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1. 发明授权

EP3075840B1 DEVICE FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTIMICROBIAL DRUGS 有权转让
公开(公告)号：EP3075840B1
公开(公告)日：2018-10-17
申请号：EP14866121.8
申请日：2014-10-27
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12M1/26 , C12Q1/06 , C12Q1/18
CPC分类号： C12Q1/18 , C12M23/12 , C12M41/34
摘要： The invention relates to the field of microbiology. A device for determining the sensitivity of microorganisms to antimicrobial drugs is configured in the form of a sterile plate made from a plastic material with indentations and is provided with a hermetically sealing element which covers the sterile plate. The indentations are filled with a solid culture medium containing agar. In different indentations, the culture medium contains antimicrobial drugs or combinations thereof or serves as a control. Between the plate and the hermetically sealing element, the device contains a moisture-absorbing material with a rigid mesh situated therebelow. The device is provided with a transparent protective lid made from a rigid durable plastic.

2. 发明公开

EP3384918A1 DRUGS (VARIANTS) AND METHODS FOR RESTORING MICROFLORA 有权
公开(公告)号：EP3384918A1
公开(公告)日：2018-10-10
申请号：EP16871132.3
申请日：2016-12-02
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： A61K35/66 , C12N1/20
CPC分类号： A61K35/66 , C12N1/20
摘要： The invention relates to microbiology and medicine and can be used to prevent and treat diseases and conditions associated with disruption of normal (autochthonous) microflora (microbiota) in humans or animals. In particular, a solution for recovery or creation of the subject's microflora comprising an active component containing microorganisms isolated from the microflora of the subject or the donor, wherein the active component can be enriched with bacteriophages of said microflora and/or additional microorganisms of the microflora cultivated on a nutrient medium, while the additional microorganisms of the microflora include microorganisms of the microflora that are yet nonculturable in the absence of the host organism, is proposed. Also provided are a pharmaceutical dosage form comprising the above solution and methods for prevention or treatment of diseases and/or conditions associated with and/or accompanied by a disorder or lack of the subject's own microflora, comprising administering the solution or pharmaceutical dosage form.

3. 发明公开

EP3315597A1 NUTRIENT MEDIUM FOR CULTIVATING BACTERIA 有权
标题翻译：培养细菌的营养培养基
公开(公告)号：EP3315597A1
公开(公告)日：2018-05-02
申请号：EP16814798.1
申请日：2016-06-23
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
IPC分类号： C12N1/20 , C12R1/01
CPC分类号： C12N1/20 , C12R1/01
摘要： The invention relates to microbiology, and more particularly to nutrient media used for cultivating bacteria for the subsequent study thereof. A nutrient medium comprising a pancreatic digest of casein, a peptic digest of meat, a heart pancreatic digest, yeast extract, starch and water is characterized in that it additionally contains violuric acid and beef infusion, wherein the ratio of ingredients is (wt%): 0.3-1.0 pancreatic digest of casein; 0.1-1.5 peptic digest of meat; 0.1-0.9 heart pancreatic digest; 0.1-2.0 yeast extract, 0.3-0.8 starch; 0.001-0.05 violuric acid; 2.0-15 beef infusion; the remainder water. The nutrient medium can additionally contain 0.3-2.5 wt% agar-agar and/or 1-20 wt% whole or hemolyzed sheep red blood cells and/or 1-20 wt% whole or hemolyzed human red blood cells and/or 1-15 wt% horse blood serum. This provides for the simultaneous growth of the maximum possible number of bacteria present in an inoculate.
摘要翻译：本发明涉及微生物学，并且更具体地涉及用于培养细菌的营养培养基以用于随后的研究。包含胰酪氨酸消化液，肉消化液消化液，心脏胰脏消化液，酵母提取物，淀粉和水的营养培养基，其特征在于它还含有紫苏酸和牛肉浸液，其中成分比例为（wt％）：0.3-1.0胰酪氨酸消化物; 0.1-1.5消化肉消化; 0.1-0.9心脏胰腺消化; 0.1-2.0酵母提取物，0.3-0.8淀粉; 0.001-0.05三聚乙酸; 2.0-15牛肉输液; 剩下的水。营养培养基可另外含有0.3-2.5重量％琼脂琼脂和/或1-20重量％全血或溶血羊红细胞和/或1-20重量％全血或溶血的人红细胞和/或1-15 wt％马血清。这提供了接种物中存在的最大可能数量的细菌的同时增长。

4. 发明公开

EP3162800A4 FUNGICIDAL AGENT 审中-实审
公开(公告)号：EP3162800A4
公开(公告)日：2018-01-10
申请号：EP14896241
申请日：2014-06-24
申请人： TETS VIKTOR VENIAMINOVICH , TETS GEORGY VIKTOROVICH
发明人： KRUTIKOV VIKTOR IOSIFOVICH
IPC分类号： A01N43/54 , A01N25/12 , A01P3/00 , A61K31/513 , A61P31/10 , C07D239/10
CPC分类号： A61K31/513 , A01N33/08 , A01N43/54 , A61K31/133 , C07C215/10 , C07D239/10 , C07D239/545 , A01N25/12
摘要： The invention relates to a novel fungicidal agent in the form of a salt associate having the structural formula shown. The agent can be used for treating diseases caused by fungi, and also for preventing fungal damage to various materials and agricultural products. The present fungicidal agent is an associate of 5-[3,5-dichloro-2-hydroxy benzylidene)amino]-4-hydroxy-1H-pyrimidine-2-on with 1,2,3,4,5-pentahydroxy-6-methylaminohexane and has the formula (I). This fungicidal agent exhibits a broad range of activity and high solubility, which increases the effectiveness of the use thereof in the form of solutions. Compounds were obtained in a crystalline form, and the structure thereof was established by means of magnetic resonance spectra in dimethyl sulfoxide.

5. 发明公开

EP3006020A1 METHOD FOR TREATING RECURRING SKIN AND MUCOUS MEMBRANE DISEASES CAUSED BY HSV-1 AND HSV-2 有权
标题翻译：方法用于治疗由HSV-1和HSV-2引起RECURRING皮肤和粘膜疾病
公开(公告)号：EP3006020A1
公开(公告)日：2016-04-13
申请号：EP14806838.0
申请日：2014-06-06
申请人： Tets, Viktor Veniaminovich , TETS, Georgy Viktorovich
发明人： Tets, Viktor Veniaminovich , TETS, Georgy Viktorovich
IPC分类号： A61K9/02 , A61K9/06 , A61K31/63 , A61P31/22
摘要： The invention relates to medicine and specifically to methods for treating recurring forms of diseases related to the family of herpes viruses. A method for treating recurring diseases of the skin and mucous membranes caused by HSV-1 and HSV-2 involves applying a preparation to an affected area, said preparation including a base containing 0.5% or 1% of an active substance, namely a (2,6-dichlorophenyl)amide salt of carbopentoxysulfanilic acid of general formula (I): where X is Na, K, NH 4 ; the preparation is applied twice daily for 3-5 days and, should prodromes appear, a second course of treatment is carried out, in which the preparation is applied 1-2 times daily for 2-3 days; the base containing the active substance can be in the form of a cream, an ointment, a gel, a suspension, suppositories, a patch or a film. Carrying out the second course of treatment provides a sharp increase in therapeutic efficacy, even to the extent of preventing relapse over a prolonged period of observation as a result of the effect of the preparation, upon reuse, on the viruses persisting in nerve cells.

6. 发明授权

EP3006020B1 METHOD FOR TREATING RECURRING SKIN AND MUCOUS MEMBRANE DISEASES CAUSED BY HSV-1 AND HSV-2 有权
公开(公告)号：EP3006020B1
公开(公告)日：2020-06-24
申请号：EP14806838.0
申请日：2014-06-06
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： TETS, Viktor Veniaminovich , TETS, Georgy Viktorovich , KRUTIKOV, Viktor Iosifovich
IPC分类号： A61K9/00 , A61K9/02 , A61K9/06 , A61K31/63 , A61P31/22 , A61K9/10

7. 发明公开

EP3315501A1 DRUG WITH ANTIVIRAL ACTIVITY (VARIANTS) 有权
标题翻译：具有抗病毒活性的药物（变体）
公开(公告)号：EP3315501A1
公开(公告)日：2018-05-02
申请号：EP16773558.8
申请日：2016-04-06
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： KRASNOV, Konstantin Andreevich
IPC分类号： C07D491/147 , C07D239/10 , C07H19/073 , A61K31/519 , A61K31/513 , A61P31/14 , A61P31/12
摘要： The invention relates to the field of organic chemistry and medicine, and more particularly to synthetic substances of the pyrimidine series, namely 2-chloro-5-phenyl-5 H- pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivatives, having antiviral activity. Claimed are a drug with antiviral activity against HIV infection and hepatitis B virus, containing 2-chloro-5-phenyl-5H-pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivatives of the general formula shown, where: X is selected from the group: H, NO 2 , Hal, OMe; R1 is selected from the group: Cl, OH; and R2 is selected from the group: Cl, SH, OH; and a drug with antiviral activity against HIV infection, containing a 2-chloro-5-phenyl-5H-pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivative of the general formula shown, where: X is selected from the group: H, NO 2 , Hal, OMe; R1 is selected from the group: Cl, OH; and R2 is selected from the group: Cl, SH, OH in combination with a reverse transcriptase inhibitor selected from Retrovir, or in combination with a protease inhibitor selected from Lopinavir, in an effective amount. The result is an effective drug with antiviral activity.
摘要翻译：本发明涉及有机化学和医药领域，更具体地涉及嘧啶系列的合成物质，即2-氯-5-苯基-5H-嘧啶并[5'，4'：5,6]吡喃并[2,1- 3-d]嘧啶-4-醇衍生物，具有抗病毒活性。声称含有2-氯-5-苯基-5H-嘧啶并[5'，4'：5,6]吡喃并[2,3-d]嘧啶-4-酮的抗HIV感染和乙型肝炎病毒的抗病毒活性的药物，其中：X选自：H，NO 2，Hal，OMe; R1选自：Cl，OH; 并且R2选自：Cl，SH，OH; 和一种具有抗HIV感染的抗病毒活性的药物，该药物含有2-氯-5-苯基-5H-嘧啶并[5'，4'：5,6]吡喃并[2,3-d]嘧啶-4-醇衍生物所示通式表示，其中：X选自：H，NO 2，Hal，OMe; R1选自：Cl，OH; R2选自：Cl，SH，OH与选自Retrovir的逆转录酶抑制剂或与选自洛匹那韦的蛋白酶抑制剂组合的有效量的组合。其结果是具有抗病毒活性的有效药物。

8. 发明公开

EP3300735A1 DRUG WITH HEPATOPROTECTIVE ACTIVITY 有权
标题翻译：具有HEPATOPROTECTIVE活性的药物
公开(公告)号：EP3300735A1
公开(公告)日：2018-04-04
申请号：EP16773555.4
申请日：2016-03-23
申请人： Tets, Viktor Veniaminovich , Tets, Georgy Viktorovich
发明人： KRASNOV, Konstantin Andreevich
IPC分类号： A61K31/513 , A61P1/16
CPC分类号： A61K31/513 , A61K45/06 , A61P1/16 , C07D239/545
摘要： The invention relates to pharmacology and can be used for treating liver diseases of various etiologies, inter alia, in combination with other preparations. Claimed is a drug with hepatoprotective activity comprised of 3-(4-bromophenyl)-6,6-dihydroxy-5-hydroxyiminohexahydro-2,4-pyrimidinedione and salts thereof of general formula (I),

where X is selected from the group: H, Na, K, or from the group of hydroxyalkylammonia derivatives of general formula (II),

where R1, R2 are selected from the group: H, CH 3 , CH 2 CH 3 , CH 2 CH 2 OH;
R3 is selected from the group: H, H 2 OH; and n = 1,2;
the drug can be prepared in the form of tablets or capsules for enteral administration; or in the form of a liquid or lyophilized substance for parenteral administration; or in the form of rectal suppositories; or in the form of capsules or tablets, or sweets for sucking; and may additionally contain the hepatoprotector Heptral; or the hepatoprotector Essentiale; or the hepatoprotector ursodeoxycholic acid. This increases the effectiveness of a drug with hepatoprotective activity.
摘要翻译：本发明涉及药理学，并且可以用于治疗各种病因的肝病，特别是与其他制剂组合。要求保护的是具有保肝活性的药物，其由3-（4-溴苯基）-6,6-二羟基-5-羟基亚氨基六氢-2,4-嘧啶二酮及其通式（I）的盐组成，其中X选自： H，Na，K或来自通式（II）的羟烷基氨衍生物的基团，其中R 1，R 2选自：H，CH 3，CH 2 CH 3，CH 2 CH 2 OH; R3选自：H，H2OH; 和n = 1,2; 该药物可以以用于肠内施用的片剂或胶囊剂的形式制备; 或者以液体或冻干物质的形式用于肠胃外给药; 或以直肠栓剂的形式; 或以胶囊或片剂的形式或用于吸吮的糖果; 并可另外含有肝保护剂Heptral; 或Essentiale肝保护剂; 或肝保护剂熊去氧胆酸。这增加了具有保肝活性的药物的有效性。

9. 发明公开

EP3297657A1 EXTRACELLULAR DNA AS A THERAPEUTIC TARGET IN NEURODEGENERATION 有权
标题翻译：细胞外DNA作为神经降解的治疗靶点
公开(公告)号：EP3297657A1
公开(公告)日：2018-03-28
申请号：EP16800375.4
申请日：2016-05-11
申请人： GENKIN, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
发明人： GENKIN, Dmitry Dmitrievich , Tets, Georgy Viktorovich , Tets, Viktor Veniaminovich
IPC分类号： A61K38/46 , A61P25/16 , A61P25/28
CPC分类号： A61K38/465 , A61K9/0019 , A61K9/0053 , A61K9/0085 , A61K47/61 , A61P25/16 , A61P25/18 , A61P25/28 , C12Y301/02021 , C12Y301/21001
摘要： The invention relates to the use of deoxyribonuclease (DNase) enzyme for inhibiting progression and for prevention and treatment of neurodegeneration.

10. 发明公开

EP3006020A4 METHOD FOR TREATING RECURRING SKIN AND MUCOUS MEMBRANE DISEASES CAUSED BY HSV-1 AND HSV-2 有权
标题翻译：方法用于治疗由HSV-1和HSV-2引起RECURRING皮肤和粘膜疾病
公开(公告)号：EP3006020A4
公开(公告)日：2017-02-15
申请号：EP14806838
申请日：2014-06-06
申请人： TETS VIKTOR VENIAMINOVICH , TETS GEORGY VIKTOROVICH
发明人： TETS VIKTOR VENIAMINOVICH , TETS GEORGY VIKTOROVICH
IPC分类号： A61K9/02 , A61K9/06 , A61K9/10 , A61K31/63 , A61P31/22
CPC分类号： A61K31/63 , A61K9/0014 , A61K9/0034 , A61K9/02 , A61K9/06 , A61K9/10
摘要： The invention relates to medicine and specifically to methods for treating recurring forms of diseases related to the family of herpes viruses. A method for treating recurring diseases of the skin and mucous membranes caused by HSV-1 and HSV-2 involves applying a preparation to an affected area, said preparation including a base containing 0.5% or 1% of an active substance, namely a (2,6-dichlorophenyl)amide salt of carbopentoxysulfanilic acid of general formula (I): where X is Na, K, NH 4 ; the preparation is applied twice daily for 3-5 days and, should prodromes appear, a second course of treatment is carried out, in which the preparation is applied 1-2 times daily for 2-3 days; the base containing the active substance can be in the form of a cream, an ointment, a gel, a suspension, suppositories, a patch or a film. Carrying out the second course of treatment provides a sharp increase in therapeutic efficacy, even to the extent of preventing relapse over a prolonged period of observation as a result of the effect of the preparation, upon reuse, on the viruses persisting in nerve cells.
摘要翻译：本发明涉及医学和专门用于处理有关家庭的疱疹病毒疾病的复发形式的方法。一种用于治疗皮肤的重复疾病和粘膜由HSV-1和HSV-2引起的方法包括在受影响的区域施加的制剂，该制剂包含含有0.5％或活性物质的1％时，基体即（2 ，6-二氯苯基）（I）通式carbopentoxysulfanilic酸的酰胺盐：其中X为Na，K，NH 4; 所述制剂3-5天每天施用两次，并且，shoulderstand前驱症状出现，治疗的第二过程中进行，其中所述制剂每天1-2次的应用2-3天; 含有活性物质的碱可以是乳膏，软膏，凝胶，悬浮液，栓剂，贴剂或膜的形式。进行处理的第二个疗程提供治疗功效的急剧增加，甚至防止复发整个观察长期作为制剂的效果的结果，在重复使用，对病毒在神经细胞中持续的程度。

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