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2. 发明公开

EP1225226A1 Peptides and nucleic acid sequences related to Epstein Barr Virus 失效
标题翻译： Epstein-Barr-Virus verwandte Peptide undNukleinsäuresegmente
公开(公告)号：EP1225226A1
公开(公告)日：2002-07-24
申请号：EP02075193.9
申请日：1993-03-10
申请人： Organon Teknika B.V.
发明人： Middeldorp, J.M.
IPC分类号： C12N15/38 , C12N5/18 , C07K14/05 , C07K16/08 , C07K16/42 , G01N33/569 , G01N33/68
CPC分类号： C07K16/085 , C07K14/005 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C07K2319/735 , C12N2710/16222
摘要： The present invention relates to peptides immunochemically reactive with antibodies to the Epstein-Barr virus (EBV), comprising at least part of the VCA-p18 or VCA-p40 protein, encoded within the EBV open reading frames BFRF3 and BdRF1 respectively, or a functional variant thereof. The invention further relates to nucleic acid sequences encoding these peptides, monoclonal antibodies against these peptides, cell lines capable of producing monoclonal antibodies and anti-idiotype antibodies. The invention also relates to recombinant vector molecules comprising a nucleic acid sequence according to the invention and host cells transformed or transfected with these vector molecules. The invention is further concerned with immunological reagents and methods for the detection of EBV or anti-EBV antibodies and a method for the amplification and detection of Epstein Barr viral nucleic acid.
摘要翻译：本发明涉及与Epstein-Barr病毒（EBV）的抗体免疫化学反应的肽，其包含分别编码在EBV开放阅读框BFRF3和BdRF1内的VCA-p18或VCA-p40蛋白的至少一部分，或功能性其变体。本发明还涉及编码这些肽的核酸序列，针对这些肽的单克隆抗体，能够产生单克隆抗体的细胞系和抗独特型抗体。本发明还涉及包含根据本发明的核酸序列和用这些载体分子转化或转染的宿主细胞的重组载体分子。本发明还涉及用于检测EBV或抗EBV抗体的免疫试剂和方法以及扩增和检测爱泼斯坦巴尔病毒核酸的方法。

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