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1. 发明授权

EP1731030B1 METHOD OF CONSTRUCTING ANIMAL HAVING CANCER CELLS TRANSPLANTED THEREINTO 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG EINES TIERS MIT HINEINTRANSPLANTIERTEN KREBSZELLEN
公开(公告)号：EP1731030B1
公开(公告)日：2017-06-21
申请号：EP05720067
申请日：2005-03-04
申请人： CELLSEED INC
发明人： OKANO TERUO , KIKUCHI AKIHIKO , YAMATO MASAYUKI , MASUDA AKIRA
IPC分类号： C12N5/09 , A01K67/027 , A61K49/00 , G01N33/15
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008 , C12N5/0693

2. 发明公开

EP2642286A4 NOVEL METHOD FOR ANALYZING GLYCOSAMINOGLYCAN 审中-公开
标题翻译：新方法分析糖胺聚糖
公开(公告)号：EP2642286A4
公开(公告)日：2015-06-03
申请号：EP11841620
申请日：2011-11-18
申请人： CELLSEED INC , UNIV HOKKAIDO NAT UNIV CORP
发明人： TAKEGAWA YASUHIRO , SHINOHARA YASURO , SAKAI HIDEAKI
IPC分类号： G01N30/88 , G01N27/62 , G01N30/06 , G01N30/72 , G01N30/74
CPC分类号： G01N21/6486 , G01N30/7233 , G01N30/74 , G01N30/96 , G01N2021/6439 , G01N2030/067 , G01N2030/8836

3. 发明公开

EP2617438A4 MIDDLE EAR MUCOUS MEMBRANE-LIKE CELL SHEET, PRODUCTION METHOD THEREFOR AND UTILIZATION THEREOF 有权
标题翻译：中耳粘膜细胞层，工艺生产同样及其用途
公开(公告)号：EP2617438A4
公开(公告)日：2015-01-21
申请号：EP11825246
申请日：2011-09-15
申请人： UNIV TOKYO WOMENS MEDICAL , JIKEI UNIVERSITY , CELLSEED INC
发明人： HAMA TAKANORI , KOJIMA HIROMI , MORIYAMA HIROSHI , YAMATO MASAYUKI , OKANO TERUO
IPC分类号： A61L27/00 , A61F2/18 , C12N5/071
CPC分类号： A61F2/18 , A61F2002/183 , A61F2310/00365 , A61K35/12 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/3886 , A61L2430/14 , C12N5/062 , C12N2533/30
摘要： The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cells in the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80°C, wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.

4. 发明授权

EP1600498B1 SUBSTRATES FOR HIGH-DENSITY CELL ARRAYS AND PREPARATION PROCESSES AND USES THEREOF 有权
标题翻译：用于高密度ZELLA ORDER板，处理衬底制备和使用它的方法
公开(公告)号：EP1600498B1
公开(公告)日：2012-08-15
申请号：EP03703212.5
申请日：2003-02-06
申请人： Cellseed Inc.
发明人： YAMATO, Masayuki , OKANO, Teruo
IPC分类号： G01N33/50
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/5011 , G01N33/5014
摘要： It is intended to provide a culture board, cell arrays, an automatic injector for chemicals and an assay system which are required in conveniently assaying various chemicals such as drugs and toxins. Use is made of a high-density cell array board characterized in that, on the surface thereof, domains coated with a cell-adhesive polymer are discontinuously, finely and regularly aligned and these domains are surrounded by domains coated with a cell-nonadhesive and hydrophilic polymer which are further continuously surrounded with domains coated with a cell-nonadhesive and strongly hydrophobic material. Using this high-density cell array board and an assay system with the use of the same, the concentration of a drug (for example, an anticancer agent) to be used can be optimized and thus side effects of the drug can be largely lessened. At the same time, the therapeutic achievement of the drug on a disease can be largely improved. Moreover, this is a highly effective technique which is also applicable to development of drugs, environmental assessment and fundamental studies in life science.

5. 发明公开

EP2298858A1 Bed material for cell culture, method for co-culture of cell and co-cultured cell sheet obtainable therefrom 审中-公开
标题翻译：垫用于细胞培养过程的细胞的共培养和可生产从其共培养细胞片
公开(公告)号：EP2298858A1
公开(公告)日：2011-03-23
申请号：EP10188520.0
申请日：2001-03-16
申请人： Cellseed Inc.
发明人： Okano, Teruo , Yamato, Masayuki , Kikuchi, Akihiko
IPC分类号： C12M3/00
CPC分类号： C12N5/0619 , C12M35/08 , C12N5/0068 , C12N5/067 , C12N5/0688 , C12N2502/1323 , C12N2502/28 , C12N2535/10 , C12N2539/10
摘要： By using a bed material for cell culture having a surface composed of two domains of domain A coated with a temperature-responsive polymer and domain B composed of any one or a combination of a domain coated with a polymer having high affinity with cells, a domain coated with the temperature-responsive polymer in an amount different from the amount of the temperature-responsive polymer of domain A, and a domain coated with a polymer which responds to a temperature different from the temperature to which domain A responds, a method for the co-culture of a plurality of kinds of cells which has heretofore been difficult becomes possible.
摘要翻译：通过使用床材料，其具有涂覆有涂覆有具有与细胞中的高亲和力，一个结构域的聚合物的任何一种或一个域的组合组成的温度响应性聚合物和域B域A的两个结构域构成的表面的细胞培养涂覆有在量从域A的温度响应性聚合物的量不同的温度响应性聚合物，和涂覆有它响应于来自温度到哪个域A响应时，该方法的不同的温度下的聚合物的域种细胞的多个迄今为止还难以共培养成为可能。

6. 发明公开

EP1602383A4 CELL SHEETS FOR ECTOCORNEA FORMATION, METHOD OF PRODUCING THE SAME AND METHOD OF USING THE SAME 有权转让
标题翻译：电池片形成用于生产和使用外角膜和方法
公开(公告)号：EP1602383A4
公开(公告)日：2009-07-22
申请号：EP04708896
申请日：2004-02-06
申请人： CELLSEED INC , NISHIDA KOHJI
发明人： OKANO TERUO , NISHIDA KOHJI , YAMATO MASAYUKI
IPC分类号： C12N11/02 , A61F2/14 , A61F9/007 , A61L27/00 , A61L27/38 , C12N5/07 , C12N5/071 , C12N5/00
CPC分类号： A61L27/3891 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80 DEG C, optionally stratifying the layer of cultured cells, and thereafter, (1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature, (2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and (3) detaching the sheet together with the carrier under specified conditions.

7. 发明公开

EP1600498A4 HIGH-DENSITY CELL ARRAY BOARD, PROCESS FOR PRODUCING THE SAME AND METHOD OF USING THE SAME 有权
标题翻译：高密度ZELLA ORDER板，工艺用于生产和使用方法相同
公开(公告)号：EP1600498A4
公开(公告)日：2007-11-07
申请号：EP03703212
申请日：2003-02-06
申请人： CELLSEED INC
发明人： YAMATO MASAYUKI , OKANO TERUO
IPC分类号： G01N33/50 , C12M3/04 , C12N5/00 , C12N15/00 , C12Q1/02
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/5011 , G01N33/5014
摘要： It is intended to provide a culture board, cell arrays, an automatic injector for chemicals and an assay system which are required in conveniently assaying various chemicals such as drugs and toxins. Use is made of a high-density cell array board characterized in that, on the surface thereof, domains coated with a cell-adhesive polymer are discontinuously, finely and regularly aligned and these domains are surrounded by domains coated with a cell-nonadhesive and hydrophilic polymer which are further continuously surrounded with domains coated with a cell-nonadhesive and strongly hydrophobic material. Using this high-density cell array board and an assay system with the use of the same, the concentration of a drug (for example, an anticancer agent) to be used can be optimized and thus side effects of the drug can be largely lessened. At the same time, the therapeutic achievement of the drug on a disease can be largely improved. Moreover, this is a highly effective technique which is also applicable to development of drugs, environmental assessment and fundamental studies in life science.

8. 发明公开

EP1302535A4 HEART MUSCLE-LIKE CELL SHEET, THREE-DIMENSIONAL CONSTRUCT, HEART MUSCLE-LIKE TISSUE AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：心肌样细胞层三维构建，心脏肌肉LIKE用于生产织物与方法
公开(公告)号：EP1302535A4
公开(公告)日：2007-08-29
申请号：EP01945762
申请日：2001-07-02
申请人： CELLSEED INC
发明人： OKANO TERUO , SHIMIZU TATSUYA , YAMATO MASAYUKI , KIKUCHI AKIHIKO
IPC分类号： A61K35/12 , A61L27/38 , C12N5/077 , C12N5/06 , C12N5/08
CPC分类号： A61L27/383 , A61K35/12 , A61L27/3826 , A61L27/3839 , C12N5/0657 , C12N2539/10
摘要： A heart muscle cell sheet can be three-dimensionally cultured and a heart muscle-like tissue can be constructed by culturing cells on a cell culture support which comprises a base material coated with a temperature-responsive polymer having an upper or lower critical temperature of dissolution in water of from 0 to 80°C, and then (1) adjusting the temperature of the liquid culture medium to a level higher than the upper critical dissolution temperature or lower than the lower critical dissolution temperature; and, if necessary, (2) closely adhering the cultured cell sheet to a polymer film; and (3) peeling off as such together with the polymer film.

9. 发明公开

EP1602383A1 CELL SHEETS FOR ECTOCORNEA FORMATION, METHOD OF PRODUCING THE SAME AND METHOD OF USING THE SAME 有权转让
标题翻译：电池片形成用于生产和使用外角膜和方法
公开(公告)号：EP1602383A1
公开(公告)日：2005-12-07
申请号：EP04708896.8
申请日：2004-02-06
申请人： Cellseed Inc. , Nishida, Kohji
发明人： OKANO, Teruo , NISHIDA, Kohji , YAMATO, Masayuki
IPC分类号： A61L27/38 , C12N5/00 , C12N11/02
CPC分类号： A61L27/3891 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80°C, optionally stratifying the layer of cultured cells, and thereafter,

(1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature,
(2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and
(3) detaching the sheet together with the carrier under specified conditions.
摘要翻译：本发明具有作为其目的提供acorneal上皮形成thatwill很好地粘附到前眼部组织细胞片。为了达到这个目的，角膜上皮形成细胞片是通过包括培养的步骤中指定的条件下在细胞培养载体，其包括基板角膜上皮形成细胞的方法产生的具有在其表面覆盖有一个温度响应性聚合物的水合力变化的温度范围内的0-80℃，任选地分层的培养细胞的层，此后，（1）调节所述培养液的温度升高到上述的上临界溶解温度的任一者或低于下临界溶解温度，（ 2）使所培养的角膜上皮形成细胞与载体紧密接触，（3）用所述载体在特定条件下一起拆卸片。

10. 发明公开

EP1312669A1 CULTURED EPIDERMAL CELL SHEET, LAMINATED CULTURED SKIN SHEET AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：培养表皮细胞层层叠培养的皮肤层和方法及其
公开(公告)号：EP1312669A1
公开(公告)日：2003-05-21
申请号：EP01945763.9
申请日：2001-07-02
申请人： Cellseed Inc.
发明人： OKANO, Teruo , YAMATO, Masayuki , UTSUMI, Mika , KUSHIDA, Ai , KONNO, Chie , KIKUCHI, Akihiko
IPC分类号： C12N5/06 , C12N5/08 , A61L27/38
CPC分类号： A61L27/3804 , A61L27/362 , A61L27/60 , C12N5/0698 , C12N2502/094 , C12N2502/1323 , C12N2539/10
摘要： Cells are cultured on a cell culture support having a substrate surface coated with a temperature-responsive polymer whose upper or lower critical solution temperature in water is 0~80°C, optionally forming multiple cultured cell layers by a conventional technique, and subsequently:

(1) the temperature of the culture solution is brought to above the upper critical solution temperature or below the lower critical solution temperature;
(2) the cultured epidermal cell sheet or multi-layered skin sheet is brought into close contact with the polymer membrane; and
(3) the sheet is peeled off together with the polymer membrane. The thus obtained epidermal cultured cell sheet and multi-layered cultured skin sheet do not degrade E-cadherin or laminin 5 as contrasted with Dispase treatment and they still involve very few structural defects; these sheets hence hold great promise in clinical applications such as skin grafting.
摘要翻译：细胞在具有涂覆有温度响应性聚合物，其上或低临界溶解温度在水中是0代字号及80℃下，通过常规技术OPTIONALLY形成多个培养细胞的层，并且随后在基板表面上的细胞培养载体培养的：（ 1）培养液的温度高于上临界溶液温度或低于下临界溶解温度升至; （2）培养的表皮细胞片或多层表层板被带入与该聚合物膜紧密接触; 和（3）片材与聚合物膜一起被剥离。将如此得到的培养表皮细胞片和多层培养皮肤片不降解E-钙粘蛋白或层粘连蛋白5与分散酶处理和护理观照它们涉及非常少的结构缺陷; 论文床单因此保持在临床应用中巨大潜力：如皮肤移植。

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