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1. 发明公开

EP3194594A1 HIGH-THROUGHPUT SAMPLE PROCESSING SYSTEMS AND METHODS OF USE 审中-公开
标题翻译：高通量样品处理系统和使用方法
公开(公告)号：EP3194594A1
公开(公告)日：2017-07-26
申请号：EP15832008.5
申请日：2015-06-02
申请人： Counsyl, Inc.
发明人： LAPHAM, Kyle Allen , CREGG, James Frederick , DELUBAC, Daniel , GLASER, Stuart Ira
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： G01N35/1074 , B01L3/021 , B01L3/5025 , B01L3/527 , B01L7/00 , B01L99/00 , B01L2200/082 , B01L2200/143 , B01L2300/021 , B01L2300/0627 , B01L2300/0829 , B01L2400/0487 , C12Q1/6806 , G01N1/38 , G01N35/00732 , G01N35/028 , G01N35/1002 , G01N35/1004 , G01N35/1016 , G01N2035/00356 , G01N2035/00376 , G01N2035/00396 , G01N2035/00752 , G01N2035/1025 , G01N2035/1034
摘要： Disclosed herein are high-throughput sample processing systems and waste management systems, and methods of using the same. I some embodiments, a high throughput sample processing system comprises a sample dispensing device, a plurality of contactless liquid level sensors, a plurality of aspirators, a plurality of contactless treatment stations, a waste management system, and a control system.
摘要翻译：本文公开了高通量样本处理系统和废物管理系统以及使用该系统的方法。

2. 发明公开

EP2940477A4 AUTOMATIC ANALYZER 审中-公开
公开(公告)号：EP2940477A4
公开(公告)日：2016-08-31
申请号：EP13868392
申请日：2013-12-13
申请人： HITACHI HIGH TECH CORP
发明人： MAKINO AKIHISA , YOSHIKAWA KEIKO , YOKOKAWA TAKESHI
IPC分类号： G01N35/10 , G01N21/77 , G01N33/49 , G01N33/86 , G01N35/00 , G01N35/02
CPC分类号： G01N33/4905 , G01N33/86 , G01N35/00663 , G01N35/025 , G01N35/1002 , G01N35/1016 , G01N2035/00346 , G01N2035/00376 , G01N2035/00386 , G01N2035/00425 , G01N2035/00435 , G01N2035/00673 , G01N2035/1048
摘要： Provided is an automatic analyzer which realizes stable reagent heating and high dispensing accuracy regardless of a variation in the temperature outside the device and the temperature of supply water to the device, and can perform an analysis with high reproducibility. The automatic analyzer includes: a reaction disk, on which reaction cells for allowing a sample and a reagent to mix and react with each other are arranged on the circumference thereof, and which alternately repeats rotation and stop; a thermostat bath for controlling the reagent or a reaction solution in the reaction cell to have a constant temperature; a first reagent dispensing mechanism which dispenses the reagent into the reaction cell; a photometer which detects transmitted light or scattered light by irradiating light onto the reaction solution in the reaction cell; a reaction container supply section which supplies a disposable reaction container for allowing the sample and the reagent to mix and react with each other; a second reagent dispensing mechanism with a reagent heating function which dispenses the reagent into the disposable reaction container; a coagulation time detection section which detects transmitted light or scattered light by irradiating light onto the reaction solution in the disposable reaction container; a reaction container temperature control block which has the coagulation time detection section and is used for controlling the reagent or the reaction solution in the disposable reaction container to have a constant temperature; a reagent dispensing syringe which is connected to the second reagent dispensing mechanism with a heating function; and a fluid temperature control mechanism which controls the temperature of an internal fluid of the reagent dispensing syringe.

3. 发明公开

EP2176667A2 SAMPLE PROCESSOR 审中-公开
标题翻译：样本处理
公开(公告)号：EP2176667A2
公开(公告)日：2010-04-21
申请号：EP08776112.8
申请日：2008-08-01
申请人： Enigma Diagnostics Limited
发明人： LEE, Martin, Alan , SQUIRRELL, David, James , WITHERS, Michael, John , BECKETT, Trevor, John , SILK, Christopher, John
IPC分类号： G01N35/00
CPC分类号： G01N35/1079 , B01L3/5029 , B01L9/00 , B01L2200/025 , B01L2200/141 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0867 , G01N2035/00376 , G01N2035/00534 , G01N2035/103
摘要： An integral magnet and heater device comprising a heating element with integral permanent magnet for use in a sample preparation or analysis apparatus. Also disclosed is a sheath adapted to cover a reusable processing component, such as a heater or sonicator, of an apparatus during use. Other associated aspects of the system are described and claimed.

4. 发明公开

EP1579190A1 ADVANCED PROGRAMMED SAMPLE PROCESSING SYSTEM AND METHODS OF BIOLOGICAL SLIDE PROCESSING 审中-公开
标题翻译：高级可编程样本处理系统和方法用于处理生物SLIDE
公开(公告)号：EP1579190A1
公开(公告)日：2005-09-28
申请号：EP03814194.1
申请日：2003-12-19
申请人： DakoCytomation Denmark A/S
发明人： WELCHER, Rosanne , KEY, Marc , FEINGOLD, Gordon , SWEET, Doug , FAVUZZI, John
IPC分类号： G01N5/02 , G01N15/06 , G01N21/00 , G01N27/04 , G01N27/12 , G01N31/00 , G01N33/48 , G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

5. 发明公开

EP1572979A1 A METHOD AND APPARATUS FOR AUTOMATIC STAINING OF TISSUE SAMPLES 审中-公开
标题翻译：方法和设备的组织样本的自动染色
公开(公告)号：EP1572979A1
公开(公告)日：2005-09-14
申请号：EP03808490.1
申请日：2003-12-19
申请人： DakoCytomation Denmark A/S
发明人： SWEET, Doug , KEY, Mark , FEINGOLD, Gordon , BUCHANAN, Kristopher , LATHROP, Bob , FAVUZZI, John
IPC分类号： C12N1/04 , C12M1/36 , C12M1/34 , G01N31/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

6. 发明公开

EP1462176A3 Apparatus for performing heat-exchanging, chemical reactions 有权
标题翻译：装置用于执行热交换的化学反应
公开(公告)号：EP1462176A3
公开(公告)日：2004-10-13
申请号：EP04015287.8
申请日：2000-12-15
申请人： Cepheid
发明人： Chang, Ronald , Dority, Douglas, B. , Christel, Lee, A. , Petersen, Kurt, E.
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/00873 , B01J2219/00963 , B01J2219/0097 , B01L3/508 , B01L9/00 , B01L2300/042 , B01L2300/0858 , B01L2300/1827 , F28D2021/0077 , F28F13/00 , G01N21/0332 , G01N35/0099 , G01N2035/00376 , G01N2035/0405 , Y10T436/2575
摘要： An apparatus for controlling the temperature of a reaction mixture contained in a reaction vessel, wherein the vessel includes a reaction chamber and at least one port for adding fluid to the chamber, and wherein the chamber has at least one flexible wall, comprises a) a thermal surface for contacting the flexible wall; b) a platen for heat sealing the vessel to seal the port closed and increase the pressure in the chamber, wherein the pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface; and c) at least one thermal element for heating or cooling the thermal surface to induce a temperature change within the chamber.

7. 发明公开

EP1373907A2 ROTARY INCUBATION STATION FOR IMMUNOASSAY SYSTEMS 有权
标题翻译：免疫系统的旋转孵化站
公开(公告)号：EP1373907A2
公开(公告)日：2004-01-02
申请号：EP02725186.7
申请日：2002-03-15
申请人： Beckman Coulter, Inc.
发明人： GJERDINGEN, Donald, J. , QURESHI, Humayun , WERNESS, Peter, G. , WILSON, Brian, D. , KITTOCK, Mark, J.
IPC分类号： G01N35/02 , B01L7/00 , G01N33/53
CPC分类号： G01N35/025 , B01L7/00 , G01N2035/00376
摘要： A rotary incubation station (10) for an automated analyzer is provided. The rotary incubation station (10) includes a platform (11), a circular ring-shaped outside rotary wheel (14) having a plurality of nesting locations (18) for washing and reading vessels, and a circular disc-shaped inside rotary wheel (12) having a plurality of nesting locations (16) for incubation and storage of vessels. The rotary incubation station (10) also includes a spur gear mechanism for rotating the outside and inside rotary wheels (14, 12), including spur gear drivers (32, 36) respectively engaged with spur gear teeth (30, 40) of the outside and inside rotary wheel (14, 12), providing accurate control of the rotation of the outside and inside rotary wheels (14, 12).
摘要翻译：提供了用于自动分析仪的旋转培养站（10）。旋转培养站（10）包括平台（11），具有用于清洗和读取容器的多个套叠位置（18）的圆环形外部旋转轮（14），以及圆盘形内部旋转轮 12）具有用于培养和储存血管的多个巢穴位置（16）。旋转培养站（10）还包括用于旋转外侧和内侧旋转轮（14,12）的正齿轮机构，所述正齿轮机构包括分别与外侧的正齿轮齿（30,40）接合的正齿轮驱动器（32,36）和旋转轮（14,12）内部，从而精确控制外侧和内侧旋转轮（14,12）的旋转。

8. 发明公开

EP1230553A1 ANALYSEUR CHIMIQUE OU BIOCHIMIQUE A REGULATION DE LA TEMPERATURE REACTIONNELLE 有权
标题翻译：带温度调节化学或生物反应分析仪
公开(公告)号：EP1230553A1
公开(公告)日：2002-08-14
申请号：EP00983378.1
申请日：2000-11-16
申请人： Maxmat SA
发明人： CHOJNACKI, André , RANDRIANARIVO, Jeanet
IPC分类号： G01N35/02 , B01L3/00
CPC分类号： B01L3/50851 , G01N35/025 , G01N2035/00376 , G01N2035/00425 , G01N2035/00524 , G01N2035/00752 , G01N2035/0427 , G01N2035/0455 , G01N2035/1076
摘要： The invention concerns a chemical or biochemical analyser comprising a pair of automatic sampling units (66A, 66B) operating independently, each equipped with a retractable suction pipette (68A, 68B) for transferring predetermined amounts of samples and reagents from the tray (14) to a reaction vessel (22) of an analysing module. The reaction vessel (22) is heated by convection by means of a heating plate (54) arranged proximate to the lower portion of the wells (23), and controlled by a heat-sensing regulating circuit (58). A fast preheating device (72) is incorporated in the sampling unit (66A) for preheating the reactive liquid before it is introduced into the wells (23) of the reaction vessel (22). A mixing device (84) is controlled by a relay magnet (86) to provoke a reciprocating oscillating movement of the pipette (68A) when the latter is in lowered position in the well (23) of the reaction vessel (22) so as to stir the mixture of samples and reagents.

9. 发明公开

EP0955097A1 Thermal cycler having an automatically positionable cover 失效
标题翻译： Thermozyklierapparat mit einem automatisch positionierbaren Deckel
公开(公告)号：EP0955097A1
公开(公告)日：1999-11-10
申请号：EP98810400.6
申请日：1998-05-04
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Schneebeli, Rolf
IPC分类号： B01L7/00 , G01N35/02 , B01L3/00
CPC分类号： B01L3/50851 , B01L7/52 , G01N35/026 , G01N2035/00376
摘要： A thermal cycler for performing amplification of nucleic acids, comprising

(a) a thermal block (71) having a plurality of chambers;
(b) a movable cover (14) having heating means (15) positioned within it;
(c) transport means for moving said cover (14) from said first position to said second position and viceversa, the path followed by the cover (14) comprising: a first path segment which lies above and at a predetermined distance from said thermal block (71) and along which said cover (14) is moved towards a stopper (16) until it abuts against it and a second path segment along which said cover (14) is moved away from said stopper (16) and downwards until it is vertically aligned with said thermal block (71) and exerts a predetermined pressure on reaction vessels (13) positioned in said chambers (72) of said thermal block.
摘要翻译：一种用于进行核酸扩增的热循环仪，包括（a）具有多个室的热块（71）; （b）具有位于其内的加热装置（15）的活动盖（14）; （c）用于将所述盖（14）从所述第一位置移动到所述第二位置并且反过来的传送装置，所述盖（14）后面的路径包括：第一路径段，其位于距所述热块的上方并且距预定距离（71），并且所述盖（14）沿着所述盖（14）朝止动件（16）移动，直到其抵靠在其上，并且第二路径段沿着所述盖（14）沿着所述第二路径段移动远离所述止动件（16）并且向下移动直到它与所述热块（71）垂直对准并对位于所述热块的所述室（72）中的反应容器（13）施加预定压力。

10. 发明授权

EP0462796B1 Release and isolation of N-glycans and O-glycans 失效
标题翻译：制备和分离N-聚糖和O-聚糖的
公开(公告)号：EP0462796B1
公开(公告)日：1998-10-21
申请号：EP91305497.9
申请日：1991-06-18
申请人： Oxford GlycoSciences (UK) Limited
发明人： Parekh, Rajesh Bhikhu , Merry, Anthony Hugh , Bruce, James
IPC分类号： C07H1/00 , C07H1/06 , C08B37/00 , C13K13/00
CPC分类号： G01N1/28 , B01L7/00 , C07H1/00 , C07H1/06 , G01N30/06 , G01N30/24 , G01N30/466 , G01N30/6043 , G01N30/6091 , G01N35/00712 , G01N2030/8881 , G01N2035/00376 , G01N2035/00415 , G01N30/30

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