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1. 发明公开

EP1304911A1 Flexible circuit 有权
标题翻译：灵活的Schaltung
公开(公告)号：EP1304911A1
公开(公告)日：2003-04-23
申请号：EP02256369.6
申请日：2002-09-13
申请人： Agilent Technologies, Inc.
发明人： Barth, Phillip W. , Killeen, Kevin
IPC分类号： H05K1/11 , G02B6/42
CPC分类号： H05K1/118 , G02B6/125 , G02B6/13 , G02B6/4453 , Y10T137/86348
摘要： A planar extensible structure (110) in a flat planar flex circuit (75, 700, 800, 900) can be extended out of the plane (102) of the circuit by a distance of more than the width of the structure to carry fluids, electrical signals or optical signals into and out of the circuit. The planar extensible structure (110) may be an Archimedes spiral, a parabolic spiral, a polygonal spiral, a non-spiral extensible shape, or other extensible shape. The system can be used to siphon fluid samples from each well in a multiple-well microtiter plate into a microfluidic manifold for utility in chemical and biochemical analysis. The system can also be used to allow electrical interconnect between adjacent circuits or circuit boards, and can allow signals carried in optical fibers to be transferred between optical circuits in different planes.
摘要翻译：平面平面柔性电路（75,700,800,900）中的平面可延伸结构（110）可以延伸出电路的平面（102）的距离超过结构的宽度以承载流体，电信号或光信号进出电路。平面可延伸结构（110）可以是阿基米德螺旋，抛物线螺旋，多边形螺旋，非螺旋形可延伸形状或其它可延伸形状。该系统可用于将多孔微量滴定板中的每个孔的流体样品虹吸到微流控歧管中，用于化学和生物化学分析。该系统还可用于允许相邻电路或电路板之间的电互连，并且可以允许光纤中承载的信号在不同平面中的光电路之间传输。

2. 发明公开

EP1788388A1 Devices and methods using fluid-transporting features with differing residence times 有权
标题翻译：的装置和方法包括具有不同的停留时间的液体输送机制
公开(公告)号：EP1788388A1
公开(公告)日：2007-05-23
申请号：EP06255923.2
申请日：2006-11-20
申请人： Agilent Technologies, Inc.
发明人： Brennen, Reid , Yin, Hongfeng , Killeen, Kevin , Schleifer, Arthur
IPC分类号： G01N30/34 , G01N30/36
CPC分类号： G01N30/34 , B01F13/0059 , B01F13/0094 , B01L3/502746 , B01L2300/0867 , B01L2400/0418 , B01L2400/0487 , B01L2400/084 , Y10T137/2224
摘要： A fluidic device (10) is provided that includes a plurality of fluid-transporting features (19) extending from a common inlet (46) to a common outlet (48) and a means for effecting fluid flow through the fluid-transporting features (19). The features (19) are associated with differing fluid dwell times. The means for effecting fluid flow cooperates with the fluid-transporting features (19) to merge fluids from the fluid-transporting features (19) in a manner effective to produce an output stream from the common outlet (48) that exhibits at least one desired characteristic generated as a result of the differing dwell times. Also provided is a method for producing a fluid stream exhibiting at least one desired characteristic. Optionally, the device (10) and/or method are used in microfluidic applications.
摘要翻译：流体装置（10）设置没有包括的流体输送特征从一个公共入口（46）延伸到一个共同的出口（48）和用于通过所述流体输送特征 - 影响流体流动的指多个（19）（19 ）。的特征（19）具有不同的流体停留时间相关联。用于实现流体流动的装置与所述流体输送特征（19）在有效从公共出口（48）在输出流，以产生方式合并从流体输送特征（19）的流体组织合作的并具有至少一个希望的作为不同的停留时间的结果特性产生。这样提供了一种用于制备流体流展现期望的至少一个特性的方法。任选地，所述装置（10）和/或方法在微流体应用中。

3. 发明公开

EP1338894A3 Mobile phase gradient generation microfluidic device 有权
标题翻译：流动相梯度生成微流体装置
公开(公告)号：EP1338894A3
公开(公告)日：2004-08-11
申请号：EP03251113.1
申请日：2003-02-25
申请人： Agilent Technologies, Inc.
发明人： Yin, Hongfeng , Killeen, Kevin , Sobek, Daniel
IPC分类号： G01N30/34
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/285
摘要： The present invention relates to a microfluidic device (10) for separating the components of a fluid sample. A cover plate (40) is arranged over the first surface (14) of a substrate (12) , which, in combination with a microchannel (18) formed in the first (14) surface, defines a separation conduit (19) for separating the components of the fluid sample. An inlet port (72) in fluid communication with the separation conduit (19) allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means (60) to the separation conduit (19) . A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.
摘要翻译：本发明涉及用于分离流体样品的成分的微流体装置（10）。盖板（40）布置在基板（12）的第一表面（14）上方，该基板与形成在第一表面（14）中的微通道（18）结合限定用于分离的分离导管（19）流体样本的成分。与分离导管（19）流体连通的入口端口（72）允许将含有选定流动相组分梯度的流动相从集成梯度生成装置（60）引入分离导管（19）。还提供了使用含有选定的流动相组分的梯度的流动相分离流体样品的组分的方法，其中梯度在小体积的流动相内产生。

4. 发明授权

EP1788388B1 Devices and methods using fluid-transporting features with differing residence times 有权
标题翻译：的装置和方法包括具有不同的停留时间的液体输送机制
公开(公告)号：EP1788388B1
公开(公告)日：2010-06-30
申请号：EP06255923.2
申请日：2006-11-20
申请人： Agilent Technologies, Inc.
发明人： Brennen, Reid , Yin, Hongfeng , Killeen, Kevin , Schleifer, Arthur
IPC分类号： G01N30/34 , G01N30/36
CPC分类号： G01N30/34 , B01F13/0059 , B01F13/0094 , B01L3/502746 , B01L2300/0867 , B01L2400/0418 , B01L2400/0487 , B01L2400/084 , Y10T137/2224

5. 发明授权

EP1521064B1 Method and system for monitoring fluid flow 有权
标题翻译：方法和系统，用于监测流体流动
公开(公告)号：EP1521064B1
公开(公告)日：2007-03-28
申请号：EP04255913.8
申请日：2004-09-28
申请人： Agilent Technologies, Inc.
发明人： Sobek, Daniel , Yin, Hongfeng , Rocklin, Roy D. , Killeen, Kevin
IPC分类号： G01F1/708
CPC分类号： G01F1/7084

6. 发明公开

EP1447136A1 PAEK-based microfluidic device 审中-公开
标题翻译： Mikrofluidische Vorrichtung auf Basis von Polyaryletherketonen
公开(公告)号：EP1447136A1
公开(公告)日：2004-08-18
申请号：EP04250623.8
申请日：2004-02-05
申请人： Agilent Technologies, Inc.
发明人： Roitman, Daniel B. , Killeen, Kevin , Yin, Hongfeng , Seaward, Karen L.
IPC分类号： B01L3/00 , B81B1/00
CPC分类号： B29C66/324 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00862 , B01J2219/00891 , B01J2219/00957 , B01L3/0268 , B01L3/502707 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , B01L2300/12 , B01L2400/0622 , B01L2400/0644 , B29C65/48 , B29C65/4835 , B29C66/001 , B29C66/02 , B29C66/1122 , B29C66/53461 , B29C66/54 , B29C66/71 , B29C66/82661 , B29K2071/00 , B29L2031/756 , B81B1/00 , G01N30/20 , G01N30/6095 , G01N30/7266
摘要： A polyaryl-ether-ketone-based microfluidic device (10) having an integrated electrospray emitter (90) is disclosed. Bonding of at least one polyaryl-ether-ketone substrate (12) forming the microfluidic device (10) is accomplished using a solvent-resistant adhesive (270), such as a polyimide-based adhesive, in combination with an adhesion enhancement treatment. By providing the polyaryl-ether-ketone-based microfluidic device (10) with an integrated electrospray emitter (90), efficient and effective analysis of fluid samples is enabled.
摘要翻译：公开了具有集成电喷雾发射器（90）的聚芳基醚 - 酮基微流体装置（10）。形成微流体装置（10）的至少一种聚芳基醚酮基材（12）的粘合是使用耐溶剂粘合剂（270），例如聚酰亚胺基粘合剂，结合粘附增强处理来实现的。通过提供具有集成电喷雾发射器（90）的基于聚芳基醚 - 酮的微流体装置（10），能够对流体样品进行有效和有效的分析。

7. 发明授权

EP1338894B1 Mobile phase gradient generation microfluidic device 有权
标题翻译：流动相梯度生成微流体装置
公开(公告)号：EP1338894B1
公开(公告)日：2016-07-20
申请号：EP03251113.1
申请日：2003-02-25
申请人： Agilent Technologies, Inc.
发明人： Yin, Hongfeng , Killeen, Kevin , Sobek, Daniel
IPC分类号： G01N30/34
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/201 , G01N2030/202 , G01N2030/285

8. 发明公开

EP1564779A2 Ion source frequency feedback device and method 审中-公开
标题翻译： Ionenquellenfrequenzrückkopplungsgerät和Methode
公开(公告)号：EP1564779A2
公开(公告)日：2005-08-17
申请号：EP04029244.3
申请日：2004-12-09
申请人： Agilent Technologies Inc. a Delaware Corporation
发明人： Sobek, Daniel , Cai, Jing , Killeen, Kevin , Yin, Hongfeng
IPC分类号： H01J27/02 , H01J49/04
CPC分类号： H01J49/165
摘要： An ion source for an analytical instrument is described. The ion source comprises a capillary tip (105) and counter-electrode (103) interface and a feedback loop control device (400) connected to the capillary tip and counter-electrode interface. The feedback loop control device comprises a transimpedance amplifier (401), a DC de-coupler (403), a frequency to voltage converter (405), a controller (407), and a voltage-controlled high-voltage power supply (409) that provides a tip to counter-electrode voltage to the capillary tip and counter-electrode interface. The feedback loop control device measures the modulation frequency of ionization currents and provides a feedback adjustment of the tip-to-counter-electrode voltage to maintain ionization efficiency.
摘要翻译：描述了用于分析仪器的离子源。离子源包括毛细管尖端（105）和对电极（103）接口以及连接到毛细管尖端和对电极界面的反馈回路控制装置（400）。反馈回路控制装置包括跨阻抗放大器（401），DC去耦合器（403），频率 - 电压转换器（405），控制器（407）和压控高压电源（409）这提供了对毛细管尖端和对电极界面的对电极电压的尖端。反馈回路控制装置测量电离电流的调制频率，并提供针对对电极电压的反馈调整，以维持电离效率。

9. 发明公开

EP1521064A1 Method and system for monitoring fluid flow 有权
标题翻译： Verfahren und System zurÜberwachungeinesFlüssigkeitsdurchflusses
公开(公告)号：EP1521064A1
公开(公告)日：2005-04-06
申请号：EP04255913.8
申请日：2004-09-28
申请人： Agilent Technologies Inc
发明人： Sobek, Daniel , Yin, Hongfeng , Rocklin, Roy D. , Killeen, Kevin
IPC分类号： G01F1/708
CPC分类号： G01F1/7084
摘要： The fluid flow rate within a microfluidic passageway (12) of a microfabricated device is determined by measuring the time-of-flight of a heat pulse (74) coupled into the fluid (76). Since the propagation velocity of the heat trace is generally slower than the mean flow rate of the flow, additional processing provides the appropriate scaling needed to obtain an accurate fluid flow rate measurement. The scaling factor is based on the geometry of the structure (78, 80) and the thermal properties of the fluid and the materials used for the device.
摘要翻译：通过测量耦合到流体（76）中的加热脉冲（74）的飞行时间来确定微加工装置的微流体通道（12）内的流体流速。由于热迹的传播速度通常比流动的平均流速慢，所以额外的处理提供了获得准确的流体流速测量所需的适当的比例。比例因子基于结构的几何形状（78,80）以及流体和用于该装置的材料的热性质。

10. 发明公开

EP1816471A1 Microfluidic device 审中-公开
标题翻译： Mikrofluidische Vorrichtung
公开(公告)号：EP1816471A1
公开(公告)日：2007-08-08
申请号：EP06256503.1
申请日：2006-12-21
申请人： Agilent Technologies, Inc.
发明人： Fazzio, Shane R. , Brennen, Reid , Killeen, Kevin , Yin, Hongfeng , Goel, Atul
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , B01L3/5027 , B01L9/527 , B01L2200/027 , B01L2300/069 , B01L2300/0887 , B01L2400/0421
摘要： A fluidic device (10) is provided that includes a body (11) and a contiguous electrically conductive layer (100). The body (11) has interior and exterior surfaces. The interior surface defines at least a well (50) and a fluid-transporting feature (25), e.g., a microfeature in fluid-communication with the well (50). The well (50) has a sidewall (46S) and an exterior opening (46E) terminating at the exterior surface (44). The contiguous electrically conductive layer (100) is located on at least the sidewall (46S) of the well (50) and selected regions of the interior and exterior surfaces so as to form a contact pad region (102) on the exterior surface (44) in electrical communication with any fluid within the fluid-transporting feature (25). Also provided is a method for forming a fluidic device (10).
摘要翻译：提供一种流体装置（10），其包括主体（11）和邻接的导电层（100）。主体（11）具有内表面和外表面。内表面限定至少一个井（50）和流体输送特征（25），例如与井（50）流体连通的微特征。井（50）具有终止在外表面（44）处的侧壁（46S）和外部开口（46E）。连续的导电层（100）至少位于阱（50）的侧壁（46S）和内表面和外表面的选定区域之间，以在外表面（44）上形成接触焊盘区域（102））与所述流体输送特征（25）内的任何流体电连通。还提供了一种用于形成流体装置（10）的方法。

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