专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1849786A1 METHOD FOR PRODUCING NUCLEOSIDE DERIVATIVE 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON NUKLEOSIDDERIVATEN
公开(公告)号：EP1849786A1
公开(公告)日：2007-10-31
申请号：EP06712291.1
申请日：2006-01-25
申请人： Ajinomoto Co., Inc.
发明人： TAKAHASHI, Satoji , KOJIMA, Mitsuhiko , KONDOU, Shouichi , ISHIKAWA, Tatsuya , OGAWA, Yoshinori
IPC分类号： C07D487/04 , C12P19/40 , C07B61/00
CPC分类号： C12P17/182 , C07D473/30 , C07D473/34 , Y02P20/55
摘要： The present invention relates to a method for producing a nucleoside derivative represented by formula (2), comprising the step of reducing a nucleoside of formula (1) in the presence of a noble metal catalyst comprising a carrier and a noble metal supported thereby, selected from the group consisting of (A) a homogeneously supported catalyst where the specific surface area of the noble metal is 95.0 m 2 /g or more and the particle size of the noble metal is 4.3 nm or less, and (B) a surface-loaded catalyst where the specific surface area of the noble metal is 56.0 m 2 /g or more and the particle size of the noble metal is 8.0 nm or less,

wherein R 1 is hydrogen or a protective group, R 2 is NH 2 or OH, R 3 is an acyl group, and X is a chlorine or bromine atom. According to the present invention, the yield can be made equal even when the amount of catalyst is smaller than that used for the conventional products.
摘要翻译：本发明涉及一种制备由式（2）表示的核苷衍生物的方法，其包括在贵金属催化剂存在下还原式（1）的核苷的步骤，所述贵金属催化剂包含载体和由其负载的贵金属，由（A）贵金属的比表面积为95.0m 2 / g以上且贵金属的粒径为4.3nm以下的均匀负载的催化剂组成的组，（B）表面活性剂，贵金属的比表面积为56.0m 2 / g以上，贵金属的粒径为8.0nm以下，其中R 1为氢或保护基，R 2为NH 2或OH R 3为酰基，X为氯原子或溴原子。根据本发明，即使当催化剂的用量小于常规产品时，也可以使产量相等。

2. 发明公开

EP2003113A1 PROCESS FOR PRODUCTION OF CARBOXYLIC ACID CHLORIDE COMPOUND 审中-公开
标题翻译： VERFAHREN ZUR PRODUKTION EINERCARBONSÄURECHLORIDVERBINDUNG
公开(公告)号：EP2003113A1
公开(公告)日：2008-12-17
申请号：EP07740213.9
申请日：2007-03-29
申请人： Ajinomoto Co., Inc.
发明人： ISHIKAWA, Tatsuya , KONDOU, Shouichi , TAKAHASHI, Satoji
IPC分类号： C07C51/60 , C07C61/15 , C07C231/02 , C07C233/63 , C07B53/00 , C07B61/00
CPC分类号： C07C231/02 , C07B53/00 , C07C51/60 , C07C2601/14 , C07C61/15 , C07C233/63
摘要： The present invention discloses methods for producing a carboxylic acid chloride compound which comprises the step of reacting an alkyl-substituted cyclohexyl carboxylic acid with a chlorinating agent in the presence of a specific urea compound. According to this invention, it is possible to produce a carboxylic acid chloride compound which has high reaction speed, and whose product has high purity or high yield. Thus produced carboxylic acid chloride compound is useful as an intermediate for producing D-phenylalanine derivatives which are used as agents for treating diabetes.
摘要翻译：本发明公开了制备羧酰氯化合物的方法，其包括在特定脲化合物存在下使烷基取代的环己基羧酸与氯化剂反应的步骤。根据本发明，可以制备反应速度快，产物纯度高，产率高的羧酸酰氯化合物。这样制得的羧酰氯化合物可用作生产D-苯丙氨酸衍生物的中间体，其用作治疗糖尿病的药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式