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2. 发明公开

EP3329282A1 QUALITY OF IMMUNOLOGICAL SYNAPSE PREDICTS EFFECTIVENESS OF CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS 审中-实审转让
公开(公告)号：EP3329282A1
公开(公告)日：2018-06-06
申请号：EP16833620.4
申请日：2016-07-29
申请人： Liu, Dongfang
发明人： Liu, Dongfang
IPC分类号： G01N33/544 , G01N33/554 , C07K17/02 , C12N5/0783 , C07K16/30 , C07K19/00 , A61K35/17
CPC分类号： G01N33/5032 , A61K35/17 , C07K16/30 , C07K17/02 , C07K19/00 , G01N33/502 , G01N33/505 , G01N33/544 , G01N2333/9645 , G01N2500/00 , G01N2500/04 , G01N2500/10
摘要： Embodiments of the disclosure concern methods of determining the effectiveness of immune cells, such as T cells, with particular chimeric antigen receptors. In specific embodiments, a synapse between the CAR and the tumor antigen is measured for structure, signaling, and functionality by imaging. As such, the quality of the synapse is determined and positively correlates with effectiveness of the particular CAR immune cells.

3. 发明公开

EP3315971A1 METHOD AND APPARATUS FOR COLLECTING SIGNAL, AND METHOD AND APPARATUS FOR TRACKING CELL BY USING LIGHT SENSITIVE CHIP 审中-公开
标题翻译：用于收集信号的方法和设备以及使用光敏芯片跟踪细胞的方法和设备
公开(公告)号：EP3315971A1
公开(公告)日：2018-05-02
申请号：EP16820726.4
申请日：2016-06-06
申请人： Sanghai E-Blot Photoelectric Technology Co., Ltd
发明人： ZHANG, Yinghao , ZHANG, Zhihao , ZHAN, Ketuan , WAN, Jia
IPC分类号： G01N33/68 , G01N21/76
CPC分类号： G01N33/6842 , C09K11/61 , C12Q1/66 , G01N21/76 , G01N33/544 , G01N33/68
摘要： A method and apparatus for collecting signals and a method and apparatus for tracking cells by using light sensitive chip, relate to the technical field of signal collection, wherein the method for collecting signals by using light sensitive chip comprises closely fitting a luminous surface of a membrane carrying optical signals to be collected on a light sensitive chip (101), placing the light sensitive chip fitted with the membrane carrying optical signals to be collected in a dark room (102), collecting optical signals (103) by the light sensitive chip in the dark room, and processing and outputting the collected optical signals (104). The method and apparatus for collecting signals by using the light sensitive chip can collect signals by contacting the light sensitive chip to convert optical signals into digital signals so as to complete quantitative analysis.
摘要翻译：采用光敏芯片采集信号的方法和装置以及跟踪细胞的方法和装置涉及信号采集技术领域，其中采用光敏芯片采集信号的方法包括将膜的发光面将待采集的光信号收集在光敏芯片上，将装有承载光信号的膜片的光敏芯片收集到暗室中，由光敏芯片收集光信号，暗室，并处理和输出收集的光信号（104）。采用光敏芯片采集信号的方法和装置，通过接触感光芯片采集信号，将光信号转换为数字信号，完成定量分析。

4. 发明公开

EP3172312A1 FABRICATION OF A FLUORESCENT MATERIAL FOR SENSING AN ANALYTE 有权
标题翻译：用于检测分析物的荧光材料的制备
公开(公告)号：EP3172312A1
公开(公告)日：2017-05-31
申请号：EP15824391.5
申请日：2015-07-23
申请人： Senseonics, Incorporated
发明人： HUFFSTETLER, Philip , EMKEN, Jeremy , WHITEHURST, Todd
IPC分类号： C12M1/30 , C12M3/00
CPC分类号： G01N21/6428 , G01N21/77 , G01N31/22 , G01N33/544 , G01N33/582 , G01N2021/773 , G01N2021/7786
摘要： An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.
摘要翻译：分析物指示器可以包括多孔基底并且可以包括在分析物传感器中。分析物指示剂可以在压缩的情况下保持其物理，化学和光学性质。多孔基材的不透明度可能不会变化。分析物指示剂可以包括（i）连接或聚合到多孔基底上或从多孔基底离开的聚合物单元和（ii）连接到聚合物单元或与聚合物单元共聚的分析物感测元件。分析物检测元件可以包括一个或多个指示剂分子。分析物检测元件可以包括一个或多个指示剂聚合物链。分析物指示剂可以包括（i）连接或聚合到多孔基底上或从多孔基底上聚合的指示剂聚合物链和（ii）连接到指示剂聚合物链上的指示剂分子。

6. 发明公开

EP3017304A2 ELECTROCHEMICAL APTASENSORS WITH A GELATIN B MATRIX 有权
标题翻译： ELEKTROCHEMISCHE APTASENSOREN MIT GELATIN-B-MATRIX
公开(公告)号：EP3017304A2
公开(公告)日：2016-05-11
申请号：EP14737196.7
申请日：2014-07-03
申请人： Universiteit Antwerpen
发明人： BLUST, Ronny J.P. , DARDENNE, Freddy , DE WAEL, Karolien , NAGELS, Lucien , VAN CAMP, Guido F.E.
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , G01N27/3275 , G01N33/5308 , G01N33/5436 , G01N33/544 , G01N33/9413 , G01N33/9446 , G01N33/946 , G01N2333/78
摘要： This invention provides: - an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix; - a method of manufacturing said aptamer-based electrochemical sensor; - the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and - a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.
摘要翻译：本发明提供： - 基于适体的电化学传感器，其中所述适体共价结合或电化学吸附在电极上，所述适体与靶分子形成复合物并被明胶B基质包封; - 制造所述基于适体的电化学传感器的方法; - 使用基于适体的电化学传感器用于电化学测定靶分子的浓度; 和 - 组合聚合物材料和用于选择性分析物检测的导电颗粒的复合电极，其中所述电极涂覆有明胶类型B.

7. 发明公开

EP2889622A4 MICROPARTICLES FOR ANALYZING BIOMOLECULES, METHOD FOR PREPARING SAME, KIT FOR ANALYZING BIOMOLECULES, AND METHOD FOR ANALYZING BIOMOLECULES USING THE KIT 审中-公开
标题翻译： MICRO生物分子的颗粒分析，制造方法，KIT FOR分析生物分子和方法的生物分子的分析使用该试剂盒
公开(公告)号：EP2889622A4
公开(公告)日：2015-11-04
申请号：EP13831292
申请日：2013-08-26
申请人： UNIV DANKOOK IACF , SPECIALTY LAB SOLUTION CO LTD
发明人： LIM HEUNG BIN
IPC分类号： G01N33/52 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54313 , G01N33/54326 , G01N33/5434 , G01N33/54393 , G01N33/544 , G01N33/552 , G01N33/582 , G01N2446/20

8. 发明公开

EP2825557A1 SOLUBLE ENGINEERED MONOMERIC FC 有权
标题翻译： MANIPULIERTESLÖSLICHESMONOMERES FC
公开(公告)号：EP2825557A1
公开(公告)日：2015-01-21
申请号：EP13713301.3
申请日：2013-03-14
申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services
发明人： DIMITROV, Dimiter, S. , YING, Tianlei
IPC分类号： C07K16/00 , C07K16/10
CPC分类号： C07K16/283 , A61K2039/505 , C07K14/005 , C07K16/00 , C07K16/1045 , C07K16/1063 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C07K2319/74 , C12N7/00 , C12N2740/16111 , G01N33/544 , G01N33/573 , G01N33/6863
摘要： Fc domains and CH3 domains are disclosed that bind the neonatal Fc (FcRn) receptor and are at least 99% monomeric. Monomeric Fc domain molecules and CH3 domain molecules are disclosed herein that include a monomeric Fc domain or a monomeric CH3 domain and an effector molecule. In some embodiments, the monomeric Fc or monomeric CH3 domain include amino acid substitutions and/or CDR insertions in the beta strands such that they specifically bind an antigen. Methods for using these monomeric Fc domains, monomeric CH3 domains, monomeric Fc domain molecules and CH3 domain molecules are also provided.
摘要翻译：公开了结合新生儿Fc（FcRn）受体并且至少99％是单体的Fc结构域和CH3结构域。本文公开了单体Fc结构域分子和CH3结构域分子，其包括单体Fc结构域或单体CH 3结构域和效应分子。在一些实施方案中，单体Fc或单体CH3结构域包括β链中的氨基酸取代和/或CDR插入，使得它们特异性结合抗原。还提供了使用这些单体Fc结构域，单体CH3结构域，单体Fc结构域分子和CH3结构域分子的方法。

9. 发明公开

EP2765422A2 MEMBRANE SENSOR ENABLED WITH SEQUENTIAL CHANGE OF REACTION CONDITION WITH SINGLE SAMPLE INJECTION 有权
标题翻译： DURCH SEQUENTIELLEÄNDERUNGVON REAKINGSBEDINGUNGEN MIT EINZELPROBENINJEKTION AKTIVIERTER MEMBRANSENSOR
公开(公告)号：EP2765422A2
公开(公告)日：2014-08-13
申请号：EP12837916.1
申请日：2012-10-05
申请人： Ingibio, Ltd.
发明人： KIM, Min-Gon , JOUNG, Hyou-Arm , AHN, Jun-Hyoung
IPC分类号： G01N33/538 , G01N33/52 , G01N33/68
CPC分类号： G01N33/54306 , G01N33/544 , G01N33/558
摘要： Disclosed herein are a membrane sensor capable of changing a reaction condition by a single sample injection and a method for measuring a reaction using the same, and more specifically, a membrane sensor designed so that a bio reaction having two or more reaction conditions is sequentially generated by a single sample injection, by forming an asymmetric membrane between a reactant storing part and a reaction membrane.
摘要翻译：本文公开了能够通过单个样品注入改变反应条件的膜传感器和使用其的反应的测定方法，更具体地，设计成使得具有两个或更多个反应条件的生物反应顺序产生的膜传感器通过单次样品注入，通过在反应物储存部分和反应膜之间形成不对称膜。

10. 发明公开

EP2612751A3 Method of manufacturing a biopolymer optical waveguide 审中-公开
标题翻译： Herstellungsverfahren eines Biopolymer-Lichtwellenleiter
公开(公告)号：EP2612751A3
公开(公告)日：2013-11-13
申请号：EP13156510.3
申请日：2007-11-05
申请人： Trustees of Tufts College
发明人： Kaplan, David , Omenetto, Fiorenzo , Lawrence, Brian , Cronin-Golumb, Mark , Georgakoudi, Irene
IPC分类号： B29D11/00 , B29C39/02 , B82Y20/00 , G02B1/04 , G01N33/543 , G02B6/138 , G02B6/12
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method comprising the steps of:
providing (i) a substrate; and, (ii) an aqueous silk fibroin solution, wherein the aqueous silk fibroin solution contains a silk fibroin concentration of 1% to 30%;
printing the aqueous silk fibroin solution on the substrate.
摘要翻译：一种方法，包括以下步骤：提供（i）基底; 和（ii）水性丝素蛋白溶液，其中所述水性丝素蛋白溶液含有1％至30％的丝素蛋白浓度; 将水性丝素蛋白溶液印刷在基材上。

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