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1. 发明公开

EP2970328A1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 失效
标题翻译： NEUARTIGE INHIBITORVERBINDUNGEN DER PHOSPHODIESTERASE TYP 10A
公开(公告)号：EP2970328A1
公开(公告)日：2016-01-20
申请号：EP14709320.7
申请日：2014-03-12
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： JANTOS, Katja , OCHSE, Michael , GENESTE, Hervé , FROGGETT, Jayne , JAKOB, Clarissa , DRESCHER, Karla , DINGES, Jürgen
IPC分类号： C07D495/04 , A61K31/5025 , A61P25/00
CPC分类号： C07D495/04
摘要： The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof: (I). In formula I the variables X
1 is CH or N, X
2 is O or S and where R
1 , R
2 , R
3 , R
4 and Q are as defined in the claims. The compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A. Thus, the invention also relates to the use of the compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
摘要翻译：本发明涉及式I化合物，N-氧化物，互变异构体，前药及其药学上可接受的盐：在式I中，变量X1是CH或N，X2是O或S，并且其中R1，R2，R3 R4和Q如权利要求中所定义。式I化合物，N-氧化物，互变异构体，其前药和药学上可接受的盐是10A型磷酸二酯酶的抑制剂。因此，本发明还涉及式I化合物，N-氧化物，互变异构体，前药和其药学上可接受的盐在制备药物中的用途，因此其适用于治疗或控制医学病症选自神经障碍和精神障碍，用于改善与这种障碍相关的症状并降低这种障碍的风险。

2. 发明授权

EP2970328B1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 失效
标题翻译：新型的磷酸二酯酶抑制剂化合物10A
公开(公告)号：EP2970328B1
公开(公告)日：2017-04-26
申请号：EP14709320.7
申请日：2014-03-12
申请人： AbbVie Deutschland GmbH & Co. KG , AbbVie Inc.
发明人： JANTOS, Katja , OCHSE, Michael , GENESTE, Hervé , FROGGETT, Jayne , JAKOB, Clarissa , DRESCHER, Karla , DINGES, Jürgen
IPC分类号： C07D495/04 , A61K31/5025 , A61P25/00
CPC分类号： C07D495/04

3. 发明公开

EP3191459A1 FUSED HETEROCYCLIC OR CARBOCYCLIC COMPOUNDS CARRYING A SUBSTITUTED CYCLOALIPHATIC RADICAL AND USE THEREOF FOR TREATING VASOPRESSIN-RELATED DISEASES 审中-公开
标题翻译：带有取代的环脂肪酸自由基的稠合杂环或碳环化合物及其用于治疗血管收缩素相关疾病的用途
公开(公告)号：EP3191459A1
公开(公告)日：2017-07-19
申请号：EP15759450.8
申请日：2015-09-04
申请人： AbbVie Deutschland GmbH & Co. KG
发明人： BRAJE, Wilfried , FROGGETT, Jayne , GENESTE, Hervé , HORNBERGER, Wilfried , JANTOS, Katja , KLING, Andreas , VAN GAALEN, Marcel
IPC分类号： C07D239/91
CPC分类号： C07D239/91 , C07D401/12 , C07D403/12 , C07D455/02 , C07D491/107
摘要： The present invention relates to novel fused heterocyclic or carbocyclic compounds of formula (I) wherein the variables are as defined in the claims and the description. The invention further relates to pharmaceutical compositions comprising these compounds, and to their use for the treatment of vasopressin-related disorders.
摘要翻译：本发明涉及新的式I的稠合杂环或碳环化合物，其中变量如权利要求和描述中所定义。本发明还涉及包含这些化合物的药物组合物，并涉及它们用于治疗加压素相关病症的用途。

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