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1. 发明授权

EP2970328B1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 失效
标题翻译：新型的磷酸二酯酶抑制剂化合物10A
公开(公告)号：EP2970328B1
公开(公告)日：2017-04-26
申请号：EP14709320.7
申请日：2014-03-12
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： JANTOS, Katja , OCHSE, Michael , GENESTE, Hervé , FROGGETT, Jayne , JAKOB, Clarissa , DRESCHER, Karla , DINGES, Jürgen
IPC分类号： C07D495/04 , A61K31/5025 , A61P25/00
CPC分类号： C07D495/04

2. 发明公开

EP2885299A1 INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 失效
标题翻译：抑制剂化合物型磷酸二酯酶10A
公开(公告)号：EP2885299A1
公开(公告)日：2015-06-24
申请号：EP13750071.6
申请日：2013-08-16
申请人： AbbVie Deutschland GmbH & Co KG , AbbVie Inc.
发明人： GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , JAKOB, Clarissa
IPC分类号： C07D471/04 , A61K31/4745 , A61P35/00
CPC分类号： C07D471/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof, where in formula I the variables R
1 , R
2 , R
3 , R
4 and R
5 are as defined in the claims and where X is C-R
6 or N,Y is C-R
7 or N, where R
6 and R
7 are, inter alia, hydrogen, halogen, alkoxy, haloalkoxy and the like. The compounds of the formula I, the N-oxides, tautomers,the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.

3. 发明公开

EP2726479A1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 审中-公开
标题翻译： NEU抑制剂DEN磷酸二酯酶类型10A
公开(公告)号：EP2726479A1
公开(公告)日：2014-05-07
申请号：EP12731416.9
申请日：2012-06-28
申请人： AbbVie Deutschland GmbH & Co KG , AbbVie Inc.
发明人： GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , BEHL, Berthold , LAPLANCHE, Loic , DINGES, Jürgen , JAKOB, Clarissa , JANTOS, Katja
IPC分类号： C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , A61K31/44
CPC分类号： C07D471/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel carboxamide compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating or controlling medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
摘要翻译：本发明涉及新的羧酰胺化合物，含有它们的药物组合物及其在治疗中的用途。该化合物具有有价值的治疗性质，并且特别适用于治疗或控制选自神经障碍和精神疾病的医学病症，用于改善与此类疾病相关的症状并降低此类疾病的风险。

4. 发明授权

EP2780324B1 HETEROCYCLIC CARBOXAMIDES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE TYPE 10A 有权
标题翻译：杂环化合物羧酰胺抑制剂抑制剂磷酸二酯酶类型10A
公开(公告)号：EP2780324B1
公开(公告)日：2017-05-17
申请号：EP12781349.1
申请日：2012-11-08
申请人： Abbvie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , DINGES, Jürgen , JAKOB, Clarissa
IPC分类号： C07D217/26 , C07D237/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , A61K31/472 , A61K31/502 , A61K31/4375 , A61P25/00
CPC分类号： C07D217/26 , A61K31/47 , C07D217/24 , C07D237/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/08 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04
摘要： The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
摘要翻译：本发明涉及作为10A型磷酸二酯酶抑制剂的化合物及其用于制备药物的用途，因此其适用于治疗或控制选自神经障碍和精神疾病的医学病症，以改善与此类症状相关的症状疾病和降低这种疾病的风险。

5. 发明公开

EP2970328A1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 失效
标题翻译： NEUARTIGE INHIBITORVERBINDUNGEN DER PHOSPHODIESTERASE TYP 10A
公开(公告)号：EP2970328A1
公开(公告)日：2016-01-20
申请号：EP14709320.7
申请日：2014-03-12
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： JANTOS, Katja , OCHSE, Michael , GENESTE, Hervé , FROGGETT, Jayne , JAKOB, Clarissa , DRESCHER, Karla , DINGES, Jürgen
IPC分类号： C07D495/04 , A61K31/5025 , A61P25/00
CPC分类号： C07D495/04
摘要： The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof: (I). In formula I the variables X
1 is CH or N, X
2 is O or S and where R
1 , R
2 , R
3 , R
4 and Q are as defined in the claims. The compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A. Thus, the invention also relates to the use of the compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
摘要翻译：本发明涉及式I化合物，N-氧化物，互变异构体，前药及其药学上可接受的盐：在式I中，变量X1是CH或N，X2是O或S，并且其中R1，R2，R3 R4和Q如权利要求中所定义。式I化合物，N-氧化物，互变异构体，其前药和药学上可接受的盐是10A型磷酸二酯酶的抑制剂。因此，本发明还涉及式I化合物，N-氧化物，互变异构体，前药和其药学上可接受的盐在制备药物中的用途，因此其适用于治疗或控制医学病症选自神经障碍和精神障碍，用于改善与这种障碍相关的症状并降低这种障碍的风险。

6. 发明公开

EP2922842A2 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 无效
标题翻译：化合物作为磷酸二酯酶10A型抑制剂
公开(公告)号：EP2922842A2
公开(公告)日：2015-09-30
申请号：EP13798625.3
申请日：2013-11-25
申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co KG
发明人： GENESTE, Hervé , TURNER, Sean , OCHSE, Michael , DRESCHER, Karla , BLACK, Lawrence A. , JANTOS, Katja , JAKOB, Clarissa
IPC分类号： C07D401/14 , A61K31/4353 , A61K31/4427 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04 , A61P25/00
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of the formula I and their salts etc. which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders wherein Y
1 and Y
2 are adjacent atoms in Het
1 , which are independently selected from the group consisting of carbon and nitrogen; k is 0, 1, 2 or 3; Het
1 is a bivalent monocyclic 5- or 6-membered heteroaromatic radical, having 1, 2 or 3 heteroatoms or heteroatom moieties selected from O, S, N and N-R
a as ring members, or a bivalent fused bicyclic 8-, 9- or 10-membered heteroaromatic radical, having 1, 2, 3 or 4 heteroatoms or heteroatom moieties selected from O, S, N and N-R
a as ring members; Het
2 is inter alia monocyclic 5- or 6-membered hetaryl, having 1, 2 or 3 heteroatoms or heteroatom moieties selected from O, S, N and N-R
1a as ring members, Cyc is inter alia optionally substituted monocyclic 5- or 6-membered hetaryl or optionally substituted fused 8-, 9- or 10-membered bicyclic hetaryl; Ar is optionally substituted phenylene or optionally substituted bivalent 6-membered hetaryl; R is attached to a carbon atom of Het
1 and inter alia - halogen, C
1 -C
6 -alkyl, C
2 -C
6 -alkenyl, C
2 -C
6 -alkynyl, C
1 -C
6 -alkoxy, C
1 -C
6 -fluoroalkyl, C
1 -C
6 -fluoroalkoxy, C
3 -C
6 -cycloalkyl etc.

7. 发明授权

EP2895489B1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 失效
标题翻译：新型的磷酸二酯酶抑制剂化合物10A
公开(公告)号：EP2895489B1
公开(公告)日：2017-10-18
申请号：EP13765695.5
申请日：2013-09-16
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , JAKOB, Clarissa , TORRENT, Maricel
IPC分类号： C07D491/04 , C07D495/04 , C07D498/04 , A61K31/502 , A61P25/00
CPC分类号： C07D471/14 , A61K31/4985 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14 , C07D498/04 , C07D498/14 , C07D513/14

8. 发明公开

EP2895489A1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 失效
标题翻译： NEUARTIGE INHIBITORVERBINDUNGEN DER PHOSPHODIESTERASE TYP 10A
公开(公告)号：EP2895489A1
公开(公告)日：2015-07-22
申请号：EP13765695.5
申请日：2013-09-16
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , JAKOB, Clarissa , TORRENT, Maricel
IPC分类号： C07D491/04 , C07D495/04 , C07D498/04 , A61K31/502 , A61P25/00
CPC分类号： C07D471/14 , A61K31/4985 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14 , C07D498/04 , C07D498/14 , C07D513/14
摘要： The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof. where in formula I the variables X, Y, Q
1 , Q
2 have the following meanings: X is C-R
3 or N; Q
1 is S or O and Q
2 is C-R
4 or N and Q
2 is connected to X via a double bond while Q
1 is connected to X via a single bond; or Q
2 is S or O and Q
1 is C-R
4 or N and Q
1 is connected to X via a double bond while Q
2 is connected to X via a single bond; Y is C-R
5 or N; where in formula I the variables R
1 , R
2 , R
3 , R
4 and R
5 are as defined in the claims The compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
摘要翻译：本发明涉及式I化合物，N-氧化物，互变异构体，前药及其药学上可接受的盐。在式I中，变量X，Y，Q1，Q2具有以下含义：X为C-R3或N; Q1是S或O，Q2是C-R4或N，Q2通过双键连接到X，而Q1通过单键连接到X; 或Q2是S或O，Q1是C-R4或N，并且Q1通过双键连接到X，而Q2通过单键连接到X; Y为C-R5或N; 在式I中，变量R1，R2，R3，R4和R5如权利要求中所定义。式I化合物，N-氧化物，互变异构体，其前药和药学上可接受的盐是磷酸二酯酶10A型和用于制造药物，因此其适用于治疗或控制选自神经障碍和精神障碍的医学病症，用于改善与此类障碍相关的症状并降低此类疾病的风险。

9. 发明公开

EP2780324A1 HETEROCYCLIC CARBOXAMIDES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE TYPE 10A 有权
标题翻译：杂环羧酰胺作为抑制剂磷酸二酯酶10A型
公开(公告)号：EP2780324A1
公开(公告)日：2014-09-24
申请号：EP12781349.1
申请日：2012-11-08
申请人： Abbvie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , DINGES, Jürgen , JAKOB, Clarissa
IPC分类号： C07D217/26 , C07D237/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04 , A61K31/472 , A61K31/502 , A61K31/4375 , A61P25/00
CPC分类号： C07D217/26 , A61K31/47 , C07D217/24 , C07D237/32 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/08 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04
摘要： The present invention relates to compounds which are inhibitors of phosphodiesterase type 10A and to their use for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.

10. 发明授权

EP2922842B1 INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 无效
标题翻译： VERBINDUNGEN ALS磷酸二酯酶类型10A-HEMMER
公开(公告)号：EP2922842B1
公开(公告)日：2017-06-14
申请号：EP13798625.3
申请日：2013-11-25
申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co KG
发明人： GENESTE, Hervé , TURNER, Sean , OCHSE, Michael , DRESCHER, Karla , BLACK, Lawrence A. , JANTOS, Katja , JAKOB, Clarissa
IPC分类号： C07D401/14 , A61K31/4353 , A61K31/4427 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04 , A61P25/00
CPC分类号： C07D401/14 , C07D401/04 , C07D401/10 , C07D471/04 , C07D487/04

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