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    • 6. 发明公开
    • AUTOMATIC ISOTHERMAL TITRATION MICROCALORIMETER APPARATUS AND METHOD OF USE
    • 摩托车自行车司机ISOTHERMALE TITRIERUNG UND VERWENDUNGSVERFAHRENDAFÜR
    • EP2352993A4
    • 2015-10-21
    • EP09830940
    • 2009-12-01
    • MALVERN INSTR INC
    • BROGA MARTINPRICE PHILLIP ESMITH STEPHEN
    • G01N25/48
    • G01N25/4873G01K17/006G01N1/14G01N25/20G01N25/48G01N25/4813G01N25/4866G01N35/00584G01N35/0092G01N35/1002
    • An isothermal titration micro calorimetry (ITC) system (300), comprising: a microcalorimeter (20), an automatic pipette assembly (30), a pipette translation unit (310) and a wash station.. The microcalorimeter (20) has a sample cell (50) and a reference cell (40), the sample cell (50) accessible via a sample cell stem (180) and the reference cell accessible via a reference cell stem (170). The automatic pipette assembly (30) comprise a syringe (200) with a titration needle (210) arranged to be inserted into the sample cell (50) for supplying titrant and a fill port (500) at an upper section of the syringe (200), providing fluidic contact with the syringe cavity when the plunger (230) is positioned above the fill port (500). The pipette assembly (30) also comprises an activator (220) for driving a plunger (230) in the syringe (200). The pipette translation unit (310) comprises a pipette arm (380) that is supported for rotation about an axis (A), supports the pipette assembly (30) at its other end and is further arranged to move the pipette assembly vertically. The pipette translation unit (310) is arranged to place the pipette assembly (30) in position for titration, washing and filling operations. The wash station is for the titrant needle (210).
    • 自动等温滴定微量热法(ITC)系统,其包括具有样品池和参考细胞的微量热计,样品池可通过样品细胞干获得,并且参考细胞可通过参考细胞茎进入。 所述系统还包括自动移液管组件,其包括具有滴定针的注射器,所述滴定针布置成插入到所述样品池中用于供应滴定剂,所述移液管组件包括用于驱动所述注射器中的柱塞的活化剂,支持所述移液管组件的移液管平移单元, 布置成将移液管放置在适当位置用于滴定,洗涤和灌装操作,用于滴定针的洗涤台,以及细胞制备单元,其被配置为当移液管放置在另一位置时执行替换样品池中的样品液体的操作, 滴定的位置。