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1. 发明公开

EP3358007A1 METHODS OF GENERATING NATURAL KILLER CELLS 审中-公开
公开(公告)号：EP3358007A1
公开(公告)日：2018-08-08
申请号：EP17211121.3
申请日：2011-07-13
申请人： Celularity, Inc.
发明人： Hariri, Robert J. , Heidaran, Mohammad A. , Jasko, Stephen , Kang, Lin , Law, Eric , Pal, Ajai , Stout, Bhavani , Voskinarian-Berse, Vanessa , Zeitlin, Andrew , Zhang, Xiaokui
IPC分类号： C12N5/0783 , A61K35/17 , A61K35/12
CPC分类号： C12N5/0646 , A61K35/17 , A61K2035/124 , C12N2500/05 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2500/84 , C12N2501/125 , C12N2501/145 , C12N2501/2302 , C12N2501/2303 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2501/59 , C12N2501/91 , C12N2501/998 , C12N2506/11
摘要： Provided herein are in vitro two-step methods of producing populations of activated natural killer (NK) cells, comprising an expansion and a differentiation step. Also provided herein are populations of activated NK cells obtained by the method of the invention, and the use of the same in methods for treating cancer in an individual. Provided herein are also in vitro methods of suppressing the proliferation of tumor cells comprising contacting the tumor cells with a population of NK produced by the methods provided herein.

2. 发明公开

EP3240552A4 NATURAL KILLER CELLS AND USES THEREOF 审中-公开
公开(公告)号：EP3240552A4
公开(公告)日：2018-06-20
申请号：EP15876255
申请日：2015-12-30
申请人： ANTHROGENESIS CORP
发明人： MURPHY BRIAN , VOSKINARIAN-BERSE VANESSA , NORDBERG ANDREA , WILSON KEITH , KANG LIN
IPC分类号： A61K35/51 , A61K35/17 , A61K35/50 , C12N5/0783
CPC分类号： A61K35/17 , A61K35/50 , A61K35/51 , C07D473/00 , C12N5/0646 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2506/11
摘要： Provided herein are methods of producing natural killer (NK) cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells and the NK cell populations produced by the three-stage methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK ce3lls and the NK cell populations produced by the three-stage methods described herein to an individual having the cancer or viral infection.

3. 发明公开

EP3322424A1 USE OF ANTI THIRD PARTY CENTRAL MEMORY T CELLS 有权
公开(公告)号：EP3322424A1
公开(公告)日：2018-05-23
申请号：EP16745186.3
申请日：2016-07-14
申请人： Yeda Research and Development Co., Ltd.
发明人： REISNER, Yair , OR-GEVA, Noga , OPHIR, Eran , EIDELSTEIN, Yaki , GIDRON BUDOVSKY, Rotem
IPC分类号： A61K35/17 , C12N5/10 , A61P35/00 , A61P31/00 , A61P33/00 , A61P1/00 , A61P25/00 , A61K39/00 , A61K39/12 , A61K39/002
CPC分类号： A61K39/001 , A61K35/17 , A61K39/39566 , A61K2035/122 , A61K2039/5158 , A61P31/00 , A61P35/04 , C07K16/2896 , C12N5/0636 , C12N5/0637 , C12N5/0648 , C12N2501/2307 , C12N2501/2315 , C12N2501/2321 , Y02A50/467
摘要： An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

4. 发明公开

EP3305890A1 REVERSING THE EFFECTS OF THE TUMOR MICROENVIRONMENT USING CHIMERIC CYTOKINE RECEPTORS 有权
标题翻译：利用嵌合型细胞因子受体逆转肿瘤微环境的作用
公开(公告)号：EP3305890A1
公开(公告)日：2018-04-11
申请号：EP17190649.8
申请日：2012-04-05
申请人： Baylor College of Medicine
发明人： LEEN, Ann Marie , VERA, Juan F
IPC分类号： C12N5/00
CPC分类号： A61K35/12 , A61K39/0011 , A61K2039/5156 , A61K2039/5158 , C07K14/715 , C12N5/0634 , C12N5/0638 , C12N15/85 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2510/00
摘要： Disclosed are compositions and methods related to rendering ineffective Thl T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Thl immunostimulatory/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IE 10, IE 13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.
摘要翻译：公开了与使无效Th1T细胞对存在于癌症微环境中的抑制性细胞因子环境具有抗性相关的组合物和方法。修改肿瘤特异性T细胞以使用结合抑制性/抑制性细胞因子并将其细胞内结果转化为Th1免疫刺激/激活信号的嵌合受体。 T细胞使用嵌合抗原受体，所述嵌合抗原受体具有IE 10，IE 13和/或IL4的外显子，其与IL2和/或IL7的信号转导内脏结构域融合。

5. 发明公开

EP3143134A4 MODIFIED NATURAL KILLER CELLS AND USES THEREOF 有权转让
公开(公告)号：EP3143134A4
公开(公告)日：2017-10-18
申请号：EP15792972
申请日：2015-05-14
申请人： NAT UNIV SINGAPORE , ST JUDE CHILDREN'S RES HOSPITAL INC
发明人： CAMPANA DARIO , SHOOK DAVID , IMAMURA MASARU
IPC分类号： C12N5/0783 , A61K35/17 , A61K38/20 , C07K14/54 , C07K14/705 , C12N15/24 , C12N15/62
CPC分类号： C12N5/0646 , A61K35/17 , A61K38/2013 , A61K38/2086 , C07K14/5443 , C07K14/70517 , C07K2319/03 , C12N5/0006 , C12N15/62 , C12N2501/2315 , C12N2510/00
摘要： The present invention provides, in certain aspects, a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15), and methods for producing such cells. The invention further provides methods of using a natural killer (NK) cell that expresses all or a functional portion of interleukin-15 (IL-15) to treat cancer in a subject or to enhance expansion and/or survival of NK cells.

6. 发明公开

EP3138905A1 METHOD FOR NATURAL KILLER CELL EXPANSION 审中-公开
标题翻译： VERFAHRENFÜRNATÜRLICHEKILLERZELLENEXPANSION
公开(公告)号：EP3138905A1
公开(公告)日：2017-03-08
申请号：EP15183968.5
申请日：2015-09-04
申请人： Miltenyi Biotec GmbH
发明人： GRANZIN, Markus , HUPPERT, Volker
IPC分类号： C12N5/0783
CPC分类号： C12N5/0646 , C12N2501/2302 , C12N2501/2315 , C12N2501/2321
摘要： The present invention provides a method for in-vitro culturing and expanding natural killer (NK) cells in a cell culture medium comprising a population of NK cells, the method comprising a) adding an effective concentration of interleukin-21 (IL-21) at the beginning of the culturing process to said medium, b) adding repeatedly an effective concentration of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) to said medium, and c) adding repeatedly feeder cells or membrane particles thereof to said medium, wherein said feeder cells are B cell derived which are EBV immortalized; and wherein said expansion of NK cells in said cell culture medium is maintained for at least 3 weeks.
摘要翻译：本发明提供了在包含NK细胞群的细胞培养基中体外培养和扩增天然杀伤（NK）细胞的方法，所述方法包括：a）将有效浓度的白细胞介素-21（IL-21）加入到培养过程开始于所述培养基，b）向所述培养基反复加入白细胞介素-2（IL-2）和/或白细胞介素-15（IL-15）的有效浓度，c）重复加入饲养细胞或膜其中所述饲养细胞是B细胞衍生的，其是EBV永生化的; 并且其中所述细胞培养基中NK细胞的所述扩增保持至少3周。

7. 发明授权

EP2470644B1 GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES 有权
标题翻译： GENERATION具有特异性CTL细胞系对多种肿瘤抗原或多种病毒的
公开(公告)号：EP2470644B1
公开(公告)日：2016-09-21
申请号：EP10814245.6
申请日：2010-08-24
申请人： Baylor College Of Medicine , Wilson Wolf Manufacturing
发明人： LEEN, Ann Marie , ROONEY, Cliona , GERDEMANN, Ulrike , VERA, Juan , WILSON, John Robert
IPC分类号： C12N5/0783
CPC分类号： C12N5/0638 , A61K39/0011 , A61K39/12 , A61K39/155 , A61K39/245 , A61K2039/5158 , A61K2039/54 , A61K2039/572 , C12N5/0636 , C12N2501/23 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2502/11
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
摘要翻译：本发明包括用于细胞毒性的产生和使用的T淋巴细胞做靶多种病毒或没有特异性针对多种肿瘤抗原的方法和组合物。在具体的实施方案中，产生方法采用使用某些细胞因子的促进增殖和减少细胞死亡在活化的T细胞群和/或没有使用具有气体透过膜的特定的生物反应器。

8. 发明授权

EP2613801B1 USE OF ANTI THIRD PARTY CENTRAL MEMORY T CELLS FOR ANTI-LEUKEMIA/LYMPHOMA TREATMENT 有权
标题翻译： CENTRAL ANTI-THIRD T-存储器单元，其使用在一个“抗白血病/淋巴瘤”处理
公开(公告)号：EP2613801B1
公开(公告)日：2016-06-08
申请号：EP11773325.3
申请日：2011-09-08
申请人： Yeda Research and Development Co. Ltd.
发明人： REISNER, Yair , LASK, Assaf , OPHIR, Eran , OR-GEVA, Noga , COHEN, Adva , AFIK, Ran , BACHAR-LUSTIG, Esther , EIDELSTEIN, Yaki
IPC分类号： A61K35/28 , C12N5/071 , C12N5/0783 , A61K35/12 , A61K31/517 , A61K35/17
CPC分类号： A61K35/17 , A61K31/517 , A61K35/28 , A61K39/001 , A61K45/06 , A61K2035/124 , A61K2039/5158 , C12N5/0602 , C12N5/0636 , C12N5/0637 , C12N2501/2307 , C12N2501/2315 , C12N2501/2321 , A61K2300/00
摘要： A method of treating a disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting a non-syngeneic cell or tissue graft to the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, and further wherein the cells are either: (i) non-syngeneic with both the subject and the graft; or (ii) non-syngeneic with the graft and syngeneic with the subject, thereby treating the subject.

9. 发明公开

EP2882847A4 NATURAL KILLER CELLS AND USES THEREOF 审中-公开
标题翻译：自然杀伤细胞和它们的用途
公开(公告)号：EP2882847A4
公开(公告)日：2016-03-23
申请号：EP13829894
申请日：2013-08-13
申请人： ANTHROGENESIS CORP , LAW ERIC , KANG LIN , JANKOVIC VLADIMIR , ZHANG XIAOKUI , ABBOT STEWART , HARIRI ROBERT J
发明人： LAW ERIC , KANG LIN , JANKOVIC VLADIMIR , ZHANG XIAOKUI , ABBOT STEWART , HARIRI ROBERT J
IPC分类号： C12N5/07 , C12N5/078 , C12N5/0783
CPC分类号： C12N5/0646 , A01N1/02 , A61K35/17 , C12N2500/38 , C12N2500/44 , C12N2500/46 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/2306 , C12N2501/2307 , C12N2501/2315 , C12N2501/26 , C12N2506/11
摘要： Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of NK cells and NK progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein to an individual having the cancer or viral infection.

10. 发明公开

EP2755487A4 TARGETING THE TUMOR MICROENVIRONMENT USING MANIPULATED NKT CELLS 有权
标题翻译： GEGEN DIE TUMORMIKROUMGEBUNG GERICHTETE MANIPULIERTE NKT-ZELLEN
公开(公告)号：EP2755487A4
公开(公告)日：2015-07-15
申请号：EP12831178
申请日：2012-09-14
申请人： BAYLOR COLLEGE MEDICINE
发明人： METELITSA LEONID S , LIU DAOFENG , DOTTI GIANPIETRO , HECZEY ANDRAS
IPC分类号： A01N63/00 , A61K39/00 , C12N5/0783
CPC分类号： A61K35/17 , A61K31/4545 , A61K31/522 , A61K39/00 , A61K39/0011 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , A61K2039/55527 , C12N5/0646 , C12N2500/02 , C12N2501/2315
摘要： The present invention regards methods and/or compositions related to Natural Killer T cells that are engineered to harbor an expression construct that encodes IL-2, IL-4, IL-7, and/or IL-15 and additionally or alternatively comprise a chimeric antigen receptor (CAR). In specific embodiments, the CAR is a CAR that targets the GD2 antigen, for example in neuroblastoma.
摘要翻译：本发明涉及与天然杀伤T细胞相关的方法和/或组合物，其被工程化以含有编码IL-2，IL-4，IL-7和/或IL-15的表达构建体，并且另外地或替代地包含嵌合抗原受体（CAR）。在具体实施方案中，CAR是靶向GD2抗原的CAR，例如成神经细胞瘤。

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