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1. 发明公开

EP0168093A1 Binder for low density lipoproteins 失效
标题翻译：粘结剂的低密度脂蛋白。
公开(公告)号：EP0168093A1
公开(公告)日：1986-01-15
申请号：EP85200979.4
申请日：1985-06-20
申请人： Organon Teknika B.V.
发明人： Maaskant, Nico , Bantjes, Adriaan , Kempen, Hermanus Johannes Marie
IPC分类号： C08F8/36 , G01N33/96
CPC分类号： C08J3/28 , C08F8/18 , C08F8/28 , C08F8/36 , C08F2810/20 , C08J2329/04 , Y10T436/10 , Y10T436/104165 , Y10T436/106664 , C08F16/06
摘要： A binder for low density lipoproteins (LDL) consisting of sulphated polyvinyl alcohol which is cross-linked by the chemical or the physical route to a waterinsoluble product. The binder may be in the form of a hydrogel which is applied or not to a carrier or it may be present on the surface of a polyvinyl alcohol fibre which is preferably in the form of tape having a thickness of 0,1 to 2 µm and a width of 0, 5 to 6 µm. The fibre shaped binder is prepared by successively cross-linking with an acidified aqueous solution of glutardialdehyde and sulphating with chlorosulphonic acid.

2. 发明授权

EP0850244B1 TOXOPLASMA GONDII GLYCOCONJUGATES 失效
标题翻译：弓形虫GLYKOKONJUGATE
公开(公告)号：EP0850244B1
公开(公告)日：2002-07-31
申请号：EP96931804.7
申请日：1996-09-12
申请人： Organon Teknika B.V.
发明人： KOOLEN, Marcus, Josephus, Marie , DAMM, Jan, Bas, Louis , STRIEPEN, Boris , SCHWARZ, Ralph, T.
IPC分类号： C07H3/06 , C07K14/45 , C12N5/20 , A61K31/70 , C07K16/20 , G01N33/569 , C12P21/08 , A61K39/002
CPC分类号： A61K39/002 , C07H3/06 , C07K16/20
摘要： The present invention relates to a glycoconjugate immunoreactive with Toxoplasma gondii antibodies, (monoclonal) antibodies against these glycoconjugates, and cell lines capable of producing monoclonal antibodies. The invention is further concerned with immunochemical reagents and methods for the detection of T. gondii or antibodies directed agains T. gondii. Furthermore the invention relates to a therapeutic reagent for the inhibition of replication of T. gondii parasites and a method for the production of a live attenuated T. gondii vaccine. It has now been found, and in contrast with earlier publications in this art, that several glycoconjugates are immunoreactive with Toxoplasma gondii specific antibodies comprising a glycan core structure having general formula (I) wherein R1 = Hydrogen, -PO3-CH2-CH2-NH2 (ethanolamine-phosphate), or -PO3-CH2-CH2-NH-X, wherein X = a T. gondii specific antigen; wherein R2 = α-O-R4, α(1-4)-O-anhydromannitol or α(1-4)-O-glucoseamine optionally α(1-6)-linked to the inositol moiety of a phosphatidylinositol membrane anchor; wherein R3 = a monosaccharide moiety, wherein R4 = Hydrogen or -L-R5, wherein L = a bivalent organic radical and R5 = a functional group that allows coupling to a carrier. A preferred embodiment of the monosaccharide moiety is a hexose moiety, more preferred is a glucose moiety, and most preferred is a glucose moiety which is bonded to the GalNAc-moiety by an α-1,4 glycosidic bond. It has been found that the glycoconjugates according to the present invention are particularly suitable for diagnosing T. gondii infected humans.

3. 发明公开

EP1202808A1 DEVICE AND METHOD FOR MIXING MAGNETIC PARTICALS WITH A FLUID 有权
标题翻译：方法用液体的磁量
公开(公告)号：EP1202808A1
公开(公告)日：2002-05-08
申请号：EP00953054.4
申请日：2000-07-14
申请人： Organon Teknika B.V.
发明人： KREUWEL, Hermanus, Johannes, Maria , VERWIMP, Emiel, Gerebern, Maria
IPC分类号： B03C1/28 , C12Q1/68
CPC分类号： B01F13/0809 , B03C1/288 , C12Q1/6806 , Y10T436/143333 , Y10T436/255 , C12Q2563/143
摘要： This invention relates to the use of magnetic or magnetizable particles, and, in particular, to methods of mixing magnetic or (super)paramagnetic particles efficiently with a fluid and the separation of the magnetic particles from a fluid, optionally followed by resuspension of the particles in another fluid. The present invention provides a method of mixing, in one or more container(s), magnetic or (super)paramagnetic particles with a fluid, using more than one magnets, whereby the containers are subjected to magnetic fields with different and changing directions by moving the magnets with respect to the position of the container(s) and/or by moving the containers with respect to the positions of the magnets. The invention further provided a device for doing the same. Preferably the holders for the containers and the magnets in the device are placed in intervening array geometries and the magnets are placed in line in such a way that all magnets that are in line have their poles oriented in the same direction, and that all magnets in a neighboring line have their poles oriented in the reverse direction with respect to the poles of the magnets in the first line.

4. 发明授权

EP0004403B1 A sodium zirconium carbonate compound and the method of its preparation 失效
标题翻译：一种碳酸三正辛酯化合物及其制备方法
公开(公告)号：EP0004403B1
公开(公告)日：1981-10-07
申请号：EP79200131.5
申请日：1979-03-16
申请人： Organon Teknika B.V.
发明人： Mc Arthur, Mary J. , Marantz, Laurence B. , Scarbrough, Abb L.
IPC分类号： C01G25/00
CPC分类号： C01B25/372 , C01G25/006 , C01P2004/52 , C01P2004/61 , C01P2006/80

5. 发明授权

EP0574048B1 Peptides and nucleic acid sequences related to Epstein Barr Virus 失效
标题翻译： Epstein-Barr病毒相关肽和核酸区段
公开(公告)号：EP0574048B1
公开(公告)日：2002-08-14
申请号：EP93200691.9
申请日：1993-03-10
申请人： Organon Teknika B.V.
发明人： Middeldorp, J.M.
IPC分类号： C12N15/38 , C12P21/08 , C12Q1/68 , C07K14/05 , C07K16/18 , G01N33/536 , G01N33/68
CPC分类号： C07K16/085 , C07K14/005 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C07K2319/735 , C12N2710/16222

6. 发明公开

EP1225226A1 Peptides and nucleic acid sequences related to Epstein Barr Virus 失效
标题翻译： Epstein-Barr-Virus verwandte Peptide undNukleinsäuresegmente
公开(公告)号：EP1225226A1
公开(公告)日：2002-07-24
申请号：EP02075193.9
申请日：1993-03-10
申请人： Organon Teknika B.V.
发明人： Middeldorp, J.M.
IPC分类号： C12N15/38 , C12N5/18 , C07K14/05 , C07K16/08 , C07K16/42 , G01N33/569 , G01N33/68
CPC分类号： C07K16/085 , C07K14/005 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C07K2319/735 , C12N2710/16222
摘要： The present invention relates to peptides immunochemically reactive with antibodies to the Epstein-Barr virus (EBV), comprising at least part of the VCA-p18 or VCA-p40 protein, encoded within the EBV open reading frames BFRF3 and BdRF1 respectively, or a functional variant thereof. The invention further relates to nucleic acid sequences encoding these peptides, monoclonal antibodies against these peptides, cell lines capable of producing monoclonal antibodies and anti-idiotype antibodies. The invention also relates to recombinant vector molecules comprising a nucleic acid sequence according to the invention and host cells transformed or transfected with these vector molecules. The invention is further concerned with immunological reagents and methods for the detection of EBV or anti-EBV antibodies and a method for the amplification and detection of Epstein Barr viral nucleic acid.
摘要翻译：本发明涉及与Epstein-Barr病毒（EBV）的抗体免疫化学反应的肽，其包含分别编码在EBV开放阅读框BFRF3和BdRF1内的VCA-p18或VCA-p40蛋白的至少一部分，或功能性其变体。本发明还涉及编码这些肽的核酸序列，针对这些肽的单克隆抗体，能够产生单克隆抗体的细胞系和抗独特型抗体。本发明还涉及包含根据本发明的核酸序列和用这些载体分子转化或转染的宿主细胞的重组载体分子。本发明还涉及用于检测EBV或抗EBV抗体的免疫试剂和方法以及扩增和检测爱泼斯坦巴尔病毒核酸的方法。

7. 发明授权

EP0168093B1 Binder for low density lipoproteins 失效
标题翻译：低密度脂蛋白的粘合剂
公开(公告)号：EP0168093B1
公开(公告)日：1988-11-23
申请号：EP85200979.4
申请日：1985-06-20
申请人： Organon Teknika B.V.
发明人： Maaskant, Nico , Bantjes, Adriaan , Kempen, Hermanus Johannes Marie
IPC分类号： C08F8/36 , G01N33/96
CPC分类号： C08J3/28 , C08F8/18 , C08F8/28 , C08F8/36 , C08F2810/20 , C08J2329/04 , Y10T436/10 , Y10T436/104165 , Y10T436/106664 , C08F16/06

8. 发明授权

EP0121275B1 Macromolecular carbonyl groups-containing material suitable for use as sorbent for urea 失效
标题翻译：适用于UREA SORBENT的大分子碳素组合材料
公开(公告)号：EP0121275B1
公开(公告)日：1988-06-01
申请号：EP84200373.3
申请日：1984-03-15
申请人： Organon Teknika B.V.
发明人： Smakman, Robert
IPC分类号： C08F8/06 , C08G85/00
CPC分类号： A61M1/1696 , C08F8/06 , C08F2800/20 , C08F2810/20 , C08G85/004 , C08F212/08 , C08F212/36 , C08F8/10 , C08F8/48 , C08F212/14 , C08F216/36

9. 发明授权

EP0747481B1 Epstein-Barr virus peptides and antibodies against these peptides 失效
标题翻译： EB病毒肽和抗体针对这些肽
公开(公告)号：EP0747481B1
公开(公告)日：2001-12-19
申请号：EP96201457.7
申请日：1996-05-28
申请人： Organon Teknika B.V.
发明人： Middeldorp, Jaap Michiel
IPC分类号： C12N15/38 , C07K14/05 , C07K16/08 , C12N5/20 , A61K39/245 , A61K39/395 , G01N33/569
CPC分类号： C07K16/081 , A61K38/00 , C07K14/005 , C07K16/085 , C07K2319/00 , C12N2710/16222 , Y10S435/96 , Y10S530/811

10. 发明公开

EP0261728A1 Manufacture of bundles of semi-permeable hollow fibres 失效
标题翻译： Herstellung von sempermeablenHohlfaserbündeln。
公开(公告)号：EP0261728A1
公开(公告)日：1988-03-30
申请号：EP87201765.2
申请日：1987-09-17
申请人： Organon Teknika B.V.
发明人： Daamen, Jacobus Josephus Hendrikus Gerardus , de Haan, Peter Johannes , Klip, Evert Jan
IPC分类号： A61M1/18 , B01D61/28 , B01D63/02
CPC分类号： B01D63/021 , Y10T156/103 , Y10T156/1052
摘要： Manufacture of bundles of at least 1000 semi-permeable hollow fibres for use in filters such as, e.g., blood, plasma and dialysate filters, and in artificial kidneys. One or more hollow filaments are wound onto a reel (3) until the formed package contains the number of filaments required for bundle (6) formation. After which the package is cut into fibre bundles of the desired length. The package is held in one place of the reel (11) and a free end (10) is introduced into a sleeve (13) having a length which is a number of times that of the length of the fibre bundle in the final filter. The sleeve (13) is cut into fibre bundles of the desired length.
摘要翻译：制造用于过滤器例如血液，血浆和透析液过滤器以及人造肾中的至少1000个半渗透空心纤维束。将一个或多个中空丝卷绕到卷轴（3）上，直到形成的包装包含形成束（6）所需的细丝数量。之后将包装切割成所需长度的纤维束。包装被保持在卷轴（11）的一个位置，并且自由端（10）被引入套筒（13）中，该套筒的长度是最终过滤器中的纤维束长度的数量。套筒（13）被切割成所需长度的纤维束。

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