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1. 发明授权

EP1999088B1 APPARATUS AND METHODS FOR BONDING CARBON-CARBON COMPOSITES THROUGH A REACTANT LAYER 有权
标题翻译： DEVICE AND METHOD FOR碳 - 碳复合材料的研究反应层约束力
公开(公告)号：EP1999088B1
公开(公告)日：2011-10-19
申请号：EP07759459.6
申请日：2007-03-27
申请人： Honeywell International Inc. , The University of Notre Dame du Lac
发明人： SIMPSON, Allen H. , FRYSKA, Slawomir T. , LA FOREST, Mark L. , KLINEDINST, Roger L. , MUKASYAN, Alexander , D'AMICO, Charles D.
IPC分类号： C04B37/00 , B23K1/00
CPC分类号： F16D69/023 , B32B2315/02 , C04B37/005 , C04B37/006 , C04B2235/404 , C04B2235/422 , C04B2237/083 , C04B2237/122 , C04B2237/385
摘要： An apparatus and a method for bonding a first carbon composite (86) to a second carbon composite (88) through a reactant layer (20) includes a housing, and a pair of conductive press plates electrically isolated from the housing (12). The press plates (74, 78) are adapted to position the two parts to be bonded with a reactant layer therebetween. The press plates are subjected to an electrical potential and a clamping force, sufficient to initiate a combustion reaction that creates a molten ceramic to bond together the carbon-carbon composites.

2. 发明公开

EP2084060A2 METHODS AND APPARATUS FOR REDUCING DRAG VIA A PLASMA ACTUATOR 审中-公开
标题翻译：方法和装置牵引复位等离子驱动器
公开(公告)号：EP2084060A2
公开(公告)日：2009-08-05
申请号：EP07854573.8
申请日：2007-11-02
申请人： The University of Notre Dame du Lac
发明人： CORKE, Thomas C. , SPIVEY, Richard
IPC分类号： B64C23/00
CPC分类号： B64C23/005 , B62D35/00 , B62D35/001 , B64C2230/12 , F05D2270/172 , H05H1/2406 , Y02T50/166
摘要： A vehicle includes a surface over which airflow passes. A plasma actuator is configured to generate plasma above the surface, the plasma coupling a directed momentum into the air surrounding the surface to reduce separation of the airflow from the surface. A method of reducing separation of airflow from a surface of the vehicle includes generating plasma in air surrounding the surface at a position where the airflow would separate from the surface in the absence of the plasma.

3. 发明公开

EP0460883A2 Process for beta-hydroxy-alpha-amino acids 失效
标题翻译： Verfahren zur Herstellung vonβ-Hydroxy-alpha-Aminosäuren。
公开(公告)号：EP0460883A2
公开(公告)日：1991-12-11
申请号：EP91304977.1
申请日：1991-06-03
申请人： THE UNIVERSITY OF NOTRE DAME DU LAC
发明人： Miller, Marvin Joseph
IPC分类号： C12P13/04 , C07C229/02
CPC分类号： C12N9/1014 , C12P13/04 , C12P13/08
摘要： β-Hydroxy-α-amino acids are obtained via serine hydroxymethyltransferase catalyzed condensation of aldehydes with glycine. The predominant product with most aldehydes is the L-erythro diastereomer. For example, succinic semialdehyde methyl ester is condensed with glycine in the process to provide L-erythro α-amino-β-hydroxy adipic acid mono methyl ester.
摘要翻译： β-羟基-α-氨基酸通过丝氨酸羟甲基转移酶催化醛与甘氨酸的缩合获得。大多数醛的主要产物是L-赤式非对映异构体。例如，琥珀酸半醛甲酯与甘氨酸缩合，得到L-赤式α-氨基-β-羟基己二酸单甲酯。

4. 发明公开

EP0123442A1 Improvements in or relating to a process for producing beta-lactam compounds 有权
标题翻译： Verfahren zur Herstellung von beta-Lactam-Verbindungen。
公开(公告)号：EP0123442A1
公开(公告)日：1984-10-31
申请号：EP84302005.8
申请日：1984-03-26
申请人： THE UNIVERSITY OF NOTRE DAME DU LAC
发明人： Miller, Marvin Joseph
IPC分类号： C07D205/08
CPC分类号： C07D205/08 , C07D205/085 , Y02P20/55
摘要： There is described a process for preparing a compound of Formula (IV):
or an addition salt thereof, in which R is amino, a protected amino group, hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxycarbonyl, carboxy, protected carboxy, or C 1 -C 4 alkyl substituted by hydroxy, halogen, methoxy, amino, protected amino, protected carboxy, or cyano; R' is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxycarbonyl, protected carboxy, carboxy, phenyl, substituted phenyl substituted by C 1 -C 4 alkyl, hydroxy, halogen, C 1 -C 4 alkoxy, amino, protected amino, carboxy, protected carboxy, or cyano, or C 1 -C 4 alkyl substituted by hydroxy, halogen, methoxy, amino, protected amino, carboxy, protected carboxy or cyano; and Z is hydrogen, an acyl group or sulfo group of the formula-SO - 3 M + in which M + is an alkali metal cation or tri- or tetrasubstituted ammonium ion);
which comprises

a) ring closure of.a compound of Formula (III):
in which R, R 1 are as defined above for Formula (IV), Z is acyl or SO 3 - M + , and Y is hydroxy, bromo or chloro, to provide a compound of Formula (IV) in which Z is acyl or SO 3 M+; or,
b) acylating or treating with pyridine-SO 3 , a compound of Formula (IV) in which Z is hydrogen to produce a compound of Formula (IV) in which Z is other than hydrogen; or
c) exposing a compound of Formula (IV), in which Z is acyl other than pivaloyl to solvolytic conditions to produce a compound of Formula (IV) in which Z is hydrogen;
d) and, if desired, removing any protecting groups present and forming an addition salt thereof; and certain compounds per se resulting therefrom.
摘要翻译：描述了制备式（IV）化合物的方法：其中R为氨基，被保护的氨基，氢，C 1 -C 4烷基，C 1 -C 4烷氧基羰基，羧基被保护的羧基或被羟基，卤素，甲氧基，氨基，保护的氨基，被保护的羧基或氰基取代的C 1 -C 4烷基; R 1是氢，C 1 -C 4烷基，C 1 -C 4烷氧基羰基，保护的羧基，羧基，苯基，被C 1 -C 4烷基取代的取代苯基，羟基，卤素，C 1 -C 4烷氧基，氨基，被保护的氨基，羧基或氰基，或被羟基，卤素，甲氧基，氨基，保护的氨基，羧基，保护的羧基或氰基取代的C 1 -C 4烷基; 并且Z是氢，式-SO 3 M +的酰基或磺基，其中M +是碱金属阳离子或三取代或四取代的铵离子），其包括：a）环封闭式（III）化合物：其中R 1，R 1如对式（IV）所定义，Z是酰基或SO 3 - ，M +，Y是羟基，溴或氯，得到其中Z为酰基或SO 3 M +的式（Ⅳ）化合物; 或b）用吡啶-SO 3，其中Z是氢的式（Ⅳ）化合物进行酰化或处理，得到其中Z不是氢的式（Ⅳ）化合物; 或c）将式（Ⅳ）化合物（其中Z是除新戊酰以外的酰基）暴露于溶剂分解条件以制备其中Z为氢的式（Ⅳ）化合物; d），并且如果需要，除去存在的并形成其加成盐的任何保护基团;以及由其产生的某些化合物本身。

5. 发明授权

EP2179841B8 Functionally graded high temperature bonding of fiberglass fibers to steel 有权
标题翻译：与钢玻璃纤维的功能梯度的高温组合
公开(公告)号：EP2179841B8
公开(公告)日：2015-10-28
申请号：EP09173460.8
申请日：2009-10-19
申请人： Honeywell International, Inc. , The University of Notre Dame du Lac
发明人： Simpson, Allen H. , La Forest, Mark L. , Mukasyan, Alexander
IPC分类号： B22F7/08 , C04B37/02 , B32B15/18 , B32B7/04 , B32B9/04
CPC分类号： C04B37/026 , B22F7/08 , B32B7/04 , B32B9/007 , B32B9/041 , B32B2262/101 , B32B2307/30 , B32B2307/50 , B32B2605/08 , B32B2605/18 , C04B2237/083 , C04B2237/121 , C04B2237/122 , C04B2237/385 , C04B2237/406 , C04B2237/708 , C04B2237/72 , Y10T428/12007 , Y10T428/12181 , Y10T428/12535 , Y10T428/24893 , Y10T428/24967 , Y10T428/31678

6. 发明授权

EP0395366B1 Improvement in metal oxide catalysts 失效
标题翻译：金属氧化物催化剂。
公开(公告)号：EP0395366B1
公开(公告)日：1994-03-02
申请号：EP90304412.1
申请日：1990-04-25
申请人： THE UNIVERSITY OF NOTRE DAME DU LAC
发明人： Carberry, James John , Alcock, C. Benjamin
IPC分类号： B01J23/26 , B01D53/36
CPC分类号： B01D53/945 , B01J23/26 , Y02T10/22

7. 发明公开

EP0395366A2 Improvement in metal oxide catalysts 失效
标题翻译： Metalloxid-Katalysatoren。
公开(公告)号：EP0395366A2
公开(公告)日：1990-10-31
申请号：EP90304412.1
申请日：1990-04-25
申请人： THE UNIVERSITY OF NOTRE DAME DU LAC
发明人： Carberry, James John , Alcock, C. Benjamin
IPC分类号： B01J23/26 , B01D53/36
CPC分类号： B01D53/945 , B01J23/26 , Y02T10/22
摘要： Solid oxide compositions of the formula La 1-x Sr x CrO 3-δ have been found to exhibit surprisingly high specific activity as catalysts for oxidation and hydrogenation reactions. They may be used in particulate form or applied as films to the surfaces of refractory substrates. These catalysts are expected to be a viable alternative to the noble metal catalysts now used commercially for treatment of combustion chamber exhaust gases to reduce environmental pollutants.
摘要翻译：已经发现式La1-xSrxCrO3-δ的固体氧化物组合物作为用于氧化和氢化反应的催化剂表现出惊人的高比活性。它们可以以颗粒形式使用或作为薄膜施加到耐火基材的表面。这些催化剂预期是现在商业上用于处理燃烧室废气以减少环境污染物的贵金属催化剂的可行替代方案。

8. 发明公开

EP3172325A1 MOLECULAR CONSTRUCTS AND USES THEREOF 有权转让
标题翻译：分子结构及其用途
公开(公告)号：EP3172325A1
公开(公告)日：2017-05-31
申请号：EP15824305.5
申请日：2015-07-22
申请人： The University of Notre Dame du Lac
发明人： BAKER, Brian , HELLMAN, Lance , PIERCE, Brian , WENG, Zhiping
IPC分类号： C12N15/63 , C12N15/86 , C12N15/62 , C12N5/0783 , A61K31/7088
CPC分类号： A61K38/1774 , A61K31/7088 , A61K35/17 , A61K2035/124 , C07K14/7051 , C07K2319/00 , C12N5/0636 , C12N15/62 , C12N15/86 , C12N2510/00
摘要： Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and other cells transformed with the molecular contracts express a modified TCR that imparts a reduction, in non-specific binding, an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed (wild-type, native) T-cells, are described. The modified TCRs possess an affinity enhancing motif and an affinity weakening motif. Methods of transforming cells and methods of using enriched populations of transformed cells, in the treatment of cancer and infections arid T-cell mediated pathologies are provided. The affinity weakening motif imparts a weakened interaction, of a TCR with major histocompatibility complex proteins, such as HLA proteins in humans. Soluble modified TCRs are also provided, Therapeutic preparations comprising modified T-cells, modified TCRs, and modified TCR-therapeutic agent-conjugates, are also provided.
摘要翻译：呈现了具有编码TCR亲和弱化基序的序列以及与其相对应的DNA和RNA序列的分子构建体和双重识别构建体。与未转化的T细胞相比，用分子契约转化的修饰的T细胞和其他细胞表达修饰的TCR，与未转化的T细胞相比，非修饰TCR能够减少非特异性结合，增强结合特异性并增强对靶抗原的结合亲和力描述了野生型，天然）T细胞。修饰的TCR具有亲和力增强基序和亲和力减弱基序。提供了转化细胞的方法和使用富集的转化细胞群的方法，用于治疗癌症和感染以及T细胞介导的病状。亲和弱化基序赋予TCR与主要组织相容性复合物蛋白（例如人类中的HLA蛋白）的弱相互作用。还提供了可溶性修饰的TCR。还提供了包含修饰的T细胞，修饰的TCR和修饰的TCR-治疗剂缀合物的治疗制剂。

9. 发明授权

EP2297786B1 METHODS AND APPARATUS FOR ANTIMONIDE-BASED BACKWARD DIODE MILLIMETER-WAVE DETECTORS 失效
标题翻译：方法和设备落后二极管安森ANTIMONIDBASIS毫米波探测器
公开(公告)号：EP2297786B1
公开(公告)日：2013-07-24
申请号：EP09805314.3
申请日：2009-05-27
申请人： The University of Notre Dame du Lac
发明人： FAY, Patrick , SU, Ning
IPC分类号： H01L29/88 , H01L21/329 , H01L29/36 , H01L29/205
CPC分类号： H01L29/205 , H01L29/365 , H01L29/66219 , H01L29/88 , H01L31/109

10. 发明公开

EP2350258A1 METHODS AND APPARATUS TO OBTAIN SUSPENDED PARTICLE INFORMATION 审中-公开
标题翻译：方法和设备有关暂停的获取信息
公开(公告)号：EP2350258A1
公开(公告)日：2011-08-03
申请号：EP09822774.7
申请日：2009-10-23
申请人： The University of Notre Dame du Lac
发明人： RUGGIERO, Steven , TANNER, Carol
IPC分类号： C12M1/34
CPC分类号： G01N15/0205 , G01N21/00 , G01N21/31 , G01N21/39 , G01N21/4785 , G01N21/51 , G01N21/59 , G01N2015/0294 , G01N2021/4707 , G01N2201/06113 , G01N2201/105 , G02B21/0096 , G02B21/18
摘要： Example methods and apparatus for obtaining suspended particle information are disclosed. A disclosed example method includes emitting light from a light source, dividing the light source into a first path and a second path, and directing the first path to a first container comprising a plurality of particles in a suspension material. The example method also includes directing the second path to a second container containing a suspension material devoid of particles, retrieving a first transmission value of the first path through the first container, and retrieving a second transmission value of the second path through the second container. The example method further includes directing the first and second paths to the second and first containers, respectively, retrieving a third transmission value of the first path a through the second container, retrieving a fourth transmission value of the second path through the first container, and calculating a ratio of the first and second transmission values to the third and fourth transmission values to determine an indication of transmissivity for a given wavelength.
摘要翻译：用于获得悬浮颗粒信息的示例性方法和装置是游离缺失盘。一种盘实施例游离缺失方法包括：从光源发射光，将所述光源为第一路径和第二路径，并且将所述第一路径的第一容器中的悬浮液材料，其包含颗粒的复数。因此，该实施例的方法包括：引导所述第二路径的第二容器含悬浮材料不含颗粒的，通过所述第一容器取出所述第一路径的第一传输值，并通过第二容器取出所述第二路径的第二传输值。该示例性方法还包括将所述第一和第二路径的第二和第一容器，分别通过第二容器取出所述第一路径的第三传输值，通过所述第一容器取出所述第二路径的第四传输值，以及计算所述第一和第二传输值与第三和第四传输值的比率，以在透射率的指示对于给定的波长确定性矿。

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