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1. 发明公开

EP1600177A4 ENDOTHELIAL CELL SHEET FOR CORNEA REGENERATION, METHOD OF PRODUCING THE SAME AND METHOD OF USING THE SAME 有权转让
标题翻译：内皮DISK角膜再生，工艺及其制造使用的光碟和方法
公开(公告)号：EP1600177A4
公开(公告)日：2011-03-02
申请号：EP04713172
申请日：2004-02-20
申请人： CELLSEED INC , NISHIDA KOHJI
发明人： OKANO TERUO , NISHIDA KOHJI , YAMATO MASAYUKI
IPC分类号： A61L27/38 , A61L27/50 , C12N5/071 , A61L27/44
CPC分类号： A61L27/3808 , A61L27/3839 , A61L27/3895 , A61L27/50 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： An improved process for producing a regenerated corneal endothelial cell sheet, comprising the steps of allowing corneal endothelial cells collected from a tissue to be cultivated on a cell culture support having its surface covered with a polymer of which the hydrating force varies in a temperature range of 0-80 DEG C, and after the culture, (1) adjusting the temperature of the culture solution to the temperature at which the polymer on the substrate surface is hydrated, (2) bringing the cultured corneal endothelial cell sheet into close contact with a carrier, and (3) detaching the sheet together with the carrier. The regenerated corneal endothelial cell sheet obtained by the process will adhere very well to living tissues.

2. 发明公开

EP2450065A1 Corneal epithelium forming cell sheets, processes for producing the same, and methods of using the same 有权转让
标题翻译：对于Hornhautepithelbildung细胞片层，其制备方法和为此使用的方法
公开(公告)号：EP2450065A1
公开(公告)日：2012-05-09
申请号：EP11192961.8
申请日：2004-02-06
申请人： Cellseed Inc. , Nishida, Kohji
发明人： Nishida, Kohji , Okano, Teruo , Yamato, Masayuki
IPC分类号： A61L27/38 , C12N5/00 , C12N11/02
CPC分类号： A61L27/3891 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80°C, optionally stratifying the layer of cultured cells, and thereafter,
(1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature,
(2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and
(3) detaching the sheet together with the carrier under specified conditions.
摘要翻译：本发明具有作为其目的提供acorneal上皮形成thatwill很好地粘附到前眼部组织细胞片。为了达到这个目的，角膜上皮形成细胞片是通过包括培养的步骤中指定的条件下在细胞培养载体，其包括基板角膜上皮形成细胞的方法产生的具有在其表面覆盖有一个温度响应性聚合物的水合力变化的温度范围内的0-80℃，任选地分层的培养细胞的层，此后，（1）调节所述培养液的温度升高到上述的上临界溶解温度的任一者或低于下临界溶解温度，（ 2）使所培养的角膜上皮形成细胞与载体紧密接触，和（3）与载体规定的条件下一起拆卸片。

3. 发明公开

EP1690929A4 REGENERATION TREATMENT SYSTEM 审中-公开
标题翻译： REGENERATIONSBEHANDLUNGSSYSTEM
公开(公告)号：EP1690929A4
公开(公告)日：2007-07-18
申请号：EP04792726
申请日：2004-10-14
申请人： NISHIDA KOHJI , MAEDA KAZUHISA
发明人： NISHIDA KOHJI , MAEDA KAZUHISA
IPC分类号： A61K35/12 , C12N5/071 , C12N5/077
CPC分类号： A61K35/30 , A61K35/12 , A61K35/24 , A61K35/33 , A61K35/36 , A61K35/44 , C12N5/0621 , C12N5/0629 , C12N5/0653 , C12N2502/1305 , C12N2539/10
摘要： The present invention aims at providing a technology that allows cells to be used efficiently and effectively in regenerative medicine. Therefore, the present invention provide a method for preparing a transplant for regenerating an organ, tissue or cell of a subject, comprising the steps of: A) providing part of a desired organ, tissue or cell or a stem cell capable of differentiation thereinto; and B) culturing the part or the stem cell on a feeder cell comprising an adipose tissue derived cell. The present invention also provide a feeder cell, system and so on used in such a method.

4. 发明公开

EP1602383A4 CELL SHEETS FOR ECTOCORNEA FORMATION, METHOD OF PRODUCING THE SAME AND METHOD OF USING THE SAME 有权转让
标题翻译：电池片形成用于生产和使用外角膜和方法
公开(公告)号：EP1602383A4
公开(公告)日：2009-07-22
申请号：EP04708896
申请日：2004-02-06
申请人： CELLSEED INC , NISHIDA KOHJI
发明人： OKANO TERUO , NISHIDA KOHJI , YAMATO MASAYUKI
IPC分类号： C12N11/02 , A61F2/14 , A61F9/007 , A61L27/00 , A61L27/38 , C12N5/07 , C12N5/071 , C12N5/00
CPC分类号： A61L27/3891 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80 DEG C, optionally stratifying the layer of cultured cells, and thereafter, (1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature, (2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and (3) detaching the sheet together with the carrier under specified conditions.

5. 发明公开

EP1690929A1 REGENERATION TREATMENT SYSTEM 审中-公开
标题翻译： REGENERATIONSBEHANDLUNGSSYSTEM
公开(公告)号：EP1690929A1
公开(公告)日：2006-08-16
申请号：EP04792726.4
申请日：2004-10-14
申请人： Nishida, Kohji , Maeda, Kazuhisa
发明人： Nishida, Kohji , Maeda, Kazuhisa
IPC分类号： C12N5/08 , A61K35/12
CPC分类号： A61K35/30 , A61K35/12 , A61K35/24 , A61K35/33 , A61K35/36 , A61K35/44 , C12N5/0621 , C12N5/0629 , C12N5/0653 , C12N2502/1305 , C12N2539/10 , Y02A50/471
摘要： The present invention aims at providing a technology that allows cells to be used efficiently and effectively in regenerative medicine. Therefore, the present invention provide a method for preparing a transplant for regenerating an organ, tissue or cell of a subject, comprising the steps of: A) providing part of a desired organ, tissue or cell or a stem cell capable of differentiation thereinto; and B) culturing the part or the stem cell on a feeder cell comprising an adipose tissue derived cell. The present invention also provide a feeder cell, system and so on used in such a method.
摘要翻译：本发明的目的在于提供一种能够在再生医学中有效且有效地使用细胞的技术。因此，本发明提供了一种制备用于再生受试者的器官，组织或细胞的移植物的方法，包括以下步骤：A）提供部分所需的器官，组织或细胞或能够分化的干细胞; 和B）在包含脂肪组织衍生细胞的饲养细胞上培养所述部分或干细胞。本发明还提供了一种在这种方法中使用的饲养细胞，系统等。

6. 发明公开

EP1602383A1 CELL SHEETS FOR ECTOCORNEA FORMATION, METHOD OF PRODUCING THE SAME AND METHOD OF USING THE SAME 有权转让
标题翻译：电池片形成用于生产和使用外角膜和方法
公开(公告)号：EP1602383A1
公开(公告)日：2005-12-07
申请号：EP04708896.8
申请日：2004-02-06
申请人： Cellseed Inc. , Nishida, Kohji
发明人： OKANO, Teruo , NISHIDA, Kohji , YAMATO, Masayuki
IPC分类号： A61L27/38 , C12N5/00 , C12N11/02
CPC分类号： A61L27/3891 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80°C, optionally stratifying the layer of cultured cells, and thereafter,

(1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature,
(2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and
(3) detaching the sheet together with the carrier under specified conditions.
摘要翻译：本发明具有作为其目的提供acorneal上皮形成thatwill很好地粘附到前眼部组织细胞片。为了达到这个目的，角膜上皮形成细胞片是通过包括培养的步骤中指定的条件下在细胞培养载体，其包括基板角膜上皮形成细胞的方法产生的具有在其表面覆盖有一个温度响应性聚合物的水合力变化的温度范围内的0-80℃，任选地分层的培养细胞的层，此后，（1）调节所述培养液的温度升高到上述的上临界溶解温度的任一者或低于下临界溶解温度，（ 2）使所培养的角膜上皮形成细胞与载体紧密接触，（3）用所述载体在特定条件下一起拆卸片。

7. 发明授权

EP2450065B1 Corneal epithelium forming cell sheets, processes for producing the same, and methods of using the same 有权转让
标题翻译：角膜上皮形成细胞片，其制造方法及其使用方法
公开(公告)号：EP2450065B1
公开(公告)日：2017-08-23
申请号：EP11192961.8
申请日：2004-02-06
申请人： CellSeed Inc. , Nishida, Kohji
发明人： Nishida, Kohji , Okano, Teruo , Yamato, Masayuki
IPC分类号： A61L27/38 , C12N5/00 , C12N11/02 , C12N5/079
CPC分类号： A61L27/3891 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80 DEG C, optionally stratifying the layer of cultured cells, and thereafter, (1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature, (2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and (3) detaching the sheet together with the carrier under specified conditions.
摘要翻译：本发明的目的在于提供一种能够很好地粘附到眼前节组织上的形成角膜上皮的细胞片。为了实现该目的，通过包括以下步骤的方法来生产角膜上皮形成细胞片：在特定条件下在包含表面覆盖有温度响应性聚合物的细胞培养支持体上培养角膜上皮细胞的步骤，所述温度响应性聚合物的水合力在0-80℃的温度范围内变化，任选地对培养细胞层进行分层，然后，（1）将培养液的温度调节至高于临界溶解温度或低于临界溶解温度，（ 2）使培养的角膜上皮形成细胞与载体紧密接触，以及（3）在特定条件下将片材与载体分离。

8. 发明授权

EP1600177B1 ENDOTHELIAL CELL SHEET FOR CORNEA REGENERATION, METHOD OF PRODUCING THE SAME AND METHOD OF USING THE SAME 有权转让
标题翻译：内皮DISK角膜再生，工艺及其制造使用的光碟和方法
公开(公告)号：EP1600177B1
公开(公告)日：2016-05-25
申请号：EP04713172.7
申请日：2004-02-20
申请人： Cellseed Inc. , Nishida, Kohji
发明人： OKANO, Teruo , NISHIDA, Kohji , YAMATO, Masayuki
IPC分类号： A61L27/38
CPC分类号： A61L27/3808 , A61L27/3839 , A61L27/3895 , A61L27/50 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： An improved process for producing a regenerated corneal endothelial cell sheet, comprising the steps of allowing corneal endothelial cells collected from a tissue to be cultivated on a cell culture support having its surface covered with a polymer of which the hydrating force varies in a temperature range of 0-80 DEG C, and after the culture, (1) adjusting the temperature of the culture solution to the temperature at which the polymer on the substrate surface is hydrated, (2) bringing the cultured corneal endothelial cell sheet into close contact with a carrier, and (3) detaching the sheet together with the carrier. The regenerated corneal endothelial cell sheet obtained by the process will adhere very well to living tissues.

9. 发明授权

EP1602383B1 CELL SHEETS FOR ECTOCORNEA FORMATION, METHOD OF PRODUCING THE SAME AND METHOD OF USING THE SAME 有权转让
标题翻译：电池片形成用于生产和使用外角膜和方法
公开(公告)号：EP1602383B1
公开(公告)日：2015-05-27
申请号：EP04708896.8
申请日：2004-02-06
申请人： Cellseed Inc. , Nishida, Kohji
发明人： OKANO, Teruo , NISHIDA, Kohji , YAMATO, Masayuki
IPC分类号： A61L27/38 , C12N5/00 , C12N11/02
CPC分类号： A61L27/3891 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80 DEG C, optionally stratifying the layer of cultured cells, and thereafter, (1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature, (2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and (3) detaching the sheet together with the carrier under specified conditions.

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