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1. 发明授权

EP1752744B1 Apparatus and method for dispensing small quantities of particles 有权
标题翻译：装置和方法，用于分配少量颗粒的
公开(公告)号：EP1752744B1
公开(公告)日：2013-04-10
申请号：EP06023883.9
申请日：2000-11-03
申请人： PowderJect Research Limited
发明人： Macmichael, Bruce , Westland, Duncan
IPC分类号： G01G13/06
CPC分类号： G01G13/04 , G01G13/06

2. 发明授权

EP1563862B1 Needleless syringe 有权
标题翻译：无针注射器
公开(公告)号：EP1563862B1
公开(公告)日：2012-12-12
申请号：EP05010246.6
申请日：2000-06-09
申请人： PowderJect Research Limited
发明人： Kendall, Mark Anthony Fernance , Brown, Garry
IPC分类号： A61M5/30 , G11B20/00
CPC分类号： G11B20/00 , A61M5/2046 , A61M5/3015

3. 发明公开

EP1752744A3 Apparatus and method for dispensing small quantities of particles 有权
标题翻译：装置和方法，用于分配少量颗粒的
公开(公告)号：EP1752744A3
公开(公告)日：2008-05-21
申请号：EP06023883.9
申请日：2000-11-03
申请人： PowderJect Research Limited
发明人： Macmichael, Bruce , Westland, Duncan
IPC分类号： G01G13/06
CPC分类号： G01G13/04 , G01G13/06
摘要： There is disclosed an apparatus and method which is capable of dispensing very small (typically less than 5 mg) quantities of particles to a high accuracy in a repeatable way and without undue wastage. Also, the need for advanced particle formulation is reduced. The apparatus comprises a closed loop control system which uses an electro-mechanical actuator to deliver impact energy to a supply of particles initially held on a sieve in a hopper. The impact energy causes a small number of particles to fall through the sieve and onto a weight measuring balance. The weight obtained is scrutinised by a processor to see if further actuations are required. In preferred embodiments, the energy of actuation is varied in accordance with the rate of dispensation calculated by the processor. Also, a correction amount can be obtained to take account of the fact that the balance can take a considerable amount of time to settle to its final value.

4. 发明公开

EP1847286A2 Silencing device and method of operating a needleless syringe 审中-公开
标题翻译： Schalldämpfereinrichtungund verfahren zum betreiben einer nadellose spritze
公开(公告)号：EP1847286A2
公开(公告)日：2007-10-24
申请号：EP07015671.6
申请日：2002-07-25
申请人： PowderJect Research Limited
发明人： Kendall, Mark Anthony Fernance
IPC分类号： A61M5/30
CPC分类号： A61M5/3015 , A61M5/24
摘要： The invention provides a silencer and silencing method which ensures adequate silencing with no deleterious increase in back pressure (which creates a lift-off force) or decrease in device performance. Pressurised gas is supplied to a driver chamber by a bleed-hole having an effective bleed-hole area and, during use of the device for particle delivery, gas is vented to the atmosphere via a silencer having an effective venting area. The bleed-hole area and venting area are chosen to ensure that the mass flow rate of gas through the effective venting area is substantially equal to or greater than the mass flow rate of gas through the effective bleed-hole area. This ensures that there is no build up of gas in the silencer device which tends to increase back pressure and hence lift-off force. Preferred embodiments of the device comprise a silencer having a large volume and a small particle exit opening. Further, there is disclosed an embodiment using one or more transfer ducts to assist particle mixing.
摘要翻译：本发明提供了一种消音器和消音方法，其确保了足够的沉默，而没有有害的背压增加（产生剥离力）或降低了设备性能。加压气体通过具有有效排放孔面积的排放孔提供给驱动室，并且在用于颗粒输送的装置的使用期间，气体通过具有有效排气面积的消音器排放到大气中。排气孔区域和排气区域被选择以确保通过有效排气区域的气体的质量流量基本上等于或大于通过有效渗漏孔区域的气体的质量流量。这确保消声器装置中不会积聚气体，这倾向于增加背压并因此增加剥离力。该装置的优选实施例包括具有大体积和小颗粒出口的消音器。此外，公开了使用一个或多个传送管道来辅助颗粒混合的实施例。

5. 发明授权

EP1418965B1 SILENCING DEVICE AND METHOD FOR NEEDLELESS SYRINGE 有权
标题翻译：消音装置及方法无针注射器
公开(公告)号：EP1418965B1
公开(公告)日：2006-03-08
申请号：EP02755103.5
申请日：2002-07-25
申请人： PowderJect Research Limited
发明人： KENDALL, Mark Anthony Fernance
IPC分类号： A61M5/30
CPC分类号： A61M5/3015 , A61M5/24
摘要： The invention provides a silencer and silencing method which ensures adequate silencing with no deleterious increase in back pressure (which creates a lift-off force) or decrease in device performance. Pressurised gas is supplied to a driver chamber by a bleed-hole having an effective bleed-hole area and, during use of the device for particle delivery, gas is vented to the atmosphere via a silencer having an effective venting area. The bleed-hole area and venting area are chosen to ensure that the mass flow rate of gas through the effective venting are is substantially equal to or greater than the mass flow rate of gas through the effective bleed-hole area. This ensures that there is no build up of gas in the silencer device which tends to increase back pressure and hence lift-off force. Preferred embodiments of the device comprise a silencer having a large volume and a small particle exit opening. Further, there is disclosed an embodiment using one or more transfer ducts to assist particle mixing.

6. 发明公开

EP1545593A1 NUCLEIC ACID COATED PARTICLES 审中-公开
标题翻译：与核酸涂布粒子
公开(公告)号：EP1545593A1
公开(公告)日：2005-06-29
申请号：EP03750990.8
申请日：2003-09-29
申请人： PowderJect Research Limited
发明人： LIVELY, Chris Robert , DELONG, Robert,c/o Lineberger Cancer Certer
IPC分类号： A61K39/00 , A61K9/00 , A61K38/02
CPC分类号： C12N15/895 , A61K9/1611 , A61K9/1676 , A61K47/6923 , A61K48/00 , A61K48/0008 , A61K48/0091 , A61K2039/53 , A61K2039/55555 , C12N2730/10122
摘要： Particles are provided which are suitable for delivery from a particle-mediated delivery device. The particles are obtained by precipitating a nucleic acid on inert metal carrier particles in the presence of a nucleic acid condensing agent and a metal ion chelating agent. Also described are processes for preparing the particles, and therapeutic methods using the particles including methods of nucleic acid immunisation and gene therapy.

7. 发明授权

EP1146861B1 HYDROGEL PARTICLE FORMULATIONS 有权
标题翻译：水凝胶配方
公开(公告)号：EP1146861B1
公开(公告)日：2005-06-29
申请号：EP00901795.5
申请日：2000-02-03
申请人： PowderJect Research Limited
发明人： O'CONNOR, Barbara, H. , PRESTRELSKI, Steven, Joseph , MAA, Yuh-Fun , MUDDLE, Andrew , HAFNER, Roderick , BURKOTH, Terry Lee
IPC分类号： A61K9/16
CPC分类号： A61K9/1652 , A61K9/0021

8. 发明公开

EP1468281A1 DIAGNOSTIC SENSING APPARATUS 审中-公开
标题翻译：诊断传感器
公开(公告)号：EP1468281A1
公开(公告)日：2004-10-20
申请号：EP02805075.5
申请日：2002-12-13
申请人： Powderject Research Limited
发明人： KWON, Sung-Yun
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , G01N21/6428 , G01N27/3271 , G01N33/542 , G01N2333/42
摘要： A sensing apparatus and methods for measuring or detecting an analyte present in a biological system are provided. The methods entail use of the sensing apparatus that contains a reporter system specific for the analyte of interest, where the reporter system is either affixed to a planar backing or attached to particles that are delivered to the superficial layers of the skin. The reporter system includes a reporting reagent that absorbs or emits a detectable radiation and is placed in communication with the analyte, or in communication with tissue or body fluids suspected of containing the analyte. The sensing apparatus is illuminated, and a radiation signal from the reporting reagent is measured or detected and then associated with the presence or quantity of analyte.

9. 发明公开

EP1468109A1 NON- OR MINIMALLY INVASIVE MONITORING METHODS 审中-公开
标题翻译： NOR微创监测程序
公开(公告)号：EP1468109A1
公开(公告)日：2004-10-20
申请号：EP02805931.9
申请日：2002-12-13
申请人： Powderject Research Limited
发明人： KWON, Sung-Yun , BURKOTH, Terry, L.
IPC分类号： C12Q1/54 , C12Q1/00 , C12M1/00 , C12M1/34
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/1486 , A61B17/545 , A61B2010/008 , A61B2017/00747 , A61B2017/00765 , G01N33/66
摘要： An apparatus for sensing an analyte is described, wherein the apparatus includes an interface contact element that is used to establish an interface with a quantity of body fluid. The interface contact element is adapted to facilitate diffusion of a target analyte across the interface essentially free of net mass fluid transport. The quantity of body fluid is exposed to the interface contact element through micro-pathways. The apparatus can also include a sensing material adapted to sense the target analyte with at least one analytical method. Methods for using the apparatus in a non- or minimally invasive monitoring technique are also described. Figure (1) illustrates a non-limiting embodiment of the apparatus used to test the principles of the invention.

10. 发明授权

EP0892649B1 NEEDLELESS SYRINGE WITH THERAPEUTIC AGENT PARTICLES ENTRAINED IN SUPERSONIC GAS FLOW 失效
标题翻译：一种无针注射器活性颗粒与超声气流-PACK THERAPY
公开(公告)号：EP0892649B1
公开(公告)日：2004-06-23
申请号：EP97907219.6
申请日：1997-03-17
申请人： PowderJect Research Limited
发明人： BELLHOUSE, Brian John , POTTER, Charles David Ogilvy , GREENFORD, John Christopher
IPC分类号： A61M5/30
CPC分类号： A61M5/3015 , A61M5/2053 , A61M2005/3123 , A61M2205/42
摘要： A needleless syringe, in which particles of a therapeutic agent are entrained in a supersonic gas flow, has a nozzle surrounded by a silencer through which gas reflected from the target may be vented to atmosphere through a porous material which acts to retain any particles reflected in the gas.

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