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1. 发明公开

EP0426877A4 METHOD OF PRODUCING COMPOUND SEMICONDUCTOR DEVICES 失效
标题翻译：生产化合物半导体器件的方法
公开(公告)号：EP0426877A4
公开(公告)日：1993-01-27
申请号：EP90907474
申请日：1990-05-29
申请人： NIPPON MINING COMPANY
发明人： SHIMAKURA, HARUHITO NIPPON MINING CO., LTD , ODA, OSAMU NIPPON MINING CO., LTD , KAINOSHO, KEIJI NIPPON MINING CO., LTD
IPC分类号： H01L21/28 , H01L21/285 , H01L21/316 , H01L21/336 , H01L29/78 , H01L29/812 , H01L29/872 , H01L21/31
CPC分类号： H01L29/66522 , H01L21/02241 , H01L21/02255 , H01L21/28264 , H01L21/28581 , H01L21/31666 , H01L29/78 , H01L29/812 , H01L29/872 , Y10S148/065 , Y10S148/118 , Y10S148/119
摘要： A method of producing semiconductor devices wherein a compound semiconductor substrate is contained in a quartz ampoule together with an oxygen gas and elements having higher vapor pressures among those elements constituting the substrate, the ampoule is then sealed and is heated to form an oxide film on the surface of the compound semiconductor substrate, followed by the formation of an electrode metal layer thereon. Thus, there are formed a MOS diode having a small interface level density and a Schottky electrode having a great barrier height and a small ideal factor. Namely, there are obtained a Schottky diode having a good forward current vs. voltage characteristic, a small reverse current and excellent rectifying property and MESFET having small variations in the threshold voltage.
摘要翻译：一种制造半导体器件的方法，其中化合物半导体衬底与构成衬底的那些元素中的氧气和较高蒸气压的元素一起包含在石英安瓿中，然后将安瓿密封并加热以形成氧化膜化合物半导体衬底的表面，然后在其上形成电极金属层。因此，形成了具有小的界面密度的MOS二极管和具有大的势垒高度和小的理想因子的肖特基电极。即，得到肖特基二极管具有良好的正向电流对电压特性，小的反向电流和优异的整流特性以及阈值电压变化小的MESFET。

2. 发明公开

EP0412526A3 Expression vector for hirudin, hirudin fusion protein, transformed microorganism, and method for production of hirudin 失效
标题翻译： HIRUDIN，HIRUDIN FUSION蛋白，转化微生物的表达载体和生产HIRUDIN的方法
公开(公告)号：EP0412526A3
公开(公告)日：1991-03-06
申请号：EP90115226.4
申请日：1990-08-08
申请人： NIPPON MINING COMPANY LIMITED
发明人： Misawa, Satoru, c/o Nippon Mining Co. Ltd. , Matsuda, Hitoshi, c/o Nippon Mining Co. Ltd. , Abe, Shinichiro, c/o Nippon Mining Co. Ltd.
IPC分类号： C12N15/15 , C12P21/02 , C12N15/62 , C07H21/04 , C12N1/21
CPC分类号： C07K14/815 , A61K38/00
摘要： Expression method for hirudin or its variant which is highly expressed and efficiently produced according to the preparation of vector which hirudin or its variant is expressed in the form of a fused protein with all or a part of porcine adenylate kinase, following transformation of Escherichia coli with prepared vector and culturing Moreover, when methionine codon of porcine adenylate kinase is substituted by leucine codon, expression of hirudin and so on can be carried out more efficiently.

3. 发明公开

EP0357865A3 Process for producing omega-hydroxy fatty acids 失效
标题翻译：生产欧米茄 - 羟基脂肪酸的方法
公开(公告)号：EP0357865A3
公开(公告)日：1990-05-16
申请号：EP89104300.2
申请日：1989-03-10
申请人： NIPPON MINING COMPANY LIMITED
发明人： Yokota, Tadafumi , Watanabe, Akio
IPC分类号： C07C59/01 , C07C51/347
CPC分类号： C07C51/367 , C07C59/01
摘要： ω-Hydroxy fatty acids usable for the synthesis of medicaments, perfumes and polymers are produced by subjecting an alkali or alkaline earth metal salt of long-chain dicarboxylic acid monoester to a reduction with a borohydride compound or catalytic hydrogenating reduction treatment.
摘要翻译：可用于合成药物，香料和聚合物的ω-羟基脂肪酸通过用硼氢化合物还原或催化氢化还原处理使长链二羧酸单酯的碱金属或碱土金属盐进行还原来制备。

4. 发明公开

EP0285372A3 Method for purifying macrocyclic ketones 失效
标题翻译：纯化大分子克隆的方法
公开(公告)号：EP0285372A3
公开(公告)日：1990-04-25
申请号：EP88302784.9
申请日：1988-03-29
申请人： NIPPON MINING COMPANY LIMITED
发明人： Yokota, Tadafumi c/o Nippon Mining Co. Ltd. , Okino, Hiroshi c/o Nippon Mining Co. Ltd.
IPC分类号： C07C45/78 , C07C45/79 , C07C45/85 , C07C49/385 , C07C45/45 , C07C45/65
CPC分类号： C07C45/85 , C07C45/45 , C07C45/65 , C07C45/78 , C07C45/79 , C07C49/385
摘要： A method for purifying a macrocyclic ketone is disclosed which comprises light-irradiating a macrocyclic ketone containing a macrocyclic diketone as an impurity. Preferably, the macrocyclic ketone as light-irradiated is treated with an active charcoal so as to elevate the purity of the resulting macrocyclic ketone. For light-irradiation, the macrocyclic ketone may be in the form of an alcohol solution.

5. 发明公开

EP0324556A2 Method to improve mRNA translation and use thereof for production of platelet factor-4 失效
标题翻译：用于改善mRNA及其用于生产血小板因子的应用的翻译。4
公开(公告)号：EP0324556A2
公开(公告)日：1989-07-19
申请号：EP89300128.9
申请日：1989-01-06
申请人： NIPPON MINING COMPANY
发明人： Johnson, Paul H
IPC分类号： C12N15/00 , C12P21/02
CPC分类号： C12N15/62 , A61K38/00 , C07K14/522 , C07K2319/00 , C07K2319/75 , C12N15/67
摘要： The present invention provides a method to improve the expression of a poorly expressed recombinant protein, such as platelet factor 4, by constructing a gene fusion such that unfavorable secondary structure formed between the region of the messenger RNA specifying the recombinant protein and the region of the messenger RNA containing the ribosome binding site is disrupted. The gene fusion is constructed by inserting a DNA segment of sufficient length to disrupt unfavorable long-range folding interactions which render the ribosome binding site inaccessible to ribosomes thereby interfering with the translation of mRNA. The invention further provides for the expression of recombinant platelet factor 4 and provides recombinant DNA vectors and methods for the bacterial production and recovery of said platelet factor 4.
摘要翻译：本发明提供了一个方法来改善过表达很差重组蛋白，颜色的表达：如血小板因子4，通过构建的基因融合搜索做的信使RNA指定重组蛋白的区域和的所述区域之间形成不利的二级结构信使RNA含有核糖体结合位点被破坏。基因融合是通过将足够长度的DNA片段以破坏不利远距离折叠相互作用其使得核糖体结合位点无法进入核糖体从而与mRNA的翻译干扰构成。本发明进一步提供用于重组血小板因子4的表达，并提供的重组DNA载体和方法细菌生产和血小板因子的恢复所述第四

6. 发明公开

EP0324270A1 Biologically active peptides 失效转让
标题翻译：生物生物志贺卡肽。
公开(公告)号：EP0324270A1
公开(公告)日：1989-07-19
申请号：EP88312278.0
申请日：1988-12-23
申请人： NIPPON MINING COMPANY LIMITED
发明人： Suzuki, Naoyoshi , Osaki, Humio
IPC分类号： C07K7/06 , A61K37/02
CPC分类号： C07K14/4703 , A61K38/00
摘要： Biologically active peptides each having an activity to inhibit multiplication of toxoplasma and having a structure composed of amino acid sequence by the formula Gly-Glu-Glu-Glu-Glu-Glu; Glu-Glu-Glu-Glu-Glu; Asp-Asp-Asp-Asp-Asp; or Ala-Asp-Asp-Asp-Asp-Asp. These peptides are estimated to form active units or cores of Obioactin. The peptides may be applied in various dosage forms to human being and animals as immunoregulators against attack by toxoplasma, since they exhibit no specie specificity and have Toxo-GIF activities of 10 or more times on weight basis, and 40 or more time on molar basis, of that of the crude Obioactin.
摘要翻译：生物活性肽各自具有抑制弓形体增殖并具有由Gly-Glu-Glu-Glu-Glu-Glu-Glu的氨基酸序列构成的结构的活性; GLU-GLU-GLU-GLU-谷氨酸; ASP-ASP-ASP-ASP-ASP; 或Ala-Asp-Asp-Asp-Asp-Asp。估计这些肽形成活性单位或核苷酸的生物活性。肽可以各种剂型施用于人和动物作为抗弓形虫侵袭的免疫调节剂，因为它们不表现出特异性，并且以重量为基准具有10倍或更多倍的Toxo-GIF活性，并且以摩尔计为40个或更多次，原始的Obioactin的。

7. 发明公开

EP0308962A2 Process for production of dimethylnaphthalenes 失效
标题翻译： Verfahren zur Erzeugung von Dimethylnaphthalenen。
公开(公告)号：EP0308962A2
公开(公告)日：1989-03-29
申请号：EP88115698.8
申请日：1988-09-23
申请人： NIPPON MINING COMPANY LIMITED
发明人： Yano, Kyoji, c/o Nippon Mining Co. Ltd. , Aizawa, Shirou, c/o Nippon Mining Co. Ltd.
IPC分类号： C10G45/68 , C10G67/06
CPC分类号： C10G45/68 , C10G69/02
摘要： A process for production of dimethylnaphthalenes is disclosed, comprising a raffinate resulting from the recovery of normal paraffins form a hydrodesulfurized kerosene fraction to reforming reaction and then recovering dimethylnaphthalenes from the product oil.
摘要翻译：公开了一种生产二甲基萘的方法，其中包括由正链烷烃回收形成加氢脱硫煤油馏分至重整反应产生的萃余液，然后从产物油中回收二甲基萘。

8. 发明授权

EP0185851B1 Process for producing alkanesulfonic acids 有权转让
标题翻译：生产碱性磷酸的方法
公开(公告)号：EP0185851B1
公开(公告)日：1988-12-14
申请号：EP85111500.6
申请日：1985-09-11
申请人： NIPPON MINING COMPANY LIMITED
发明人： Sato, Yasukazu, c/o Nippon Mining Co.,Ltd. , Matsuda, Kenichi, c/o Nippon Mining Co.,Ltd. , Ozaki, Hiromi, c/o Nippon Mining Co.,Ltd. , Suzuka, Teruo, c/o Nippon Mining Co.,Ltd. , Yamane, Mamoru, c/o Nippon Mining Co.,Ltd.
IPC分类号： C07C139/04
CPC分类号： C07C303/14 , C07C309/04

9. 发明公开

EP0293069A1 Improvement of the Cetane Number of Diesel Engine Fuels 失效
标题翻译： Verbesserung der Cetanzahl von Dieselkraftstoffen。
公开(公告)号：EP0293069A1
公开(公告)日：1988-11-30
申请号：EP88302532.2
申请日：1988-03-23
申请人： NIPPON MINING COMPANY LIMITED , KYODO OIL TECHNICAL RESEARCH CENTER CO., LTD.
发明人： Date, Kazuto c/o Kyodo Oil Technical Research , Tamanouchi, Mitsuo c/o Kyodo Oil Technical , Kudoh, Masuo c/o Kyodo Oil Technical Center , Tanaka, Hideo c/o Technical Research Center, , Kawate, Akihiro , Akada, Takumi , Sasaki, Takanobu
IPC分类号： C10L1/18
CPC分类号： C10L1/1811 , F02B3/06 , F02B47/00
摘要： Disclosed is a novel cetane number improver additive for diesel engine fuels comprising tetralin hydroperoxide as the active ingredient. A diesel engine fuel composition having a high cetane number may be obtained by adding this additive to a diesel engine fuel in such an amount as to adjust its peroxide number to a value of 100 to 1,000. Also disclosed is a process for the production of a diesel engine fuel which comprises the steps of hdyrogenating a naphthalene- or alkylnaphthalenes-containing hydrocarbon oil and partially oxidizing the hydrogenated oil to yield a hydrocarbon oil containing tetralin hydroperoxide.
摘要翻译：公开了一种用于柴油发动机燃料的新型十六烷值改进剂添加剂，其包含氢化四氢化萘作为活性成分。通过将该添加剂添加到柴油发动机燃料中可以获得具有高十六烷值的柴油发动机燃料组合物，其量将其过氧化物数量调节至100至1,000的值。还公开了一种用于生产柴油发动机燃料的方法，其包括将含萘或烷基萘的烃油进行氢化并部分氧化氢化油以产生含有四氢化萘氢过氧化物的烃油。

10. 发明公开

EP0290015A1 Process for preparing macrocyclic 2-Halogenoketones 失效
标题翻译： Verfahren und Herstellung makrozyklischer 2-卤代酮。
公开(公告)号：EP0290015A1
公开(公告)日：1988-11-09
申请号：EP88107216.9
申请日：1988-05-05
申请人： SAGAMI CHEMICAL RESEARCH CENTER , NIPPON MINING COMPANY LIMITED
发明人： Matsumoto, Masakatsu , Fujimoto, Tamotsu , Ejiri, Emiko
IPC分类号： C07C49/457 , C07C45/63
CPC分类号： C07C49/457 , C07C45/63
摘要： Macrocyclic 2-halogenoketones are prepared by reacting a macrocyclic 2-hydroxyketone with a halogenating agent. This reaction may be carried out in the presence of a solvent and/or a catalyst.
摘要翻译：大环2-卤代酮通过大环2-羟基酮与卤化剂反应来制备。该反应可以在溶剂和/或催化剂的存在下进行。

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