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1. 发明公开

EP1789831A1 FOCUSING METHOD FOR THE HIGH-SPEED DIGITALISATION OF MICROSCOPE SLIDES AND SLIDE DISPLACING DEVICE, FOCUSING OPTICS, AND OPTICAL RANGEFINDER 有权
标题翻译：聚焦法快速数值化显微镜载玻片，并支持变速装置，聚焦光学系统和光学测距仪
公开(公告)号：EP1789831A1
公开(公告)日：2007-05-30
申请号：EP05702806.0
申请日：2005-01-27
申请人： 3Dhistech Kft.
发明人： VIRÁG, Tibor , LÁSZLÓ, Attila , MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor, Sebestyén
IPC分类号： G02B21/24 , G02B21/26
CPC分类号： G02B21/245 , G02B21/242 , G02B21/26 , G02B21/34
摘要： A focusing method is provided for the high speed digitalisation of microscope slides using an imaging device, wherein the slide is divided into fields of view according to the imaging device and focusing is performed by applying a rough focusing or a fine focusing. During the rough focusing, several images are captured within the focus range using large focus steps. On the basis of this set of images the position of the best contrast is determined. Fine focusing is performed by adjusting the focus according to the focus distance already determined for another field of view and by focusing with fine steps. A slide displacing device is provided, which enables the displacement of a slide parallel to the optical axis. The slide displacing device comprises slide holding means affixed to one side of a supporting means having two parallel sides, which are connected by stiffening elements defining at least two parallel planes. The stiffening elements are adjoined to said sides via resilient elements (29).

2. 发明授权

EP2962081B1 AUTOMATED INTEGRATED SLIDE-PROCESSING SYSTEM 有权
标题翻译：自动集成的滑动处理系统
公开(公告)号：EP2962081B1
公开(公告)日：2017-05-10
申请号：EP14745228.8
申请日：2014-02-28
申请人： 3DHistech Kft.
发明人： HEGEDÜS, Márton , MOLNÁR, Béla , VIRÁG, Tibor
IPC分类号： G01N1/31 , G01N35/00 , G01N35/04
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00584 , G01N35/1002 , G01N35/1011 , G01N2035/00089 , G01N2035/00138 , G01N2035/00168 , G01N2035/00356 , G01N2035/0463
摘要： The present invention relates to an integrated automated slide processing system, especially to stain, to cover and to digitize one or more microscope slides (49) in one turn. Said system comprises, as a single apparatus, at least one incubation drawer, an incubation drawer carrier (1), a manipulation tray (2), a manipulation arm (3), a reagent changing unit (4), a washing and rinsing unit, a drop removal unit, a staining/pipetting unit (13), a coverslipping unit (14), a preview image recording unit (15), a digitizing unit (16) and a control computer (18) electrically connected with and providing control over said units, wherein each of the one or more unstained and un-covered microscope slides with sample to be stained, covered and digitized is arranged in an incubation drawer having sidewalls defining a vertically constrained slide receiving space, and wherein the above listed units form a treating path along which said microscope slide (49) is converted into a stained, covered and, at least partially, digitized microscope slide when simultaneously guided over said treating path upon and in harmony with respective control signals provided by the control computer (18) to the respective units.
摘要翻译：本发明涉及一种集成的自动化载玻片处理系统，尤其是用于染色，一次覆盖和数字化一个或多个显微镜载玻片（49）。所述系统包括作为单个装置的至少一个孵化抽屉，孵化抽屉载体（1），操作托盘（2），操作臂（3），试剂更换单元（4），洗涤和漂洗单元，脱液单元，染色/移液单元（13），盖片单元（14），预览图像记录单元（15），数字化单元（16）和控制计算机（18），所述控制计算机电连接并提供控制其中所述一个或多个未染色和未覆盖的显微镜载玻片中的待染色，覆盖和数字化的样本中的每一个设置在具有限定垂直约束的载玻片容纳空间的侧壁的孵化抽屉中，并且其中上述单元形成一个处理路径，当同时在所述处理路径上引导时，所述显微镜载玻片（49）被转换成染色的，被覆盖的和至少部分数字化的显微镜载玻片，并与由控制系统提供的各个控制信号电脑（18）到各自的单位。

3. 发明公开

EP2962081A2 AUTOMATED INTEGRATED SLIDE-PROCESSING SYSTEM 有权
标题翻译：自动集成系统FOLIENVERARBEITUNG
公开(公告)号：EP2962081A2
公开(公告)日：2016-01-06
申请号：EP14745228.8
申请日：2014-02-28
申请人： 3DHISTECH KFT.
发明人： HEGEDÜS, Márton , MOLNÁR, Béla , VIRÁG, Tibor
IPC分类号： G01N1/31 , G01N35/00 , G01N35/04
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00584 , G01N35/1002 , G01N35/1011 , G01N2035/00089 , G01N2035/00138 , G01N2035/00168 , G01N2035/00356 , G01N2035/0463
摘要： The present invention relates to an integrated automated slide processing system, especially to stain, to cover and to digitize one or more microscope slides (49) in one turn. Said system comprises, as a single apparatus, at least one incubation drawer, an incubation drawer carrier (1), a manipulation tray (2), a manipulation arm (3), a reagent changing unit (4), a washing and rinsing unit, a drop removal unit, a staining/pipetting unit (13), a coverslipping unit (14), a preview image recording unit (15), a digitizing unit (16) and a control computer (18) electrically connected with and providing control over said units, wherein each of the one or more unstained and un-covered microscope slides with sample to be stained, covered and digitized is arranged in an incubation drawer having sidewalls defining a vertically constrained slide receiving space, and wherein the above listed units form a treating path along which said microscope slide (49) is converted into a stained, covered and, at least partially, digitized microscope slide when simultaneously guided over said treating path upon and in harmony with respective control signals provided by the control computer (18) to the respective units.

4. 发明公开

EP2165200A1 SYSTEM FOR HANDLING SLIDES 有权
标题翻译：制度来处理幻灯片
公开(公告)号：EP2165200A1
公开(公告)日：2010-03-24
申请号：EP08762668.5
申请日：2008-06-06
申请人： 3Dhistech Kft.
发明人： VIRÁG, Tibor , MOLNÁR, Béla , SZIPÖCS, Ferenc , NÉMETH, Ottó , BILETZKY, Attila , VARGA, Viktor Sebestyén , LÁSZLÓ, Attila
IPC分类号： G01N35/00 , G01N35/04 , G02B21/34
CPC分类号： G02B21/34 , G01N2035/00138 , G01N2035/00376
摘要： The invention relates to a system for handling slides comprising a tray moving on a carriage provided with seats for the slides and with a tray moving mechanism; a slide loading arm; and a slide holding frame provided with a slide loading arm driving motor, wherein the slide holder (30) is provided with slide holding elements; there are outstretched Maltese crosses (13) on the lower side of the tray (6) of the slide feeder (1 ) and a crank (14) is arranged in the carriage (4), opposite to and parallel with the crosses (13), said crank being coupled to said crosses; said slide loading arm (9) is arranged movably and tillable above (30) and a supporting plate (11 ) is arranged movably and tiltable below the slide holder, said supporting plate cooperating with said slide loading arm. The slide holding frame (7) is provided with lifting means for tilting the slide loading arm (9) and the supporting plate (11 ), said lifting means being actuated by controlling means arranged on the disk (15) of the crank (14).

5. 发明授权

EP1994398B8 AUTOMATED DIGITAL IMAGE RECORDING SYSTEM FOR AND METHOD OF DIGITIZING SLIDES 有权转让
标题翻译：全自动数字成像系统数字化DIAS和方法THEREOF
公开(公告)号：EP1994398B8
公开(公告)日：2010-02-03
申请号：EP07713006.0
申请日：2007-03-05
申请人： 3DHISTECH KFT
发明人： MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén , VIRÁG, Tibor
IPC分类号： G01N21/84 , G01N15/14 , G06K9/00 , B01L3/00
CPC分类号： G01N21/84 , G02B21/365

6. 发明授权

EP2165200B1 SYSTEM FOR HANDLING SLIDES 有权
标题翻译：制度来处理幻灯片
公开(公告)号：EP2165200B1
公开(公告)日：2016-08-10
申请号：EP08762668.5
申请日：2008-06-06
申请人： 3DHistech Kft.
发明人： VIRÁG, Tibor , MOLNÁR, Béla , SZIPÖCS, Ferenc , NÉMETH, Ottó , BILETZKY, Attila , VARGA, Viktor Sebestyén , LÁSZLÓ, Attila
IPC分类号： G01N35/00 , G01N35/04 , G02B21/34
CPC分类号： G02B21/34 , G01N2035/00138 , G01N2035/00376

7. 发明授权

EP1994398B1 AUTOMATED DIGITAL IMAGE RECORDING SYSTEM FOR AND METHOD OF DIGITIZING SLIDES 有权转让
标题翻译：全自动数字成像系统数字化DIAS和方法THEREOF
公开(公告)号：EP1994398B1
公开(公告)日：2009-08-12
申请号：EP07713006.0
申请日：2007-03-05
申请人： 3Dhistech Kft.
发明人： MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén , VIRÁG, Tibor
IPC分类号： G01N21/84 , G01N15/14 , G06K9/00 , B01L3/00
CPC分类号： G01N21/84 , G02B21/365
摘要： The present invention relates to an automated digital image recording system (1) for digitizing slides (6). The image recording system (1) comprises a slide holding means (7, 17), a mechanism for actuating it, a first digital image recording means, a second digital image recording means of high magnification and a control unit (4) for a software-based control of the automated image recording. The image recording system (1) is adapted for digitizing a slide (6) having one or more regions with sample and at least one separate region that comprises a field of information. The first digital image recording means is adapted for reading out the at least one region comprising the field of information and comprises a digital preview camera (2) capturing a low resolution preview image of each of the one or more regions with sample separately. The control unit is provided with a routine for searching points of the low resolution preview images that belong to the sample.

8. 发明公开

EP1994398A1 AUTOMATED DIGITAL IMAGE RECORDING SYSTEM FOR AND METHOD OF DIGITIZING SLIDES 有权转让
标题翻译：全自动数字成像系统数字化DIAS和方法THEREOF
公开(公告)号：EP1994398A1
公开(公告)日：2008-11-26
申请号：EP07713006.0
申请日：2007-03-05
申请人： 3Dhistech Kft.
发明人： MOLNÁR, Béla , TAGSCHERER, Attila , VARGA, Viktor Sebestyén , VIRÁG, Tibor
IPC分类号： G01N21/84 , G01N15/14 , G06K9/00 , B01L3/00
CPC分类号： G01N21/84 , G02B21/365
摘要： The present invention relates to an automated digital image recording system (1) for digitizing slides (6). The image recording system (1) comprises a slide holding means (7, 17), a mechanism for actuating it, a first digital image recording means, a second digital image recording means of high magnification and a control unit (4) for a software-based control of the automated image recording. The image recording system (1) is adapted for digitizing a slide (6) having one or more regions with sample and at least one separate region that comprises a field of information. The first digital image recording means is adapted for reading out the at least one region comprising the field of information and comprises a digital preview camera (2) capturing a low resolution preview image of each of the one or more regions with sample separately. The control unit is provided with a routine for searching points of the low resolution preview images that belong to the sample.

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