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1. 发明公开

EP2269737A2 Assay device comprising serial reaction zones 有权转让
标题翻译： Testvorrichtung mit seriellen Reaktionszonen
公开(公告)号：EP2269737A2
公开(公告)日：2011-01-05
申请号：EP10166665.9
申请日：2010-06-21
申请人： Amic AB
发明人： Mendel-Hartvig, Ib , Rundström, Gerd , Öhman, Per Ove
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/126 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0475
摘要： There is disclosed an analysis device comprising a substrate having at least one sample addition zone (A), at least one sink (C), and at least one flow path (B) connecting the at least one sample addition zone (A) and the at least one sink (C), wherein the at least one flow path (B) comprises projections substantially vertical to the surface of said substrate and having a height (H), diameter (D) and reciprocal spacing (t1,t2) such that lateral capillary flow of a liquid sample is achieved, wherein the device comprises at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the at least two reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.
摘要翻译：公开了一种分析装置，其包括具有至少一个样品添加区（A），至少一个沉（C）和至少一个流路（B）的基板，所述至少一个流路（B）连接至少一个样品添加区（A）和至少一个水槽（C），其中所述至少一个流动路径（B）包括基本上垂直于所述衬底的表面并具有高度（H），直径（D）和往复间隔（t1，t2）的突起，使得实现液体样品的侧向毛细管流动，其中该装置包括至少两个串联的反应区，其中每个反应区适于促进来自一个和相同分析物的响应的测量，并且其中该至少两个反应区被定位成允许计算至少一种分析物的浓度。优点包括可以计算更准确的值，降低变化，并且可以计算出响应的不确定度的估计。

2. 发明公开

EP2141497A1 Method for the analysis of circulating antibodies 有权转让
标题翻译： Verfahren zur分析von umlaufendenAntikörpern
公开(公告)号：EP2141497A1
公开(公告)日：2010-01-06
申请号：EP09163976.5
申请日：2009-06-29
申请人： Amic AB
发明人： Mendel-Hartvig, Ib , Pettersson, Christer , Rundström, Gerd
IPC分类号： G01N33/558 , B01L3/00
CPC分类号： G01N33/558 , B01L3/502723 , B01L3/502761 , B01L2200/0668 , B01L2300/0825 , B01L2300/087 , B01L2300/089 , B01L2400/086
摘要： There is provided a method for the analysis of circulating antibodies comprising the steps:
a) providing an analysis device comprising a substrate, and provided on said substrate at least one sample addition zone, at least one retaining zone, at least one sink, and at least one flow path connecting the sample addition zone, the retaining zone and the sink, wherein the flow path is open and comprises projections substantially vertical to the surface of said substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of said sample is achieved and such that cells can flow through the projections, wherein said retaining zone comprises at least one affinity binding means to which cell structures are bound,
b) adding at least one sample to a sample addition zone, and
c) reading a result,

wherein circulating antibodies directed against cell structures are determined.
摘要翻译：提供了用于分析循环抗体的方法，包括以下步骤：a）提供包括基底的分析装置，并且在所述基底上提供至少一个样品加入区，至少一个保留区，至少一个沉，并且至少一个流动路径，其连接所述样品添加区域，所述保持区域和所述水槽，其中所述流动路径是开放的，并且包括基本上垂直于所述衬底表面的突起，并且具有高度（H），直径（D）和往复间隔 t1，t2），使得所述样品的侧向毛细管流动被实现并且使得细胞可以流过所述突起，其中所述保留区包含至少一个结合细胞结构的亲和力结合装置，b）将至少一个样品加到样品加入区，以及c）读取结果，其中确定针对细胞结构的循环抗体。

3. 发明公开

EP2269737A3 Assay device comprising serial reaction zones 有权转让
标题翻译：具有串行反应区测试装置
公开(公告)号：EP2269737A3
公开(公告)日：2013-06-05
申请号：EP10166665.9
申请日：2010-06-21
申请人： Amic AB
发明人： Mendel-Hartvig, Ib , Rundström, Gerd , Öhman, Per Ove
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/126 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0475
摘要： There is disclosed an analysis device comprising a substrate having at least one sample addition zone (A), at least one sink (C), and at least one flow path (B) connecting the at least one sample addition zone (A) and the at least one sink (C), wherein the at least one flow path (B) comprises projections substantially vertical to the surface of said substrate and having a height (H), diameter (D) and reciprocal spacing (t1,t2) such that lateral capillary flow of a liquid sample is achieved, wherein the device comprises at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the at least two reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.

4. 发明授权

EP2269737B1 Assay device comprising serial reaction zones 有权转让
标题翻译：含有连续反应区的测定装置
公开(公告)号：EP2269737B1
公开(公告)日：2017-09-13
申请号：EP10166665.9
申请日：2010-06-21
申请人： Amic AB
发明人： Mendel-Hartvig, Ib , Rundström, Gerd , Öhman, Per Ove
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/126 , B01L2400/0406 , B01L2400/0409 , B01L2400/0418 , B01L2400/0475

5. 发明授权

EP2141497B1 Method for the analysis of circulating antibodies 有权转让
标题翻译：分析循环抗体的方法
公开(公告)号：EP2141497B1
公开(公告)日：2014-03-26
申请号：EP09163976.5
申请日：2009-06-29
申请人： Amic AB
发明人： Mendel-Hartvig, Ib , Pettersson, Christer , Rundström, Gerd
IPC分类号： G01N33/558 , B01L3/00
CPC分类号： G01N33/558 , B01L3/502723 , B01L3/502761 , B01L2200/0668 , B01L2300/0825 , B01L2300/087 , B01L2300/089 , B01L2400/086

6. 发明公开

EP2270506A3 Amplified labeled conjugate for use in immunoassays 审中-公开
标题翻译：在免疫测定放大标记共轭
公开(公告)号：EP2270506A3
公开(公告)日：2011-03-09
申请号：EP10166674.1
申请日：2010-06-21
申请人： Amic AB
发明人： Mendel-Hartvig, Ib , Rundström, Gerd
IPC分类号： G01N33/532 , G01N33/544 , G01N33/58
CPC分类号： G01N33/532 , G01N33/544 , G01N33/58
摘要： A conjugate, for use as a detection reagent in an immunoassay, is based on a hydrophilic monodisperse macromolecule, i.e. a macromolecule having a substantially uniform size and shape, said macromolecule forming a practically useful and manageable carrier, to which carrier at least one binding entity and at least one label are bound.

7. 发明公开

EP2270506A2 Amplified labeled conjugate for use in immunoassays 审中-公开
标题翻译：扩增标记的缀合物用于免疫测定
公开(公告)号：EP2270506A2
公开(公告)日：2011-01-05
申请号：EP10166674.1
申请日：2010-06-21
申请人： Amic AB
发明人： Mendel-Hartvig, Ib , Rundström, Gerd
IPC分类号： G01N33/532 , G01N33/544 , G01N33/58
CPC分类号： G01N33/532 , G01N33/544 , G01N33/58
摘要： A conjugate, for use as a detection reagent in an immunoassay, is based on a hydrophilic monodisperse macromolecule, i.e. a macromolecule having a substantially uniform size and shape, said macromolecule forming a practically useful and manageable carrier, to which carrier at least one binding entity and at least one label are bound.
摘要翻译：用作免疫测定中的检测试剂的缀合物基于亲水性单分散性大分子，即具有基本均匀大小和形状的大分子，所述大分子形成实用有用且可管理的载体，载体上具有至少一种结合实体并至少绑定一个标签。

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