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1. 发明授权

EP2593542B1 METHODS OF GENERATING NATURAL KILLER CELLS 有权转让
标题翻译：产生天然杀伤细胞的方法
公开(公告)号：EP2593542B1
公开(公告)日：2018-01-03
申请号：EP11738896.7
申请日：2011-07-13
申请人： Anthrogenesis Corporation
发明人： HARIRI, Robert, J. , HEIDARAN, Mohammad, A. , JASKO, Stephen , KANG, Lin , LAW, Eric , PAL, Ajai , STOUT, Bhavani , VOSKINARIAN-BERSE, Vanessa , ZEITLIN, Andrew , ZHANG, Xiaokui
IPC分类号： C12N5/0783 , A61K35/12 , A61K35/17
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are in vitro two-step methods of producing populations of activated natural killer (NK) cells, comprising an expansion and a differentiation step. Also provided herein are populations of activated NK cells obtained by the method of the invention, and the use of the same in methods for treating cancer in an individual. Provided herein are also in vitro methods of suppressing the proliferation of tumor cells comprising contacting the tumor cells with a population of NK produced by the methods provided herein.

2. 发明公开

EP3204022A1 PLACENTA-DERIVED ADHERENT CELL EXOSOMES AND USES THEREOF 有权转让
标题翻译： PLACENTA衍生的粘附细胞外体及其用途
公开(公告)号：EP3204022A1
公开(公告)日：2017-08-16
申请号：EP15849339.5
申请日：2015-10-08
申请人： Anthrogenesis Corporation
发明人： LAW, Eric , MORSCHAUSER, Andrew , FRANCKI, Aleksandar , PAREDES, Jennifer , KARASIEWICZ-MENDEZ, Kathy E. , REDUTA, Allan , JANKOVIC, Vladimir , DJURETIC, Ivana
IPC分类号： A61K35/50
CPC分类号： A61K35/50 , A61K31/7105 , A61K35/28 , A61P9/00 , A61P17/02 , C12N5/0605 , C12N5/0668
摘要： Provided herein are compositions of placenta-derived adherent cell exosomes and methods of making and using the same. In one aspect, provided herein are compositions comprising exosomes produced by and/or derived from placental cells, e.g., placenta-derived adherent cells. In certain embodiments, the exosomes provided herein are produced by placenta-derived adherent cells that have been cultured in vitro for, e.g., 1, 2, 3, 4, 5, 6 or more passages.
摘要翻译：本文提供了胎盘衍生贴壁细胞外泌体的组合物及其制备和使用方法。在一个方面，本文提供了包含由胎盘细胞产生的和/或从胎盘细胞衍生的外来体的组合物，例如胎盘来源的贴壁细胞。在某些实施方案中，本文提供的外来体由胎盘来源的贴壁细胞产生，所述贴壁细胞已经在体外例如1,2,3,4,5,6或更多代传代培养。

3. 发明公开

EP2651451A1 TREATMENT OF SPINAL CORD INJURY AND TRAUMATIC BRAIN INJURY USING PLACENTAL STEM CELLS 审中-公开
标题翻译：治疗脊髓损伤和外伤性脑损伤胎盘使用干细胞
公开(公告)号：EP2651451A1
公开(公告)日：2013-10-23
申请号：EP11848627.3
申请日：2011-12-15
申请人： Anthrogenesis Corporation
发明人： ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , LAING, Bitao , HARIRI, Robert, J.
IPC分类号： A61K48/00 , C12N5/00
CPC分类号： A61K35/50
摘要： Provided herein are methods of treatment of individuals having an injury to the central nervous system, such as a spinal cord injury or a traumatic brain injury, using placental stem cells and placental multipotent stem cells described herein, and populations of such placental cells.

4. 发明公开

EP3088512A1 USE OF PLACENTAL STEM CELLS FOR TREATING HEART AND CIRCULATORY DISEASES BY PROMOTING ANGIOGENESIS 有权转让
标题翻译： ANGIOGENESE MITHILFE VON PLAZENTA-STAMMZELLEN
公开(公告)号：EP3088512A1
公开(公告)日：2016-11-02
申请号：EP16160000.2
申请日：2011-04-06
申请人： Anthrogenesis Corporation
发明人： ABBOT, Stewart , Edinger, James , FRANCKI, Aleksander , HARIRI, Robert, J. , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav , PAREDES, Jennifer , WANG, Jia-Lun
IPC分类号： C12N5/073 , A61K35/50 , A61L27/36 , A61K9/00 , A61P9/10 , A61P9/00 , A61L27/38 , A61K35/28
摘要： The invention provides a population of placental-derived adherent cells that are CD10+, CD34-, CD105+, and CD200+ for use in a method for treatment of an individual having a disease or injury of the heart or circulatory system. Said placental-derived adherent cells may additionally be one or more of CD45-, CD90+, or OCT-4+.
摘要翻译：本发明提供了用于治疗患有心脏或循环系统的疾病或损伤的个体的方法中的CD10 +，CD34-，CD105 +和CD200 +的胎盘衍生贴壁细胞群。所述胎盘衍生的贴壁细胞还可以是CD45-，CD90 +或OCT-4 +中的一种或多种。

5. 发明公开

EP2953635A1 NATURAL KILLER CELLS FROM PLACENTA 无效转让
标题翻译： NATÜRLICHEKILLERZELLEN AUS PLAZENTA
公开(公告)号：EP2953635A1
公开(公告)日：2015-12-16
申请号：EP14748811.8
申请日：2014-02-04
申请人： Anthrogenesis Corporation
发明人： ZHANG, Xiaokui , HARIRI, Robert, J. , VOSKINARIAN-BERSE, Vanessa , KANG, Lin , LAW, Eric , ABBOT, Stewart
IPC分类号： A61K35/14
CPC分类号： A61K35/17 , A61K31/454 , A61K2035/122 , C12N5/0646 , C12N2501/05
摘要： Provided herein are placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, combined natural killer cells from placenta and umbilical cord blood, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, and combined natural killer cells and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells. Also provided herein are methods of treating an individual having a tumor or graft-versus-host disease with placental perfusate, placental perfusate-derived cells, natural killer cells from placenta,
e.g ., from placental perfusate, and/or combined natural killer cells comprising natural killer cells from placenta,
e.g ., from placental perfusate, and umbilical cord blood.
摘要翻译：本文提供的是胎盘灌洗液，胎盘灌洗液细胞，来自胎盘的中间体天然杀伤细胞，来自胎盘和脐带血的合并的天然杀伤细胞及其组合。本文还提供了包含其的组合物，以及使用胎盘灌注液，胎盘灌洗液细胞，胎盘衍生的中间体天然杀伤细胞和组合的天然杀伤细胞及其组合的方法，以抑制肿瘤细胞，癌细胞的生长或增殖，并治疗患有肿瘤细胞的个体。本文还提供了使用胎盘灌注液，胎盘灌洗液衍生的细胞，来自胎盘的天然杀伤细胞（例如胎盘灌注液）和/或包含天然的组合的天然杀伤细胞来治疗具有肿瘤或移植物抗宿主病的个体的方法来自胎盘的杀伤细胞，例如胎盘灌洗液和脐带血。

6. 发明授权

EP2556145B1 ANGIOGENESIS USING PLACENTAL STEM CELLS 有权转让
标题翻译：胎儿干细胞的血管生成
公开(公告)号：EP2556145B1
公开(公告)日：2016-07-20
申请号：EP11766619.8
申请日：2011-04-06
申请人： Anthrogenesis Corporation
发明人： ABBOT, Stewart , EDINGER, James , FRANCKI, Aleksander , HARIRI, Robert, J. , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav , PAREDES, Jennifer , WANG, Jia-Lun
IPC分类号： A61K35/50 , A61L27/36 , C12N5/073 , A61K9/00 , A61P9/10 , A61L27/38 , A61K35/28
CPC分类号： A61K35/50 , A61K9/0019 , A61K9/0085 , A61K35/28 , A61L27/3633 , A61L27/3683 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/3895 , C12N5/0605 , A61K2300/00
摘要： The invention provides a population of placental-derived adherent cells that are CD10+, CD34-, CD105+, and CD200+ for use in a method for treatment of an individual having a disease or injury of the heart or circulatory system. Said placental-derived adherent cells may additionally be one or more of CD45-, CD90+, or OCT-4+.

7. 发明公开

EP2882847A2 NATURAL KILLER CELLS AND USES THEREOF 审中-公开
标题翻译：自然杀伤细胞和它们的用途
公开(公告)号：EP2882847A2
公开(公告)日：2015-06-17
申请号：EP13829894.8
申请日：2013-08-13
申请人： Anthrogenesis Corporation , Law, Eric , Kang, Lin , Jankovic, Vladimir , Zhang, Xiaokui , Abbot, Stewart , Hariri, Robert, J.
发明人： LAW, Eric , KANG, Lin , JANKOVIC, Vladimir , ZHANG, Xiaokui , ABBOT, Stewart , HARIRI, Robert, J.
IPC分类号： C12N5/07 , C12N5/078 , C12N5/0783
CPC分类号： C12N5/0646 , A01N1/02 , A61K35/17 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/2306 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2506/11
摘要： Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of NK cells and NK progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein to an individual having the cancer or viral infection.

8. 发明公开

EP2651452A1 TREATMENT OF SPINAL CORD INJURY AND TRAUMATIC BRAIN INJURY USING AMNION DERIVED ADHERENT CELLS 审中-公开
标题翻译：治疗脊髓损伤以及二次与羊膜OFF贴壁细胞的创伤性脑损伤
公开(公告)号：EP2651452A1
公开(公告)日：2013-10-23
申请号：EP11849031.7
申请日：2011-12-15
申请人： Anthrogenesis Corporation
发明人： ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , LIANG, Bitao , HARIRI, Robert, J.
IPC分类号： A61K48/00 , C12N5/00
CPC分类号： C12N5/0605 , A61K35/50 , C12N5/0618 , C12N5/0636 , C12N5/0637 , C12N5/0639 , C12N5/0646 , C12N2502/025 , C12N2506/025
摘要： Provided herein are methods of treating spinal cord and traumatic brain injuries using cells from amnion, and populations of such cells, referred to herein as “amnion derived adherent cells” (“AMDACs”).

9. 发明公开

EP2593542A1 METHODS OF GENERATING NATURAL KILLER CELLS 有权转让
标题翻译： VERFAHREN ZUR ERZEUGUNG VONNATÜRLICHENKILLERZELLEN
公开(公告)号：EP2593542A1
公开(公告)日：2013-05-22
申请号：EP11738896.7
申请日：2011-07-13
申请人： Anthrogenesis Corporation
发明人： HARIRI, Robert, J. , HEIDARAN, Mohammad, A. , JASKO, Stephen , KANG, Lin , LAW, Eric , PAL, Ajai , STOUT, Bhavani , VOSKINARIAN-BERSE, Vanessa , ZEITLIN, Andrew , ZHANG, Xiaokui
IPC分类号： C12N5/0783
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
摘要翻译：本文提供使用两步膨胀和分化方法生产天然杀伤细胞的方法。本文还提供了抑制肿瘤细胞增殖，治疗患有癌症或病毒感染的个体的方法，包括将通过该方法产生的NK细胞施用于具有癌症或病毒感染的个体。

10. 发明公开

EP2556145A1 ANGIOGENESIS USING PLACENTAL STEM CELLS 有权转让
标题翻译：胎儿干细胞的血管生成
公开(公告)号：EP2556145A1
公开(公告)日：2013-02-13
申请号：EP11766619.8
申请日：2011-04-06
申请人： Anthrogenesis Corporation
发明人： ABBOT, Stewart , EDINGER, James , FRANCKI, Aleksander , HARIRI, Robert, J. , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav , PAREDES, Jennifer , WANG, Jia-Lun
IPC分类号： C12N5/073 , A61K35/50
CPC分类号： A61K35/50 , A61K9/0019 , A61K9/0085 , A61K35/28 , A61L27/3633 , A61L27/3683 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/3895 , C12N5/0605 , A61K2300/00
摘要： The invention provides a population of placental-derived adherent cells that are CD10+, CD34-, CD105+, and CD200+ for use in a method for treatment of an individual having a disease or injury of the heart or circulatory system. Said placental-derived adherent cells may additionally be one or more of CD45-, CD90+, or OCT-4+.
摘要翻译：本文提供了使用胎盘细胞（例如本文所述的胎盘干细胞和胎盘多能细胞（PDAC））和此类胎盘细胞群来治疗患有循环系统疾病或病症的个体的方法。本发明还提供了使用这种细胞或包含这种细胞的细胞群的血管生成方法。

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