAHREN ZUR HERSTELLUNG VON NITRILEN UND ISONITRILEN DURCH DEHYDRATISIERUNGSREAKTIONEN MIT PROPANPHOSPHONSÄUREANHYDRIDEN 有权转让
标题翻译：用于生产和腈异腈涉及脱水与PROPANPHOSPHONSAEUREANHYDRIDEN
公开(公告)号：EP1713763A1
公开(公告)日：2006-10-25
申请号：EP05700951.6
申请日：2005-01-15
申请人： Archimica GmbH
发明人： MEUDT, Andreas , SCHERER, Stefan , NERDINGER, Sven
IPC分类号： C07C253/20 , C07C253/22 , C07C291/10 , C07C255/50
CPC分类号： C07C253/20 , C07C253/22 , C07C291/10 , C07C255/50
摘要： The invention concerns a method for producing: a) nitriles of formula (II) and; b) isonitriles of formula (III) by reacting: a) carboxylic acid amides (RCO-NH2), ammonium salts of carboxylic acids (RCOO-NH4+) or carboxylic acids in the presence of ammonia or ammonium salts (RCOOH +NH3, RCOOH + NH4+) or; b) formamides (H-CO-NHR) or mixtures of amines with formic acid, with cyclic phosphonic acid anhydrides while eliminating water at a temperature ranging from -30 to +120 °C, in which R represents an arbitrarily substituted linear or branched C1-C8 alkyl radical, a C3-C10 cycloalkyl radical, alkenyl radical, alkynyl radical or an aryl radical or heteroaryl radical. As a cyclic phosphonic acid anhydride, a 2,4,6,-substituted 1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide of formula (I) is used, in which: x = 3, 4 or 5; R', independent of one another, represents open-chain or branched, saturated or unsaturated, straight-chain C1 to C16 alkyl radicals or cyclic C3 to C16 alkyl radicals or aryl or heteroaryl.

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